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MOUSE:TRAF6

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Traf6
Protein Name(s) TNF receptor-associated factor 6

E3 ubiquitin-protein ligase TRAF6

External Links
UniProt P70196
EMBL D84655
AK041172
AK155434
AL929571
CH466519
CH466519
BC060705
CCDS CCDS16464.1
RefSeq NP_033450.2
XP_006499219.1
UniGene Mm.292729
ProteinModelPortal P70196
SMR P70196
BioGrid 204307
DIP DIP-29812N
IntAct P70196
MINT MINT-252449
STRING 10090.ENSMUSP00000004949
PhosphoSite P70196
MaxQB P70196
PaxDb P70196
PRIDE P70196
Ensembl ENSMUST00000004949
GeneID 22034
KEGG mmu:22034
UCSC uc008lhl.1
uc008lhm.1
CTD 7189
MGI MGI:108072
eggNOG NOG289765
GeneTree ENSGT00550000074359
HOGENOM HOG000006625
HOVERGEN HBG060248
InParanoid P70196
KO K03175
OMA NFQETIH
OrthoDB EOG7966G5
PhylomeDB P70196
TreeFam TF321154
Reactome REACT_198521
REACT_198527
REACT_198536
REACT_198539
REACT_198543
REACT_198546
REACT_198690
REACT_202271
REACT_202898
REACT_204812
REACT_205561
REACT_211125
REACT_214670
REACT_218614
REACT_218887
REACT_219800
REACT_224208
REACT_225145
REACT_229712
REACT_230045
REACT_237946
REACT_245896
REACT_256727
UniPathway UPA00143
NextBio 301798
PRO PR:P70196
Proteomes UP000000589
Bgee P70196
CleanEx MM_TRAF6
Genevestigator P70196
GO GO:0035631
GO:0005938
GO:0009898
GO:0005829
GO:0005811
GO:0005739
GO:0005730
GO:0048471
GO:0043234
GO:0016874
GO:0004871
GO:0031624
GO:0061630
GO:0004842
GO:0008270
GO:0007250
GO:0019886
GO:0046849
GO:0045453
GO:0048468
GO:0071222
GO:0007249
GO:0006955
GO:0070498
GO:0007254
GO:0043011
GO:0000122
GO:0001843
GO:0042475
GO:0009887
GO:0001503
GO:0030316
GO:0043123
GO:0045084
GO:0032743
GO:0045410
GO:0043507
GO:0031666
GO:0051092
GO:0045672
GO:0048661
GO:0002726
GO:0042102
GO:0045944
GO:2000679
GO:0051865
GO:0006461
GO:0070534
GO:0016567
GO:0042981
GO:0051023
GO:0007165
GO:0050852
GO:0042088
Gene3D 3.30.40.10
InterPro IPR002083
IPR012227
IPR008974
IPR027139
IPR001841
IPR013083
IPR017907
IPR001293
PANTHER PTHR10131:SF52
Pfam PF00917
PIRSF PIRSF015614
SMART SM00061
SM00184
SUPFAM SSF49599
PROSITE PS50144
PS00518
PS50089
PS50145

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0035631

CD40 receptor complex

PMID:20614026[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0009898

cytoplasmic side of plasma membrane

PMID:20614026[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0070534

protein K63-linked ubiquitination

PMID:16252010[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0070498

interleukin-1-mediated signaling pathway

PMID:10421844[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051092

positive regulation of NF-kappaB transcription factor activity

PMID:20345905[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(CL:0000057)

Seeded From UniProt

complete

involved_in

GO:0046849

bone remodeling

PMID:10421844[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045453

bone resorption

PMID:10215628[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

PMID:20345905[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(CL:0000057)

Seeded From UniProt

complete

involved_in

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

PMID:15322147[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042102

positive regulation of T cell proliferation

PMID:10421844[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031666

positive regulation of lipopolysaccharide-mediated signaling pathway

PMID:10215628[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030316

osteoclast differentiation

PMID:10421844[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007249

I-kappaB kinase/NF-kappaB signaling

PMID:17633018[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:16831874[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005811

lipid droplet

PMID:21435586[9]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004842

ubiquitin-protein transferase activity

PMID:16252010[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0001843

neural tube closure

PMID:11007897[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0070534

protein K63-linked ubiquitination

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:108072
PANTHER:PTN000805706
UniProtKB:Q9Y4K3

