HUMAN:CUL4B

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	CUL4B (synonyms: KIAA0695)
Protein Name(s)	Cullin-4B CUL-4B
External Links
UniProt	Q13620
EMBL	AY365125 AF212995 AK123688 AK299081 AK315037 BX537787 AC002476 AL451005 AC002476 CH471107 BC036216 AB014595 U58091
CCDS	CCDS35379.1 CCDS43987.1
RefSeq	NP_001073341.1 NP_003579.3
UniGene	Hs.102914
PDB	2DO7 4A0C 4A0L 4A64
PDBsum	2DO7 4A0C 4A0L 4A64
ProteinModelPortal	Q13620
SMR	Q13620
BioGrid	114028
DIP	DIP-31609N
IntAct	Q13620
MINT	MINT-4774381
STRING	9606.ENSP00000384109
PhosphoSite	Q13620
DMDM	296439468
MaxQB	Q13620
PaxDb	Q13620
PRIDE	Q13620
DNASU	8450
Ensembl	ENST00000371322 ENST00000404115
GeneID	8450
KEGG	hsa:8450
UCSC	uc004esv.3 uc004esw.3
CTD	8450
GeneCards	GC0XM119658
H-InvDB	HIX0017025
HGNC	HGNC:2555
HPA	CAB017786 HPA003046 HPA011880
MIM	300304 300354
neXtProt	NX_Q13620
Orphanet	85293
PharmGKB	PA27051
eggNOG	COG5647
GeneTree	ENSGT00760000119212
HOVERGEN	HBG003619
InParanoid	Q13620
KO	K10609
OMA	LQKGLNH
OrthoDB	EOG75TMB5
PhylomeDB	Q13620
TreeFam	TF101153
UniPathway	UPA00143
ChiTaRS	CUL4B
EvolutionaryTrace	Q13620
GeneWiki	CUL4B
GenomeRNAi	8450
NextBio	31618
PMAP-CutDB	Q13620
PRO	PR:Q13620
Proteomes	UP000005640
Bgee	Q13620
CleanEx	HS_CUL4B
ExpressionAtlas	Q13620
Genevestigator	Q13620
GO	GO:0031465 GO:0005737 GO:0070062 GO:0005634 GO:0005886 GO:0007049 GO:0035518 GO:1900087 GO:0045732 GO:0006511 GO:0070914
Gene3D	1.10.10.10
InterPro	IPR016157 IPR016158 IPR001373 IPR019559 IPR016159 IPR011991
Pfam	PF00888 PF10557
SMART	SM00182 SM00884
SUPFAM	SSF74788 SSF75632
PROSITE	PS01256 PS50069

