MOUSE:MDM2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Mdm2
Protein Name(s)	E3 ubiquitin-protein ligase Mdm2 Double minute 2 protein Oncoprotein Mdm2 p53-binding protein Mdm2
External Links
UniProt	P23804
EMBL	X58876 U40145 U47944 U47935 U47936 U47937 U47938 U47939 U47940 U47941 U47942 U47943 U47934 AK004719 AK088638 BC050902
CCDS	CCDS24194.1 CCDS70110.1
PIR	S15349
RefSeq	NP_001275515.1 NP_034916.1 XP_006513374.1
UniGene	Mm.22670 Mm.447669
ProteinModelPortal	P23804
SMR	P23804
BioGrid	201372
DIP	DIP-24174N DIP-24196N
IntAct	P23804
MINT	MINT-139756
PhosphoSite	P23804
PRIDE	P23804
Ensembl	ENSMUST00000020408 ENSMUST00000105263
GeneID	17246
KEGG	mmu:17246
UCSC	uc007hdl.1
CTD	4193
MGI	MGI:96952
eggNOG	NOG46328
GeneTree	ENSGT00530000063539
HOGENOM	HOG000293341
HOVERGEN	HBG013472
InParanoid	P23804
KO	K06643
OMA	FEREETQ
OrthoDB	EOG7RRF7T
TreeFam	TF105306
Reactome	REACT_188970 REACT_188971 REACT_196588 REACT_220918 REACT_256790
ChiTaRS	Mdm2
NextBio	291706
PMAP-CutDB	Q91XK7
PRO	PR:P23804
Proteomes	UP000000589
Bgee	P23804
CleanEx	MM_MDM2
ExpressionAtlas	P23804
Genevestigator	P23804
GO	GO:0005737 GO:0005829 GO:0016604 GO:0005730 GO:0005634 GO:0005886 GO:0043234 GO:0045202 GO:0016874 GO:0002039 GO:0097110 GO:0004842 GO:0008270 GO:0071229 GO:0071312 GO:0071236 GO:0071391 GO:0071363 GO:0070301 GO:0071456 GO:0071375 GO:0071494 GO:0071301 GO:0006977 GO:0045184 GO:0071157 GO:0043154 GO:0043518 GO:0000122 GO:0018205 GO:0045787 GO:0032436 GO:0046827 GO:0030163 GO:0006461 GO:0031648 GO:0034504 GO:0016567 GO:0042787 GO:0009743 GO:0042220 GO:0042493 GO:0045472 GO:0010039 GO:0032026 GO:0043278 GO:0007089
Gene3D	1.10.245.10 3.30.40.10
InterPro	IPR028340 IPR015459 IPR016495 IPR003121 IPR001876 IPR001841 IPR013083
PANTHER	PTHR10360:SF11
Pfam	PF02201 PF00641
PIRSF	PIRSF500700 PIRSF006748
SMART	SM00184
SUPFAM	SSF47592
PROSITE	PS01358 PS50199 PS50089