P

Seeded From UniProt

complete

involved_in

GO:0070498

interleukin-1-mediated signaling pathway

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:108072
PANTHER:PTN002562173
RGD:1306853

P

Seeded From UniProt

complete

involved_in

GO:0051092

positive regulation of NF-kappaB transcription factor activity

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:108072
PANTHER:PTN000805706
UniProtKB:Q9Y4K3

P

Seeded From UniProt

complete

involved_in

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:108072
PANTHER:PTN000805706
UniProtKB:Q9Y4K3

P

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:101835
MGI:MGI:107548
MGI:MGI:108041
MGI:MGI:108072
PANTHER:PTN000805648
RGD:1306853
RGD:1310457
UniProtKB:Q12933
UniProtKB:Q9Y4K3

C

Seeded From UniProt

complete

enables

GO:0005164

tumor necrosis factor receptor binding

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000805706
UniProtKB:Q9Y4K3

F

Seeded From UniProt

complete

enables

GO:0004842

ubiquitin-protein transferase activity

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:108072
PANTHER:PTN000805706
UniProtKB:Q9Y4K3

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:2000679

positive regulation of transcription regulatory region DNA binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y4K3

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1904996

positive regulation of leukocyte adhesion to vascular endothelial cell

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y4K3

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1901224

positive regulation of NIK/NF-kappaB signaling

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y4K3

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0071345

cellular response to cytokine stimulus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y4K3

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0071222

cellular response to lipopolysaccharide

PMID:23776175[12]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y4K3

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0070555

response to interleukin-1

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y4K3

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0070534

protein K63-linked ubiquitination

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y4K3

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0070498

interleukin-1-mediated signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1306853

P

Seeded From UniProt

complete

enables

GO:0061630

ubiquitin protein ligase activity

PMID:23042151[13]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

has_direct_input:(MGI:MGI:1859212)

Seeded From UniProt

complete

enables

GO:0061630

ubiquitin protein ligase activity

PMID:16252010[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051865

protein autoubiquitination

PMID:23776175[12]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y4K3

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051865

protein autoubiquitination

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y4K3

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051092

positive regulation of NF-kappaB transcription factor activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y4K3

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051091

positive regulation of DNA-binding transcription factor activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y4K3

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051023

regulation of immunoglobulin secretion

PMID:12958312[14]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050852

T cell receptor signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y4K3

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048661

positive regulation of smooth muscle cell proliferation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1306853

P

Seeded From UniProt

complete

part_of

GO:0048471

perinuclear region of cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y4K3

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048468

cell development

PMID:15705807[15]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2675469

P

  • occurs_in:(EMAPA:17523)
  • occurs_in:(CL:0000066)

Seeded From UniProt

complete

enables

GO:0047485

protein N-terminus binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y4K3

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y4K3

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045892

negative regulation of transcription, DNA-templated

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y4K3

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045672

positive regulation of osteoclast differentiation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y4K3

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045410

positive regulation of interleukin-6 biosynthetic process

PMID:14499111[16]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2678775

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045084

positive regulation of interleukin-12 biosynthetic process

PMID:14499111[16]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2678775

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043507

positive regulation of JUN kinase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y4K3

P

Seeded From UniProt

complete

enables

GO:0043422

protein kinase B binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y4K3

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

PMID:22863753[17]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:2444070

P

regulates_o_occurs_in:(CL:0000235)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y4K3

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

GO_REF:0000008

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y423

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043011

myeloid dendritic cell differentiation

PMID:14499111[16]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2678775

P

Seeded From UniProt

complete

enables

GO:0042826

histone deacetylase binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y4K3

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y4K3

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042475

odontogenesis of dentin-containing tooth

PMID:14699584[18]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2675469

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042088

T-helper 1 type immune response

PMID:14499111[16]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2678775

P

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

PMID:23776175[12]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y4K3

C

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1306853

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032743

positive regulation of interleukin-2 production

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y4K3

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032147

activation of protein kinase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y4K3