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0004842	ubiquitin-protein ligase activity	PMID:23479742^[1]	ECO:0000314			F		Figure 1	complete CACAO 9185
involved_in	GO:0042254	ribosome biogenesis	PMID:26711351^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	PMID:28437394^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(UniProtKB:Q14498)	Seeded From UniProt	complete
part_of	GO:0080008	Cul4-RING E3 ubiquitin ligase complex	PMID:16949367^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0070914	UV-damage excision repair	PMID:22334663^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19056867^[6]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
involved_in	GO:0035518	histone H2A monoubiquitination	PMID:22334663^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:Q7L7L0)	Seeded From UniProt	complete
part_of	GO:0031465	Cul4B-RING E3 ubiquitin ligase complex	PMID:22334663^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
contributes_to	GO:0003684	damaged DNA binding	PMID:22334663^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(GO:0000788) happens_during:(GO:0070914)	Seeded From UniProt	complete
part_of	GO:0031465	Cul4B-RING E3 ubiquitin ligase complex	PMID:18794347^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000082	G1/S transition of mitotic cell cycle	PMID:8681378^[8]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0031465	Cul4B-RING E3 ubiquitin ligase complex	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000232265 UniProtKB:Q13620	C		Seeded From UniProt	complete
part_of	GO:0031461	cullin-RING ubiquitin ligase complex	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000231993 UniProtKB:Q13616 UniProtKB:Q57UJ3	C		Seeded From UniProt	complete
involved_in	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1349658 PANTHER:PTN000231993 PomBase:SPAC17G6.12 SGD:S000002290 UniProtKB:Q13616 UniProtKB:Q5AJB7	P		Seeded From UniProt	complete
part_of	GO:0019005	SCF ubiquitin ligase complex	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015509 MGI:MGI:1349658 PANTHER:PTN000231993 PomBase:SPAC17G6.12 SGD:S000002290 UniProtKB:Q13616 dictyBase:DDB_G0291972	C		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000232236 UniProtKB:A0A1D8PDR1	P		Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1914487 PANTHER:PTN000231993 SGD:S000002290 SGD:S000003235 UniProtKB:Q13618 UniProtKB:Q57UJ3	P		Seeded From UniProt	complete
part_of	GO:0080008	Cul4-RING E3 ubiquitin ligase complex	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0033260 PANTHER:PTN000748578 TAIR:locus:2162060 UniProtKB:Q13619 UniProtKB:Q13620	C		Seeded From UniProt	complete
contributes_to	GO:0061630	ubiquitin protein ligase activity	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000231993 SGD:S000002290	F		Seeded From UniProt	complete
involved_in	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0261268 MGI:MGI:1347360 MGI:MGI:1349658 MGI:MGI:1914487 PANTHER:PTN000231993 PomBase:SPAC17G6.12 SGD:S000002290 UniProtKB:Q13616 UniProtKB:Q13618 UniProtKB:Q13619 UniProtKB:Q5AJB7 WB:WBGene00000837 WB:WBGene00000839	P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015509 FB:FBgn0032956 FB:FBgn0033260 FB:FBgn0039632 FB:FBgn0261268 PANTHER:PTN000231993 UniProtKB:Q13617 UniProtKB:Q93034	F		Seeded From UniProt	complete
part_of	GO:0031465	Cul4B-RING E3 ubiquitin ligase complex	PMID:21628527^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0010498	proteasomal protein catabolic process	PMID:25970626^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010498	proteasomal protein catabolic process	PMID:25970626^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A2A432 ensembl:ENSMUSP00000110771	P		Seeded From UniProt	complete
involved_in	GO:0045732	positive regulation of protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A2A432 ensembl:ENSMUSP00000110771	P		Seeded From UniProt	complete
involved_in	GO:0042254	ribosome biogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A2A432 ensembl:ENSMUSP00000110771	P		Seeded From UniProt	complete
involved_in	GO:0031175	neuron projection development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZK73 ensembl:ENSRNOP00000060639	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZK73 ensembl:ENSRNOP00000060639	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZK73 ensembl:ENSRNOP00000060639	C		Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001373 InterPro:IPR016157	P		Seeded From UniProt	complete
part_of	GO:0031461	cullin-RING ubiquitin ligase complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016157	C		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001373 InterPro:IPR016157	F		Seeded From UniProt	complete
involved_in	GO:0070911	global genome nucleotide-excision repair	Reactome:R-HSA-5696399	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043687	post-translational protein modification	Reactome:R-HSA-597592	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042769	DNA damage response, detection of DNA damage	Reactome:R-HSA-110314	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033683	nucleotide-excision repair, DNA incision	Reactome:R-HSA-5696400	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006296	nucleotide-excision repair, DNA incision, 5'-to lesion	Reactome:R-HSA-5690988	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006295	nucleotide-excision repair, DNA incision, 3'-to lesion	Reactome:R-HSA-5690990	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006294	nucleotide-excision repair, preincision complex assembly	Reactome:R-HSA-5691000 Reactome:R-HSA-5689861 Reactome:R-HSA-5689317	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006293	nucleotide-excision repair, preincision complex stabilization	Reactome:R-HSA-5690991	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006283	transcription-coupled nucleotide-excision repair	Reactome:R-HSA-6781827	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-8956045 Reactome:R-HSA-8955285 Reactome:R-HSA-8955245 Reactome:R-HSA-8952639 Reactome:R-HSA-8952638 Reactome:R-HSA-6790487 Reactome:R-HSA-6790454 Reactome:R-HSA-6782943 Reactome:R-HSA-6782234 Reactome:R-HSA-6782227 Reactome:R-HSA-6782224 Reactome:R-HSA-6782211 Reactome:R-HSA-6782208 Reactome:R-HSA-6782204 Reactome:R-HSA-6782141 Reactome:R-HSA-6782138 Reactome:R-HSA-6782131 Reactome:R-HSA-6782069 Reactome:R-HSA-6782004 Reactome:R-HSA-6781867 Reactome:R-HSA-6781833 Reactome:R-HSA-5696670 Reactome:R-HSA-5696664 Reactome:R-HSA-5696655 Reactome:R-HSA-5691006 Reactome:R-HSA-5691000 Reactome:R-HSA-5690996 Reactome:R-HSA-5690991 Reactome:R-HSA-5690990 Reactome:R-HSA-5690988 Reactome:R-HSA-5690213 Reactome:R-HSA-5689861 Reactome:R-HSA-5689317 Reactome:R-HSA-5652009 Reactome:R-HSA-5652005	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000717	nucleotide-excision repair, DNA duplex unwinding	Reactome:R-HSA-5690996	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000715	nucleotide-excision repair, DNA damage recognition	Reactome:R-HSA-5696394	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00143	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Zou, Y et al. (2013) CUL4B promotes replication licensing by up-regulating the CDK2-CDC6 cascade. J. Cell Biol. 200 743-56 PubMed GONUTS page
↑ Badertscher, L et al. (2015) Genome-wide RNAi Screening Identifies Protein Modules Required for 40S Subunit Synthesis in Human Cells. Cell Rep 13 2879-91 PubMed GONUTS page
↑ Uehara, T et al. (2017) Selective degradation of splicing factor CAPERα by anticancer sulfonamides. Nat. Chem. Biol. 13 675-680 PubMed GONUTS page
↑ Jin, J et al. (2006) A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. Mol. Cell 23 709-21 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Lan, L et al. (2012) Monoubiquitinated histone H2A destabilizes photolesion-containing nucleosomes with concomitant release of UV-damaged DNA-binding protein E3 ligase. J. Biol. Chem. 287 12036-49 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ Abbas, T et al. (2008) PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex. Genes Dev. 22 2496-506 PubMed GONUTS page
↑ Kipreos, ET et al. (1996) cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family. Cell 85 829-39 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 ^9.7 ^9.8 ^9.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Shibata, E et al. (2011) Selective ubiquitylation of p21 and Cdt1 by UBCH8 and UBE2G ubiquitin-conjugating enzymes via the CRL4Cdt2 ubiquitin ligase complex. Mol. Cell. Biol. 31 3136-45 PubMed GONUTS page
↑ ^11.0 ^11.1 Sjögren, B et al. (2015) FBXO44-Mediated Degradation of RGS2 Protein Uniquely Depends on a Cullin 4B/DDB1 Complex. PLoS ONE 10 e0123581 PubMed GONUTS page

