HUMAN:ITCH

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	ITCH
Protein Name(s)	E3 ubiquitin-protein ligase Itchy homolog Itch Atrophin-1-interacting protein 4 AIP4 NFE2-associated polypeptide 1 NAPP1
External Links
UniProt	Q96J02
EMBL	AF095745 AB056663 AK304090 AK315212 AL109923 AL356299 AL356299 AL109923 AL356299 AL109923 AL109923 AL356299 CH471077 CH471077 CH471077 BC006848 BC011571 AF038564
CCDS	CCDS13234.1 CCDS58768.1 CCDS58769.1
RefSeq	NP_001244066.1 NP_001244067.1 NP_113671.3 XP_011527379.1 XP_011527380.1
UniGene	Hs.632272
PDB	2DMV 2KYK 2NQ3 2P4R 2YSF 3TUG 4ROF 4ROH 4ROI 4RRE
PDBsum	2DMV 2KYK 2NQ3 2P4R 2YSF 3TUG 4ROF 4ROH 4ROI 4RRE
ProteinModelPortal	Q96J02
SMR	Q96J02
BioGrid	123747
DIP	DIP-29849N
IntAct	Q96J02
MINT	MINT-148272
STRING	9606.ENSP00000363998
PhosphoSite	Q96J02
BioMuta	ITCH
DMDM	37537897
MaxQB	Q96J02
PaxDb	Q96J02
PRIDE	Q96J02
Ensembl	ENST00000262650 ENST00000374864 ENST00000535650 ENST00000610336 ENST00000621101
GeneID	83737
KEGG	hsa:83737
UCSC	uc002xak.3 uc010geu.2
CTD	83737
GeneCards	GC20P032951
H-InvDB	HIX0015745
HGNC	HGNC:13890
HPA	HPA021126 HPA049032
MIM	606409 613385
neXtProt	NX_Q96J02
Orphanet	228426
PharmGKB	PA29934
eggNOG	COG5021
GeneTree	ENSGT00760000118966
HOVERGEN	HBG004134
InParanoid	Q96J02
KO	K05632
OMA	SICLDGL
OrthoDB	EOG7RFTGT
PhylomeDB	Q96J02
TreeFam	TF323658
BRENDA	6.3.2.19
Reactome	REACT_115828 REACT_118614 REACT_25271 REACT_268156 REACT_268718 REACT_75776 REACT_75842
SignaLink	Q96J02
UniPathway	UPA00143
ChiTaRS	ITCH
EvolutionaryTrace	Q96J02
GenomeRNAi	83737
NextBio	72745
PRO	PR:Q96J02
Proteomes	UP000005640
Bgee	Q96J02
CleanEx	HS_ITCH
Genevisible	Q96J02
GO	GO:0005938 GO:0005737 GO:0031410 GO:0005829 GO:0070062 GO:0016020 GO:0005634 GO:0005886 GO:0045236 GO:0016874 GO:0043021 GO:0061630 GO:0004842 GO:0006915 GO:0051607 GO:0006954 GO:0045087 GO:0046642 GO:0043066 GO:0050687 GO:0046329 GO:0032088 GO:0032480 GO:0007219 GO:0035872 GO:0070423 GO:0045732 GO:0002669 GO:0035519 GO:0070936 GO:0070534 GO:0016567 GO:0042787 GO:0001558 GO:0090085 GO:0006511 GO:0046718
Gene3D	2.60.40.150
InterPro	IPR000008 IPR000569 IPR001202
Pfam	PF00168 PF00632 PF00397
SMART	SM00239 SM00119 SM00456
SUPFAM	SSF49562 SSF51045 SSF56204
PROSITE	PS50004 PS50237 PS01159 PS50020