P

Seeded From UniProt

complete

enables

GO:0031996

thioesterase binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y4K3

F

Seeded From UniProt

complete

enables

GO:0031625

ubiquitin protein ligase binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y4K3

F

Seeded From UniProt

complete

enables

GO:0031624

ubiquitin conjugating enzyme binding

PMID:23776175[12]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y4K3

F

Seeded From UniProt

complete

enables

GO:0031435

mitogen-activated protein kinase kinase kinase binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y4K3

F

Seeded From UniProt

complete

enables

GO:0019901

protein kinase binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y4K3

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0019886

antigen processing and presentation of exogenous peptide antigen via MHC class II

PMID:14499111[16]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2678775

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0019221

cytokine-mediated signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1306853

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0016567

protein ubiquitination

PMID:22095711[19]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:97072

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0016567

protein ubiquitination

PMID:23042151[13]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0009887

animal organ morphogenesis

PMID:15705807[15]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2675469

P

has_participant:(EMAPA:17523)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007254

JNK cascade

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1306853

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007250

activation of NF-kappaB-inducing kinase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y4K3

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007165

signal transduction

PMID:12958312[14]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006955

immune response

PMID:15705807[15]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2675469

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y4K3

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y4K3

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y4K3

C

Seeded From UniProt

complete

enables

GO:0005164

tumor necrosis factor receptor binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y4K3

F

Seeded From UniProt

complete

enables

GO:0004842

ubiquitin-protein transferase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y4K3

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002726

positive regulation of T cell cytokine production

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y4K3

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001503

ossification

PMID:10215628[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1859953

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0000209

protein polyubiquitination

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y4K3

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0000122

negative regulation of transcription by RNA polymerase II

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y4K3

P

Seeded From UniProt

complete

involved_in

GO:0070498

interleukin-1-mediated signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:B5DF45
ensembl:ENSRNOP00000006148

P

Seeded From UniProt

complete

involved_in

GO:0048661

positive regulation of smooth muscle cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:B5DF45
ensembl:ENSRNOP00000006148

P

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:B5DF45
ensembl:ENSRNOP00000006148

C

Seeded From UniProt

complete

involved_in

GO:0019221

cytokine-mediated signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:B5DF45
ensembl:ENSRNOP00000006148

P

Seeded From UniProt

complete

involved_in

GO:0007254

JNK cascade

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:B5DF45
ensembl:ENSRNOP00000006148

P

Seeded From UniProt

complete

involved_in

GO:2000679

positive regulation of transcription regulatory region DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Y4K3
ensembl:ENSP00000433623

P

Seeded From UniProt

complete

involved_in

GO:1904996

positive regulation of leukocyte adhesion to vascular endothelial cell

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Y4K3
ensembl:ENSP00000433623

P

Seeded From UniProt

complete

involved_in

GO:1901224

positive regulation of NIK/NF-kappaB signaling

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Y4K3
ensembl:ENSP00000433623

P

Seeded From UniProt

complete

involved_in

GO:0071345

cellular response to cytokine stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Y4K3
ensembl:ENSP00000433623

P

Seeded From UniProt

complete

involved_in

GO:0071222

cellular response to lipopolysaccharide

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Y4K3
ensembl:ENSP00000433623

P

Seeded From UniProt

complete

involved_in

GO:0070555

response to interleukin-1

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Y4K3
ensembl:ENSP00000433623

P

Seeded From UniProt

complete

involved_in

GO:0070534

protein K63-linked ubiquitination

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Y4K3
ensembl:ENSP00000433623

P

Seeded From UniProt

complete

involved_in

GO:0051865

protein autoubiquitination

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Y4K3
ensembl:ENSP00000433623

P

Seeded From UniProt

complete

involved_in

GO:0051092

positive regulation of NF-kappaB transcription factor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Y4K3
ensembl:ENSP00000433623

P

Seeded From UniProt

complete

involved_in

GO:0051091

positive regulation of DNA-binding transcription factor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Y4K3
ensembl:ENSP00000433623

P

Seeded From UniProt

complete

involved_in

GO:0050852

T cell receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Y4K3
ensembl:ENSP00000433623

P

Seeded From UniProt

complete

part_of

GO:0048471

perinuclear region of cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Y4K3
ensembl:ENSP00000433623

