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MOUSE:TRAF6
Contents
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
part_of |
GO:0035631 |
CD40 receptor complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0009898 |
cytoplasmic side of plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0070534 |
protein K63-linked ubiquitination |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0070498 |
interleukin-1-mediated signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051092 |
positive regulation of NF-kappaB transcription factor activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(CL:0000057) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0046849 |
bone remodeling |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045453 |
bone resorption |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0043123 |
positive regulation of I-kappaB kinase/NF-kappaB signaling |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(CL:0000057) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0043123 |
positive regulation of I-kappaB kinase/NF-kappaB signaling |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0042102 |
positive regulation of T cell proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0031666 |
positive regulation of lipopolysaccharide-mediated signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030316 |
osteoclast differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007249 |
I-kappaB kinase/NF-kappaB signaling |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005811 |
lipid droplet |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0004842 |
ubiquitin-protein transferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0001843 |
neural tube closure |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0070534 |
protein K63-linked ubiquitination |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:108072 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0070498 |
interleukin-1-mediated signaling pathway |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:108072 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0051092 |
positive regulation of NF-kappaB transcription factor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:108072 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0043123 |
positive regulation of I-kappaB kinase/NF-kappaB signaling |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:108072 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0032991 |
protein-containing complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:101835 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0005164 |
tumor necrosis factor receptor binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000805706 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0004842 |
ubiquitin-protein transferase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:108072 |
F |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:2000679 |
positive regulation of transcription regulatory region DNA binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:1904996 |
positive regulation of leukocyte adhesion to vascular endothelial cell |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:1901224 |
positive regulation of NIK/NF-kappaB signaling |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0071345 |
cellular response to cytokine stimulus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0071222 |
cellular response to lipopolysaccharide |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0070555 |
response to interleukin-1 |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0070534 |
protein K63-linked ubiquitination |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0070498 |
interleukin-1-mediated signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1306853 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0061630 |
ubiquitin protein ligase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
has_direct_input:(MGI:MGI:1859212) |
Seeded From UniProt |
complete | ||
enables |
GO:0061630 |
ubiquitin protein ligase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0051865 |
protein autoubiquitination |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0051865 |
protein autoubiquitination |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0051092 |
positive regulation of NF-kappaB transcription factor activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0051091 |
positive regulation of DNA-binding transcription factor activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0051023 |
regulation of immunoglobulin secretion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0050852 |
T cell receptor signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0048661 |
positive regulation of smooth muscle cell proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1306853 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0048471 |
perinuclear region of cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0048468 |
cell development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2675469 |
P |
|
Seeded From UniProt |
complete | |
enables |
GO:0047485 |
protein N-terminus binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0045672 |
positive regulation of osteoclast differentiation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0045410 |
positive regulation of interleukin-6 biosynthetic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2678775 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0045084 |
positive regulation of interleukin-12 biosynthetic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2678775 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0043507 |
positive regulation of JUN kinase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0043422 |
protein kinase B binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0043123 |
positive regulation of I-kappaB kinase/NF-kappaB signaling |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:2444070 |
P |
regulates_o_occurs_in:(CL:0000235) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0043123 |
positive regulation of I-kappaB kinase/NF-kappaB signaling |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0043123 |
positive regulation of I-kappaB kinase/NF-kappaB signaling |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0043011 |
myeloid dendritic cell differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2678775 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0042826 |
histone deacetylase binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0042802 |
identical protein binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0042475 |
odontogenesis of dentin-containing tooth |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2675469 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0042088 |
T-helper 1 type immune response |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2678775 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0032991 |
protein-containing complex |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0032991 |
protein-containing complex |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1306853 |
C |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0032743 |
positive regulation of interleukin-2 production |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0032147 |
activation of protein kinase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0031996 |
thioesterase binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0031625 |