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:1990763	arrestin family protein binding	PMID:23886940^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q96B67	F		Seeded From UniProt	complete
enables	GO:1990763	arrestin family protein binding	PMID:23886940^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8N5I2	F		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	PMID:24790097^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0051865	protein autoubiquitination	PMID:24790097^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	PMID:24790097^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:O14964)	Seeded From UniProt	complete
colocalizes_with	GO:0005769	early endosome	PMID:24790097^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:1990869)	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:24790097^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
	GO:2000060	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process	PMID:16387660^[3]	ECO:0000315			P		Figure 4EFGHI	complete CACAO 10985
enables	GO:0044389	ubiquitin-like protein ligase binding	PMID:24790097^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8TDB6	F		Seeded From UniProt	complete
involved_in	GO:2000646	positive regulation of receptor catabolic process	PMID:24790097^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P61073)	Seeded From UniProt	complete
	GO:0006511	ubiquitin-dependent protein catabolic process	PMID:25518932^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Figure 3A	complete CACAO 10986
	GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process	PMID:25518932^[4]	ECO:0000315			P		Figure 3A-B	complete CACAO 10987
involved_in	GO:0016567	protein ubiquitination	PMID:25631046^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:23533145^[6]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:19946888^[7]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0090085	regulation of protein deubiquitination	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8C863	P		Seeded From UniProt	complete
involved_in	GO:0046329	negative regulation of JNK cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8C863	P		Seeded From UniProt	complete
involved_in	GO:0032088	negative regulation of NF-kappaB transcription factor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8C863	P		Seeded From UniProt	complete
involved_in	GO:0070936	protein K48-linked ubiquitination	PMID:19881509^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070534	protein K63-linked ubiquitination	PMID:19592251^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070534	protein K63-linked ubiquitination	PMID:18718448^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050687	negative regulation of defense response to virus	PMID:19881509^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0045236	CXCR chemokine receptor binding	PMID:19116316^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P61073	F		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:20068034^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043021	ribonucleoprotein complex binding	PMID:19881509^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q15366	F		Seeded From UniProt	complete
involved_in	GO:0035519	protein K29-linked ubiquitination	PMID:17028573^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035519	protein K29-linked ubiquitination	PMID:18628966^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	PMID:17592138^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:9462742^[16]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	PMID:9462742^[16]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:14602072^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	PMID:17592138^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	PMID:10940313^[18]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001558	regulation of cell growth	PMID:9462742^[16]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070936	protein K48-linked ubiquitination	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1202301 PANTHER:PTN000134867 UniProtKB:Q96J02	P		Seeded From UniProt	complete
involved_in	GO:0070534	protein K63-linked ubiquitination	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000134867 UniProtKB:Q96J02	P		Seeded From UniProt	complete
enables	GO:0061630	ubiquitin protein ligase activity	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0259174 MGI:MGI:1861728 MGI:MGI:1914144 MGI:MGI:1933754 MGI:MGI:97297 PANTHER:PTN000134256 PomBase:SPAC11G7.02 PomBase:SPAC1805.15c UniProtKB:P46934 UniProtKB:Q96J02 UniProtKB:Q9HCE7	F		Seeded From UniProt	complete