[PMID:23479742-1] Zou, Y et al. (2013) CUL4B promotes replication licensing by up-regulating the CDK2-CDC6 cascade. J. Cell Biol. 200 743-56 PubMed GONUTS page

[PMID:26711351-2] Badertscher, L et al. (2015) Genome-wide RNAi Screening Identifies Protein Modules Required for 40S Subunit Synthesis in Human Cells. Cell Rep 13 2879-91 PubMed GONUTS page

[PMID:28437394-3] Uehara, T et al. (2017) Selective degradation of splicing factor CAPERα by anticancer sulfonamides. Nat. Chem. Biol. 13 675-680 PubMed GONUTS page

[PMID:16949367-4] Jin, J et al. (2006) A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. Mol. Cell 23 709-21 PubMed GONUTS page

[PMID:22334663-5] 5.0 ^5.1 ^5.2 ^5.3 Lan, L et al. (2012) Monoubiquitinated histone H2A destabilizes photolesion-containing nucleosomes with concomitant release of UV-damaged DNA-binding protein E3 ligase. J. Biol. Chem. 287 12036-49 PubMed GONUTS page

[PMID:19056867-6] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:18794347-7] Abbas, T et al. (2008) PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex. Genes Dev. 22 2496-506 PubMed GONUTS page

[PMID:8681378-8] Kipreos, ET et al. (1996) cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family. Cell 85 829-39 PubMed GONUTS page

[PMID:21873635-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 ^9.7 ^9.8 ^9.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21628527-10] Shibata, E et al. (2011) Selective ubiquitylation of p21 and Cdt1 by UBCH8 and UBE2G ubiquitin-conjugating enzymes via the CRL4Cdt2 ubiquitin ligase complex. Mol. Cell. Biol. 31 3136-45 PubMed GONUTS page

[PMID:25970626-11] 11.0 ^11.1 Sjögren, B et al. (2015) FBXO44-Mediated Degradation of RGS2 Protein Uniquely Depends on a Cullin 4B/DDB1 Complex. PLoS ONE 10 e0123581 PubMed GONUTS page

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HUMAN:CUL4B

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Notes

References

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