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HUMAN:SMUF2

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) SMURF2
Protein Name(s) E3 ubiquitin-protein ligase SMURF2

hSMURF2 SMAD ubiquitination regulatory factor 2 SMAD-specific E3 ubiquitin-protein ligase 2

External Links
UniProt Q9HAU4
EMBL AF310676
AF301463
AY014180
BC093876
BC111945
CCDS CCDS32707.1
RefSeq NP_073576.1
UniGene Hs.515011
PDB 1ZVD
2DJY
2JQZ
2KXQ
2LTZ
PDBsum 1ZVD
2DJY
2JQZ
2KXQ
2LTZ
ProteinModelPortal Q9HAU4
SMR Q9HAU4
BioGrid 122265
DIP DIP-33061N
IntAct Q9HAU4
MINT MINT-1180022
STRING 9606.ENSP00000262435
PhosphoSite Q9HAU4
DMDM 17865624
MaxQB Q9HAU4
PaxDb Q9HAU4
PRIDE Q9HAU4
Ensembl ENST00000262435
GeneID 64750
KEGG hsa:64750
UCSC uc002jep.1
CTD 64750
GeneCards GC17M062540
HGNC HGNC:16809
MIM 605532
neXtProt NX_Q9HAU4
PharmGKB PA134985524
eggNOG COG5021
GeneTree ENSGT00760000118966
HOGENOM HOG000208451
HOVERGEN HBG004134
InParanoid Q9HAU4
KO K04678
OMA KIDIHDW
PhylomeDB Q9HAU4
TreeFam TF323658
Reactome REACT_12034
REACT_120727
REACT_121111
REACT_172638
REACT_200766
REACT_75842
SignaLink Q9HAU4
UniPathway UPA00143
ChiTaRS SMURF2
EvolutionaryTrace Q9HAU4
GeneWiki SMURF2
GenomeRNAi 64750
NextBio 66708
PRO PR:Q9HAU4
Proteomes UP000005640
Bgee Q9HAU4
CleanEx HS_SMURF2
ExpressionAtlas Q9HAU4
Genevestigator Q9HAU4
GO GO:0005737
GO:0005829
GO:0045121
GO:0005654
GO:0005634
GO:0005886
GO:0000151
GO:0042802
GO:0016874
GO:0046332
GO:0004842
GO:0030509
GO:0010467
GO:0000122
GO:0045892
GO:0030512
GO:0042787
GO:0017015
GO:0006367
GO:0006351
GO:0007179
GO:0006511
GO:0030579
Gene3D 2.60.40.150
InterPro IPR000008
IPR024928
IPR000569
IPR001202
Pfam PF00168
PF00632
PF00397
PIRSF PIRSF001569
SMART SM00239
SM00119
SM00456
SUPFAM SSF49562
SSF51045
SSF56204
PROSITE PS50004
PS50237
PS01159
PS50020

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0030512

negative regulation of transforming growth factor beta receptor signaling pathway

PMID:19255252[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1901165

positive regulation of trophoblast cell migration

PMID:19255252[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0046332

SMAD binding

PMID:19122240[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q15796

F

Seeded From UniProt

complete

enables

GO:0046332

SMAD binding

PMID:19122240[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P84022

F

Seeded From UniProt

complete

involved_in

GO:0030579

ubiquitin-dependent SMAD protein catabolic process

PMID:19122240[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

PMID:11016919[3]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

GO:1901165

positive regulation of trophoblast cell migration

PMID:19255252[1]

ECO:0000314

P

Over-expression of Smurf2 enhanced the migration and invasion of HTR-8/SVneo Cells, Figure 2.

complete
CACAO 9585

involved_in

GO:0017015

regulation of transforming growth factor beta receptor signaling pathway

PMID:11158580[4]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

GO:0030512

negative regulation of transforming growth factor beta receptor signaling pathway

PMID:19255252[1]

