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HUMAN:UBE3A
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | UBE3A (synonyms: E6AP, EPVE6AP, HPVE6A) | |
| Protein Name(s) | Ubiquitin-protein ligase E3A
E6AP ubiquitin-protein ligase Human papillomavirus E6-associated protein Oncogenic protein-associated protein E6-AP Renal carcinoma antigen NY-REN-54 | |
| External Links | ||
| UniProt | Q05086 | |
| EMBL | X98021 X98027 X98022 X98023 X98024 X98025 X98026 X98028 X98029 X98030 X98031 X98032 X98033 AC100774 AK292514 AC124997 CH471151 L07557 AF016708 AF016703 AF016704 AF016705 AF016706 AF016707 U84404 AJ001107 AJ001108 AJ001109 AJ001110 AJ001111 AJ001112 | |
| CCDS | CCDS32177.1 CCDS45191.1 CCDS45192.1 | |
| RefSeq | NP_000453.2 NP_570853.1 NP_570854.1 XP_005268324.1 XP_005268325.1 XP_005268326.1 XP_005268327.1 XP_005268328.1 XP_006720736.1 XP_006720737.1 XP_006720738.1 XP_006720739.1 | |
| UniGene | Hs.598862 | |
| PDB | 1C4Z 1D5F 1EQX 2KR1 4GIZ | |
| PDBsum | 1C4Z 1D5F 1EQX 2KR1 4GIZ | |
| ProteinModelPortal | Q05086 | |
| SMR | Q05086 | |
| BioGrid | 113185 | |
| DIP | DIP-6002N | |
| IntAct | Q05086 | |
| MINT | MINT-147444 | |
| PhosphoSite | Q05086 | |
| DMDM | 215274240 | |
| MaxQB | Q05086 | |
| PaxDb | Q05086 | |
| PRIDE | Q05086 | |
| DNASU | 7337 | |
| Ensembl | ENST00000232165 ENST00000397954 ENST00000428984 ENST00000438097 ENST00000566215 ENST00000614096 | |
| GeneID | 7337 | |
| KEGG | hsa:7337 | |
| UCSC | uc001zaq.3 uc001zas.3 | |
| CTD | 7337 | |
| GeneCards | GC15M025582 | |
| GeneReviews | UBE3A | |
| HGNC | HGNC:12496 | |
| HPA | HPA039410 | |
| MIM | 105830 601623 | |
| neXtProt | NX_Q05086 | |
| Orphanet | 72 | |
| PharmGKB | PA37144 | |
| eggNOG | COG5021 | |
| GeneTree | ENSGT00760000119192 | |
| HOVERGEN | HBG059326 | |
| InParanoid | Q05086 | |
| KO | K10587 | |
| OMA | DTDHNEE | |
| OrthoDB | EOG7NKKJP | |
| PhylomeDB | Q05086 | |
| TreeFam | TF315189 | |
| Reactome | REACT_75842 | |
| UniPathway | UPA00143 | |
| EvolutionaryTrace | Q05086 | |
| GeneWiki | UBE3A | |
| GenomeRNAi | 7337 | |
| NextBio | 28722 | |
| PRO | PR:Q05086 | |
| Proteomes | UP000005640 | |
| Bgee | Q05086 | |
| ExpressionAtlas | Q05086 | |
| Genevestigator | Q05086 | |
| GO | GO:0005737 GO:0005829 GO:0005634 GO:0000502 GO:0016874 GO:0003713 GO:0004842 GO:0030521 GO:0007420 GO:0001541 GO:0014068 GO:0045944 GO:0060736 GO:0051865 GO:0070936 GO:0042787 GO:0006508 GO:0035037 GO:0006511 GO:0016032 | |
| InterPro | IPR000569 IPR017134 | |
| Pfam | PF00632 | |
| PIRSF | PIRSF037201 | |
| SMART | SM00119 | |
| SUPFAM | SSF56204 | |
| PROSITE | PS50237 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0031398 |
regulation of protein ubiquitination |
ECO:0000314 |
P |
Figures 4-10: Ubiquitin ligase E6AP binds to HCV (Hepatitis C Virus) core protein to mediate and promote ubiquitination and degradation of the core protein. |
complete | |||||
| GO:0004842 |
ubiquitin-protein ligase activity |
ECO:0000314 |
F |
Figure 4c. shows ubiquitinated forms of PML |
complete | |||||
| GO:0061630 |
ubiquitin protein ligase activity |
ECO:0000315 |
F |
Fig4; panel A shows E3 ubiquitin-protein ligase activity. |
complete | |||||
|
involved_in |
GO:0032570 |
response to progesterone |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050847 |
progesterone receptor signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0061630 |
ubiquitin protein ligase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2000058 |
regulation of ubiquitin-dependent protein catabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042752 |
regulation of circadian rhythm |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0031398 |
positive regulation of protein ubiquitination |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0070936 |
protein K48-linked ubiquitination |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004842 |
ubiquitin-protein transferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043161 |
proteasome-mediated ubiquitin-dependent protein catabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0061469 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006511 |
ubiquitin-dependent protein catabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0061469 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0000209 |
protein polyubiquitination |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0061469 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004842 |
ubiquitin-protein transferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051865 |
protein autoubiquitination |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1990416 |
cellular response to brain-derived neurotrophic factor stimulus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:F1M7B8 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0061002 |
negative regulation of dendritic spine morphogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:F1M7B8 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042542 |