involved_in	GO:0045732	positive regulation of protein catabolic process	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1202301 MGI:MGI:97297 PANTHER:PTN000134745 RGD:735047 UniProtKB:P46934	P		Seeded From UniProt	complete
involved_in	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1861728 MGI:MGI:1914144 PANTHER:PTN001679348 UniProtKB:O00308	P		Seeded From UniProt	complete
involved_in	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1861728 MGI:MGI:1914144 PANTHER:PTN000134745 SGD:S000000927 UniProtKB:O00308 UniProtKB:Q96PU5 UniProtKB:Q9HCE7	P		Seeded From UniProt	complete
involved_in	GO:0035519	protein K29-linked ubiquitination	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000134867 UniProtKB:Q96J02	P		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0259174 MGI:MGI:1861728 MGI:MGI:1914144 MGI:MGI:1923038 MGI:MGI:97297 PANTHER:PTN000134256 SGD:S000000927 SGD:S000002865 TAIR:locus:2135630 UniProtKB:O00308 UniProtKB:P46934 UniProtKB:Q5BDP1 UniProtKB:Q8IYU2 UniProtKB:Q96J02 UniProtKB:Q96PU5 UniProtKB:Q9HCE7 WB:WBGene00007009	P		Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1202301 PANTHER:PTN001679348 UniProtKB:Q96J02	P		Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0029006 MGI:MGI:1202301 MGI:MGI:97297 PANTHER:PTN000134745 PomBase:SPAC11G7.02 SGD:S000000927 UniProtKB:O15033 UniProtKB:P46934 UniProtKB:Q96J02 UniProtKB:Q96PU5 UniProtKB:Q9HAU4 UniProtKB:Q9HCE7	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003557 FB:FBgn0259174 MGI:MGI:1202301 MGI:MGI:1914144 MGI:MGI:97297 PANTHER:PTN000134256 PomBase:SPAC11G7.02 PomBase:SPAC1805.15c SGD:S000000927 TAIR:locus:2135630 UniProtKB:P46934 UniProtKB:Q7Z6Z7 UniProtKB:Q9HCE7 WB:WBGene00007009	C		Seeded From UniProt	complete
involved_in	GO:0000209	protein polyubiquitination	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1202301 PANTHER:PTN000134745 SGD:S000000927 UniProtKB:Q9HCE7	P		Seeded From UniProt	complete
enables	GO:0061630	ubiquitin protein ligase activity	PMID:15678106^[20]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	PMID:15678106^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0090085	regulation of protein deubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8C863 ensembl:ENSMUSP00000105307	P		Seeded From UniProt	complete
involved_in	GO:0070936	protein K48-linked ubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8C863 ensembl:ENSMUSP00000105307	P		Seeded From UniProt	complete
involved_in	GO:0050687	negative regulation of defense response to virus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8C863 ensembl:ENSMUSP00000105307	P		Seeded From UniProt	complete
involved_in	GO:0046642	negative regulation of alpha-beta T cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8C863 ensembl:ENSMUSP00000105307	P		Seeded From UniProt	complete
involved_in	GO:0046329	negative regulation of JNK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8C863 ensembl:ENSMUSP00000105307	P		Seeded From UniProt	complete
involved_in	GO:0045732	positive regulation of protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8C863 ensembl:ENSMUSP00000105307	P		Seeded From UniProt	complete
involved_in	GO:0032088	negative regulation of NF-kappaB transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8C863 ensembl:ENSMUSP00000105307	P		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8C863 ensembl:ENSMUSP00000105307	C		Seeded From UniProt	complete
enables	GO:0016874	ligase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8C863 ensembl:ENSMUSP00000105307	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8C863 ensembl:ENSMUSP00000105307	C		Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8C863 ensembl:ENSMUSP00000105307	P		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8C863 ensembl:ENSMUSP00000105307	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8C863 ensembl:ENSMUSP00000105307	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8C863 ensembl:ENSMUSP00000105307	C		Seeded From UniProt	complete
involved_in	GO:0002669	positive regulation of T cell anergy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8C863 ensembl:ENSMUSP00000105307	P		Seeded From UniProt	complete
involved_in	GO:0000209	protein polyubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8C863 ensembl:ENSMUSP00000105307	P		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000569 InterPro:IPR035983	F		Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR024928	P		Seeded From UniProt	complete
enables	GO:0061630	ubiquitin protein ligase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR024928	F		Seeded From UniProt	complete
