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HUMAN:FBW1A
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | BTRC (synonyms: BTRCP, FBW1A, FBXW1A) | |
Protein Name(s) | F-box/WD repeat-containing protein 1A
E3RSIkappaB Epididymis tissue protein Li 2a F-box and WD repeats protein beta-TrCP pIkappaBalpha-E3 receptor subunit | |
External Links | ||
UniProt | Q9Y297 | |
EMBL | AF101784 Y14153 AF129530 GU727631 AK313353 AL133387 AL445463 AL627424 AL133387 AL445463 AL627424 AL445463 AL133387 AL627424 AL445463 AL133387 AL627424 AL627424 AL133387 AL445463 AL627424 AL133387 AL445463 CH471066 CH471066 BC027994 | |
CCDS | CCDS7511.1 CCDS7512.1 | |
RefSeq | NP_003930.1 NP_378663.1 | |
UniGene | Hs.643802 | |
PDB | 1P22 2P64 | |
PDBsum | 1P22 2P64 | |
ProteinModelPortal | Q9Y297 | |
SMR | Q9Y297 | |
BioGrid | 114457 | |
DIP | DIP-31607N | |
IntAct | Q9Y297 | |
MINT | MINT-108636 | |
STRING | 9606.ENSP00000359206 | |
PhosphoSite | Q9Y297 | |
DMDM | 13124271 | |
MaxQB | Q9Y297 | |
PaxDb | Q9Y297 | |
PRIDE | Q9Y297 | |
DNASU | 8945 | |
Ensembl | ENST00000370187 ENST00000408038 | |
GeneID | 8945 | |
KEGG | hsa:8945 | |
UCSC | uc001kta.4 uc001ktb.4 | |
CTD | 8945 | |
GeneCards | GC10P103103 | |
HGNC | HGNC:1144 | |
HPA | CAB032986 | |
MIM | 603482 | |
neXtProt | NX_Q9Y297 | |
Orphanet | 2440 | |
PharmGKB | PA25465 | |
eggNOG | COG2319 | |
GeneTree | ENSGT00760000119106 | |
HOGENOM | HOG000006638 | |
HOVERGEN | HBG002521 | |
InParanoid | Q9Y297 | |
KO | K03362 | |
OMA | NNDEPPR | |
OrthoDB | EOG76DTS5 | |
PhylomeDB | Q9Y297 | |
TreeFam | TF105679 | |
Reactome | REACT_11063 REACT_115697 REACT_118656 REACT_160315 REACT_200731 REACT_206597 REACT_22442 REACT_231645 REACT_24941 REACT_267605 REACT_6821 REACT_75842 REACT_9031 | |
SignaLink | Q9Y297 | |
UniPathway | UPA00143 | |
ChiTaRS | BTRC | |
EvolutionaryTrace | Q9Y297 | |
GeneWiki | BTRC_(gene) | |
GenomeRNAi | 8945 | |
NextBio | 33645 | |
PRO | PR:Q9Y297 | |
Proteomes | UP000005640 | |
Bgee | Q9Y297 | |
CleanEx | HS_BTRC | |
ExpressionAtlas | Q9Y297 | |
Genevestigator | Q9Y297 | |
GO | GO:0005829 GO:0005634 GO:0019005 GO:0016874 GO:0004842 GO:0031145 GO:0060444 GO:0071407 GO:0000086 GO:0033598 GO:0000278 GO:0043433 GO:0045879 GO:0045892 GO:0042753 GO:0045862 GO:0045893 GO:0051437 GO:0043161 GO:0006470 GO:0031648 GO:0000209 GO:0016567 GO:0051726 GO:0042752 GO:0043122 GO:0061136 GO:0051439 GO:0048511 GO:0031146 GO:0007165 GO:0006511 GO:0016032 GO:0016055 | |
Gene3D | 2.130.10.10 | |
InterPro | IPR021977 IPR001810 IPR020472 IPR015943 IPR001680 IPR019775 IPR017986 | |
Pfam | PF12125 PF12937 PF00400 | |
PRINTS | PR00320 | |
SMART | SM01028 SM00256 SM00320 | |
SUPFAM | SSF50978 SSF81383 | |
PROSITE | PS50181 PS00678 PS50082 PS50294 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
involved_in |
GO:0016567 |
protein ubiquitination |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0016567 |
protein ubiquitination |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0031146 |
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060828 |
regulation of canonical Wnt signaling pathway |
ECO:0000305 |
curator inference used in manual assertion |
GO:0000209,GO:0008013 |
P |
Seeded From UniProt |
complete | ||
contributes_to |
GO:0061630 |
ubiquitin protein ligase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
has_direct_input:(UniProtKB:P35222) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0000209 |
protein polyubiquitination |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_direct_input:(UniProtKB:P35222) |
Seeded From UniProt |
complete | ||
enables |
GO:0008013 |
beta-catenin binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
has_direct_input:(UniProtKB:P35222) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0000209 |
protein polyubiquitination |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
has_direct_input:(UniProtKB:P25963) |
Seeded From UniProt |
complete | ||
part_of |
GO:0019005 |
SCF ubiquitin ligase complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045862 |
positive regulation of proteolysis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0043161 |
proteasome-mediated ubiquitin-dependent protein catabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0042753 |
positive regulation of circadian rhythm |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0042752 |
regulation of circadian rhythm |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0031648 |
protein destabilization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0019005 |
SCF ubiquitin ligase complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0016567 |