response to hydrogen peroxide |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:F1M7B8 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042220 |
response to cocaine |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:F1M7B8 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0061630 |
ubiquitin protein ligase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08759 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060736 |
prostate gland growth |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08759 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08759 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042752 |
regulation of circadian rhythm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08759 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0035037 |
sperm entry |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08759 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030521 |
androgen receptor signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08759 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0016567 |
protein ubiquitination |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08759 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0014068 |
positive regulation of phosphatidylinositol 3-kinase signaling |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08759 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006511 |
ubiquitin-dependent protein catabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08759 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08759 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08759 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003713 |
transcription coactivator activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08759 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001541 |
ovarian follicle development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08759 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004842 |
ubiquitin-protein transferase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006511 |
ubiquitin-dependent protein catabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0061630 |
ubiquitin protein ligase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007420 |
brain development |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006511 |
ubiquitin-dependent protein catabolic process |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0048511 |
rhythmic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016032 |
viral process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000502 |
proteasome complex |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016567 |
protein ubiquitination |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniPathway:UPA00143 |
P |
Seeded From UniProt |
complete | ||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Shirakura, M et al. (2007) E6AP ubiquitin ligase mediates ubiquitylation and degradation of hepatitis C virus core protein. J. Virol. 81 1174-85 PubMed GONUTS page
- ↑ Louria-Hayon, I et al. (2009) E6AP promotes the degradation of the PML tumor suppressor. Cell Death Differ. 16 1156-66 PubMed GONUTS page
- ↑ 3.0 3.1 Huibregtse, JM et al. (1995) A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase. Proc. Natl. Acad. Sci. U.S.A. 92 2563-7 PubMed GONUTS page
- ↑ 4.0 4.1 Dhananjayan, SC et al. (2006) WW domain binding protein-2, an E6-associated protein interacting protein, acts as a coactivator of estrogen and progesterone receptors. Mol. Endocrinol. 20 2343-54 PubMed GONUTS page
- ↑ 5.0 5.1 Gossan, NC et al. (2014) The E3 ubiquitin ligase UBE3A is an integral component of the molecular circadian clock through regulating the BMAL1 transcription factor. Nucleic Acids Res. 42 5765-75 PubMed GONUTS page
- ↑ 6.0 6.1 Wu-Baer, F et al. (2003) The BRCA1/BARD1 heterodimer assembles polyubiquitin chains through an unconventional linkage involving lysine residue K6 of ubiquitin. J. Biol. Chem. 278 34743-6 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 8.0 8.1 Lee, YI et al. (2014) Protein microarray characterization of the S-nitrosoproteome. Mol. Cell Proteomics 13 63-72 PubMed GONUTS page
- ↑ Kishino, T et al. (1997) UBE3A/E6-AP mutations cause Angelman syndrome. Nat. Genet. 15 70-3 PubMed GONUTS page
- ↑ 10.0 10.1 Scheffner, M et al. (1993) The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53. Cell 75 495-505 PubMed GONUTS page
c
o
p
- GO:0031398 ! positive regulation of protein ubiquitination
- GO:0045944 ! positive regulation of transcription by RNA polymerase II
- Primates
- GO:0050847 ! progesterone receptor signaling pathway
- GO:0060736 ! prostate gland growth
- GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process
- GO:0000502 ! proteasome complex
- GO:0051865 ! protein autoubiquitination
- GO:0070936 ! protein K48-linked ubiquitination
- GO:0000209 ! protein polyubiquitination
- GO:0016567 ! protein ubiquitination
- GO:0006508 ! proteolysis
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