C

Seeded From UniProt

complete

enables

GO:0047485

protein N-terminus binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Y4K3
ensembl:ENSP00000433623

F

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Y4K3
ensembl:ENSP00000433623

P

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Y4K3
ensembl:ENSP00000433623

P

Seeded From UniProt

complete

involved_in

GO:0045672

positive regulation of osteoclast differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Y4K3
ensembl:ENSP00000433623

P

Seeded From UniProt

complete

involved_in

GO:0043507

positive regulation of JUN kinase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Y4K3
ensembl:ENSP00000433623

P

Seeded From UniProt

complete

enables

GO:0043422

protein kinase B binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Y4K3
ensembl:ENSP00000433623

F

Seeded From UniProt

complete

involved_in

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Y4K3
ensembl:ENSP00000433623

P

Seeded From UniProt

complete

enables

GO:0042826

histone deacetylase binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Y4K3
ensembl:ENSP00000433623

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Y4K3
ensembl:ENSP00000433623

F

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Y4K3
ensembl:ENSP00000433623

C

Seeded From UniProt

complete

involved_in

GO:0032743

positive regulation of interleukin-2 production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Y4K3
ensembl:ENSP00000433623

P

Seeded From UniProt

complete

involved_in

GO:0032147

activation of protein kinase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Y4K3
ensembl:ENSP00000433623

P

Seeded From UniProt

complete

enables

GO:0031996

thioesterase binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Y4K3
ensembl:ENSP00000433623

F

Seeded From UniProt

complete

enables

GO:0031625

ubiquitin protein ligase binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Y4K3
ensembl:ENSP00000433623

F

Seeded From UniProt

complete

enables

GO:0031624

ubiquitin conjugating enzyme binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Y4K3
ensembl:ENSP00000433623

F

Seeded From UniProt

complete

enables

GO:0031435

mitogen-activated protein kinase kinase kinase binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Y4K3
ensembl:ENSP00000433623

F

Seeded From UniProt

complete

enables

GO:0019901

protein kinase binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Y4K3
ensembl:ENSP00000433623

F

Seeded From UniProt

complete

involved_in

GO:0007250

activation of NF-kappaB-inducing kinase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Y4K3
ensembl:ENSP00000433623

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Y4K3
ensembl:ENSP00000433623

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Y4K3
ensembl:ENSP00000433623

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Y4K3
ensembl:ENSP00000433623

C

Seeded From UniProt

complete

enables

GO:0005164

tumor necrosis factor receptor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Y4K3
ensembl:ENSP00000433623

F

Seeded From UniProt

complete

enables

GO:0004842

ubiquitin-protein transferase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Y4K3
ensembl:ENSP00000433623

F

Seeded From UniProt

complete

involved_in

GO:0002726

positive regulation of T cell cytokine production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Y4K3
ensembl:ENSP00000433623

P

Seeded From UniProt

complete

involved_in

GO:0000209

protein polyubiquitination

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Y4K3
ensembl:ENSP00000433623

P

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Y4K3
ensembl:ENSP00000433623

P

Seeded From UniProt

complete

enables

GO:0004842

ubiquitin-protein transferase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR027139
InterPro:IPR037309

F

Seeded From UniProt

complete

enables

GO:0005164

tumor necrosis factor receptor binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR027139
InterPro:IPR037309

F

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR012227

P

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001293
InterPro:IPR012227

F

Seeded From UniProt

complete

involved_in

GO:0016567

protein ubiquitination

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR027139
InterPro:IPR037309

P

Seeded From UniProt

complete

involved_in

GO:0042981

regulation of apoptotic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR012227

P

Seeded From UniProt

complete

involved_in

GO:0043122

regulation of I-kappaB kinase/NF-kappaB signaling

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR037309

P

Seeded From UniProt

complete

involved_in

GO:0051865

protein autoubiquitination

PMID:16378096[20]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-MMU-933534
Reactome:R-MMU-205060

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

involved_in

GO:0001503

ossification

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0892

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0227

P

Seeded From UniProt

complete

involved_in

GO:0002376

immune system process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0391

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

part_of

GO:0005811

lipid droplet

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0551
UniProtKB-SubCell:SL-0154

