Category:GO:0007254 ! JNK cascade

name: JNK cascade
namespace: biological_process
def: "A MAPK cascade containing at least the JNK (MAPK8) MAP kinase. It starts with the activation of JUN3K (a MAPK3K), which activates JNKK a MAP2K), which in turn activates JNK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier. The JNK cascade is activated by stress signals, as well as by G protein-coupled receptors, growth factors, and cytokines, and results in cellular responses such as cell proliferation, cell differentiation, apoptosis and inflammation." [PMID:11790549, PMID:20811974, PMID:23125017]
synonym: "c-Jun N-terminal kinase cascade" EXACT [PMID:20811974]
synonym: "JNK1 cascade" NARROW [GOC:add]
synonym: "JNK2 cascade" NARROW [GOC:add]
synonym: "JNK3 cascade" NARROW [GOC:add]
synonym: "MAPK10 cascade" NARROW [GOC:add]
synonym: "MAPK8 cascade" EXACT [GOC:add]
synonym: "MAPK9 cascade" NARROW [GOC:add]
synonym: "SAPK cascade" BROAD []
synonym: "stress-activated protein kinase cascade" BROAD []
is_a: GO:0000165 ! MAPK cascade

AmiGO <GOterm>GO:0007254</GOterm>
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