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PMID:15705807
| Citation |
Akiyama, T, Maeda, S, Yamane, S, Ogino, K, Kasai, M, Kajiura, F, Matsumoto, M and Inoue, J (2005) Dependence of self-tolerance on TRAF6-directed development of thymic stroma. Science 308:248-51 |
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| Abstract |
The microenvironments of the thymus are generated by thymic epithelial cells (TECs) and are essential for inducing immune self-tolerance or developing T cells. However, the molecular mechanisms that underlie the differentiation of TECs and thymic compartmentalization are not fully understood. Here we show that deficiency in the tumor necrosis factor receptor-associated factor (TRAF) 6 results in disorganized distribution of medullary TECs (mTECs) and the absence of mature mTECs. Engraftment of thymic stroma of TRAF6(-/-) embryos into athymic nude mice induced autoimmunity. Thus, TRAF6 directs the development of thymic stroma and represents a critical point of regulation for self-tolerance and autoimmunity. |
| Links |
PubMed Online version:10.1126/science.1105677 |
| Keywords |
Animals; Autoimmunity; Cell Line; Epithelial Cells/immunology; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Nude; Organ Culture Techniques; Proto-Oncogene Proteins/physiology; Self Tolerance; T-Lymphocytes/immunology; TNF Receptor-Associated Factor 6/immunology; TNF Receptor-Associated Factor 6/physiology; Thymus Gland/cytology; Thymus Gland/embryology; Thymus Gland/immunology; Transcription Factor RelB; Transcription Factors/physiology |
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Significance
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| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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