Category:GO:0038061 ! non-canonical NF-kappaB signal transduction

name: non-canonical NF-kappaB signal transduction
namespace: biological_process
def: "An intracellular signaling cassette characterized by the NIK-dependent processing and activation of NF-kappaB. Begins with activation of the NF-kappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-kappa B2 protein (p100) leading to p100 processing and release of an active NF-kappaB (p52). The non-canonical NF-kappaB signaling pathway is generally activated by ligands of the TNF receptor superfamily, including lymphotoxin beta (LTB), CD40, OX40, RANK, TWEAK and B cell-activating factor (BAFF)." [GOC:bf, GOC:mg2, GOC:signaling, GOC:vs, PMID:11239468, PMID:15140882, PMID:34659217]
synonym: "NF-kappaB cascade" BROAD []
synonym: "NIK-IKK kinase cascade" EXACT [GOC:rph, PMID:10094049, PMID:10581243, PMID:9244310]
synonym: "NIK-IKK signaling pathway" EXACT [GOC:rph, PMID:10094049, PMID:10581243, PMID:9244310]
synonym: "NIK-IKK-alpha cascade" EXACT [GOC:rph, PMID:10094049, PMID:10581243, PMID:9244310]
synonym: "NIK/NF-kappaB cascade" EXACT [GOC:signaling]
synonym: "NIK/NF-kappaB signal transduction" EXACT [GOC:signaling]
synonym: "NIK/NF-kappaB signaling" EXACT []
synonym: "non-canonical NF-KB signaling" EXACT [PMID:21173796]
synonym: "noncanonical NF-kappaB signaling" EXACT [PMID:20501935]
synonym: "noncanonical nuclear factor kappaB (NF-kappaB) pathway" EXACT [PMID:20501935]
synonym: "p52-dependent NF-kappaB signaling" NARROW [PMID:18292232]
is_a: GO:0141124 ! intracellular signaling cassette

AmiGO <GOterm>GO:0038061</GOterm>
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