MOUSE:TRAF6

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Traf6
Protein Name(s)	TNF receptor-associated factor 6 E3 ubiquitin-protein ligase TRAF6
External Links
UniProt	P70196
EMBL	D84655 AK041172 AK155434 AL929571 CH466519 CH466519 BC060705
CCDS	CCDS16464.1
RefSeq	NP_033450.2 XP_006499219.1
UniGene	Mm.292729
ProteinModelPortal	P70196
SMR	P70196
BioGrid	204307
DIP	DIP-29812N
IntAct	P70196
MINT	MINT-252449
STRING	10090.ENSMUSP00000004949
PhosphoSite	P70196
MaxQB	P70196
PaxDb	P70196
PRIDE	P70196
Ensembl	ENSMUST00000004949
GeneID	22034
KEGG	mmu:22034
UCSC	uc008lhl.1 uc008lhm.1
CTD	7189
MGI	MGI:108072
eggNOG	NOG289765
GeneTree	ENSGT00550000074359
HOGENOM	HOG000006625
HOVERGEN	HBG060248
InParanoid	P70196
KO	K03175
OMA	NFQETIH
OrthoDB	EOG7966G5
PhylomeDB	P70196
TreeFam	TF321154
Reactome	REACT_198521 REACT_198527 REACT_198536 REACT_198539 REACT_198543 REACT_198546 REACT_198690 REACT_202271 REACT_202898 REACT_204812 REACT_205561 REACT_211125 REACT_214670 REACT_218614 REACT_218887 REACT_219800 REACT_224208 REACT_225145 REACT_229712 REACT_230045 REACT_237946 REACT_245896 REACT_256727
UniPathway	UPA00143
NextBio	301798
PRO	PR:P70196
Proteomes	UP000000589
Bgee	P70196
CleanEx	MM_TRAF6
Genevestigator	P70196
GO	GO:0035631 GO:0005938 GO:0009898 GO:0005829 GO:0005811 GO:0005739 GO:0005730 GO:0048471 GO:0043234 GO:0016874 GO:0004871 GO:0031624 GO:0061630 GO:0004842 GO:0008270 GO:0007250 GO:0019886 GO:0046849 GO:0045453 GO:0048468 GO:0071222 GO:0007249 GO:0006955 GO:0070498 GO:0007254 GO:0043011 GO:0000122 GO:0001843 GO:0042475 GO:0009887 GO:0001503 GO:0030316 GO:0043123 GO:0045084 GO:0032743 GO:0045410 GO:0043507 GO:0031666 GO:0051092 GO:0045672 GO:0048661 GO:0002726 GO:0042102 GO:0045944 GO:2000679 GO:0051865 GO:0006461 GO:0070534 GO:0016567 GO:0042981 GO:0051023 GO:0007165 GO:0050852 GO:0042088
Gene3D	3.30.40.10
InterPro	IPR002083 IPR012227 IPR008974 IPR027139 IPR001841 IPR013083 IPR017907 IPR001293
PANTHER	PTHR10131:SF52
Pfam	PF00917
PIRSF	PIRSF015614
SMART	SM00061 SM00184
SUPFAM	SSF49599
PROSITE	PS50144 PS00518 PS50089 PS50145