protein ubiquitination |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006511 |
ubiquitin-dependent protein catabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006470 |
protein dephosphorylation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
contributes_to |
GO:0004842 |
ubiquitin-protein transferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0034388 |
Pwp2p-containing subcomplex of 90S preribosome |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000457905 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0032040 |
small-subunit processome |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000457905 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0000462 |
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000457905 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0071407 |
cellular response to organic cyclic compound |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q3ULA2 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0061630 |
ubiquitin protein ligase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q3ULA2 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0061136 |
regulation of proteasomal protein catabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q3ULA2 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0060828 |
regulation of canonical Wnt signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q3ULA2 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0060444 |
branching involved in mammary gland duct morphogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q3ULA2 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0051726 |
regulation of cell cycle |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q3ULA2 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q3ULA2 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0045309 |
protein phosphorylated amino acid binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q3ULA2 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0043122 |
regulation of I-kappaB kinase/NF-kappaB signaling |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q3ULA2 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0042753 |
positive regulation of circadian rhythm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q3ULA2 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0033598 |
mammary gland epithelial cell proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q3ULA2 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0031146 |
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q3ULA2 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030163 |
protein catabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q3ULA2 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0008013 |
beta-catenin binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q3ULA2 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006470 |
protein dephosphorylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q3ULA2 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q3ULA2 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q3ULA2 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0000209 |
protein polyubiquitination |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q3ULA2 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0046983 |
protein dimerization activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007165 |
signal transduction |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006511 |
ubiquitin-dependent protein catabolic process |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045879 |
negative regulation of smoothened signaling pathway |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0043433 |
negative regulation of DNA-binding transcription factor activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
has_regulation_target:(UniProtKB:P08151) |
Seeded From UniProt |
complete | ||
involved_in |
GO:1901990 |
regulation of mitotic cell cycle phase transition |
Reactome:R-HSA-174113 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0070498 |
interleukin-1-mediated signaling pathway |
Reactome:R-HSA-9020702 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0051403 |
stress-activated MAPK cascade |
Reactome:R-HSA-450294 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0050852 |
T cell receptor signaling pathway |
Reactome:R-HSA-202403 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0043687 |
post-translational protein modification |
Reactome:R-HSA-597592 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0038095 |
Fc-epsilon receptor signaling pathway |