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0002039	p53 binding	PMID:20818388^[1]	ECO:0000021		UniProtKB:P02340	F		the TSD mutation partially disrupted the interaction between p53 and its negative regulator Mdm2, accounting for the increased p53 stability and activity in p53TSD/– cells (Fig. 1g, h and Supplementary Information, Fig. S1g).	complete
	GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process	PMID:25720496^[2]	ECO:0000315			P		The organism Mus Musculus and the protein is MDM2. Figure 4B is a ubiquitination assay that shows that MDM2 ubiquitinates C/EBPβ (CCAAT-enhancer-binding protein). Figure 4 shows that "Mdm2 ubiquitinates and targets C/EBPβ for degradation"	complete CACAO 13030
	GO:0051149	positive regulation of muscle cell differentiation	PMID:25720496^[2]	ECO:0000315			P		The organism is Mus Musculus and the protein is MDM2. Figure 5B shows that mice lacking MDM2 have 90% less cell differential compared to the control group with MDM2. this shows that presence of MDM2 positively regulates muscle cell differentiation since the loss of MDM2 shows much less muscle cell differentiation	complete CACAO 13031
enables	GO:0043130	ubiquitin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00987	F		Seeded From UniProt	complete
enables	GO:0043021	ribonucleoprotein complex binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00987	F		Seeded From UniProt	complete
enables	GO:0008097	5S rRNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00987	F		Seeded From UniProt	complete
enables	GO:0097110	scaffold protein binding	PMID:19372219^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P32121	F		Seeded From UniProt	complete
enables	GO:0002039	p53 binding	PMID:20818388^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P02340	F		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00987	P		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	PMID:15195100^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1990785	response to water-immersion restraint stress	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1305332	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1990000	amyloid fibril formation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00987	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904754	positive regulation of vascular associated smooth muscle cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1305332	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904707	positive regulation of vascular smooth muscle cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1305332	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902254	negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00987	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901797	negative regulation of signal transduction by p53 class mediator	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00987	P		Seeded From UniProt	complete
enables	GO:0097718	disordered domain specific binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00987	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072717	cellular response to actinomycin D	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00987	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071480	cellular response to gamma radiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00987	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071157	negative regulation of cell cycle arrest	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00987	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0065003	protein-containing complex assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00987	P		Seeded From UniProt	complete
enables	GO:0061663	NEDD8 ligase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00987	F		Seeded From UniProt	complete
enables	GO:0061630	ubiquitin protein ligase activity	PMID:12145204^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(MGI:MGI:88064)	Seeded From UniProt	complete
enables	GO:0061630	ubiquitin protein ligase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00987	F		Seeded From UniProt	complete
enables	GO:0061630	ubiquitin protein ligase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1305332	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060411	cardiac septum morphogenesis	PMID:22821713^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:107934 MGI:MGI:98834	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051865	protein autoubiquitination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00987	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051603	proteolysis involved in cellular protein catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00987	P		Seeded From UniProt	complete
enables	GO:0047485	protein N-terminus binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00987	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046827	positive regulation of protein export from nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1305332	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045931	positive regulation of mitotic cell cycle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00987	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00987	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1305332	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045787	positive regulation of cell cycle	PMID:15485902^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:107738	P	regulates_o_occurs_in:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1305332	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045184	establishment of protein localization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00987	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00987	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1305332	P		Seeded From UniProt	complete