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0035631	CD40 receptor complex	PMID:20614026^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009898	cytoplasmic side of plasma membrane	PMID:20614026^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0070534	protein K63-linked ubiquitination	PMID:16252010^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070498	interleukin-1-mediated signaling pathway	PMID:10421844^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:20345905^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000057)	Seeded From UniProt	complete
involved_in	GO:0046849	bone remodeling	PMID:10421844^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045453	bone resorption	PMID:10215628^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	PMID:20345905^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000057)	Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	PMID:15322147^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042102	positive regulation of T cell proliferation	PMID:10421844^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031666	positive regulation of lipopolysaccharide-mediated signaling pathway	PMID:10215628^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030316	osteoclast differentiation	PMID:10421844^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007249	I-kappaB kinase/NF-kappaB signaling	PMID:17633018^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:16831874^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005811	lipid droplet	PMID:21435586^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	PMID:16252010^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001843	neural tube closure	PMID:11007897^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070534	protein K63-linked ubiquitination	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108072 PANTHER:PTN000805706 UniProtKB:Q9Y4K3	P		Seeded From UniProt	complete
involved_in	GO:0070498	interleukin-1-mediated signaling pathway	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108072 PANTHER:PTN002562173 RGD:1306853	P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108072 PANTHER:PTN000805706 UniProtKB:Q9Y4K3	P		Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108072 PANTHER:PTN000805706 UniProtKB:Q9Y4K3	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101835 MGI:MGI:107548 MGI:MGI:108041 MGI:MGI:108072 PANTHER:PTN000805648 RGD:1306853 RGD:1310457 UniProtKB:Q12933 UniProtKB:Q9Y4K3	C		Seeded From UniProt	complete
enables	GO:0005164	tumor necrosis factor receptor binding	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000805706 UniProtKB:Q9Y4K3	F		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108072 PANTHER:PTN000805706 UniProtKB:Q9Y4K3	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000679	positive regulation of transcription regulatory region DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y4K3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904996	positive regulation of leukocyte adhesion to vascular endothelial cell	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y4K3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901224	positive regulation of NIK/NF-kappaB signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y4K3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071345	cellular response to cytokine stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y4K3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071222	cellular response to lipopolysaccharide	PMID:23776175^[12]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y4K3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070555	response to interleukin-1	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y4K3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070534	protein K63-linked ubiquitination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y4K3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070498	interleukin-1-mediated signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1306853	P		Seeded From UniProt	complete
enables	GO:0061630	ubiquitin protein ligase activity	PMID:23042151^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	has_direct_input:(MGI:MGI:1859212)	Seeded From UniProt	complete
enables	GO:0061630	ubiquitin protein ligase activity	PMID:16252010^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051865	protein autoubiquitination	PMID:23776175^[12]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y4K3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051865	protein autoubiquitination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y4K3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y4K3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051091	positive regulation of DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y4K3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051023	regulation of immunoglobulin secretion	PMID:12958312^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050852	T cell receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y4K3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048661	positive regulation of smooth muscle cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1306853	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y4K3	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048468	cell development	PMID:15705807^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2675469	P	occurs_in:(EMAPA:17523) occurs_in:(CL:0000066)	Seeded From UniProt	complete
enables	GO:0047485	protein N-terminus binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y4K3	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y4K3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y4K3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045672	positive regulation of osteoclast differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y4K3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045410	positive regulation of interleukin-6 biosynthetic process	PMID:14499111^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2678775	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045084	positive regulation of interleukin-12 biosynthetic process	PMID:14499111^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2678775	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043507	positive regulation of JUN kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y4K3	P		Seeded From UniProt	complete
enables	GO:0043422	protein kinase B binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y4K3	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	PMID:22863753^[17]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2444070	P	regulates_o_occurs_in:(CL:0000235)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y4K3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y423	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043011	myeloid dendritic cell differentiation	PMID:14499111^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2678775	P		Seeded From UniProt	complete
