MOUSE:CUL4A

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Cul4a
Protein Name(s)	Cullin-4A CUL-4A
External Links
UniProt	Q3TCH7
EMBL	AK168215 AK170722 BC010211
CCDS	CCDS52485.1
RefSeq	NP_666319.2
UniGene	Mm.212861
ProteinModelPortal	Q3TCH7
SMR	Q3TCH7
BioGrid	221235
IntAct	Q3TCH7
MINT	MINT-4122171
PhosphoSite	Q3TCH7
MaxQB	Q3TCH7
PaxDb	Q3TCH7
PRIDE	Q3TCH7
Ensembl	ENSMUST00000016680
GeneID	99375
KEGG	mmu:99375
UCSC	uc009kww.2
CTD	8451
MGI	MGI:1914487
eggNOG	COG5647
GeneTree	ENSGT00760000119212
HOGENOM	HOG000176712
HOVERGEN	HBG003619
InParanoid	Q3TCH7
KO	K10609
OMA	FQRNERF
OrthoDB	EOG75TMB5
PhylomeDB	Q3TCH7
TreeFam	TF101153
UniPathway	UPA00143
ChiTaRS	Cul4a
NextBio	353901
PRO	PR:Q3TCH7
Proteomes	UP000000589
Bgee	Q3TCH7
CleanEx	MM_CUL4A
ExpressionAtlas	Q3TCH7
Genevestigator	Q3TCH7
GO	GO:0080008 GO:0031464 GO:0006281 GO:0030097 GO:0030853 GO:0008284 GO:1900087 GO:0045732 GO:0043161 GO:0016567 GO:2000001 GO:2000819 GO:0051246 GO:0035019 GO:0006511 GO:0016032
Gene3D	1.10.10.10
InterPro	IPR016157 IPR016158 IPR001373 IPR019559 IPR016159 IPR011991
Pfam	PF00888 PF10557
SMART	SM00182 SM00884
SUPFAM	SSF74788 SSF75632
PROSITE	PS01256 PS50069