Reactome:R-HSA-2454202 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0038061 |
NIK/NF-kappaB signaling |
Reactome:R-HSA-5676590 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0016055 |
Wnt signaling pathway |
Reactome:R-HSA-195721 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-983157 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
part_of |
GO:0005654 |
nucleoplasm |
Reactome:R-HSA-3364042 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
involved_in |
GO:0002223 |
stimulatory C-type lectin receptor signaling pathway |
Reactome:R-HSA-5621481 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0000209 |
protein polyubiquitination |
Reactome:R-HSA-983168 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0000086 |
G2/M transition of mitotic cell cycle |
Reactome:R-HSA-69275 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0016032 |
viral process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0048511 |
rhythmic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0016874 |
ligase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0016055 |
Wnt signaling pathway |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0016567 |
protein ubiquitination |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniPathway:UPA00143 |
P |
Seeded From UniProt |
complete | ||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Guardavaccaro, D et al. (2008) Control of chromosome stability by the beta-TrCP-REST-Mad2 axis. Nature 452 365-9 PubMed GONUTS page
- ↑ Huang, Z et al. (2011) Deubiquitylase HAUSP stabilizes REST and promotes maintenance of neural progenitor cells. Nat. Cell Biol. 13 142-52 PubMed GONUTS page
- ↑ Tsuchiya, Y et al. (2011) Dual regulation of the transcriptional activity of Nrf1 by β-TrCP- and Hrd1-dependent degradation mechanisms. Mol. Cell. Biol. 31 4500-12 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 Wu, G et al. (2003) Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase. Mol. Cell 11 1445-56 PubMed GONUTS page
- ↑ 5.0 5.1 Peschiaroli, A et al. (2010) The ubiquitin-specific protease USP47 is a novel beta-TRCP interactor regulating cell survival. Oncogene 29 1384-93 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Peschiaroli, A et al. (2006) SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response. Mol. Cell 23 319-29 PubMed GONUTS page
- ↑ 7.0 7.1 Shirogane, T et al. (2005) SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein. J. Biol. Chem. 280 26863-72 PubMed GONUTS page
- ↑ 8.0 8.1 Zhou, BP et al. (2004) Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition. Nat. Cell Biol. 6 931-40 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 10.0 10.1 Spencer, E et al. (1999) Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP. Genes Dev. 13 284-94 PubMed GONUTS page
- ↑ 11.0 11.1 Villavicencio, EH et al. (2000) The sonic hedgehog-patched-gli pathway in human development and disease. Am. J. Hum. Genet. 67 1047-54 PubMed GONUTS page
b
c
m
n
- GO:0043433 ! negative regulation of DNA-binding transcription factor activity
- GO:0045879 ! negative regulation of smoothened signaling pathway
- GO:0045892 ! negative regulation of DNA-templated transcription
- GO:0038061 ! non-canonical NF-kappaB signal transduction
- GO:0005654 ! nucleoplasm
- GO:0005634 ! nucleus
p
- GO:0045862 ! positive regulation of proteolysis
- GO:0042753 ! positive regulation of circadian rhythm
- GO:0045893 ! positive regulation of DNA-templated transcription
- GO:0043687 ! post-translational protein modification
- Primates
- GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process
- GO:0030163 ! protein catabolic process
- GO:0006470 ! protein dephosphorylation
- GO:0031648 ! protein destabilization
- GO:0046983 ! protein dimerization activity
- GO:0045309 ! protein phosphorylated amino acid binding
- GO:0000209 ! protein polyubiquitination
- GO:0016567 ! protein ubiquitination
- GO:0034388 ! Pwp2p-containing subcomplex of 90S preribosome
r
- GO:0060828 ! regulation of canonical Wnt signaling pathway
- GO:0042752 ! regulation of circadian rhythm
- GO:0043122 ! regulation of canonical NF-kappaB signal transduction
- GO:0061136 ! regulation of proteasomal protein catabolic process
- GO:0051726 ! regulation of cell cycle
- GO:1901990 ! regulation of mitotic cell cycle phase transition
- GO:0048511 ! rhythmic process
s
- GO:0031146 ! SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
- GO:0019005 ! SCF ubiquitin ligase complex
- GO:0007165 ! signal transduction
- GO:0032040 ! small-subunit processome
- GO:0002223 ! stimulatory C-type lectin receptor signaling pathway
- GO:0051403 ! stress-activated MAPK cascade
u