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HUMAN:FBW1A

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) BTRC (synonyms: BTRCP, FBW1A, FBXW1A)
Protein Name(s) F-box/WD repeat-containing protein 1A

E3RSIkappaB Epididymis tissue protein Li 2a F-box and WD repeats protein beta-TrCP pIkappaBalpha-E3 receptor subunit

External Links
UniProt Q9Y297
EMBL AF101784
Y14153
AF129530
GU727631
AK313353
AL133387
AL445463
AL627424
AL133387
AL445463
AL627424
AL445463
AL133387
AL627424
AL445463
AL133387
AL627424
AL627424
AL133387
AL445463
AL627424
AL133387
AL445463
CH471066
CH471066
BC027994
CCDS CCDS7511.1
CCDS7512.1
RefSeq NP_003930.1
NP_378663.1
UniGene Hs.643802
PDB 1P22
2P64
PDBsum 1P22
2P64
ProteinModelPortal Q9Y297
SMR Q9Y297
BioGrid 114457
DIP DIP-31607N
IntAct Q9Y297
MINT MINT-108636
STRING 9606.ENSP00000359206
PhosphoSite Q9Y297
DMDM 13124271
MaxQB Q9Y297
PaxDb Q9Y297
PRIDE Q9Y297
DNASU 8945
Ensembl ENST00000370187
ENST00000408038
GeneID 8945
KEGG hsa:8945
UCSC uc001kta.4
uc001ktb.4
CTD 8945
GeneCards GC10P103103
HGNC HGNC:1144
HPA CAB032986
MIM 603482
neXtProt NX_Q9Y297
Orphanet 2440
PharmGKB PA25465
eggNOG COG2319
GeneTree ENSGT00760000119106
HOGENOM HOG000006638
HOVERGEN HBG002521
InParanoid Q9Y297
KO K03362
OMA NNDEPPR
OrthoDB EOG76DTS5
PhylomeDB Q9Y297
TreeFam TF105679
Reactome REACT_11063
REACT_115697
REACT_118656
REACT_160315
REACT_200731
REACT_206597
REACT_22442
REACT_231645
REACT_24941
REACT_267605
REACT_6821
REACT_75842
REACT_9031
SignaLink Q9Y297
UniPathway UPA00143
ChiTaRS BTRC
EvolutionaryTrace Q9Y297
GeneWiki BTRC_(gene)
GenomeRNAi 8945
NextBio 33645
PRO PR:Q9Y297
Proteomes UP000005640
Bgee Q9Y297
CleanEx HS_BTRC
ExpressionAtlas Q9Y297
Genevestigator Q9Y297
GO GO:0005829
GO:0005634
GO:0019005
GO:0016874
GO:0004842
GO:0031145
GO:0060444
GO:0071407
GO:0000086
GO:0033598
GO:0000278
GO:0043433
GO:0045879
GO:0045892
GO:0042753
GO:0045862
GO:0045893
GO:0051437
GO:0043161
GO:0006470
GO:0031648
GO:0000209
GO:0016567
GO:0051726
GO:0042752
GO:0043122
GO:0061136
GO:0051439
GO:0048511
GO:0031146
GO:0007165
GO:0006511
GO:0016032
GO:0016055
Gene3D 2.130.10.10
InterPro IPR021977
IPR001810
IPR020472
IPR015943
IPR001680
IPR019775
IPR017986
Pfam PF12125
PF12937
PF00400
PRINTS PR00320
SMART SM01028
SM00256
SM00320
SUPFAM SSF50978
SSF81383
PROSITE PS50181
PS00678
PS50082
PS50294

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0016567

protein ubiquitination

PMID:18354482[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016567

protein ubiquitination

PMID:21258371[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031146

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

PMID:21911472[3]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q3ULA2

P

Seeded From UniProt

complete

involved_in

GO:0060828

regulation of canonical Wnt signaling pathway

PMID:12820959[4]

ECO:0000305

curator inference used in manual assertion

GO:0000209,GO:0008013

P

Seeded From UniProt

complete

contributes_to

GO:0061630

ubiquitin protein ligase activity

PMID:12820959[4]

ECO:0000314

direct assay evidence used in manual assertion

F

has_direct_input:(UniProtKB:P35222)

Seeded From UniProt

complete

involved_in

GO:0000209

protein polyubiquitination

PMID:12820959[4]

ECO:0000314

direct assay evidence used in manual assertion

P

has_direct_input:(UniProtKB:P35222)

Seeded From UniProt

complete

enables

GO:0008013

beta-catenin binding

PMID:12820959[4]

