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PMID:10421844

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Citation

Naito, A, Azuma, S, Tanaka, S, Miyazaki, T, Takaki, S, Takatsu, K, Nakao, K, Nakamura, K, Katsuki, M, Yamamoto, T and Inoue, J (1999) Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice. Genes Cells 4:353-62

Abstract

TRAF6, a member of the tumour necrosis factor receptor-associated factor family, was first identified as a transducer of CD40 and interleukin-1 receptor (IL-1R) signals based on the interaction of TRAF6 with the cytoplasmic tail of CD40 and with the IL-1R associated kinase in vitro. However, the functions of TRAF6 in vivo remain unidentified.

Links

PubMed

Keywords

Animals; Bone Marrow Cells/cytology; Cell Differentiation; Embryonic and Fetal Development; Interleukin-1/metabolism; Lymph Nodes/embryology; Mice; Mice, Knockout; Osteoclasts/cytology; Osteopetrosis/genetics; Proteins/genetics; Proteins/metabolism; Receptors, Tumor Necrosis Factor/metabolism; Signal Transduction/genetics; Spleen/cytology; TNF Receptor-Associated Factor 6

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:TRAF6

involved_in

GO:0070498: interleukin-1-mediated signaling pathway

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:TRAF6

involved_in

GO:0046849: bone remodeling

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:TRAF6

involved_in

GO:0042102: positive regulation of T cell proliferation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:TRAF6

involved_in

GO:0030316: osteoclast differentiation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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