involved_in	GO:0046718	viral entry into host cell	PMID:12450395^[21]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902036	regulation of hematopoietic stem cell differentiation	Reactome:R-HSA-8939236	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070423	nucleotide-binding oligomerization domain containing signaling pathway	Reactome:R-HSA-168638	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0061630	ubiquitin protein ligase activity	Reactome:R-HSA-990526 Reactome:R-HSA-8956684 Reactome:R-HSA-5635864 Reactome:R-HSA-5610737	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0032480	negative regulation of type I interferon production	Reactome:R-HSA-936440	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007219	Notch signaling pathway	Reactome:R-HSA-1980143	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-990526 Reactome:R-HSA-8956684 Reactome:R-HSA-8956652 Reactome:R-HSA-688137 Reactome:R-HSA-5635868 Reactome:R-HSA-5635864 Reactome:R-HSA-5635861 Reactome:R-HSA-5610760 Reactome:R-HSA-5610737 Reactome:R-HSA-5610735 Reactome:R-HSA-1980125 Reactome:R-HSA-1912357 Reactome:R-HSA-1253300 Reactome:R-HSA-1253282	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967	C		Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0051	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P		Seeded From UniProt	complete
part_of	GO:0010008	endosome membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0100	C		Seeded From UniProt	complete
part_of	GO:0031901	early endosome membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0093	C		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00143	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Puca, L et al. (2013) Α-arrestin 1 (ARRDC1) and β-arrestins cooperate to mediate Notch degradation in mammals. J. Cell. Sci. 126 4457-68 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Holleman, J & Marchese, A (2014) The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein-coupled receptor CXCR4. Mol. Biol. Cell 25 1892-904 PubMed GONUTS page
↑ Yang, C et al. (2006) Negative regulation of the E3 ubiquitin ligase itch via Fyn-mediated tyrosine phosphorylation. Mol. Cell 21 135-41 PubMed GONUTS page
↑ ^4.0 ^4.1 Park, SH et al. (2015) Itch E3 ubiquitin ligase positively regulates TGF-β signaling to EMT via Smad7 ubiquitination. Mol. Cells 38 20-5 PubMed GONUTS page
↑ Low, LH et al. (2015) Nedd4 family interacting protein 1 (Ndfip1) is required for ubiquitination and nuclear trafficking of BRCA1-associated ATM activator 1 (BRAT1) during the DNA damage response. J. Biol. Chem. 290 7141-50 PubMed GONUTS page
↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 You, F et al. (2009) PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4. Nat. Immunol. 10 1300-8 PubMed GONUTS page
↑ Tao, M et al. (2009) ITCH K63-ubiquitinates the NOD2 binding protein, RIP2, to influence inflammatory signaling pathways. Curr. Biol. 19 1255-63 PubMed GONUTS page
↑ Lee, TL et al. (2008) Itch regulates p45/NF-E2 in vivo by Lys63-linked ubiquitination. Biochem. Biophys. Res. Commun. 375 326-30 PubMed GONUTS page
↑ Bhandari, D et al. (2009) The E3 ubiquitin ligase atrophin interacting protein 4 binds directly to the chemokine receptor CXCR4 via a novel WW domain-mediated interaction. Mol. Biol. Cell 20 1324-39 PubMed GONUTS page
↑ Zhang, P et al. (2010) The ubiquitin ligase itch regulates apoptosis by targeting thioredoxin-interacting protein for ubiquitin-dependent degradation. J. Biol. Chem. 285 8869-79 PubMed GONUTS page
↑ Chastagner, P et al. (2006) Itch/AIP4 mediates Deltex degradation through the formation of K29-linked polyubiquitin chains. EMBO Rep. 7 1147-53 PubMed GONUTS page
↑ Chastagner, P et al. (2008) AIP4/Itch regulates Notch receptor degradation in the absence of ligand. PLoS ONE 3 e2735 PubMed GONUTS page
↑ ^15.0 ^15.1 Oberst, A et al. (2007) The Nedd4-binding partner 1 (N4BP1) protein is an inhibitor of the E3 ligase Itch. Proc. Natl. Acad. Sci. U.S.A. 104 11280-5 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 Perry, WL et al. (1998) The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice. Nat. Genet. 18 143-6 PubMed GONUTS page
↑ Marchese, A et al. (2003) The E3 ubiquitin ligase AIP4 mediates ubiquitination and sorting of the G protein-coupled receptor CXCR4. Dev. Cell 5 709-22 PubMed GONUTS page
↑ Qiu, L et al. (2000) Recognition and ubiquitination of Notch by Itch, a hect-type E3 ubiquitin ligase. J. Biol. Chem. 275 35734-7 PubMed GONUTS page
↑ ^19.00 ^19.01 ^19.02 ^19.03 ^19.04 ^19.05 ^19.06 ^19.07 ^19.08 ^19.09 ^19.10 ^19.11 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^20.0 ^20.1 Rossi, M et al. (2005) The ubiquitin-protein ligase Itch regulates p73 stability. EMBO J. 24 836-48 PubMed GONUTS page
↑ Galinier, R et al. (2002) Adenovirus protein involved in virus internalization recruits ubiquitin-protein ligases. Biochemistry 41 14299-305 PubMed GONUTS page