ECO:0000314

direct assay evidence used in manual assertion

F

has_direct_input:(UniProtKB:P35222)

Seeded From UniProt

complete

involved_in

GO:0000209

protein polyubiquitination

PMID:12820959[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_direct_input:(UniProtKB:P25963)

Seeded From UniProt

complete

part_of

GO:0019005

SCF ubiquitin ligase complex

PMID:12820959[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q3ULA2

P

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

PMID:19966869[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045862

positive regulation of proteolysis

PMID:16885022[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

PMID:15917222[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042753

positive regulation of circadian rhythm

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q3ULA2

P

Seeded From UniProt

complete

involved_in

GO:0042752

regulation of circadian rhythm

PMID:15917222[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031648

protein destabilization

PMID:16885022[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0019005

SCF ubiquitin ligase complex

PMID:19966869[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0016567

protein ubiquitination

PMID:16885022[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006511

ubiquitin-dependent protein catabolic process

PMID:15448698[8]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006470

protein dephosphorylation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q3ULA2

P

Seeded From UniProt

complete

contributes_to

GO:0004842

ubiquitin-protein transferase activity

PMID:15448698[8]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0034388

Pwp2p-containing subcomplex of 90S preribosome

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000457905
SGD:S000004212

C

Seeded From UniProt

complete

part_of

GO:0032040

small-subunit processome

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000457905
SGD:S000004212
UniProtKB:A0A1D8PNG5

C

Seeded From UniProt

complete

involved_in

GO:0000462

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000457905
SGD:S000004212

P

Seeded From UniProt

complete

involved_in

GO:0071407

cellular response to organic cyclic compound

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3ULA2
ensembl:ENSMUSP00000070728

P

Seeded From UniProt

complete

enables

GO:0061630

ubiquitin protein ligase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3ULA2
ensembl:ENSMUSP00000070728

F

Seeded From UniProt

complete

involved_in

GO:0061136

regulation of proteasomal protein catabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3ULA2
ensembl:ENSMUSP00000070728

P

Seeded From UniProt

complete

involved_in

GO:0060828

regulation of canonical Wnt signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3ULA2
ensembl:ENSMUSP00000070728

P

Seeded From UniProt

complete

involved_in

GO:0060444

branching involved in mammary gland duct morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3ULA2
ensembl:ENSMUSP00000070728

P

Seeded From UniProt

complete

involved_in

GO:0051726

regulation of cell cycle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3ULA2
ensembl:ENSMUSP00000070728

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3ULA2
ensembl:ENSMUSP00000070728

P

Seeded From UniProt

complete

enables

GO:0045309

protein phosphorylated amino acid binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3ULA2
ensembl:ENSMUSP00000070728

F

Seeded From UniProt

complete

involved_in

GO:0043122

regulation of I-kappaB kinase/NF-kappaB signaling

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3ULA2
ensembl:ENSMUSP00000070728

P

Seeded From UniProt

complete

involved_in

GO:0042753

positive regulation of circadian rhythm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3ULA2
ensembl:ENSMUSP00000070728

P

Seeded From UniProt

complete

involved_in

GO:0033598

mammary gland epithelial cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3ULA2
ensembl:ENSMUSP00000070728

P

Seeded From UniProt

complete

involved_in

GO:0031146

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3ULA2
ensembl:ENSMUSP00000070728

P

Seeded From UniProt

complete

involved_in

GO:0030163

protein catabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3ULA2
ensembl:ENSMUSP00000070728

P

Seeded From UniProt

complete

enables

GO:0008013

beta-catenin binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3ULA2
ensembl:ENSMUSP00000070728

F

Seeded From UniProt

complete

involved_in

GO:0006470

protein dephosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3ULA2
ensembl:ENSMUSP00000070728

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3ULA2
ensembl:ENSMUSP00000070728

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3ULA2
ensembl:ENSMUSP00000070728

C

Seeded From UniProt

complete

involved_in

GO:0000209

protein polyubiquitination

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3ULA2
ensembl:ENSMUSP00000070728

P

Seeded From UniProt

complete

enables

GO:0046983

protein dimerization activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR021977

F

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

PMID:9990853[10]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006511

ubiquitin-dependent protein catabolic process

PMID:9990853[10]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045879

negative regulation of smoothened signaling pathway

PMID:11001584[11]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043433

negative regulation of DNA-binding transcription factor activity

PMID:11001584[11]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

has_regulation_target:(UniProtKB:P08151)