enables	GO:0042826	histone deacetylase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y4K3	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y4K3	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042475	odontogenesis of dentin-containing tooth	PMID:14699584^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2675469	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042088	T-helper 1 type immune response	PMID:14499111^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2678775	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:23776175^[12]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y4K3	C		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1306853	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032743	positive regulation of interleukin-2 production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y4K3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032147	activation of protein kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y4K3	P		Seeded From UniProt	complete
enables	GO:0031996	thioesterase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y4K3	F		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y4K3	F		Seeded From UniProt	complete
enables	GO:0031624	ubiquitin conjugating enzyme binding	PMID:23776175^[12]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y4K3	F		Seeded From UniProt	complete
enables	GO:0031435	mitogen-activated protein kinase kinase kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y4K3	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y4K3	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	PMID:14499111^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2678775	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019221	cytokine-mediated signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1306853	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016567	protein ubiquitination	PMID:22095711^[19]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97072	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016567	protein ubiquitination	PMID:23042151^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009887	animal organ morphogenesis	PMID:15705807^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2675469	P	has_participant:(EMAPA:17523)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007254	JNK cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1306853	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007250	activation of NF-kappaB-inducing kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y4K3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007165	signal transduction	PMID:12958312^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006955	immune response	PMID:15705807^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2675469	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y4K3	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y4K3	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y4K3	C		Seeded From UniProt	complete
enables	GO:0005164	tumor necrosis factor receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y4K3	F		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y4K3	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002726	positive regulation of T cell cytokine production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y4K3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001503	ossification	PMID:10215628^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1859953	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000209	protein polyubiquitination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y4K3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y4K3	P		Seeded From UniProt	complete
involved_in	GO:0070498	interleukin-1-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B5DF45 ensembl:ENSRNOP00000006148	P		Seeded From UniProt	complete
involved_in	GO:0048661	positive regulation of smooth muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B5DF45 ensembl:ENSRNOP00000006148	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B5DF45 ensembl:ENSRNOP00000006148	C		Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B5DF45 ensembl:ENSRNOP00000006148	P		Seeded From UniProt	complete
involved_in	GO:0007254	JNK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B5DF45 ensembl:ENSRNOP00000006148	P		Seeded From UniProt	complete
involved_in	GO:2000679	positive regulation of transcription regulatory region DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y4K3 ensembl:ENSP00000433623	P		Seeded From UniProt	complete
involved_in	GO:1904996	positive regulation of leukocyte adhesion to vascular endothelial cell	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y4K3 ensembl:ENSP00000433623	P		Seeded From UniProt	complete
involved_in	GO:1901224	positive regulation of NIK/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y4K3 ensembl:ENSP00000433623	P		Seeded From UniProt	complete
involved_in	GO:0071345	cellular response to cytokine stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y4K3 ensembl:ENSP00000433623	P		Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y4K3 ensembl:ENSP00000433623	P		Seeded From UniProt	complete
involved_in	GO:0070555	response to interleukin-1	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y4K3 ensembl:ENSP00000433623	P		Seeded From UniProt	complete
involved_in	GO:0070534	protein K63-linked ubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y4K3 ensembl:ENSP00000433623	P		Seeded From UniProt	complete
involved_in	GO:0051865	protein autoubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y4K3 ensembl:ENSP00000433623	P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y4K3 ensembl:ENSP00000433623	P		Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y4K3 ensembl:ENSP00000433623	P		Seeded From UniProt	complete
involved_in	GO:0050852	T cell receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y4K3 ensembl:ENSP00000433623	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y4K3 ensembl:ENSP00000433623	C		Seeded From UniProt	complete
enables	GO:0047485	protein N-terminus binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y4K3 ensembl:ENSP00000433623	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y4K3 ensembl:ENSP00000433623	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y4K3 ensembl:ENSP00000433623	P		Seeded From UniProt	complete
involved_in	GO:0045672	positive regulation of osteoclast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y4K3 ensembl:ENSP00000433623	P		Seeded From UniProt	complete
involved_in	GO:0043507	positive regulation of JUN kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y4K3 ensembl:ENSP00000433623	P		Seeded From UniProt	complete
enables	GO:0043422	protein kinase B binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y4K3 ensembl:ENSP00000433623	F		Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y4K3 ensembl:ENSP00000433623	P		Seeded From UniProt	complete
