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MOUSE:UBR1

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Ubr1
Protein Name(s) E3 ubiquitin-protein ligase UBR1

N-recognin-1 Ubiquitin-protein ligase E3-alpha-1 Ubiquitin-protein ligase E3-alpha-I

External Links
UniProt O70481
EMBL AF061555
AH006182
AL844548
AL935168
AL935168
AL844548
AK078173
AK089616
BC090969
CCDS CCDS16628.1
PIR T14318
RefSeq NP_033487.2
UniGene Mm.389330
ProteinModelPortal O70481
SMR O70481
BioGrid 204422
IntAct O70481
MINT MINT-1580129
PhosphoSite O70481
MaxQB O70481
PaxDb O70481
PRIDE O70481
Ensembl ENSMUST00000028728
GeneID 22222
KEGG mmu:22222
UCSC uc008lxb.1
CTD 197131
MGI MGI:1277977
eggNOG NOG310244
GeneTree ENSGT00530000063055
HOGENOM HOG000231769
HOVERGEN HBG080426
InParanoid O70481
KO K10625
OMA HESTILR
OrthoDB EOG7RNJZB
TreeFam TF323875
Reactome REACT_199115
UniPathway UPA00143
NextBio 302239
PRO PR:O70481
Proteomes UP000000589
Bgee O70481
ExpressionAtlas O70481
Genevestigator O70481
GO GO:0005829
GO:0000502
GO:0000151
GO:0070728
GO:0016874
GO:0004842
GO:0008270
GO:0071233
GO:0032007
GO:0006511
Gene3D 3.30.1390.10
InterPro IPR003769
IPR014719
IPR003126
IPR013993
Pfam PF02617
PF02207
SMART SM00396
SUPFAM SSF54736
PROSITE PS51157

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0071233

cellular response to leucine

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8IWV7

P

Seeded From UniProt

complete

involved_in

GO:0032007

negative regulation of TOR signaling

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8IWV7

P

Seeded From UniProt

complete

involved_in

GO:0071596

ubiquitin-dependent protein catabolic process via the N-end rule pathway

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000486924
PomBase:SPAC15A10.11
SGD:S000003416

P

Seeded From UniProt

complete

enables

GO:0061630

ubiquitin protein ligase activity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0260970
MGI:MGI:1861099
MGI:MGI:1861100
PANTHER:PTN000486924
PomBase:SPAC15A10.11
PomBase:SPBC19C7.02

F

Seeded From UniProt

complete

involved_in

GO:0016567

protein ubiquitination

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0260970
PANTHER:PTN000486924

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000486924
SGD:S000003416

C

Seeded From UniProt

complete

part_of

GO:0000151

ubiquitin ligase complex

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1277977
MGI:MGI:1861099
PANTHER:PTN000486924

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0071233

cellular response to leucine

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q8IWV7

P

Seeded From UniProt

complete

enables

GO:0070728

leucine binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q8IWV7

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032007

negative regulation of TOR signaling

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q8IWV7

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006511

ubiquitin-dependent protein catabolic process

PMID:11689692[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2178612

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006511

ubiquitin-dependent protein catabolic process

PMID:14585983[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004842

ubiquitin-protein transferase activity

PMID:11689692[2]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1861099

F

Seeded From UniProt

complete

enables

GO:0004842

ubiquitin-protein transferase activity

PMID:14585983[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0000502

proteasome complex

PMID:11689692[2]

ECO:0000316

genetic interaction evidence used in manual assertion

SGD:S000003416

C

Seeded From UniProt

complete

part_of

GO:0000151

ubiquitin ligase complex

PMID:11689692[2]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1861099

C

Seeded From UniProt

complete

involved_in

GO:0071233

cellular response to leucine

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8IWV7
ensembl:ENSP00000290650

P

Seeded From UniProt

complete

enables

GO:0070728

leucine binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8IWV7
ensembl:ENSP00000290650

F

Seeded From UniProt

complete

involved_in

GO:0032007

negative regulation of TOR signaling

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8IWV7
ensembl:ENSP00000290650

P

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003126

F

Seeded From UniProt

complete

involved_in

GO:0030163

protein catabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003769

P

Seeded From UniProt

complete

enables

GO:0061630

ubiquitin protein ligase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR039164

F

Seeded From UniProt

complete

involved_in

GO:0071596

ubiquitin-dependent protein catabolic process via the N-end rule pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR039164

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0091

C

Seeded From UniProt

complete

involved_in

GO:0016567

protein ubiquitination

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00143

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 Kwon, YT et al. (2001) Construction and analysis of mouse strains lacking the ubiquitin ligase UBR1 (E3alpha) of the N-end rule pathway. Mol. Cell. Biol. 21 8007-21 PubMed GONUTS page
  3. ↑ 3.0 3.1 Kwon, YT et al. (2003) Female lethality and apoptosis of spermatocytes in mice lacking the UBR2 ubiquitin ligase of the N-end rule pathway. Mol. Cell. Biol. 23 8255-71 PubMed GONUTS page
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