C

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

part_of

GO:0005938

cell cortex

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0138

C

Seeded From UniProt

complete

involved_in

GO:0016567

protein ubiquitination

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00143

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Hostager, BS et al. (2010) HOIL-1L interacting protein (HOIP) as an NF-kappaB regulating component of the CD40 signaling complex. PLoS ONE 5 e11380 PubMed GONUTS page
  2. 2.0 2.1 2.2 Geetha, T et al. (2005) TRAF6-mediated ubiquitination regulates nuclear translocation of NRIF, the p75 receptor interactor. EMBO J. 24 3859-68 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Naito, A et al. (1999) Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice. Genes Cells 4 353-62 PubMed GONUTS page
  4. 4.0 4.1 Ando, K et al. (2010) Human lactoferrin activates NF-kappaB through the Toll-like receptor 4 pathway while it interferes with the lipopolysaccharide-stimulated TLR4 signaling. FEBS J. 277 2051-66 PubMed GONUTS page
  5. 5.0 5.1 5.2 Lomaga, MA et al. (1999) TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Genes Dev. 13 1015-24 PubMed GONUTS page
  6. Gohda, J et al. (2004) Cutting edge: TNFR-associated factor (TRAF) 6 is essential for MyD88-dependent pathway but not toll/IL-1 receptor domain-containing adaptor-inducing IFN-beta (TRIF)-dependent pathway in TLR signaling. J. Immunol. 173 2913-7 PubMed GONUTS page
  7. Inoue, J et al. (2007) Characteristics and biological functions of TRAF6. Adv. Exp. Med. Biol. 597 72-9 PubMed GONUTS page
  8. Dong, W et al. (2006) The IRAK-1-BCL10-MALT1-TRAF6-TAK1 cascade mediates signaling to NF-kappaB from Toll-like receptor 4. J. Biol. Chem. 281 26029-40 PubMed GONUTS page
  9. Saitoh, T et al. (2011) Antiviral protein Viperin promotes Toll-like receptor 7- and Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells. Immunity 34 352-63 PubMed GONUTS page
  10. Lomaga, MA et al. (2000) Tumor necrosis factor receptor-associated factor 6 (TRAF6) deficiency results in exencephaly and is required for apoptosis within the developing CNS. J. Neurosci. 20 7384-93 PubMed GONUTS page
  11. 11.0 11.1 11.2 11.3 11.4 11.5 11.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  12. 12.0 12.1 12.2 12.3 Dauphinee, SM et al. (2013) SASH1 is a scaffold molecule in endothelial TLR4 signaling. J. Immunol. 191 892-901 PubMed GONUTS page
  13. 13.0 13.1 Siednienko, J et al. (2012) Pellino3 targets the IRF7 pathway and facilitates autoregulation of TLR3- and viral-induced expression of type I interferons. Nat. Immunol. 13 1055-62 PubMed GONUTS page
  14. 14.0 14.1 Hostager, BS et al. (2003) Tumor necrosis factor receptor-associated factor 2 (TRAF2)-deficient B lymphocytes reveal novel roles for TRAF2 in CD40 signaling. J. Biol. Chem. 278 45382-90 PubMed GONUTS page
  15. 15.0 15.1 15.2 Akiyama, T et al. (2005) Dependence of self-tolerance on TRAF6-directed development of thymic stroma. Science 308 248-51 PubMed GONUTS page
  16. 16.0 16.1 16.2 16.3 16.4 Kobayashi, T et al. (2003) TRAF6 is a critical factor for dendritic cell maturation and development. Immunity 19 353-63 PubMed GONUTS page
  17. Schneider, M et al. (2012) The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB. Nat. Immunol. 13 823-31 PubMed GONUTS page
  18. Ohazama, A et al. (2004) Traf6 is essential for murine tooth cusp morphogenesis. Dev. Dyn. 229 131-5 PubMed GONUTS page
  19. Hu, Y et al. (2011) Guanylate binding protein 4 negatively regulates virus-induced type I IFN and antiviral response by targeting IFN regulatory factor 7. J. Immunol. 187 6456-62 PubMed GONUTS page
  20. Wang, Y et al. (2006) Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling. Nat. Immunol. 7 139-47 PubMed GONUTS page