GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
HUMAN:RFWD2
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | RFWD2 (synonyms: COP1, RNF200) | |
| Protein Name(s) | E3 ubiquitin-protein ligase RFWD2
Constitutive photomorphogenesis protein 1 homolog hCOP1 RING finger and WD repeat domain protein 2 RING finger protein 200 | |
| External Links | ||
| UniProt | Q8NHY2 | |
| EMBL | AF508940 BK000438 AF527539 AY509921 KJ534928 KJ535076 AK025789 AK314750 AL359265 AL162736 AL513329 AL590723 AL513329 AL162736 AL359265 AL590723 AL162736 AL359265 AL513329 AL590723 AL590723 AL162736 AL359265 AL513329 CH471067 BC094728 | |
| CCDS | CCDS30944.1 CCDS44279.1 | |
| RefSeq | NP_001001740.1 NP_001273573.1 NP_071902.2 | |
| UniGene | Hs.523744 | |
| ProteinModelPortal | Q8NHY2 | |
| SMR | Q8NHY2 | |
| BioGrid | 122136 | |
| DIP | DIP-36661N | |
| IntAct | Q8NHY2 | |
| MINT | MINT-260162 | |
| STRING | 9606.ENSP00000356641 | |
| PhosphoSite | Q8NHY2 | |
| DMDM | 55976539 | |
| MaxQB | Q8NHY2 | |
| PaxDb | Q8NHY2 | |
| PRIDE | Q8NHY2 | |
| DNASU | 64326 | |
| Ensembl | ENST00000308769 ENST00000367669 ENST00000474194 | |
| GeneID | 64326 | |
| KEGG | hsa:64326 | |
| UCSC | uc001gkt.1 uc001gku.1 uc001gkv.1 uc009wwv.2 | |
| CTD | 64326 | |
| GeneCards | GC01M175913 | |
| HGNC | HGNC:17440 | |
| HPA | HPA028197 | |
| MIM | 608067 | |
| neXtProt | NX_Q8NHY2 | |
| PharmGKB | PA134952161 | |
| eggNOG | COG2319 | |
| GeneTree | ENSGT00570000079069 | |
| HOGENOM | HOG000006123 | |
| HOVERGEN | HBG054995 | |
| InParanoid | Q8NHY2 | |
| KO | K10143 | |
| OMA | FSTRMTR | |
| OrthoDB | EOG75TMB6 | |
| PhylomeDB | Q8NHY2 | |
| TreeFam | TF328912 | |
| Reactome | REACT_20549 | |
| SignaLink | Q8NHY2 | |
| UniPathway | UPA00143 | |
| ChiTaRS | RFWD2 | |
| GeneWiki | RFWD2 | |
| GenomeRNAi | 64326 | |
| NextBio | 35502913 | |
| PRO | PR:Q8NHY2 | |
| Proteomes | UP000005640 | |
| Bgee | Q8NHY2 | |
| CleanEx | HS_RFWD2 | |
| ExpressionAtlas | Q8NHY2 | |
| Genevestigator | Q8NHY2 | |
| GO | GO:0005813 GO:0005737 GO:0005829 GO:0005925 GO:0000139 GO:0016607 GO:0005654 GO:0005634 GO:0016874 GO:0061630 GO:0008270 GO:0006977 GO:0032436 GO:0010212 | |
| Gene3D | 2.130.10.10 3.30.40.10 | |
| InterPro | IPR015943 IPR001680 IPR019775 IPR017986 IPR018957 IPR001841 IPR013083 IPR017907 | |
| Pfam | PF00400 PF00097 | |
| SMART | SM00184 SM00320 | |
| SUPFAM | SSF50978 | |
| PROSITE | PS00678 PS50082 PS50294 PS00518 PS50089 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0043161 |
proteasome-mediated ubiquitin-dependent protein catabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
has_input:(UniProtKB:P05412) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0031464 |
Cul4A-RING E3 ubiquitin ligase complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010212 |
response to ionizing radiation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0061630 |
ubiquitin protein ligase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032436 |
positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000139 |
Golgi membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:A0A096UWG1 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043687 |
post-translational protein modification |
Reactome:R-HSA-597592 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-264458 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
part_of |
GO:0005654 |
nucleoplasm |
Reactome:R-HSA-8956045 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
enables |
GO:0004842 |
ubiquitin-protein transferase activity |
Reactome:R-HSA-264444 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016607 |
nuclear speck |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016567 |
protein ubiquitination |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniPathway:UPA00143 |
P |
Seeded From UniProt |
complete | ||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Wertz, IE et al. (2004) Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase. Science 303 1371-4 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Li, DQ et al. (2009) E3 ubiquitin ligase COP1 regulates the stability and functions of MTA1. Proc. Natl. Acad. Sci. U.S.A. 106 17493-8 PubMed GONUTS page
c
p
u
