HUMAN:MK08

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	MAPK8 (synonyms: JNK1, PRKM8, SAPK1, SAPK1C)
Protein Name(s)	Mitogen-activated protein kinase 8 MAP kinase 8 MAPK 8 JNK-46 Stress-activated protein kinase 1c SAPK1c Stress-activated protein kinase JNK1 c-Jun N-terminal kinase 1
External Links
UniProt	P45983
EMBL	L26318 U34822 U35004 U35005 DQ234352 AC016397 AC074325 AB451231 CH471187 CH471187 CH471187 CH471187 CH471187 CH471187 BC144063
CCDS	CCDS60527.1 CCDS7223.1 CCDS7224.1 CCDS7225.1 CCDS7226.1
PIR	S71097 S71099
RefSeq	NP_001265476.1 NP_001265477.1 NP_002741.1 NP_620634.1 NP_620637.1 XP_006717980.1 XP_006717981.1 XP_006717982.1
UniGene	Hs.138211 Hs.522924
PDB	1UKH 1UKI 2G01 2GMX 2H96 2NO3 2XRW 2XS0 3ELJ 3O17 3O2M 3PZE 3V3V 3VUD 3VUG 3VUH 3VUI 3VUK 3VUL 3VUM 4AWI 4E73 4G1W 4HYS 4HYU 4IZY 4L7F 4QTD
PDBsum	1UKH 1UKI 2G01 2GMX 2H96 2NO3 2XRW 2XS0 3ELJ 3O17 3O2M 3PZE 3V3V 3VUD 3VUG 3VUH 3VUI 3VUK 3VUL 3VUM 4AWI 4E73 4G1W 4HYS 4HYU 4IZY 4L7F 4QTD
ProteinModelPortal	P45983
SMR	P45983
BioGrid	111585
DIP	DIP-249N
IntAct	P45983
MINT	MINT-1211982
STRING	9606.ENSP00000353483
BindingDB	P45983
ChEMBL	CHEMBL2096667
GuidetoPHARMACOLOGY	1496
PhosphoSite	P45983
DMDM	2507195
MaxQB	P45983
PaxDb	P45983
PRIDE	P45983
DNASU	5599
Ensembl	ENST00000360332 ENST00000374176 ENST00000374179 ENST00000374182 ENST00000374189 ENST00000395611
GeneID	5599
KEGG	hsa:5599
UCSC	uc001jgo.3 uc001jgp.3 uc001jgq.3 uc009xoa.3
CTD	5599
GeneCards	GC10P049514
HGNC	HGNC:6881
HPA	CAB004463
MIM	601158
neXtProt	NX_P45983
PharmGKB	PA283
eggNOG	COG0515
GeneTree	ENSGT00550000074271
HOVERGEN	HBG014652
InParanoid	P45983
KO	K04440
OMA	REHTLEQ
OrthoDB	EOG7PCJGV
PhylomeDB	P45983
TreeFam	TF105100
BRENDA	2.7.11.24
Reactome	REACT_13638 REACT_13643 REACT_163701 REACT_169436 REACT_2100 REACT_21326 REACT_21368 REACT_25299
SignaLink	P45983
ChiTaRS	MAPK8
EvolutionaryTrace	P45983
GeneWiki	MAPK8
GenomeRNAi	5599
NextBio	21738
PRO	PR:P45983
Proteomes	UP000005640
Bgee	P45983
CleanEx	HS_MAPK8
ExpressionAtlas	P45983
Genevestigator	P45983
GO	GO:0005829 GO:0005739 GO:0005654 GO:0005634 GO:0005524 GO:0042826 GO:0035033 GO:0004705 GO:0004674 GO:0006915 GO:0097190 GO:0070301 GO:0071222 GO:0071260 GO:0071732 GO:0038095 GO:0045087 GO:0097193 GO:0007254 GO:0007258 GO:0002755 GO:0002756 GO:0043066 GO:0032091 GO:0048011 GO:0001503 GO:0018105 GO:0018107 GO:0043065 GO:0090045 GO:2000017 GO:0010628 GO:1900740 GO:0097300 GO:0031063 GO:0032880 GO:0051090 GO:0046686 GO:0006950 GO:0009411 GO:0051403 GO:0034166 GO:0034134 GO:0034138 GO:0034142 GO:0034146 GO:0034162 GO:0002224 GO:0038123 GO:0038124 GO:0035666
InterPro	IPR011009 IPR003527 IPR008351 IPR000719 IPR002290 IPR008271
Pfam	PF00069
PRINTS	PR01772
SMART	SM00220
SUPFAM	SSF56112
PROSITE	PS01351 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0097441	basal dendrite	PMID:22683681^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q91Y86	C	exists_during:(GO:0006468)	Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:22683681^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q91Y86	C	exists_during:(GO:0006468)	Seeded From UniProt	complete
involved_in	GO:0071276	cellular response to cadmium ion	PMID:26514923^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034614	cellular response to reactive oxygen species	PMID:26514923^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034198	cellular response to amino acid starvation	PMID:11096076^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051403	stress-activated MAPK cascade	PMID:11096076^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:21856198^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	happens_during:(GO:0072708) has_regulation_target:(UniProtKB:Q9H211)	Seeded From UniProt	complete
involved_in	GO:1902595	regulation of DNA replication origin binding	PMID:21856198^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:O95251) happens_during:(GO:0072708)\|has_regulation_target(UniProtKB:O95251) happens_during:(GO:0072720)\|has_regulation_target(UniProtKB:O95251) happens_during:(GO:0072739)	Seeded From UniProt	complete