enables	GO:0043130	ubiquitin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00987	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1305332	P		Seeded From UniProt	complete
enables	GO:0043021	ribonucleoprotein complex binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00987	F		Seeded From UniProt	complete
enables	GO:0042975	peroxisome proliferator activated receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1305332	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00987	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042176	regulation of protein catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00987	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034504	protein localization to nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00987	P		Seeded From UniProt	complete
enables	GO:0033612	receptor serine/threonine kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1305332	F		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00987	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00987	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031648	protein destabilization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00987	P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00987	F		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00987	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00987	F		Seeded From UniProt	complete
enables	GO:0019789	SUMO transferase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00987	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018205	peptidyl-lysine modification	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00987	P		Seeded From UniProt	complete
enables	GO:0016874	ligase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00987	F		Seeded From UniProt	complete
colocalizes_with	GO:0016604	nuclear body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00987	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016567	protein ubiquitination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00987	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016567	protein ubiquitination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1305332	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010977	negative regulation of neuron projection development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1305332	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010955	negative regulation of protein processing	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1305332	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010629	negative regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1305332	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1305332	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010468	regulation of gene expression	PMID:22821713^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2385439	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00987	F		Seeded From UniProt	complete
enables	GO:0008097	5S rRNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00987	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007507	heart development	PMID:22821713^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:107934 MGI:MGI:98834	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007507	heart development	PMID:22821713^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2385439	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007089	traversing start control point of mitotic cell cycle	PMID:10906133^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00987	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006511	ubiquitin-dependent protein catabolic process	PMID:17591690^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006511	ubiquitin-dependent protein catabolic process	PMID:12145204^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(MGI:MGI:88064)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006511	ubiquitin-dependent protein catabolic process	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00987	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1305332	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1305332	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:19090619^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16042)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:14767071^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00987	C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	PMID:16129783^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	PMID:11718560^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00987	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00987	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:22173032^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19090619^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16042)\|part_of:(EMAPA:16042)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16129783^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:14767071^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12927808^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12154087^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11718560^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00987	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1305332	C		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	PMID:17591690^[9]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(MGI:MGI:98834)	Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00987	F		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1305332	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003283	atrial septum