ubiquitin protein ligase binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0031624 |
ubiquitin conjugating enzyme binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0031435 |
mitogen-activated protein kinase kinase kinase binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0019901 |
protein kinase binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0019886 |
antigen processing and presentation of exogenous peptide antigen via MHC class II |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2678775 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0019221 |
cytokine-mediated signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1306853 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0016567 |
protein ubiquitination |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:97072 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0016567 |
protein ubiquitination |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0009887 |
animal organ morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2675469 |
P |
has_participant:(EMAPA:17523) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0007254 |
JNK cascade |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1306853 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0007250 |
activation of NF-kappaB-inducing kinase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0007165 |
signal transduction |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0006955 |
immune response |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2675469 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0005164 |
tumor necrosis factor receptor binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004842 |
ubiquitin-protein transferase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0002726 |
positive regulation of T cell cytokine production |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0001503 |
ossification |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1859953 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0000209 |
protein polyubiquitination |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0070498 |
interleukin-1-mediated signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:B5DF45 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0048661 |
positive regulation of smooth muscle cell proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:B5DF45 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0032991 |
protein-containing complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:B5DF45 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0019221 |
cytokine-mediated signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:B5DF45 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007254 |
JNK cascade |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:B5DF45 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:2000679 |
positive regulation of transcription regulatory region DNA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Y4K3 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:1904996 |
positive regulation of leukocyte adhesion to vascular endothelial cell |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Y4K3 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:1901224 |
positive regulation of NIK/NF-kappaB signaling |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Y4K3 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0071345 |
cellular response to cytokine stimulus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Y4K3 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0071222 |
cellular response to lipopolysaccharide |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Y4K3 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0070555 |
response to interleukin-1 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Y4K3 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0070534 |
protein K63-linked ubiquitination |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Y4K3 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0051865 |
protein autoubiquitination |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Y4K3 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0051092 |
positive regulation of NF-kappaB transcription factor activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Y4K3 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0051091 |
positive regulation of DNA-binding transcription factor activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Y4K3 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0050852 |
T cell receptor signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Y4K3 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0048471 |
perinuclear region of cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Y4K3 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0047485 |
protein N-terminus binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Y4K3 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Y4K3 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Y4K3 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045672 |
positive regulation of osteoclast differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Y4K3 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0043507 |
positive regulation of JUN kinase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Y4K3 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0043422 |
protein kinase B binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Y4K3 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0043123 |
positive regulation of I-kappaB kinase/NF-kappaB signaling |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Y4K3 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0042826 |
histone deacetylase binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Y4K3 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0042802 |
identical protein binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Y4K3 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0032991 |
protein-containing complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Y4K3 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0032743 |
positive regulation of interleukin-2 production |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Y4K3 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0032147 |
activation of protein kinase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Y4K3 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0031996 |
thioesterase binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Y4K3 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0031625 |
ubiquitin protein ligase binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Y4K3 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0031624 |
ubiquitin conjugating enzyme binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Y4K3 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0031435 |
mitogen-activated protein kinase kinase kinase binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Y4K3 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0019901 |
protein kinase binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Y4K3 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007250 |
activation of NF-kappaB-inducing kinase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Y4K3 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Y4K3 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Y4K3 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Y4K3 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0005164 |