involved_in	GO:0031281	positive regulation of cyclase activity	PMID:22027397^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051247	positive regulation of protein metabolic process	PMID:22027397^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042752	regulation of circadian rhythm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q91Y86	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:22441692^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:14615289^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P12821	F		Seeded From UniProt	complete
involved_in	GO:0090045	positive regulation of deacetylase activity	PMID:20027304^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042826	histone deacetylase binding	PMID:20027304^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q96EB6	F		Seeded From UniProt	complete
enables	GO:0035033	histone deacetylase regulator activity	PMID:20027304^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0032880	regulation of protein localization	PMID:20027304^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0018107	peptidyl-threonine phosphorylation	PMID:20027304^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:20027304^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:15850461^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:22065586^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20027304^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:15850461^[9]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:Q6JBY9)	Seeded From UniProt	complete
involved_in	GO:0071260	cellular response to mechanical stimulus	PMID:19593445^[11]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:21095239^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032091	negative regulation of protein binding	PMID:21095239^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0018107	peptidyl-threonine phosphorylation	PMID:21095239^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:21095239^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007258	JUN phosphorylation	PMID:21095239^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007254	JNK cascade	PMID:8654373^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004705	JUN kinase activity	PMID:21095239^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004705	JUN kinase activity	PMID:8654373^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
	GO:0051247	positive regulation of protein metabolic process	PMID:22027397^[5]	ECO:0000315			P		Fig. 5B	complete CACAO 2991
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21095239^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
	GO:0031281	positive regulation of cyclase activity	PMID:22027397^[5]	ECO:0000315			P		Fig. 5D	complete CACAO 2992
enables	GO:0004674	protein serine/threonine kinase activity	PMID:20027304^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0071310	cellular response to organic substance	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001172432 RGD:70500	P		Seeded From UniProt	complete
involved_in	GO:0048666	neuron development	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000622286 RGD:621506 RGD:628847	P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001171983 RGD:621506 RGD:628847	P		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000622286 RGD:628847	C		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:106908 MGI:MGI:1201387 MGI:MGI:1201408 MGI:MGI:1346865 PANTHER:PTN000622075 RGD:3046 RGD:70500 RGD:71050 UniProtKB:P78362 UniProtKB:Q16539 UniProtKB:Q96SB4 UniProtKB:Q9UPZ9 WB:WBGene00004055 WB:WBGene00004056	P		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1346861 PANTHER:PTN000622075 UniProtKB:A9T142	P		Seeded From UniProt	complete