development	PMID:22821713^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:107934	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003281	ventricular septum development	PMID:22821713^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:107934	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003203	endocardial cushion morphogenesis	PMID:22821713^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:107934	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003203	endocardial cushion morphogenesis	PMID:22821713^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2385439	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003181	atrioventricular valve morphogenesis	PMID:22821713^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:107934	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003170	heart valve development	PMID:22821713^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:107934	P		Seeded From UniProt	complete
enables	GO:0002039	p53 binding	PMID:17591690^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P02340	F		Seeded From UniProt	complete
enables	GO:0002039	p53 binding	PMID:15678128^[17]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P02340	F		Seeded From UniProt	complete
enables	GO:0002039	p53 binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00987	F		Seeded From UniProt	complete
enables	GO:0002039	p53 binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1305332	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002027	regulation of heart rate	PMID:22821713^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:107934	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001974	blood vessel remodeling	PMID:22821713^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2385439	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001568	blood vessel development	PMID:22821713^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2385439	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00987	P		Seeded From UniProt	complete
involved_in	GO:0016925	protein sumoylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0019789	P		Seeded From UniProt	complete
involved_in	GO:1990000	amyloid fibril formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00987 ensembl:ENSP00000258149	P		Seeded From UniProt	complete
involved_in	GO:1902254	negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00987 ensembl:ENSP00000258149	P		Seeded From UniProt	complete
involved_in	GO:1901797	negative regulation of signal transduction by p53 class mediator	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00987 ensembl:ENSP00000258149	P		Seeded From UniProt	complete
enables	GO:0097718	disordered domain specific binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00987 ensembl:ENSP00000258149	F		Seeded From UniProt	complete
involved_in	GO:0072717	cellular response to actinomycin D	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00987 ensembl:ENSP00000258149	P		Seeded From UniProt	complete
involved_in	GO:0071480	cellular response to gamma radiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00987 ensembl:ENSP00000258149	P		Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00987 ensembl:ENSP00000258149	P		Seeded From UniProt	complete
involved_in	GO:0071157	negative regulation of cell cycle arrest	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00987 ensembl:ENSP00000258149	P		Seeded From UniProt	complete
involved_in	GO:0065003	protein-containing complex assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00987 ensembl:ENSP00000258149	P		Seeded From UniProt	complete
enables	GO:0061663	NEDD8 ligase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00987 ensembl:ENSP00000258149	F		Seeded From UniProt	complete
enables	GO:0061630	ubiquitin protein ligase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00987 ensembl:ENSP00000258149	F		Seeded From UniProt	complete
involved_in	GO:0051865	protein autoubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00987 ensembl:ENSP00000258149	P		Seeded From UniProt	complete
involved_in	GO:0051603	proteolysis involved in cellular protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00987 ensembl:ENSP00000258149	P		Seeded From UniProt	complete
enables	GO:0047485	protein N-terminus binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00987 ensembl:ENSP00000258149	F		Seeded From UniProt	complete
involved_in	GO:0046677	response to antibiotic	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00987 ensembl:ENSP00000258149	P		Seeded From UniProt	complete
involved_in	GO:0045931	positive regulation of mitotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00987 ensembl:ENSP00000258149	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00987 ensembl:ENSP00000258149	P		Seeded From UniProt	complete
involved_in	GO:0045184	establishment of protein localization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00987 ensembl:ENSP00000258149	P		Seeded From UniProt	complete
involved_in	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00987 ensembl:ENSP00000258149	P		Seeded From UniProt	complete
enables	GO:0043130	ubiquitin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00987 ensembl:ENSP00000258149	F		Seeded From UniProt	complete
enables	GO:0043021	ribonucleoprotein complex binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00987 ensembl:ENSP00000258149	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00987 ensembl:ENSP00000258149	F		Seeded From UniProt	complete
involved_in	GO:0042176	regulation of protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00987 ensembl:ENSP00000258149	P		Seeded From UniProt	complete