ECO:0000314

P

TGF-βR1 was significantly down-regulated in Smurf2 over-expressed cells, Figure 3.

complete
CACAO 9587

involved_in

GO:0006511

ubiquitin-dependent protein catabolic process

PMID:14755250[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:11163210[6]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004842

ubiquitin-protein transferase activity

PMID:14755250[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0000151

ubiquitin ligase complex

PMID:14755250[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0061630

ubiquitin protein ligase activity

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0259174
MGI:MGI:1861728
MGI:MGI:1914144
MGI:MGI:1933754
MGI:MGI:97297
PANTHER:PTN000134256
PomBase:SPAC11G7.02
PomBase:SPAC1805.15c
UniProtKB:P46934
UniProtKB:Q96J02
UniProtKB:Q9HCE7

F

Seeded From UniProt

complete

involved_in

GO:0045732

positive regulation of protein catabolic process

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1202301
MGI:MGI:97297
PANTHER:PTN000134745
RGD:735047
UniProtKB:P46934

P

Seeded From UniProt

complete

involved_in

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1861728
MGI:MGI:1914144
PANTHER:PTN000134745
SGD:S000000927
UniProtKB:O00308
UniProtKB:Q96PU5
UniProtKB:Q9HCE7

P

Seeded From UniProt

complete

involved_in

GO:0030579

ubiquitin-dependent SMAD protein catabolic process

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000135002
UniProtKB:Q9HAU4
UniProtKB:Q9HCE7

P

Seeded From UniProt

complete

involved_in

GO:0030514

negative regulation of BMP signaling pathway

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0029006
PANTHER:PTN000135002
UniProtKB:Q9HCE7

P

Seeded From UniProt

complete

involved_in

GO:0016567

protein ubiquitination

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0259174
MGI:MGI:1861728
MGI:MGI:1914144
MGI:MGI:1923038
MGI:MGI:97297
PANTHER:PTN000134256
SGD:S000000927
SGD:S000002865
TAIR:locus:2135630
UniProtKB:O00308
UniProtKB:P46934
UniProtKB:Q5BDP1
UniProtKB:Q8IYU2
UniProtKB:Q96J02
UniProtKB:Q96PU5
UniProtKB:Q9HCE7
WB:WBGene00007009

P

Seeded From UniProt

complete

involved_in

GO:0006511

ubiquitin-dependent protein catabolic process

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0029006
PANTHER:PTN000135002
UniProtKB:Q9HAU4
UniProtKB:Q9HCE7

P

Seeded From UniProt

complete

involved_in

GO:0006511

ubiquitin-dependent protein catabolic process

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0029006
MGI:MGI:1202301
MGI:MGI:97297
PANTHER:PTN000134745
PomBase:SPAC11G7.02
SGD:S000000927
UniProtKB:O15033
UniProtKB:P46934
UniProtKB:Q96J02
UniProtKB:Q96PU5
UniProtKB:Q9HAU4
UniProtKB:Q9HCE7

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003557
FB:FBgn0259174
MGI:MGI:1202301
MGI:MGI:1914144
MGI:MGI:97297
PANTHER:PTN000134256
PomBase:SPAC11G7.02
PomBase:SPAC1805.15c
SGD:S000000927
TAIR:locus:2135630
UniProtKB:P46934
UniProtKB:Q7Z6Z7
UniProtKB:Q9HCE7
WB:WBGene00007009

C

Seeded From UniProt

complete

involved_in

GO:0000209

protein polyubiquitination

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1202301
PANTHER:PTN000134745
SGD:S000000927
UniProtKB:Q9HCE7

P

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:17719543[8]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9HAU4

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:15231748[9]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9HAU4

F

Seeded From UniProt

complete

part_of

GO:0016607

nuclear speck

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0046332

SMAD binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:F1M3F2
ensembl:ENSRNOP00000019781

F

Seeded From UniProt

complete

enables

GO:0005160

transforming growth factor beta receptor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:F1M3F2
ensembl:ENSRNOP00000019781

