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MOUSE:CHFR

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Chfr
Protein Name(s) E3 ubiquitin-protein ligase CHFR

Checkpoint with forkhead and RING finger domains protein

External Links
UniProt Q810L3
EMBL AK052473
AK077629
AK147892
AK154038
AK155295
AK155525
AK169182
AK169193
CH466529
BC049792
CCDS CCDS19522.1
CCDS71637.1
RefSeq NP_001276506.1
NP_001276507.1
NP_001276508.1
NP_001276509.1
NP_766305.2
UniGene Mm.30264
ProteinModelPortal Q810L3
SMR Q810L3
BioGrid 231141
PhosphoSite Q810L3
MaxQB Q810L3
PRIDE Q810L3
Ensembl ENSMUST00000014812
ENSMUST00000112519
GeneID 231600
KEGG mmu:231600
UCSC uc008ypv.2
uc008ypw.2
uc008ypz.2
CTD 55743
MGI MGI:2444898
eggNOG NOG253207
GeneTree ENSGT00400000022306
HOVERGEN HBG048005
InParanoid Q810L3
KO K10644
OMA LYWGCAR
OrthoDB EOG78D7JS
PhylomeDB Q810L3
TreeFam TF330957
UniPathway UPA00143
ChiTaRS Chfr
NextBio 380643
PRO PR:Q810L3
Proteomes UP000000589
Bgee Q810L3
CleanEx MM_CHFR
Genevestigator Q810L3
GO GO:0005634
GO:0016605
GO:0016874
GO:0000166
GO:0061630
GO:0008270
GO:0000278
GO:0007093
GO:0007067
GO:0032436
GO:0031398
GO:0031648
GO:0000209
GO:0006511
Gene3D 2.60.200.20
3.30.40.10
InterPro IPR000253
IPR008984
IPR001841
IPR013083
IPR017907
Pfam PF00498
PF13639
SMART SM00240
SM00184
SUPFAM SSF49879
PROSITE PS50006
PS00518
PS50089

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0016605

PML body

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q96EP1

C

Seeded From UniProt

complete

involved_in

GO:0007093

mitotic cell cycle checkpoint

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q96EP1

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q96EP1

C

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q96EP1

F

Seeded From UniProt

complete

involved_in

GO:0016567

protein ubiquitination

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2444898
PANTHER:PTN000412551

P

Seeded From UniProt

complete

involved_in

GO:0007093

mitotic cell cycle checkpoint

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000412551
UniProtKB:Q96EP1

P

Seeded From UniProt

complete

involved_in

GO:0006511

ubiquitin-dependent protein catabolic process

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2444898
PANTHER:PTN000412551

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000412551
UniProtKB:Q96EP1

C

Seeded From UniProt

complete

enables

GO:0004842

ubiquitin-protein transferase activity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000412551
UniProtKB:Q96EP1

F

Seeded From UniProt

complete

enables

GO:0061630

ubiquitin protein ligase activity

PMID:15793587[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3576266

F

has_direct_input:(MGI:MGI:894678)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032436

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

PMID:22285184[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0031648

protein destabilization

PMID:22285184[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0031398

positive regulation of protein ubiquitination

PMID:22285184[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0019941

modification-dependent protein catabolic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EP1

P

Seeded From UniProt

complete

part_of

GO:0016605

PML body

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EP1

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007093

mitotic cell cycle checkpoint

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EP1

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006511

ubiquitin-dependent protein catabolic process

PMID:15793587[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EP1

C

Seeded From UniProt

complete

enables

GO:0004842

ubiquitin-protein transferase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EP1

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0000278

mitotic cell cycle

PMID:15793587[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3576266

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0000209

protein polyubiquitination

PMID:15793587[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0000209

protein polyubiquitination

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EP1

P

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EP1

F

Seeded From UniProt

complete

involved_in

GO:0019941

modification-dependent protein catabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EP1
ensembl:ENSP00000392395

P

Seeded From UniProt

complete

part_of

GO:0016605

PML body

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EP1
ensembl:ENSP00000392395

C

Seeded From UniProt

complete

involved_in

GO:0007093

mitotic cell cycle checkpoint

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EP1
ensembl:ENSP00000392395

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EP1
ensembl:ENSP00000392395

C

Seeded From UniProt

complete

enables

GO:0004842

ubiquitin-protein transferase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EP1
ensembl:ENSP00000392395

F

Seeded From UniProt

complete

involved_in

GO:0000209

protein polyubiquitination

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EP1
ensembl:ENSP00000392395

P

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EP1
ensembl:ENSP00000392395

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

involved_in

GO:0051301

cell division

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0132

P

Seeded From UniProt

complete

part_of

GO:0016605

PML body

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0465

C

Seeded From UniProt

complete

involved_in

GO:0016567

protein ubiquitination

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00143

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 Yu, X et al. (2005) Chfr is required for tumor suppression and Aurora A regulation. Nat. Genet. 37 401-6 PubMed GONUTS page
  3. 3.0 3.1 3.2 Jung, I et al. (2012) SRG3/mBAF155 stabilizes the SWI/SNF-like BAF complex by blocking CHFR mediated ubiquitination and degradation of its major components. Biochem. Biophys. Res. Commun. 418 512-7 PubMed GONUTS page