involved_in	GO:0034504	protein localization to nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00987 ensembl:ENSP00000258149	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00987 ensembl:ENSP00000258149	C		Seeded From UniProt	complete
involved_in	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00987 ensembl:ENSP00000258149	P		Seeded From UniProt	complete
involved_in	GO:0031648	protein destabilization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00987 ensembl:ENSP00000258149	P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00987 ensembl:ENSP00000258149	F		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00987 ensembl:ENSP00000258149	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00987 ensembl:ENSP00000258149	F		Seeded From UniProt	complete
involved_in	GO:0018205	peptidyl-lysine modification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00987 ensembl:ENSP00000258149	P		Seeded From UniProt	complete
enables	GO:0016874	ligase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00987 ensembl:ENSP00000258149	F		Seeded From UniProt	complete
part_of	GO:0016604	nuclear body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00987 ensembl:ENSP00000258149	C		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00987 ensembl:ENSP00000258149	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00987 ensembl:ENSP00000258149	F		Seeded From UniProt	complete
enables	GO:0008097	5S rRNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00987 ensembl:ENSP00000258149	F		Seeded From UniProt	complete
involved_in	GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00987 ensembl:ENSP00000258149	P		Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00987 ensembl:ENSP00000258149	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00987 ensembl:ENSP00000258149	C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00987 ensembl:ENSP00000258149	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00987 ensembl:ENSP00000258149	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00987 ensembl:ENSP00000258149	C		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00987 ensembl:ENSP00000258149	F		Seeded From UniProt	complete
enables	GO:0002039	p53 binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00987 ensembl:ENSP00000258149	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00987 ensembl:ENSP00000258149	P		Seeded From UniProt	complete
involved_in	GO:1990785	response to water-immersion restraint stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2JVC1 ensembl:ENSRNOP00000069425	P		Seeded From UniProt	complete
involved_in	GO:1904754	positive regulation of vascular associated smooth muscle cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2JVC1 ensembl:ENSRNOP00000069425	P		Seeded From UniProt	complete
involved_in	GO:1904707	positive regulation of vascular smooth muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2JVC1 ensembl:ENSRNOP00000069425	P		Seeded From UniProt	complete
involved_in	GO:1904404	response to formaldehyde	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2JVC1 ensembl:ENSRNOP00000069425	P		Seeded From UniProt	complete
involved_in	GO:0071494	cellular response to UV-C	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2JVC1 ensembl:ENSRNOP00000069425	P		Seeded From UniProt	complete
involved_in	GO:0071407	cellular response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2JVC1 ensembl:ENSRNOP00000069425	P		Seeded From UniProt	complete
involved_in	GO:0071391	cellular response to estrogen stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2JVC1 ensembl:ENSRNOP00000069425	P		Seeded From UniProt	complete
involved_in	GO:0071375	cellular response to peptide hormone stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2JVC1 ensembl:ENSRNOP00000069425	P		Seeded From UniProt	complete
involved_in	GO:0071363	cellular response to growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2JVC1 ensembl:ENSRNOP00000069425	P		Seeded From UniProt	complete
involved_in	GO:0071312	cellular response to alkaloid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2JVC1 ensembl:ENSRNOP00000069425	P		Seeded From UniProt	complete
involved_in	GO:0071310	cellular response to organic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2JVC1 ensembl:ENSRNOP00000069425	P		Seeded From UniProt	complete
involved_in	GO:0071301	cellular response to vitamin B1	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2JVC1 ensembl:ENSRNOP00000069425	P		Seeded From UniProt	complete
involved_in	GO:0071236	cellular response to antibiotic	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2JVC1 ensembl:ENSRNOP00000069425	P		Seeded From UniProt	complete
involved_in	GO:0070301	cellular response to hydrogen peroxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2JVC1 ensembl:ENSRNOP00000069425	P		Seeded From UniProt	complete
involved_in	GO:0048545	response to steroid hormone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2JVC1 ensembl:ENSRNOP00000069425	P		Seeded From UniProt	complete
involved_in	GO:0046827	positive regulation of protein export from nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2JVC1 ensembl:ENSRNOP00000069425	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2JVC1 ensembl:ENSRNOP00000069425	P		Seeded From UniProt	complete
involved_in	GO:0045472	response to ether	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2JVC1 ensembl:ENSRNOP00000069425	P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2JVC1 ensembl:ENSRNOP00000069425	C		Seeded From UniProt	complete
involved_in	GO:0043278	response to morphine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2JVC1 ensembl:ENSRNOP00000069425	P		Seeded From UniProt	complete
involved_in	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2JVC1 ensembl:ENSRNOP00000069425	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2JVC1 ensembl:ENSRNOP00000069425	P		Seeded From UniProt	complete
