DROME:HYD

Species (Taxon ID)	Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s)	hyd (synonyms: l(3)C43)
Protein Name(s)	E3 ubiquitin-protein ligase hyd Protein hyperplastic discs
External Links
UniProt	P51592
EMBL	L14644 AE014297
PIR	T08437
RefSeq	NP_524296.2
ProteinModelPortal	P51592
SMR	P51592
BioGrid	66340
IntAct	P51592
STRING	7227.FBpp0081568
PaxDb	P51592
PRIDE	P51592
EnsemblMetazoa	FBtr0082090
GeneID	41181
KEGG	dme:Dmel_CG9484
CTD	41181
FlyBase	FBgn0002431
eggNOG	COG5021
GeneTree	ENSGT00770000120501
InParanoid	P51592
KO	K10593
OMA	ICIGALY
OrthoDB	EOG73FQMB
PhylomeDB	P51592
SignaLink	P51592
GenomeRNAi	41181
NextBio	822597
PRO	PR:P51592
Proteomes	UP000000803
Bgee	P51592
GO	GO:0005737 GO:0005634 GO:0016874 GO:0003723 GO:0004842 GO:0008270 GO:0048749 GO:0007455 GO:0008585 GO:0007444 GO:0007446 GO:0007112 GO:0045879 GO:0042787 GO:0030162 GO:0007289 GO:0007283
Gene3D	1.10.1900.10 2.130.10.30
InterPro	IPR024725 IPR000569 IPR002004 IPR009091 IPR015940 IPR003126 IPR013993
Pfam	PF11547 PF00632 PF00658 PF02207
SMART	SM00119 SM00517 SM00396
SUPFAM	SSF50985 SSF56204 SSF63570
PROSITE	PS50237 PS51309 PS50030 PS51157

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0061630	ubiquitin protein ligase activity	PMID:7708685^[1]	ECO:0000247		UniProtKB:Q05086	F	Fig 1B shows sequence alignment, including highly conserved cysteine residue necessary for Ubiquitin thioester formation.	complete CACAO 10328
involved_in	GO:1901315	negative regulation of histone H2A K63-linked ubiquitination	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000883184 UniProtKB:O95071	P	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000134821 UniProtKB:O95071	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0002431 PANTHER:PTN000883184 UniProtKB:O95071	C	Seeded From UniProt	complete
involved_in	GO:0000209	protein polyubiquitination	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000883184 UniProtKB:O95071	P	Seeded From UniProt	complete
involved_in	GO:0007444	imaginal disc development	PMID:402295^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008585	female gonad development	PMID:402295^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007289	spermatid nucleus differentiation	PMID:20604743^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007446	imaginal disc growth	PMID:7958417^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	PMID:7958417^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:7958417^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:7958417^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	PMID:20604743^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007112	male meiosis cytokinesis	PMID:20604743^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0034450	ubiquitin-ubiquitin ligase activity	PMID:20109150^[6]	ECO:0000250	sequence similarity evidence used in manual assertion	HGNC:16806	F	Seeded From UniProt	complete
involved_in	GO:0000209	protein polyubiquitination	PMID:20109150^[6]	ECO:0000250	sequence similarity evidence used in manual assertion	HGNC:16806	P	Seeded From UniProt	complete
involved_in	GO:0007455	eye-antennal disc morphogenesis	PMID:12421709^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0061630	ubiquitin protein ligase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O95071	F	Seeded From UniProt	complete
involved_in	GO:0070936	protein K48-linked ubiquitination	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O95071	P	Seeded From UniProt	complete
involved_in	GO:0090263	positive regulation of canonical Wnt signaling pathway	PMID:28689657^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035220	wing disc development	PMID:28689657^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002004 InterPro:IPR036053	F	Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000569 InterPro:IPR035983	F	Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003126	F	Seeded From UniProt	complete
enables	GO:0043130	ubiquitin binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR024725	F	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Huibregtse, JM et al. (1995) A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase. Proc. Natl. Acad. Sci. U.S.A. 92 2563-7 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^3.0 ^3.1 Martin, P et al. (1977) Studies of l(3)c43hs1 a polyphasic, temperature-sensitive mutant of Drosophila melanogaster with a variety of imaginal disc defects. Dev. Biol. 55 213-32 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Pertceva, JA et al. (2010) The role of Drosophila hyperplastic discs gene in spermatogenesis. Cell Biol. Int. 34 991-6 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Mansfield, E et al. (1994) Genetic and molecular analysis of hyperplastic discs, a gene whose product is required for regulation of cell proliferation in Drosophila melanogaster imaginal discs and germ cells. Dev. Biol. 165 507-26 PubMed GONUTS page
↑ ^6.0 ^6.1 Omelyanchuk, LV et al. (2009) Evolutionary origin of the tumor suppressor hyperplastic discs protein. In Silico Biol. (Gedrukt) 9 203-7 PubMed GONUTS page
↑ Lee, JD et al. (2002) The ubiquitin ligase Hyperplastic discs negatively regulates hedgehog and decapentaplegic expression by independent mechanisms. Development 129 5697-706 PubMed GONUTS page
↑ ^8.0 ^8.1 Flack, JE et al. (2017) Wnt-Dependent Inactivation of the Groucho/TLE Co-repressor by the HECT E3 Ubiquitin Ligase Hyd/UBR5. Mol. Cell 67 181-193.e5 PubMed GONUTS page

[PMID:7708685-1] Huibregtse, JM et al. (1995) A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase. Proc. Natl. Acad. Sci. U.S.A. 92 2563-7 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 ^2.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:402295-3] 3.0 ^3.1 Martin, P et al. (1977) Studies of l(3)c43hs1 a polyphasic, temperature-sensitive mutant of Drosophila melanogaster with a variety of imaginal disc defects. Dev. Biol. 55 213-32 PubMed GONUTS page

[PMID:20604743-4] 4.0 ^4.1 ^4.2 Pertceva, JA et al. (2010) The role of Drosophila hyperplastic discs gene in spermatogenesis. Cell Biol. Int. 34 991-6 PubMed GONUTS page

[PMID:7958417-5] 5.0 ^5.1 ^5.2 ^5.3 Mansfield, E et al. (1994) Genetic and molecular analysis of hyperplastic discs, a gene whose product is required for regulation of cell proliferation in Drosophila melanogaster imaginal discs and germ cells. Dev. Biol. 165 507-26 PubMed GONUTS page

[PMID:20109150-6] 6.0 ^6.1 Omelyanchuk, LV et al. (2009) Evolutionary origin of the tumor suppressor hyperplastic discs protein. In Silico Biol. (Gedrukt) 9 203-7 PubMed GONUTS page

[PMID:12421709-7] Lee, JD et al. (2002) The ubiquitin ligase Hyperplastic discs negatively regulates hedgehog and decapentaplegic expression by independent mechanisms. Development 129 5697-706 PubMed GONUTS page

[PMID:28689657-8] 8.0 ^8.1 Flack, JE et al. (2017) Wnt-Dependent Inactivation of the Groucho/TLE Co-repressor by the HECT E3 Ubiquitin Ligase Hyd/UBR5. Mol. Cell 67 181-193.e5 PubMed GONUTS page

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DROME:HYD

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