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DROME:HYD

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) hyd (synonyms: l(3)C43)
Protein Name(s) E3 ubiquitin-protein ligase hyd

Protein hyperplastic discs

External Links
UniProt P51592
EMBL L14644
AE014297
PIR T08437
RefSeq NP_524296.2
ProteinModelPortal P51592
SMR P51592
BioGrid 66340
IntAct P51592
STRING 7227.FBpp0081568
PaxDb P51592
PRIDE P51592
EnsemblMetazoa FBtr0082090
GeneID 41181
KEGG dme:Dmel_CG9484
CTD 41181
FlyBase FBgn0002431
eggNOG COG5021
GeneTree ENSGT00770000120501
InParanoid P51592
KO K10593
OMA ICIGALY
OrthoDB EOG73FQMB
PhylomeDB P51592
SignaLink P51592
GenomeRNAi 41181
NextBio 822597
PRO PR:P51592
Proteomes UP000000803
Bgee P51592
GO GO:0005737
GO:0005634
GO:0016874
GO:0003723
GO:0004842
GO:0008270
GO:0048749
GO:0007455
GO:0008585
GO:0007444
GO:0007446
GO:0007112
GO:0045879
GO:0042787
GO:0030162
GO:0007289
GO:0007283
Gene3D 1.10.1900.10
2.130.10.30
InterPro IPR024725
IPR000569
IPR002004
IPR009091
IPR015940
IPR003126
IPR013993
Pfam PF11547
PF00632
PF00658
PF02207
SMART SM00119
SM00517
SM00396
SUPFAM SSF50985
SSF56204
SSF63570
PROSITE PS50237
PS51309
PS50030
PS51157

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0061630

ubiquitin protein ligase activity

PMID:7708685[1]

ISA: Inferred from Sequence Alignment

UniProtKB:Q05086


F

Fig 1B shows sequence alignment, including highly conserved cysteine residue necessary for Ubiquitin thioester formation.

complete
CACAO 10328

GO:0000209

protein polyubiquitination

PMID:20109150[2]

ISS: Inferred from Sequence or Structural Similarity

HGNC:16806

P

Seeded From UniProt

complete

GO:0003723

RNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002004

F

Seeded From UniProt

complete

GO:0004842

ubiquitin-protein transferase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000569

F

Seeded From UniProt

complete

GO:0004842

ubiquitin-protein transferase activity

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000134256

F

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:7958417[3]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:7958417[3]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0007112

male meiosis cytokinesis

PMID:20604743[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007283

spermatogenesis

PMID:20604743[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007283

spermatogenesis

PMID:7958417[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007289

spermatid nucleus differentiation

PMID:20604743[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007444

imaginal disc development

PMID:402295[5]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007446

imaginal disc growth

PMID:7958417[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007455

eye-antennal disc morphogenesis

PMID:12421709[6]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008270

zinc ion binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003126

F

Seeded From UniProt

complete

GO:0008585

female gonad development

PMID:402295[5]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016874

ligase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0436

F

Seeded From UniProt

complete

GO:0030162

regulation of proteolysis

PMID:12850443[7]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0034450

ubiquitin-ubiquitin ligase activity

PMID:20109150[2]

ISS: Inferred from Sequence or Structural Similarity

HGNC:16806

F

Seeded From UniProt

complete

GO:0042787

protein ubiquitination involved in ubiquitin-dependent protein catabolic process

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000134256

P

Seeded From UniProt

complete

GO:0043130

ubiquitin binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR024725

F

Seeded From UniProt

complete

GO:0045879

negative regulation of smoothened signaling pathway

PMID:12850443[7]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0046872

metal ion binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

GO:0048749

compound eye development

PMID:12850443[7]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Huibregtse, JM et al. (1995) A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase. Proc. Natl. Acad. Sci. U.S.A. 92 2563-7 PubMed GONUTS page
  2. 2.0 2.1 Omelyanchuk, LV et al. (2009) Evolutionary origin of the tumor suppressor hyperplastic discs protein. In Silico Biol. (Gedrukt) 9 203-7 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Mansfield, E et al. (1994) Genetic and molecular analysis of hyperplastic discs, a gene whose product is required for regulation of cell proliferation in Drosophila melanogaster imaginal discs and germ cells. Dev. Biol. 165 507-26 PubMed GONUTS page
  4. 4.0 4.1 4.2 Pertceva, JA et al. (2010) The role of Drosophila hyperplastic discs gene in spermatogenesis. Cell Biol. Int. 34 991-6 PubMed GONUTS page
  5. 5.0 5.1 Martin, P et al. (1977) Studies of l(3)c43hs1 a polyphasic, temperature-sensitive mutant of Drosophila melanogaster with a variety of imaginal disc defects. Dev. Biol. 55 213-32 PubMed GONUTS page
  6. Lee, JD et al. (2002) The ubiquitin ligase Hyperplastic discs negatively regulates hedgehog and decapentaplegic expression by independent mechanisms. Development 129 5697-706 PubMed GONUTS page
  7. 7.0 7.1 7.2 Ou, CY et al. (2003) Control of protein degradation by E3 ubiquitin ligases in Drosophila eye development. Trends Genet. 19 382-9 PubMed GONUTS page