enables	GO:0042975	peroxisome proliferator activated receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2JVC1 ensembl:ENSRNOP00000069425	F		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2JVC1 ensembl:ENSRNOP00000069425	P		Seeded From UniProt	complete
involved_in	GO:0042220	response to cocaine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2JVC1 ensembl:ENSRNOP00000069425	P		Seeded From UniProt	complete
enables	GO:0033612	receptor serine/threonine kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2JVC1 ensembl:ENSRNOP00000069425	F		Seeded From UniProt	complete
involved_in	GO:0032026	response to magnesium ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2JVC1 ensembl:ENSRNOP00000069425	P		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2JVC1 ensembl:ENSRNOP00000069425	P		Seeded From UniProt	complete
involved_in	GO:0010977	negative regulation of neuron projection development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2JVC1 ensembl:ENSRNOP00000069425	P		Seeded From UniProt	complete
involved_in	GO:0010955	negative regulation of protein processing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2JVC1 ensembl:ENSRNOP00000069425	P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2JVC1 ensembl:ENSRNOP00000069425	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2JVC1 ensembl:ENSRNOP00000069425	P		Seeded From UniProt	complete
involved_in	GO:0010039	response to iron ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2JVC1 ensembl:ENSRNOP00000069425	P		Seeded From UniProt	complete
involved_in	GO:0009636	response to toxic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2JVC1 ensembl:ENSRNOP00000069425	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2JVC1 ensembl:ENSRNOP00000069425	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2JVC1 ensembl:ENSRNOP00000069425	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2JVC1 ensembl:ENSRNOP00000069425	C		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2JVC1 ensembl:ENSRNOP00000069425	F		Seeded From UniProt	complete
enables	GO:0002039	p53 binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2JVC1 ensembl:ENSRNOP00000069425	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015459	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016495	C		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015459	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016495	P		Seeded From UniProt	complete
involved_in	GO:0071157	negative regulation of cell cycle arrest	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016495	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0188	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0190	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Liu, D et al. (2010) Puma is required for p53-induced depletion of adult stem cells. Nat. Cell Biol. 12 993-8 PubMed GONUTS page
↑ ^2.0 ^2.1 Fu, D et al. (2015) Mdm2 promotes myogenesis through the ubiquitination and degradation of CCAAT/enhancer-binding protein β. J. Biol. Chem. 290 10200-7 PubMed GONUTS page
↑ Li, X et al. (2009) Mdm2 directs the ubiquitination of beta-arrestin-sequestered cAMP phosphodiesterase-4D5. J. Biol. Chem. 284 16170-82 PubMed GONUTS page
↑ Bernardi, R et al. (2004) PML regulates p53 stability by sequestering Mdm2 to the nucleolus. Nat. Cell Biol. 6 665-72 PubMed GONUTS page
↑ ^5.0 ^5.1 Lin, HK et al. (2002) Phosphorylation-dependent ubiquitylation and degradation of androgen receptor by Akt require Mdm2 E3 ligase. EMBO J. 21 4037-48 PubMed GONUTS page
↑ ^6.00 ^6.01 ^6.02 ^6.03 ^6.04 ^6.05 ^6.06 ^6.07 ^6.08 ^6.09 ^6.10 ^6.11 ^6.12 Zhang, Q et al. (2012) Synergistic regulation of p53 by Mdm2 and Mdm4 is critical in cardiac endocardial cushion morphogenesis during heart development. J. Pathol. 228 416-28 PubMed GONUTS page
↑ Brady, SN et al. (2004) ARF impedes NPM/B23 shuttling in an Mdm2-sensitive tumor suppressor pathway. Mol. Cell. Biol. 24 9327-38 PubMed GONUTS page
↑ Boyd, MT et al. (2000) A novel cellular protein (MTBP) binds to MDM2 and induces a G1 arrest that is suppressed by MDM2. J. Biol. Chem. 275 31883-90 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Lee, JH et al. (2007) Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death. J. Cell. Sci. 120 2259-71 PubMed GONUTS page
↑ ^10.0 ^10.1 Chiu, SY et al. (2008) SUMO-specific protease 2 is essential for modulating p53-Mdm2 in development of trophoblast stem cell niches and lineages. PLoS Biol. 6 e310 PubMed GONUTS page
↑ ^11.0 ^11.1 Mesaeli, N & Phillipson, C (2004) Impaired p53 expression, function, and nuclear localization in calreticulin-deficient cells. Mol. Biol. Cell 15 1862-70 PubMed GONUTS page
↑ ^12.0 ^12.1 Mekhail, K et al. (2005) Regulation of ubiquitin ligase dynamics by the nucleolus. J. Cell Biol. 170 733-44 PubMed GONUTS page
↑ ^13.0 ^13.1 Bothner, B et al. (2001) Defining the molecular basis of Arf and Hdm2 interactions. J. Mol. Biol. 314 263-77 PubMed GONUTS page
↑ Lee, D et al. (2012) Mdm2 associates with Ras effector NORE1 to induce the degradation of oncoprotein HIPK1. EMBO Rep. 13 163-9 PubMed GONUTS page
↑ Masuhara, M et al. (2003) Enhanced degradation of MDM2 by a nuclear envelope component, mouse germ cell-less. Biochem. Biophys. Res. Commun. 308 927-32 PubMed GONUTS page
↑ Hasan, MK et al. (2002) CARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53. J. Biol. Chem. 277 37765-70 PubMed GONUTS page
↑ Saito, A et al. (2005) Modulation of p53 degradation via MDM2-mediated ubiquitylation and the ubiquitin-proteasome system during reperfusion after stroke: role of oxidative stress. J. Cereb. Blood Flow Metab. 25 267-80 PubMed GONUTS page