F

Seeded From UniProt

complete

enables

GO:0004842

ubiquitin-protein transferase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000569
InterPro:IPR035983

F

Seeded From UniProt

complete

involved_in

GO:0006511

ubiquitin-dependent protein catabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR024928

P

Seeded From UniProt

complete

enables

GO:0061630

ubiquitin protein ligase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR024928

F

Seeded From UniProt

complete

involved_in

GO:0090263

positive regulation of canonical Wnt signaling pathway

Reactome:R-HSA-4641257

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0061630

ubiquitin protein ligase activity

Reactome:R-HSA-4641129
Reactome:R-HSA-4608852

ECO:0000304

author statement supported by traceable reference used in manual assertion


F

Seeded From UniProt

complete

involved_in

GO:0060071

Wnt signaling pathway, planar cell polarity pathway

Reactome:R-HSA-4086400

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030512

negative regulation of transforming growth factor beta receptor signaling pathway

Reactome:R-HSA-2173788

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030509

BMP signaling pathway

Reactome:R-HSA-201451

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016579

protein deubiquitination

Reactome:R-HSA-5688426

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-NUL-2176393
Reactome:R-NUL-2169043
Reactome:R-NUL-2167888
Reactome:R-HSA-983157
Reactome:R-HSA-983156
Reactome:R-HSA-983147
Reactome:R-HSA-983140
Reactome:R-HSA-6781764
Reactome:R-HSA-5635865
Reactome:R-HSA-4641256
Reactome:R-HSA-4641134
Reactome:R-HSA-4641129
Reactome:R-HSA-4608854
Reactome:R-HSA-4608852
Reactome:R-HSA-2176445
Reactome:R-HSA-201821
Reactome:R-HSA-201445
Reactome:R-HSA-173542

ECO:0000304

author statement supported by traceable reference used in manual assertion


















C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-NUL-2167888
Reactome:R-HSA-8952419
Reactome:R-HSA-2179276
Reactome:R-HSA-2179274
Reactome:R-HSA-178208

ECO:0000304

author statement supported by traceable reference used in manual assertion





C

Seeded From UniProt

complete

enables

GO:0004842

ubiquitin-protein transferase activity

Reactome:R-HSA-2179276
Reactome:R-HSA-173542

ECO:0000304

author statement supported by traceable reference used in manual assertion


F

Seeded From UniProt

complete

involved_in

GO:0000209

protein polyubiquitination

Reactome:R-HSA-983168

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

Reactome:R-HSA-2173795

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

part_of

GO:0045121

membrane raft

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0370

C

Seeded From UniProt

complete

involved_in

GO:0016567

protein ubiquitination

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00143

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 Yang, Q et al. (2009) Smurf2 participates in human trophoblast cell invasion by inhibiting TGF-beta type I receptor. J. Histochem. Cytochem. 57 605-12 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Nakano, A et al. (2009) Pin1 down-regulates transforming growth factor-beta (TGF-beta) signaling by inducing degradation of Smad proteins. J. Biol. Chem. 284 6109-15 PubMed GONUTS page
  3. ↑ Lin, X et al. (2000) Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling. J. Biol. Chem. 275 36818-22 PubMed GONUTS page
  4. ↑ Zhang, Y et al. (2001) Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase. Proc. Natl. Acad. Sci. U.S.A. 98 974-9 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 Li, H & Seth, A (2004) An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein. Oncogene 23 1801-8 PubMed GONUTS page
  6. ↑ Kavsak, P et al. (2000) Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation. Mol. Cell 6 1365-75 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 7.3 7.4 7.5 7.6 7.7 7.8 7.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  8. ↑ Wiesner, S et al. (2007) Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain. Cell 130 651-62 PubMed GONUTS page
  9. ↑ Colland, F et al. (2004) Functional proteomics mapping of a human signaling pathway. Genome Res. 14 1324-32 PubMed GONUTS page
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