enables	GO:0042826	histone deacetylase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y4K3 ensembl:ENSP00000433623	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y4K3 ensembl:ENSP00000433623	F		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y4K3 ensembl:ENSP00000433623	C		Seeded From UniProt	complete
involved_in	GO:0032743	positive regulation of interleukin-2 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y4K3 ensembl:ENSP00000433623	P		Seeded From UniProt	complete
involved_in	GO:0032147	activation of protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y4K3 ensembl:ENSP00000433623	P		Seeded From UniProt	complete
enables	GO:0031996	thioesterase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y4K3 ensembl:ENSP00000433623	F		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y4K3 ensembl:ENSP00000433623	F		Seeded From UniProt	complete
enables	GO:0031624	ubiquitin conjugating enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y4K3 ensembl:ENSP00000433623	F		Seeded From UniProt	complete
enables	GO:0031435	mitogen-activated protein kinase kinase kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y4K3 ensembl:ENSP00000433623	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y4K3 ensembl:ENSP00000433623	F		Seeded From UniProt	complete
involved_in	GO:0007250	activation of NF-kappaB-inducing kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y4K3 ensembl:ENSP00000433623	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y4K3 ensembl:ENSP00000433623	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y4K3 ensembl:ENSP00000433623	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y4K3 ensembl:ENSP00000433623	C		Seeded From UniProt	complete
enables	GO:0005164	tumor necrosis factor receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y4K3 ensembl:ENSP00000433623	F		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y4K3 ensembl:ENSP00000433623	F		Seeded From UniProt	complete
involved_in	GO:0002726	positive regulation of T cell cytokine production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y4K3 ensembl:ENSP00000433623	P		Seeded From UniProt	complete
involved_in	GO:0000209	protein polyubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y4K3 ensembl:ENSP00000433623	P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y4K3 ensembl:ENSP00000433623	P		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027139 InterPro:IPR037309	F		Seeded From UniProt	complete
enables	GO:0005164	tumor necrosis factor receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027139 InterPro:IPR037309	F		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012227	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001293 InterPro:IPR012227	F		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027139 InterPro:IPR037309	P		Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012227	P		Seeded From UniProt	complete
involved_in	GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR037309	P		Seeded From UniProt	complete
involved_in	GO:0051865	protein autoubiquitination	PMID:16378096^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-MMU-933534 Reactome:R-MMU-205060	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0001503	ossification	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0892	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005811	lipid droplet	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0551 UniProtKB-SubCell:SL-0154	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0138	C		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00143	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Hostager, BS et al. (2010) HOIL-1L interacting protein (HOIP) as an NF-kappaB regulating component of the CD40 signaling complex. PLoS ONE 5 e11380 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Geetha, T et al. (2005) TRAF6-mediated ubiquitination regulates nuclear translocation of NRIF, the p75 receptor interactor. EMBO J. 24 3859-68 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Naito, A et al. (1999) Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice. Genes Cells 4 353-62 PubMed GONUTS page
↑ ^4.0 ^4.1 Ando, K et al. (2010) Human lactoferrin activates NF-kappaB through the Toll-like receptor 4 pathway while it interferes with the lipopolysaccharide-stimulated TLR4 signaling. FEBS J. 277 2051-66 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Lomaga, MA et al. (1999) TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Genes Dev. 13 1015-24 PubMed GONUTS page
↑ Gohda, J et al. (2004) Cutting edge: TNFR-associated factor (TRAF) 6 is essential for MyD88-dependent pathway but not toll/IL-1 receptor domain-containing adaptor-inducing IFN-beta (TRIF)-dependent pathway in TLR signaling. J. Immunol. 173 2913-7 PubMed GONUTS page
↑ Inoue, J et al. (2007) Characteristics and biological functions of TRAF6. Adv. Exp. Med. Biol. 597 72-9 PubMed GONUTS page
↑ Dong, W et al. (2006) The IRAK-1-BCL10-MALT1-TRAF6-TAK1 cascade mediates signaling to NF-kappaB from Toll-like receptor 4. J. Biol. Chem. 281 26029-40 PubMed GONUTS page
↑ Saitoh, T et al. (2011) Antiviral protein Viperin promotes Toll-like receptor 7- and Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells. Immunity 34 352-63 PubMed GONUTS page
↑ Lomaga, MA et al. (2000) Tumor necrosis factor receptor-associated factor 6 (TRAF6) deficiency results in exencephaly and is required for apoptosis within the developing CNS. J. Neurosci. 20 7384-93 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Dauphinee, SM et al. (2013) SASH1 is a scaffold molecule in endothelial TLR4 signaling. J. Immunol. 191 892-901 PubMed GONUTS page
↑ ^13.0 ^13.1 Siednienko, J et al. (2012) Pellino3 targets the IRF7 pathway and facilitates autoregulation of TLR3- and viral-induced expression of type I interferons. Nat. Immunol. 13 1055-62 PubMed GONUTS page
↑ ^14.0 ^14.1 Hostager, BS et al. (2003) Tumor necrosis factor receptor-associated factor 2 (TRAF2)-deficient B lymphocytes reveal novel roles for TRAF2 in CD40 signaling. J. Biol. Chem. 278 45382-90 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Akiyama, T et al. (2005) Dependence of self-tolerance on TRAF6-directed development of thymic stroma. Science 308 248-51 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 ^16.4 Kobayashi, T et al. (2003) TRAF6 is a critical factor for dendritic cell maturation and development. Immunity 19 353-63 PubMed GONUTS page
↑ Schneider, M et al. (2012) The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB. Nat. Immunol. 13 823-31 PubMed GONUTS page
↑ Ohazama, A et al. (2004) Traf6 is essential for murine tooth cusp morphogenesis. Dev. Dyn. 229 131-5 PubMed GONUTS page
↑ Hu, Y et al. (2011) Guanylate binding protein 4 negatively regulates virus-induced type I IFN and antiviral response by targeting IFN regulatory factor 7. J. Immunol. 187 6456-62 PubMed GONUTS page
↑ Wang, Y et al. (2006) Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling. Nat. Immunol. 7 139-47 PubMed GONUTS page

