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HUMAN:UBR5

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) UBR5 (synonyms: EDD, EDD1, HYD, KIAA0896)
Protein Name(s) E3 ubiquitin-protein ligase UBR5

E3 ubiquitin-protein ligase, HECT domain-containing 1 Hyperplastic discs protein homolog hHYD Progestin-induced protein

External Links
UniProt O95071
EMBL AF006010
U95000
AB020703
AP002907
AP002981
BC137234
CCDS CCDS34933.1
CCDS64946.1
RefSeq NP_001269802.1
NP_056986.2
UniGene Hs.492445
PDB 1I2T
2QHO
3PT3
PDBsum 1I2T
2QHO
3PT3
ProteinModelPortal O95071
SMR O95071
BioGrid 119501
DIP DIP-32930N
IntAct O95071
MINT MINT-196086
STRING 9606.ENSP00000220959
PhosphoSite O95071
MaxQB O95071
PaxDb O95071
PRIDE O95071
Ensembl ENST00000220959
ENST00000520539
GeneID 51366
KEGG hsa:51366
UCSC uc003ykr.2
CTD 51366
GeneCards GC08M103265
H-InvDB HIX0025542
HGNC HGNC:16806
HPA HPA024728
HPA053688
MIM 608413
neXtProt NX_O95071
PharmGKB PA162408175
eggNOG COG5021
GeneTree ENSGT00770000120501
HOGENOM HOG000046848
HOVERGEN HBG096012
InParanoid O95071
KO K10593
OMA ICIGALY
OrthoDB EOG73FQMB
PhylomeDB O95071
TreeFam TF314406
SignaLink O95071
UniPathway UPA00143
ChiTaRS UBR5
EvolutionaryTrace O95071
GeneWiki UBR5
GenomeRNAi 51366
NextBio 35534755
PRO PR:O95071
Proteomes UP000005640
Bgee O95071
CleanEx HS_UBR5
ExpressionAtlas O95071
Genevestigator O95071
GO GO:0005737
GO:0016020
GO:0005634
GO:0016874
GO:0003723
GO:0004842
GO:0034450
GO:0008270
GO:0008283
GO:0006974
GO:0006281
GO:2000780
GO:1901315
GO:0090263
GO:0035413
GO:0033160
GO:0050847
GO:0000209
GO:0042787
GO:0006511
Gene3D 1.10.1900.10
2.130.10.30
InterPro IPR024725
IPR000569
IPR002004
IPR009091
IPR003126
IPR013993
Pfam PF11547
PF00632
PF00658
PF02207
SMART SM00119
SM00517
SM00396
SUPFAM SSF50985
SSF56204
SSF63570
PROSITE PS50237
PS51309
PS51157

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0005515

protein binding

PMID:21118991[1]

ECO:0000021

UniProtKB:p49841


F

Fig 1A, 1B – Co-immunoprecipitation between GSK-3 and EDD Fig 1E – Pulldown GSK-3β bound EDD

complete

GO:0000209

protein polyubiquitination

PMID:21118991[1]

ECO:0000314

P

Fig. 5B EDD was silenced in HEK293T cells expressing HA-ubiquitin causing reduced ubiqutination of endogenous β-catenin, indicating a specific ubiquitination of β-catenin by EDD

complete

GO:0005634

nucleus

PMID:21118991[1]

ECO:0000314

C

Fig 2A, B shows EDD in nucleus. Nucleus marked by DAPI in B.

complete

part_of

GO:0016020

membrane

PMID:19946888[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0090263

positive regulation of canonical Wnt signaling pathway

PMID:21118991[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0034450

ubiquitin-ubiquitin ligase activity

PMID:21118991[1]

ECO:0000314

direct assay evidence used in manual assertion

F

has_direct_input:(UniProtKB:P35222)

Seeded From UniProt

complete

involved_in

GO:0042307

positive regulation of protein import into nucleus

PMID:21118991[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_regulation_target:(UniProtKB:P49841)

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21118991[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0000209

protein polyubiquitination

PMID:21118991[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050847

progesterone receptor signaling pathway

PMID:12011095[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

PMID:12011095[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:12011095[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:2000780

negative regulation of double-strand break repair

PMID:22884692[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1901315

negative regulation of histone H2A K63-linked ubiquitination

PMID:22884692[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

PMID:22884692[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1901315

negative regulation of histone H2A K63-linked ubiquitination

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000883184
UniProtKB:O95071

P

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000134821
UniProtKB:O95071

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0002431
PANTHER:PTN000883184
UniProtKB:O95071

C

Seeded From UniProt

complete

involved_in

GO:0000209

protein polyubiquitination

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000883184
UniProtKB:O95071

P

Seeded From UniProt

complete

part_of

GO:0048471

perinuclear region of cytoplasm

PMID:18076571[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

PMID:18076571[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

PMID:18076571[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0000209

protein polyubiquitination

PMID:28689657[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0070936

protein K48-linked ubiquitination

PMID:28689657[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:28689657[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0061630

ubiquitin protein ligase activity

PMID:28689657[7]

ECO:0000314

direct assay evidence used in manual assertion

F

has_direct_input:(UniProtKB:Q04726)

Seeded From UniProt

complete

involved_in

GO:0090263

positive regulation of canonical Wnt signaling pathway

PMID:28689657[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002004
InterPro:IPR036053

F

Seeded From UniProt

complete

enables

GO:0004842

ubiquitin-protein transferase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000569
InterPro:IPR035983

F

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003126

F

Seeded From UniProt

complete

enables

GO:0043130

ubiquitin binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR024725

F

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0234

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0227

P

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

involved_in

GO:0016032

viral process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0945

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

involved_in

GO:0016567

protein ubiquitination

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00143

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Hay-Koren, A et al. (2011) The EDD E3 ubiquitin ligase ubiquitinates and up-regulates beta-catenin. Mol. Biol. Cell 22 399-411 PubMed GONUTS page
  2. ↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Henderson, MJ et al. (2002) EDD, the human hyperplastic discs protein, has a role in progesterone receptor coactivation and potential involvement in DNA damage response. J. Biol. Chem. 277 26468-78 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 Gudjonsson, T et al. (2012) TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes. Cell 150 697-709 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 Ohshima, R et al. (2007) Putative tumor suppressor EDD interacts with and up-regulates APC. Genes Cells 12 1339-45 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 7.3 7.4 Flack, JE et al. (2017) Wnt-Dependent Inactivation of the Groucho/TLE Co-repressor by the HECT E3 Ubiquitin Ligase Hyd/UBR5. Mol. Cell 67 181-193.e5 PubMed GONUTS page
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