MOUSE:SKP1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Skp1 (synonyms: Skp1a)
Protein Name(s)	S-phase kinase-associated protein 1 Cyclin-A/CDK2-associated protein p19 S-phase kinase-associated protein 1A p19A p19skp1
External Links
UniProt	Q9WTX5
EMBL	AF083214 AK002983 AK010628 AK012498 AK014245 AK027909 AK078330 AK088339 BC002115
CCDS	CCDS24669.1
RefSeq	NP_035673.3 XP_006532849.1
UniGene	Mm.42944
ProteinModelPortal	Q9WTX5
SMR	Q9WTX5
BioGrid	203998
DIP	DIP-38596N
IntAct	Q9WTX5
MINT	MINT-4134768
PhosphoSite	Q9WTX5
REPRODUCTION-2DPAGE	Q9WTX5
MaxQB	Q9WTX5
PaxDb	Q9WTX5
PRIDE	Q9WTX5
Ensembl	ENSMUST00000037324 ENSMUST00000109072
GeneID	21402
KEGG	mmu:21402
UCSC	uc007ivf.2
CTD	21402
MGI	MGI:103575
eggNOG	COG5201
GeneTree	ENSGT00390000012652
HOGENOM	HOG000172184
HOVERGEN	HBG057008
InParanoid	Q9WTX5
KO	K03094
OMA	ICSWDAE
PhylomeDB	Q9WTX5
TreeFam	TF354233
Reactome	REACT_196464 REACT_196589 REACT_196591 REACT_196604 REACT_196635 REACT_198561 REACT_199115 REACT_199121 REACT_203336 REACT_203517 REACT_220647 REACT_224208 REACT_258573 REACT_268522 REACT_268705 REACT_270923
UniPathway	UPA00143
NextBio	300668
PRO	PR:Q9WTX5
Proteomes	UP000000589
Bgee	Q9WTX5
CleanEx	MM_SKP1A
ExpressionAtlas	Q9WTX5
Genevestigator	Q9WTX5
GO	GO:0031467 GO:0005829 GO:0019005 GO:0016567 GO:0031146 GO:0006511
InterPro	IPR011333 IPR016897 IPR001232 IPR016072 IPR016073
Pfam	PF01466 PF03931
PIRSF	PIRSF028729
SMART	SM00512
SUPFAM	SSF54695 SSF81382

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005813	centrosome	PMID:10485847^[1]	ECO:0000314			C		Figure 2	complete CACAO 7034
part_of	GO:0005813	centrosome	PMID:10485847^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031467	Cul7-RING ubiquitin ligase complex	PMID:21572988^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000031)	Seeded From UniProt	complete
involved_in	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	PMID:12140560^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0019005	SCF ubiquitin ligase complex	PMID:23452856^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0019005	SCF ubiquitin ligase complex	PMID:12140560^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0019005	SCF ubiquitin ligase complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63208	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:12140560^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0097602	cullin family protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P63208	F		Seeded From UniProt	complete
contributes_to	GO:0061630	ubiquitin protein ligase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P63208	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051457	maintenance of protein location in nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P63208	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035518	histone H2A monoubiquitination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P63208	P		Seeded From UniProt	complete
colocalizes_with	GO:0031519	PcG protein complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P63208	C		Seeded From UniProt	complete
part_of	GO:0031467	Cul7-RING ubiquitin ligase complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P63208	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P63208	P		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P63208	F		Seeded From UniProt	complete
part_of	GO:0019005	SCF ubiquitin ligase complex	PMID:12665572^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0019005	SCF ubiquitin ligase complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P63208	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016567	protein ubiquitination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P63208	P		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P63208	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006511	ubiquitin-dependent protein catabolic process	PMID:12665572^[5]	ECO:0000305	curator inference used in manual assertion	GO:0019005	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P63208	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P63208	C		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P63208	F		Seeded From UniProt	complete
contributes_to	GO:0004842	ubiquitin-protein transferase activity	PMID:12665572^[5]	ECO:0000305	curator inference used in manual assertion	GO:0019005	F		Seeded From UniProt	complete
enables	GO:0097602	cullin family protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63208 ensembl:ENSP00000231487	F		Seeded From UniProt	complete
enables	GO:0061630	ubiquitin protein ligase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63208 ensembl:ENSP00000231487	F		Seeded From UniProt	complete
involved_in	GO:0051457	maintenance of protein location in nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63208 ensembl:ENSP00000231487	P		Seeded From UniProt	complete
involved_in	GO:0035518	histone H2A monoubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63208 ensembl:ENSP00000231487	P		Seeded From UniProt	complete
part_of	GO:0031519	PcG protein complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63208 ensembl:ENSP00000231487	C		Seeded From UniProt	complete
part_of	GO:0031467	Cul7-RING ubiquitin ligase complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63208 ensembl:ENSP00000231487	C		Seeded From UniProt	complete
involved_in	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63208 ensembl:ENSP00000231487	P		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63208 ensembl:ENSP00000231487	F		Seeded From UniProt	complete
part_of	GO:0019005	SCF ubiquitin ligase complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63208 ensembl:ENSP00000231487	C		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63208 ensembl:ENSP00000231487	P		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63208 ensembl:ENSP00000231487	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63208 ensembl:ENSP00000231487	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63208 ensembl:ENSP00000231487	C		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63208 ensembl:ENSP00000231487	F		Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001232 InterPro:IPR016072 InterPro:IPR016073 InterPro:IPR016897 InterPro:IPR036296	P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-MMU-9008717 Reactome:R-MMU-9008715 Reactome:R-MMU-9008677	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00143	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Freed, E et al. (1999) Components of an SCF ubiquitin ligase localize to the centrosome and regulate the centrosome duplication cycle. Genes Dev. 13 2242-57 PubMed GONUTS page
↑ Litterman, N et al. (2011) An OBSL1-Cul7Fbxw8 ubiquitin ligase signaling mechanism regulates Golgi morphology and dendrite patterning. PLoS Biol. 9 e1001060 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Yoshida, Y et al. (2002) E3 ubiquitin ligase that recognizes sugar chains. Nature 418 438-42 PubMed GONUTS page
↑ Hirano, A et al. (2013) FBXL21 regulates oscillation of the circadian clock through ubiquitination and stabilization of cryptochromes. Cell 152 1106-18 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Tokuzawa, Y et al. (2003) Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development. Mol. Cell. Biol. 23 2699-708 PubMed GONUTS page

[PMID:10485847-1] 1.0 ^1.1 Freed, E et al. (1999) Components of an SCF ubiquitin ligase localize to the centrosome and regulate the centrosome duplication cycle. Genes Dev. 13 2242-57 PubMed GONUTS page

[PMID:21572988-2] Litterman, N et al. (2011) An OBSL1-Cul7Fbxw8 ubiquitin ligase signaling mechanism regulates Golgi morphology and dendrite patterning. PLoS Biol. 9 e1001060 PubMed GONUTS page

[PMID:12140560-3] 3.0 ^3.1 ^3.2 Yoshida, Y et al. (2002) E3 ubiquitin ligase that recognizes sugar chains. Nature 418 438-42 PubMed GONUTS page

[PMID:23452856-4] Hirano, A et al. (2013) FBXL21 regulates oscillation of the circadian clock through ubiquitination and stabilization of cryptochromes. Cell 152 1106-18 PubMed GONUTS page

[PMID:12665572-5] 5.0 ^5.1 ^5.2 Tokuzawa, Y et al. (2003) Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development. Mol. Cell. Biol. 23 2699-708 PubMed GONUTS page

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MOUSE:SKP1

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