[PMID:20614026-1] 1.0 ^1.1 Hostager, BS et al. (2010) HOIL-1L interacting protein (HOIP) as an NF-kappaB regulating component of the CD40 signaling complex. PLoS ONE 5 e11380 PubMed GONUTS page

[PMID:16252010-2] 2.0 ^2.1 ^2.2 Geetha, T et al. (2005) TRAF6-mediated ubiquitination regulates nuclear translocation of NRIF, the p75 receptor interactor. EMBO J. 24 3859-68 PubMed GONUTS page

[PMID:10421844-3] 3.0 ^3.1 ^3.2 ^3.3 Naito, A et al. (1999) Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice. Genes Cells 4 353-62 PubMed GONUTS page

[PMID:20345905-4] 4.0 ^4.1 Ando, K et al. (2010) Human lactoferrin activates NF-kappaB through the Toll-like receptor 4 pathway while it interferes with the lipopolysaccharide-stimulated TLR4 signaling. FEBS J. 277 2051-66 PubMed GONUTS page

[PMID:10215628-5] 5.0 ^5.1 ^5.2 Lomaga, MA et al. (1999) TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Genes Dev. 13 1015-24 PubMed GONUTS page

[PMID:15322147-6] Gohda, J et al. (2004) Cutting edge: TNFR-associated factor (TRAF) 6 is essential for MyD88-dependent pathway but not toll/IL-1 receptor domain-containing adaptor-inducing IFN-beta (TRIF)-dependent pathway in TLR signaling. J. Immunol. 173 2913-7 PubMed GONUTS page

[PMID:17633018-7] Inoue, J et al. (2007) Characteristics and biological functions of TRAF6. Adv. Exp. Med. Biol. 597 72-9 PubMed GONUTS page

[PMID:16831874-8] Dong, W et al. (2006) The IRAK-1-BCL10-MALT1-TRAF6-TAK1 cascade mediates signaling to NF-kappaB from Toll-like receptor 4. J. Biol. Chem. 281 26029-40 PubMed GONUTS page

[PMID:21435586-9] Saitoh, T et al. (2011) Antiviral protein Viperin promotes Toll-like receptor 7- and Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells. Immunity 34 352-63 PubMed GONUTS page

[PMID:11007897-10] Lomaga, MA et al. (2000) Tumor necrosis factor receptor-associated factor 6 (TRAF6) deficiency results in exencephaly and is required for apoptosis within the developing CNS. J. Neurosci. 20 7384-93 PubMed GONUTS page

[PMID:21873635-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:23776175-12] 12.0 ^12.1 ^12.2 ^12.3 Dauphinee, SM et al. (2013) SASH1 is a scaffold molecule in endothelial TLR4 signaling. J. Immunol. 191 892-901 PubMed GONUTS page

[PMID:23042151-13] 13.0 ^13.1 Siednienko, J et al. (2012) Pellino3 targets the IRF7 pathway and facilitates autoregulation of TLR3- and viral-induced expression of type I interferons. Nat. Immunol. 13 1055-62 PubMed GONUTS page

[PMID:12958312-14] 14.0 ^14.1 Hostager, BS et al. (2003) Tumor necrosis factor receptor-associated factor 2 (TRAF2)-deficient B lymphocytes reveal novel roles for TRAF2 in CD40 signaling. J. Biol. Chem. 278 45382-90 PubMed GONUTS page

[PMID:15705807-15] 15.0 ^15.1 ^15.2 Akiyama, T et al. (2005) Dependence of self-tolerance on TRAF6-directed development of thymic stroma. Science 308 248-51 PubMed GONUTS page

[PMID:14499111-16] 16.0 ^16.1 ^16.2 ^16.3 ^16.4 Kobayashi, T et al. (2003) TRAF6 is a critical factor for dendritic cell maturation and development. Immunity 19 353-63 PubMed GONUTS page

[PMID:22863753-17] Schneider, M et al. (2012) The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB. Nat. Immunol. 13 823-31 PubMed GONUTS page

[PMID:14699584-18] Ohazama, A et al. (2004) Traf6 is essential for murine tooth cusp morphogenesis. Dev. Dyn. 229 131-5 PubMed GONUTS page

[PMID:22095711-19] Hu, Y et al. (2011) Guanylate binding protein 4 negatively regulates virus-induced type I IFN and antiviral response by targeting IFN regulatory factor 7. J. Immunol. 187 6456-62 PubMed GONUTS page

[PMID:16378096-20] Wang, Y et al. (2006) Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling. Nat. Immunol. 7 139-47 PubMed GONUTS page

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