Seeded From UniProt

complete

involved_in

GO:1901990

regulation of mitotic cell cycle phase transition

Reactome:R-HSA-174113

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0070498

interleukin-1-mediated signaling pathway

Reactome:R-HSA-9020702

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051403

stress-activated MAPK cascade

Reactome:R-HSA-450294

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050852

T cell receptor signaling pathway

Reactome:R-HSA-202403

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043687

post-translational protein modification

Reactome:R-HSA-597592

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0038095

Fc-epsilon receptor signaling pathway

Reactome:R-HSA-2454202

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0038061

NIK/NF-kappaB signaling

Reactome:R-HSA-5676590

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016055

Wnt signaling pathway

Reactome:R-HSA-195721

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-983157
Reactome:R-HSA-983156
Reactome:R-HSA-983147
Reactome:R-HSA-983140
Reactome:R-HSA-8956200
Reactome:R-HSA-8956040
Reactome:R-HSA-8955289
Reactome:R-HSA-8955241
Reactome:R-HSA-8952620
Reactome:R-HSA-8952618
Reactome:R-HSA-5684250
Reactome:R-HSA-5684248
Reactome:R-HSA-5610746
Reactome:R-HSA-5610742
Reactome:R-HSA-5607728
Reactome:R-HSA-5607725
Reactome:R-HSA-5607723
Reactome:R-HSA-3000339
Reactome:R-HSA-3000335
Reactome:R-HSA-2130286
Reactome:R-HSA-2130282
Reactome:R-HSA-2130279
Reactome:R-HSA-209125
Reactome:R-HSA-209063
Reactome:R-HSA-180599
Reactome:R-HSA-180597
Reactome:R-HSA-180591
Reactome:R-HSA-180573
Reactome:R-HSA-174209
Reactome:R-HSA-174203
Reactome:R-HSA-174159
Reactome:R-HSA-1370500
Reactome:R-HSA-1170539
Reactome:R-HSA-1168643
Reactome:R-HSA-1168642

ECO:0000304

author statement supported by traceable reference used in manual assertion



































C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-3364042
Reactome:R-HSA-3361751

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

involved_in

GO:0002223

stimulatory C-type lectin receptor signaling pathway

Reactome:R-HSA-5621481

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000209

protein polyubiquitination

Reactome:R-HSA-983168

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000086

G2/M transition of mitotic cell cycle

Reactome:R-HSA-69275

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

involved_in

GO:0016032

viral process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0945

P

Seeded From UniProt

complete

involved_in

GO:0048511

rhythmic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0090

P

Seeded From UniProt

complete

enables

GO:0016874

ligase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0436

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0016055

Wnt signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0879

P

Seeded From UniProt

complete

involved_in

GO:0016567

protein ubiquitination

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00143

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Guardavaccaro, D et al. (2008) Control of chromosome stability by the beta-TrCP-REST-Mad2 axis. Nature 452 365-9 PubMed GONUTS page
  2. Huang, Z et al. (2011) Deubiquitylase HAUSP stabilizes REST and promotes maintenance of neural progenitor cells. Nat. Cell Biol. 13 142-52 PubMed GONUTS page
  3. Tsuchiya, Y et al. (2011) Dual regulation of the transcriptional activity of Nrf1 by β-TrCP- and Hrd1-dependent degradation mechanisms. Mol. Cell. Biol. 31 4500-12 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 4.4 4.5 Wu, G et al. (2003) Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase. Mol. Cell 11 1445-56 PubMed GONUTS page
  5. 5.0 5.1 Peschiaroli, A et al. (2010) The ubiquitin-specific protease USP47 is a novel beta-TRCP interactor regulating cell survival. Oncogene 29 1384-93 PubMed GONUTS page
  6. 6.0 6.1 6.2 Peschiaroli, A et al. (2006) SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response. Mol. Cell 23 319-29 PubMed GONUTS page
  7. 7.0 7.1 Shirogane, T et al. (2005) SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein. J. Biol. Chem. 280 26863-72 PubMed GONUTS page
  8. 8.0 8.1 Zhou, BP et al. (2004) Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition. Nat. Cell Biol. 6 931-40 PubMed GONUTS page
  9. 9.0 9.1 9.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  10. 10.0 10.1 Spencer, E et al. (1999) Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP. Genes Dev. 13 284-94 PubMed GONUTS page
  11. 11.0 11.1 Villavicencio, EH et al. (2000) The sonic hedgehog-patched-gli pathway in human development and disease. Am. J. Hum. Genet. 67 1047-54 PubMed GONUTS page