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
incorrect (CACAO)	GO:0045995	regulation of embryonic development	PMID:18339895^[1]	ECO:0000304			P		intro “...mutant embryos did not survive….”	complete
	GO:0002244	hemopoietic progenitor cell differentiation	PMID:18339895^[1]	ECO:0000315			P		Figure 3, table 1	complete
	GO:0006916	anti-apoptosis	PMID:18339895^[1]	ECO:0000315			P		Figure.4A,B ... the frequency of apoptotic cells was 4.5-fold greater in the mutant cells…	complete
	GO:0051726	regulation of cell cycle	PMID:18339895^[1]	ECO:0000315			P		figure 4C	complete
	GO:0051246	regulation of protein metabolic process	PMID:18339895^[1]	ECO:0000315			P		figure 5	complete
	GO:0001701	in utero embryonic development	PMID:12077329^[2]	ECO:0000315			P		Table 1: In the group of offspring produced from heterozygous CUL4A mutant crosses, no homozygous CUL4A mutants were viable past the blastocyte stage. There were also significanly fewer heterozygote pups than expected based on mendialian genetics. This shows that CUL4A plays an important role in embryo development.	complete CACAO 9884
involved_in	GO:0042254	ribosome biogenesis	PMID:26711351^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001701	in utero embryonic development	PMID:12077329^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0080008	Cul4-RING E3 ubiquitin ligase complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13619	C		Seeded From UniProt	complete
part_of	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13619	C		Seeded From UniProt	complete
part_of	GO:0080008	Cul4-RING E3 ubiquitin ligase complex	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0033260 PANTHER:PTN000748578 TAIR:locus:2162060 UniProtKB:Q13619 UniProtKB:Q13620	C		Seeded From UniProt	complete
contributes_to	GO:0061630	ubiquitin protein ligase activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000231993 SGD:S000002290	F		Seeded From UniProt	complete
involved_in	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0261268 MGI:MGI:1347360 MGI:MGI:1349658 MGI:MGI:1914487 PANTHER:PTN000231993 PomBase:SPAC17G6.12 SGD:S000002290 UniProtKB:Q13616 UniProtKB:Q13618 UniProtKB:Q13619 UniProtKB:Q5AJB7 WB:WBGene00000837 WB:WBGene00000839	P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015509 FB:FBgn0032956 FB:FBgn0033260 FB:FBgn0039632 FB:FBgn0261268 PANTHER:PTN000231993 UniProtKB:Q13617 UniProtKB:Q93034	F		Seeded From UniProt	complete
part_of	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000232242 UniProtKB:Q13619	C		Seeded From UniProt	complete
part_of	GO:0031461	cullin-RING ubiquitin ligase complex	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000231993 UniProtKB:Q13616 UniProtKB:Q57UJ3	C		Seeded From UniProt	complete
involved_in	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1349658 PANTHER:PTN000231993 PomBase:SPAC17G6.12 SGD:S000002290 UniProtKB:Q13616 UniProtKB:Q5AJB7	P		Seeded From UniProt	complete
part_of	GO:0019005	SCF ubiquitin ligase complex	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015509 MGI:MGI:1349658 PANTHER:PTN000231993 PomBase:SPAC17G6.12 SGD:S000002290 UniProtKB:Q13616 dictyBase:DDB_G0291972	C		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000232236 UniProtKB:A0A1D8PDR1	P		Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1914487 PANTHER:PTN000231993 SGD:S000002290 SGD:S000003235 UniProtKB:Q13618 UniProtKB:Q57UJ3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000819	regulation of nucleotide-excision repair	PMID:19481525^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3851025	P	regulates_o_occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000001	regulation of DNA damage checkpoint	PMID:19481525^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3851025	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	PMID:19056892^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0080008	Cul4-RING E3 ubiquitin ligase complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13619	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051246	regulation of protein metabolic process	PMID:19056892^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045732	positive regulation of protein catabolic process	PMID:19056892^[6]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P46527	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	PMID:16467204^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(MGI:MGI:104565)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13619	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035019	somatic stem cell population maintenance	PMID:17616641^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2183544	P		Seeded From UniProt	complete
part_of	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13619	C		Seeded From UniProt	complete
part_of	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P46527	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030853	negative regulation of granulocyte differentiation	PMID:12393421^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030097	hemopoiesis	PMID:18339895^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3805522	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016567	protein ubiquitination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13619	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	PMID:16467204^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006511	ubiquitin-dependent protein catabolic process	PMID:19481525^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3851025	P	occurs_in:(CL:0000057) has_participant:(MGI:MGI:1355314)\|occurs_in(CL:0000057) has_participant:(MGI:MGI:103557)\|occurs_in(CL:0000057) has_participant:(MGI:MGI:104556)	Seeded From UniProt	complete
part_of	GO:0080008	Cul4-RING E3 ubiquitin ligase complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13619 ensembl:ENSP00000364589	C		Seeded From UniProt	complete
involved_in	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13619 ensembl:ENSP00000364589	P		Seeded From UniProt	complete
involved_in	GO:0042254	ribosome biogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13619 ensembl:ENSP00000364589	P		Seeded From UniProt	complete
part_of	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13619 ensembl:ENSP00000364589	C		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13619 ensembl:ENSP00000364589	P		Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001373 InterPro:IPR016157	P		Seeded From UniProt	complete
part_of	GO:0031461	cullin-RING ubiquitin ligase complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016157	C		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001373 InterPro:IPR016157	F		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P		Seeded From UniProt	complete
involved_in	GO:0048511	rhythmic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0090	P		Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00143	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Waning, DL et al. (2008) Cul4A is required for hematopoietic cell viability and its deficiency leads to apoptosis. Blood 112 320-9 PubMed GONUTS page
↑ ^2.0 ^2.1 Li, B et al. (2002) CUL-4A is critical for early embryonic development. Mol. Cell. Biol. 22 4997-5005 PubMed GONUTS page
↑ Badertscher, L et al. (2015) Genome-wide RNAi Screening Identifies Protein Modules Required for 40S Subunit Synthesis in Human Cells. Cell Rep 13 2879-91 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 ^4.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Liu, L et al. (2009) CUL4A abrogation augments DNA damage response and protection against skin carcinogenesis. Mol. Cell 34 451-60 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Miranda-Carboni, GA et al. (2008) A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors. Genes Dev. 22 3121-34 PubMed GONUTS page
↑ ^7.0 ^7.1 Li, B et al. (2006) Cul4A targets p27 for degradation and regulates proliferation, cell cycle exit, and differentiation during erythropoiesis. Blood 107 4291-9 PubMed GONUTS page
↑ Li, B et al. (2007) Cul4A is required for hematopoietic stem-cell engraftment and self-renewal. Blood 110 2704-7 PubMed GONUTS page
↑ Li, B et al. (2003) Enforced expression of CUL-4A interferes with granulocytic differentiation and exit from the cell cycle. Blood 101 1769-76 PubMed GONUTS page

[PMID:18339895-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Waning, DL et al. (2008) Cul4A is required for hematopoietic cell viability and its deficiency leads to apoptosis. Blood 112 320-9 PubMed GONUTS page

[PMID:12077329-2] 2.0 ^2.1 Li, B et al. (2002) CUL-4A is critical for early embryonic development. Mol. Cell. Biol. 22 4997-5005 PubMed GONUTS page

[PMID:26711351-3] Badertscher, L et al. (2015) Genome-wide RNAi Screening Identifies Protein Modules Required for 40S Subunit Synthesis in Human Cells. Cell Rep 13 2879-91 PubMed GONUTS page

[PMID:21873635-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 ^4.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:19481525-5] 5.0 ^5.1 ^5.2 Liu, L et al. (2009) CUL4A abrogation augments DNA damage response and protection against skin carcinogenesis. Mol. Cell 34 451-60 PubMed GONUTS page

[PMID:19056892-6] 6.0 ^6.1 ^6.2 Miranda-Carboni, GA et al. (2008) A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors. Genes Dev. 22 3121-34 PubMed GONUTS page

[PMID:16467204-7] 7.0 ^7.1 Li, B et al. (2006) Cul4A targets p27 for degradation and regulates proliferation, cell cycle exit, and differentiation during erythropoiesis. Blood 107 4291-9 PubMed GONUTS page

[PMID:17616641-8] Li, B et al. (2007) Cul4A is required for hematopoietic stem-cell engraftment and self-renewal. Blood 110 2704-7 PubMed GONUTS page

[PMID:12393421-9] Li, B et al. (2003) Enforced expression of CUL-4A interferes with granulocytic differentiation and exit from the cell cycle. Blood 101 1769-76 PubMed GONUTS page

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MOUSE:CUL4A

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