tumor necrosis factor receptor binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Y4K3 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0004842 |
ubiquitin-protein transferase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Y4K3 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0002726 |
positive regulation of T cell cytokine production |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Y4K3 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0000209 |
protein polyubiquitination |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Y4K3 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Y4K3 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0004842 |
ubiquitin-protein transferase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005164 |
tumor necrosis factor receptor binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007165 |
signal transduction |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0008270 |
zinc ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0016567 |
protein ubiquitination |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0042981 |
regulation of apoptotic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0043122 |
regulation of I-kappaB kinase/NF-kappaB signaling |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051865 |
protein autoubiquitination |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005829 |
cytosol |
Reactome:R-MMU-933534 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
involved_in |
GO:0001503 |
ossification |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006974 |
cellular response to DNA damage stimulus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0002376 |
immune system process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005811 |
lipid droplet |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005938 |
cell cortex |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0016567 |
protein ubiquitination |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniPathway:UPA00143 |
P |
Seeded From UniProt |
complete | ||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Hostager, BS et al. (2010) HOIL-1L interacting protein (HOIP) as an NF-kappaB regulating component of the CD40 signaling complex. PLoS ONE 5 e11380 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Geetha, T et al. (2005) TRAF6-mediated ubiquitination regulates nuclear translocation of NRIF, the p75 receptor interactor. EMBO J. 24 3859-68 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Naito, A et al. (1999) Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice. Genes Cells 4 353-62 PubMed GONUTS page
- ↑ 4.0 4.1 Ando, K et al. (2010) Human lactoferrin activates NF-kappaB through the Toll-like receptor 4 pathway while it interferes with the lipopolysaccharide-stimulated TLR4 signaling. FEBS J. 277 2051-66 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Lomaga, MA et al. (1999) TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Genes Dev. 13 1015-24 PubMed GONUTS page
- ↑ Gohda, J et al. (2004) Cutting edge: TNFR-associated factor (TRAF) 6 is essential for MyD88-dependent pathway but not toll/IL-1 receptor domain-containing adaptor-inducing IFN-beta (TRIF)-dependent pathway in TLR signaling. J. Immunol. 173 2913-7 PubMed GONUTS page
- ↑ Inoue, J et al. (2007) Characteristics and biological functions of TRAF6. Adv. Exp. Med. Biol. 597 72-9 PubMed GONUTS page
- ↑ Dong, W et al. (2006) The IRAK-1-BCL10-MALT1-TRAF6-TAK1 cascade mediates signaling to NF-kappaB from Toll-like receptor 4. J. Biol. Chem. 281 26029-40 PubMed GONUTS page
- ↑ Saitoh, T et al. (2011) Antiviral protein Viperin promotes Toll-like receptor 7- and Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells. Immunity 34 352-63 PubMed GONUTS page
- ↑ Lomaga, MA et al. (2000) Tumor necrosis factor receptor-associated factor 6 (TRAF6) deficiency results in exencephaly and is required for apoptosis within the developing CNS. J. Neurosci. 20 7384-93 PubMed GONUTS page
- ↑ 11.0 11.1 11.2 11.3 11.4 11.5 11.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 12.0 12.1 12.2 12.3 Dauphinee, SM et al. (2013) SASH1 is a scaffold molecule in endothelial TLR4 signaling. J. Immunol. 191 892-901 PubMed GONUTS page
- ↑ 13.0 13.1 Siednienko, J et al. (2012) Pellino3 targets the IRF7 pathway and facilitates autoregulation of TLR3- and viral-induced expression of type I interferons. Nat. Immunol. 13 1055-62 PubMed GONUTS page
- ↑ 14.0 14.1 Hostager, BS et al. (2003) Tumor necrosis factor receptor-associated factor 2 (TRAF2)-deficient B lymphocytes reveal novel roles for TRAF2 in CD40 signaling. J. Biol. Chem. 278 45382-90 PubMed GONUTS page
- ↑ 15.0 15.1 15.2 Akiyama, T et al. (2005) Dependence of self-tolerance on TRAF6-directed development of thymic stroma. Science 308 248-51 PubMed GONUTS page
- ↑ 16.0 16.1 16.2 16.3 16.4 Kobayashi, T et al. (2003) TRAF6 is a critical factor for dendritic cell maturation and development. Immunity 19 353-63 PubMed GONUTS page
- ↑ Schneider, M et al. (2012) The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB. Nat. Immunol. 13 823-31 PubMed GONUTS page
- ↑ Ohazama, A et al. (2004) Traf6 is essential for murine tooth cusp morphogenesis. Dev. Dyn. 229 131-5 PubMed GONUTS page
- ↑ Hu, Y et al. (2011) Guanylate binding protein 4 negatively regulates virus-induced type I IFN and antiviral response by targeting IFN regulatory factor 7. J. Immunol. 187 6456-62 PubMed GONUTS page
- ↑ Wang, Y et al. (2006) Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling. Nat. Immunol. 7 139-47 PubMed GONUTS page
a
c
- GO:0007249 ! canonical NF-kappaB signal transduction
- GO:0035631 ! CD40 receptor complex
- GO:0071222 ! cellular response to lipopolysaccharide
- GO:0071345 ! cellular response to cytokine stimulus
- GO:0005938 ! cell cortex
- GO:0048468 ! cell development
- Chordata
- Craniata
- GO:0019221 ! cytokine-mediated signaling pathway
- GO:0005737 ! cytoplasm
- GO:0009898 ! cytoplasmic side of plasma membrane
- GO:0005829 ! cytosol
g
i
m
n
o
p
- GO:0048471 ! perinuclear region of cytoplasm
- GO:0005886 ! plasma membrane
- GO:0043123 ! positive regulation of canonical NF-kappaB signal transduction
- GO:2000679 ! positive regulation of transcription regulatory region DNA binding
- GO:1904996 ! positive regulation of leukocyte adhesion to vascular endothelial cell
- GO:1901224 ! positive regulation of non-canonical NF-kappaB signal transduction
- GO:0051091 ! positive regulation of DNA-binding transcription factor activity
- GO:0048661 ! positive regulation of smooth muscle cell proliferation
- GO:0002726 ! positive regulation of T cell cytokine production
- GO:0042102 ! positive regulation of T cell proliferation
- GO:0045944 ! positive regulation of transcription by RNA polymerase II
- GO:0045410 ! positive regulation of interleukin-6 biosynthetic process
- GO:0043507 ! positive regulation of JUN kinase activity
- GO:0045672 ! positive regulation of osteoclast differentiation
- GO:0032743 ! positive regulation of interleukin-2 production
- GO:0045084 ! positive regulation of interleukin-12 biosynthetic process
- GO:0031666 ! positive regulation of lipopolysaccharide-mediated signaling pathway
- GO:0051092 ! positive regulation of NF-kappaB transcription factor activity
- GO:0032991 ! protein-containing complex
- GO:0051865 ! protein autoubiquitination
- GO:0070534 ! protein K63-linked ubiquitination
- GO:0019901 ! protein kinase binding
- GO:0043422 ! protein kinase B binding
- GO:0000209 ! protein polyubiquitination
- GO:0016567 ! protein ubiquitination
r
t
u