involved_in	GO:0009612	response to mechanical stimulus	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001171983 RGD:628847	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0052703 FB:FBgn0267339 MGI:MGI:1201408 MGI:MGI:1346347 MGI:MGI:1346858 MGI:MGI:1346859 MGI:MGI:1346861 MGI:MGI:1346862 MGI:MGI:1346863 MGI:MGI:1346865 MGI:MGI:1354946 MGI:MGI:2444559 PANTHER:PTN000622075 PomBase:SPAC24B11.06c PomBase:SPBC119.08 PomBase:SPBC530.14c RGD:3046 RGD:621506 RGD:628847 RGD:70500 RGD:70975 RGD:71050 SGD:S000000112 SGD:S000004103 SGD:S000004829 TAIR:locus:2024887 TAIR:locus:2124943 UniProtKB:A9T142 UniProtKB:O77306 UniProtKB:P28482 UniProtKB:P78362 UniProtKB:Q10N20 UniProtKB:Q13164 UniProtKB:Q96SB4 WB:WBGene00002178 WB:WBGene00002187 WB:WBGene00003048 WB:WBGene00003401 WB:WBGene00004056 WB:WBGene00004057	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003256 FB:FBgn0015765 MGI:MGI:1201387 MGI:MGI:1201408 MGI:MGI:1336881 MGI:MGI:1346347 MGI:MGI:1346858 MGI:MGI:1346859 MGI:MGI:1346861 MGI:MGI:1346865 MGI:MGI:1354946 MGI:MGI:1934157 MGI:MGI:2444559 MGI:MGI:96913 PANTHER:PTN000622075 PomBase:SPAC24B11.06c PomBase:SPAC31G5.09c PomBase:SPBC119.08 PomBase:SPBC530.14c RGD:3046 RGD:3663 RGD:621505 RGD:621506 RGD:628675 RGD:628847 RGD:70496 RGD:70500 SGD:S000000112 SGD:S000001072 SGD:S000003272 SGD:S000003642 SGD:S000004103 TAIR:locus:2024887 TAIR:locus:2124943 UniProtKB:A9T142 UniProtKB:O77306 UniProtKB:P20794 UniProtKB:P28482 UniProtKB:P45983 UniProtKB:P78362 UniProtKB:Q10N20 UniProtKB:Q13164 UniProtKB:Q5AZN7 UniProtKB:Q8GYQ5 UniProtKB:Q96SB4 UniProtKB:Q9LV37 UniProtKB:Q9P419 WB:WBGene00002178 WB:WBGene00003048 WB:WBGene00003401 WB:WBGene00004055 WB:WBGene00004057 dictyBase:DDB_G0283903 dictyBase:DDB_G0286353	C		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015765 FB:FBgn0024846 FB:FBgn0267339 MGI:MGI:1346858 MGI:MGI:1346859 MGI:MGI:1346865 MGI:MGI:1354946 PANTHER:PTN001172432 PomBase:SPAC31G5.09c PomBase:SPBC119.08 RGD:1309340 RGD:3045 RGD:3046 RGD:621505 RGD:70496 RGD:70500 RGD:70975 SGD:S000000112 SGD:S000003272 SGD:S000006258 UniProtKB:A0A1D8PFT5 UniProtKB:A0A1D8PT38 UniProtKB:O15264 UniProtKB:P27361 UniProtKB:Q15759 UniProtKB:Q16539 WB:WBGene00003401 WB:WBGene00004055 WB:WBGene00004056 dictyBase:DDB_G0286353	F		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	CGD:CAL0000183747 FB:FBgn0015765 FB:FBgn0024846 FB:FBgn0267339 MGI:MGI:1346858 MGI:MGI:1346859 MGI:MGI:1346865 MGI:MGI:1354946 PANTHER:PTN002372889 PomBase:SPAC31G5.09c PomBase:SPBC119.08 RGD:1309340 RGD:3045 RGD:3046 RGD:621505 RGD:70496 RGD:70500 RGD:70975 SGD:S000000112 SGD:S000003272 SGD:S000006258 UniProtKB:A0A1D8PFT5 UniProtKB:A0A1D8PT38 UniProtKB:O15264 UniProtKB:P27361 UniProtKB:Q15759 UniProtKB:Q16539 WB:WBGene00003401 WB:WBGene00004055 WB:WBGene00004056 dictyBase:DDB_G0286353	F		Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	PMID:23776175^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:14967141^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009411	response to UV	PMID:14967141^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007258	JUN phosphorylation	PMID:14967141^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:14967141^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:1900740	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:1900740	C		Seeded From UniProt	complete
involved_in	GO:0031063	regulation of histone deacetylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0035033	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003527 InterPro:IPR008351	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR003527 InterPro:IPR008351	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR003527 InterPro:IPR008271 InterPro:IPR008351	P		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.11.24	F		Seeded From UniProt	complete