[PMID:20818388-1] 1.0 ^1.1 Liu, D et al. (2010) Puma is required for p53-induced depletion of adult stem cells. Nat. Cell Biol. 12 993-8 PubMed GONUTS page

[PMID:25720496-2] 2.0 ^2.1 Fu, D et al. (2015) Mdm2 promotes myogenesis through the ubiquitination and degradation of CCAAT/enhancer-binding protein β. J. Biol. Chem. 290 10200-7 PubMed GONUTS page

[PMID:19372219-3] Li, X et al. (2009) Mdm2 directs the ubiquitination of beta-arrestin-sequestered cAMP phosphodiesterase-4D5. J. Biol. Chem. 284 16170-82 PubMed GONUTS page

[PMID:15195100-4] Bernardi, R et al. (2004) PML regulates p53 stability by sequestering Mdm2 to the nucleolus. Nat. Cell Biol. 6 665-72 PubMed GONUTS page

[PMID:12145204-5] 5.0 ^5.1 Lin, HK et al. (2002) Phosphorylation-dependent ubiquitylation and degradation of androgen receptor by Akt require Mdm2 E3 ligase. EMBO J. 21 4037-48 PubMed GONUTS page

[PMID:22821713-6] 6.00 ^6.01 ^6.02 ^6.03 ^6.04 ^6.05 ^6.06 ^6.07 ^6.08 ^6.09 ^6.10 ^6.11 ^6.12 Zhang, Q et al. (2012) Synergistic regulation of p53 by Mdm2 and Mdm4 is critical in cardiac endocardial cushion morphogenesis during heart development. J. Pathol. 228 416-28 PubMed GONUTS page

[PMID:15485902-7] Brady, SN et al. (2004) ARF impedes NPM/B23 shuttling in an Mdm2-sensitive tumor suppressor pathway. Mol. Cell. Biol. 24 9327-38 PubMed GONUTS page

[PMID:10906133-8] Boyd, MT et al. (2000) A novel cellular protein (MTBP) binds to MDM2 and induces a G1 arrest that is suppressed by MDM2. J. Biol. Chem. 275 31883-90 PubMed GONUTS page

[PMID:17591690-9] 9.0 ^9.1 ^9.2 Lee, JH et al. (2007) Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death. J. Cell. Sci. 120 2259-71 PubMed GONUTS page

[PMID:19090619-10] 10.0 ^10.1 Chiu, SY et al. (2008) SUMO-specific protease 2 is essential for modulating p53-Mdm2 in development of trophoblast stem cell niches and lineages. PLoS Biol. 6 e310 PubMed GONUTS page

[PMID:14767071-11] 11.0 ^11.1 Mesaeli, N & Phillipson, C (2004) Impaired p53 expression, function, and nuclear localization in calreticulin-deficient cells. Mol. Biol. Cell 15 1862-70 PubMed GONUTS page

[PMID:16129783-12] 12.0 ^12.1 Mekhail, K et al. (2005) Regulation of ubiquitin ligase dynamics by the nucleolus. J. Cell Biol. 170 733-44 PubMed GONUTS page

[PMID:11718560-13] 13.0 ^13.1 Bothner, B et al. (2001) Defining the molecular basis of Arf and Hdm2 interactions. J. Mol. Biol. 314 263-77 PubMed GONUTS page

[PMID:22173032-14] Lee, D et al. (2012) Mdm2 associates with Ras effector NORE1 to induce the degradation of oncoprotein HIPK1. EMBO Rep. 13 163-9 PubMed GONUTS page

[PMID:12927808-15] Masuhara, M et al. (2003) Enhanced degradation of MDM2 by a nuclear envelope component, mouse germ cell-less. Biochem. Biophys. Res. Commun. 308 927-32 PubMed GONUTS page

[PMID:12154087-16] Hasan, MK et al. (2002) CARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53. J. Biol. Chem. 277 37765-70 PubMed GONUTS page

[PMID:15678128-17] Saito, A et al. (2005) Modulation of p53 degradation via MDM2-mediated ubiquitylation and the ubiquitin-proteasome system during reperfusion after stroke: role of oxidative stress. J. Cereb. Blood Flow Metab. 25 267-80 PubMed GONUTS page

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MOUSE:MDM2

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