[PMID:23886940-1] 1.0 ^1.1 Puca, L et al. (2013) Α-arrestin 1 (ARRDC1) and β-arrestins cooperate to mediate Notch degradation in mammals. J. Cell. Sci. 126 4457-68 PubMed GONUTS page

[PMID:24790097-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Holleman, J & Marchese, A (2014) The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein-coupled receptor CXCR4. Mol. Biol. Cell 25 1892-904 PubMed GONUTS page

[PMID:16387660-3] Yang, C et al. (2006) Negative regulation of the E3 ubiquitin ligase itch via Fyn-mediated tyrosine phosphorylation. Mol. Cell 21 135-41 PubMed GONUTS page

[PMID:25518932-4] 4.0 ^4.1 Park, SH et al. (2015) Itch E3 ubiquitin ligase positively regulates TGF-β signaling to EMT via Smad7 ubiquitination. Mol. Cells 38 20-5 PubMed GONUTS page

[PMID:25631046-5] Low, LH et al. (2015) Nedd4 family interacting protein 1 (Ndfip1) is required for ubiquitination and nuclear trafficking of BRCA1-associated ATM activator 1 (BRAT1) during the DNA damage response. J. Biol. Chem. 290 7141-50 PubMed GONUTS page

[PMID:23533145-6] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:19946888-7] Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page

[PMID:19881509-8] 8.0 ^8.1 ^8.2 You, F et al. (2009) PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4. Nat. Immunol. 10 1300-8 PubMed GONUTS page

[PMID:19592251-9] Tao, M et al. (2009) ITCH K63-ubiquitinates the NOD2 binding protein, RIP2, to influence inflammatory signaling pathways. Curr. Biol. 19 1255-63 PubMed GONUTS page

[PMID:18718448-10] Lee, TL et al. (2008) Itch regulates p45/NF-E2 in vivo by Lys63-linked ubiquitination. Biochem. Biophys. Res. Commun. 375 326-30 PubMed GONUTS page

[PMID:19116316-11] Bhandari, D et al. (2009) The E3 ubiquitin ligase atrophin interacting protein 4 binds directly to the chemokine receptor CXCR4 via a novel WW domain-mediated interaction. Mol. Biol. Cell 20 1324-39 PubMed GONUTS page

[PMID:20068034-12] Zhang, P et al. (2010) The ubiquitin ligase itch regulates apoptosis by targeting thioredoxin-interacting protein for ubiquitin-dependent degradation. J. Biol. Chem. 285 8869-79 PubMed GONUTS page

[PMID:17028573-13] Chastagner, P et al. (2006) Itch/AIP4 mediates Deltex degradation through the formation of K29-linked polyubiquitin chains. EMBO Rep. 7 1147-53 PubMed GONUTS page

[PMID:18628966-14] Chastagner, P et al. (2008) AIP4/Itch regulates Notch receptor degradation in the absence of ligand. PLoS ONE 3 e2735 PubMed GONUTS page

[PMID:17592138-15] 15.0 ^15.1 Oberst, A et al. (2007) The Nedd4-binding partner 1 (N4BP1) protein is an inhibitor of the E3 ligase Itch. Proc. Natl. Acad. Sci. U.S.A. 104 11280-5 PubMed GONUTS page

[PMID:9462742-16] 16.0 ^16.1 ^16.2 Perry, WL et al. (1998) The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice. Nat. Genet. 18 143-6 PubMed GONUTS page

[PMID:14602072-17] Marchese, A et al. (2003) The E3 ubiquitin ligase AIP4 mediates ubiquitination and sorting of the G protein-coupled receptor CXCR4. Dev. Cell 5 709-22 PubMed GONUTS page

[PMID:10940313-18] Qiu, L et al. (2000) Recognition and ubiquitination of Notch by Itch, a hect-type E3 ubiquitin ligase. J. Biol. Chem. 275 35734-7 PubMed GONUTS page

[PMID:21873635-19] 19.00 ^19.01 ^19.02 ^19.03 ^19.04 ^19.05 ^19.06 ^19.07 ^19.08 ^19.09 ^19.10 ^19.11 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:15678106-20] 20.0 ^20.1 Rossi, M et al. (2005) The ubiquitin-protein ligase Itch regulates p73 stability. EMBO J. 24 836-48 PubMed GONUTS page

[PMID:12450395-21] Galinier, R et al. (2002) Adenovirus protein involved in virus internalization recruits ubiquitin-protein ligases. Biochemistry 41 14299-305 PubMed GONUTS page

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HUMAN:ITCH

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