involved_in	GO:0016241	regulation of macroautophagy	PMID:26546165^[17]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway	Reactome:R-HSA-139910 Reactome:R-HSA-111446	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071345	cellular response to cytokine stimulus	Reactome:R-HSA-9007892	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051090	regulation of DNA-binding transcription factor activity	Reactome:R-HSA-450341	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	Reactome:R-HSA-193648	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038095	Fc-epsilon receptor signaling pathway	Reactome:R-HSA-2454202	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	Reactome:R-HSA-139918 Reactome:R-HSA-139908	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007254	JNK cascade	Reactome:R-HSA-450321	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-9008043 Reactome:R-HSA-451347 Reactome:R-HSA-450348 Reactome:R-HSA-205136 Reactome:R-HSA-205075 Reactome:R-HSA-193666 Reactome:R-HSA-168162 Reactome:R-HSA-139918 Reactome:R-HSA-139908	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-5683986 Reactome:R-HSA-450348 Reactome:R-HSA-193666 Reactome:R-HSA-168136 Reactome:R-HSA-168053	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004705	JUN kinase activity	Reactome:R-HSA-205075	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
involved_in	GO:0048511	rhythmic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0090	P		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 de Anda, FC et al. (2012) Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex. Nat. Neurosci. 15 1022-31 PubMed GONUTS page
↑ ^2.0 ^2.1 Lian, S et al. (2015) Cadmium induces matrix metalloproteinase-9 expression via ROS-dependent EGFR, NF-кB, and AP-1 pathways in human endothelial cells. Toxicology 338 104-16 PubMed GONUTS page
↑ ^3.0 ^3.1 Ko, YG et al. (2001) Glutamine-dependent antiapoptotic interaction of human glutaminyl-tRNA synthetase with apoptosis signal-regulating kinase 1. J. Biol. Chem. 276 6030-6 PubMed GONUTS page
↑ ^4.0 ^4.1 Miotto, B & Struhl, K (2011) JNK1 phosphorylation of Cdt1 inhibits recruitment of HBO1 histone acetylase and blocks replication licensing in response to stress. Mol. Cell 44 62-71 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Mamik, MK et al. (2011) HIV-1 and IL-1β regulate astrocytic CD38 through mitogen-activated protein kinases and nuclear factor-κB signaling mechanisms. J Neuroinflammation 8 145 PubMed GONUTS page
↑ Yoshitane, H et al. (2012) JNK regulates the photic response of the mammalian circadian clock. EMBO Rep. 13 455-61 PubMed GONUTS page
↑ Kohlstedt, K et al. (2004) Angiotensin-converting enzyme is involved in outside-in signaling in endothelial cells. Circ. Res. 94 60-7 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 ^8.7 Nasrin, N et al. (2009) JNK1 phosphorylates SIRT1 and promotes its enzymatic activity. PLoS ONE 4 e8414 PubMed GONUTS page
↑ ^9.0 ^9.1 Eyers, CE et al. (2005) The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ. Biochem. J. 389 127-35 PubMed GONUTS page
↑ Oh, YT et al. (2012) Oncogenic Ras and B-Raf proteins positively regulate death receptor 5 expression through co-activation of ERK and JNK signaling. J. Biol. Chem. 287 257-67 PubMed GONUTS page
↑ Smith, AJ et al. (2009) Expression of the Bcl-2 protein BAD promotes prostate cancer growth. PLoS ONE 4 e6224 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 ^12.6 Deng, H et al. (2011) Phosphorylation of Bcl-associated death protein (Bad) by erythropoietin-activated c-Jun N-terminal protein kinase 1 contributes to survival of erythropoietin-dependent cells. Int. J. Biochem. Cell Biol. 43 409-15 PubMed GONUTS page
↑ ^13.0 ^13.1 Gupta, S et al. (1996) Selective interaction of JNK protein kinase isoforms with transcription factors. EMBO J. 15 2760-70 PubMed GONUTS page
↑ ^14.00 ^14.01 ^14.02 ^14.03 ^14.04 ^14.05 ^14.06 ^14.07 ^14.08 ^14.09 ^14.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Dauphinee, SM et al. (2013) SASH1 is a scaffold molecule in endothelial TLR4 signaling. J. Immunol. 191 892-901 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 Yu, C et al. (2004) JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD. Mol. Cell 13 329-40 PubMed GONUTS page
↑ Maejima, Y et al. (2016) Regulation of autophagy by Beclin 1 in the heart. J. Mol. Cell. Cardiol. 95 19-25 PubMed GONUTS page

