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PMID:20109150

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Citation

Omelyanchuk, LV, Pertseva, JA and Saul, JM (2009) Evolutionary origin of the tumor suppressor hyperplastic discs protein. In Silico Biol. (Gedrukt) 9:203-7

Abstract

Previous evolutionary study of the tumor suppressor Merlin revealed that this protein family was produced by very early metazoans with the exception of some or all flatworm lineages [Golovnina et al., 2005]. We ask whether other tumor-suppressor proteins had also been in existence in these times and focus our attention on hyperplastic discs (Hyd) protein, a classic tumor suppressor in Drosophila melanogaster which, when mutated, may cause over-proliferation and malignancy. Phylogenetic analysis of the Hyd protein indicates that it was present among metazoa by the time Trichoplax adhaerens had emerged from the common unicellular ancestor of the Animalia.

Links

PubMed

Keywords

Animals; Biological Evolution; Drosophila Proteins/classification; Drosophila Proteins/genetics; Drosophila Proteins/metabolism; Drosophila melanogaster/classification; Drosophila melanogaster/genetics; Drosophila melanogaster/metabolism; Humans; Molecular Sequence Data; Phylogeny; Tumor Suppressor Proteins/genetics; Tumor Suppressor Proteins/metabolism; Ubiquitin-Protein Ligases/classification; Ubiquitin-Protein Ligases/genetics; Ubiquitin-Protein Ligases/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:HYD

enables

GO:0034450: ubiquitin-ubiquitin ligase activity

ECO:0000250: sequence similarity evidence used in manual assertion

HGNC:16806

F

Seeded From UniProt

complete

DROME:HYD

involved_in

GO:0000209: protein polyubiquitination

ECO:0000250: sequence similarity evidence used in manual assertion

HGNC:16806

P

Seeded From UniProt

complete

Notes

See also

References

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