[PMID:22683681-1] 1.0 ^1.1 de Anda, FC et al. (2012) Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex. Nat. Neurosci. 15 1022-31 PubMed GONUTS page

[PMID:26514923-2] 2.0 ^2.1 Lian, S et al. (2015) Cadmium induces matrix metalloproteinase-9 expression via ROS-dependent EGFR, NF-кB, and AP-1 pathways in human endothelial cells. Toxicology 338 104-16 PubMed GONUTS page

[PMID:11096076-3] 3.0 ^3.1 Ko, YG et al. (2001) Glutamine-dependent antiapoptotic interaction of human glutaminyl-tRNA synthetase with apoptosis signal-regulating kinase 1. J. Biol. Chem. 276 6030-6 PubMed GONUTS page

[PMID:21856198-4] 4.0 ^4.1 Miotto, B & Struhl, K (2011) JNK1 phosphorylation of Cdt1 inhibits recruitment of HBO1 histone acetylase and blocks replication licensing in response to stress. Mol. Cell 44 62-71 PubMed GONUTS page

[PMID:22027397-5] 5.0 ^5.1 ^5.2 ^5.3 Mamik, MK et al. (2011) HIV-1 and IL-1β regulate astrocytic CD38 through mitogen-activated protein kinases and nuclear factor-κB signaling mechanisms. J Neuroinflammation 8 145 PubMed GONUTS page

[PMID:22441692-6] Yoshitane, H et al. (2012) JNK regulates the photic response of the mammalian circadian clock. EMBO Rep. 13 455-61 PubMed GONUTS page

[PMID:14615289-7] Kohlstedt, K et al. (2004) Angiotensin-converting enzyme is involved in outside-in signaling in endothelial cells. Circ. Res. 94 60-7 PubMed GONUTS page

[PMID:20027304-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 ^8.7 Nasrin, N et al. (2009) JNK1 phosphorylates SIRT1 and promotes its enzymatic activity. PLoS ONE 4 e8414 PubMed GONUTS page

[PMID:15850461-9] 9.0 ^9.1 Eyers, CE et al. (2005) The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ. Biochem. J. 389 127-35 PubMed GONUTS page

[PMID:22065586-10] Oh, YT et al. (2012) Oncogenic Ras and B-Raf proteins positively regulate death receptor 5 expression through co-activation of ERK and JNK signaling. J. Biol. Chem. 287 257-67 PubMed GONUTS page

[PMID:19593445-11] Smith, AJ et al. (2009) Expression of the Bcl-2 protein BAD promotes prostate cancer growth. PLoS ONE 4 e6224 PubMed GONUTS page

[PMID:21095239-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 ^12.6 Deng, H et al. (2011) Phosphorylation of Bcl-associated death protein (Bad) by erythropoietin-activated c-Jun N-terminal protein kinase 1 contributes to survival of erythropoietin-dependent cells. Int. J. Biochem. Cell Biol. 43 409-15 PubMed GONUTS page

[PMID:8654373-13] 13.0 ^13.1 Gupta, S et al. (1996) Selective interaction of JNK protein kinase isoforms with transcription factors. EMBO J. 15 2760-70 PubMed GONUTS page

[PMID:21873635-14] 14.00 ^14.01 ^14.02 ^14.03 ^14.04 ^14.05 ^14.06 ^14.07 ^14.08 ^14.09 ^14.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:23776175-15] Dauphinee, SM et al. (2013) SASH1 is a scaffold molecule in endothelial TLR4 signaling. J. Immunol. 191 892-901 PubMed GONUTS page

[PMID:14967141-16] 16.0 ^16.1 ^16.2 ^16.3 Yu, C et al. (2004) JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD. Mol. Cell 13 329-40 PubMed GONUTS page

[PMID:26546165-17] Maejima, Y et al. (2016) Regulation of autophagy by Beclin 1 in the heart. J. Mol. Cell. Cardiol. 95 19-25 PubMed GONUTS page

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HUMAN:MK08

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