MOUSE:MP2K7

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Map2k7 (ECO:0000312 with MGI:MGI:1346871) (synonyms: Mkk7 (ECO:0000312 with EMBL:AAC16274.1))
Protein Name(s)	Dual specificity mitogen-activated protein kinase kinase 7 MAP kinase kinase 7 MAPKK 7 JNK-activating kinase 2 MAPK/ERK kinase 7 MEK 7 c-Jun N-terminal kinase kinase 2 JNK kinase 2 JNKK 2
External Links
UniProt	Q8CE90
EMBL	AF026216 U74463 U74464 AB005654 AF022112 AF022113 U93030 U93031 AF060943 AF060944 AF060945 AF060946 AF060947 AK028772 AK031137 AK165184 BC070467
CCDS	CCDS40208.1 CCDS40209.1 CCDS52474.1
RefSeq	NP_001036022.1 NP_001157644.1 NP_001278706.1 NP_001278707.1 NP_001278712.1 NP_036074.2
UniGene	Mm.3906
ProteinModelPortal	Q8CE90
SMR	Q8CE90
BioGrid	204954
IntAct	Q8CE90
PhosphoSite	Q8CE90
MaxQB	Q8CE90
PaxDb	Q8CE90
PRIDE	Q8CE90
Ensembl	ENSMUST00000003027 ENSMUST00000062686 ENSMUST00000110994 ENSMUST00000110995 ENSMUST00000110996 ENSMUST00000110998 ENSMUST00000110999 ENSMUST00000145165
GeneID	26400
KEGG	mmu:26400
UCSC	uc009kti.2 uc009ktj.2 uc009ktk.2 uc009ktm.2 uc009ktn.2
CTD	5609
MGI	MGI:1346871
eggNOG	COG0515
GeneTree	ENSGT00760000119199
HOVERGEN	HBG108518
InParanoid	Q8CE90
KO	K04431
OMA	PIIVIQL
OrthoDB	EOG7J9VPW
PhylomeDB	Q8CE90
TreeFam	TF350701
Reactome	REACT_188530 REACT_188970 REACT_204812
ChiTaRS	Map2k7
NextBio	304359
PRO	PR:Q8CE90
Proteomes	UP000000589
Bgee	Q8CE90
CleanEx	MM_MAP2K7
Genevestigator	Q8CE90
GO	GO:0005737 GO:0005829 GO:0005634 GO:0005524 GO:0008545 GO:0000287 GO:0004708 GO:0019903 GO:0004674 GO:0004713 GO:0007257 GO:0006915 GO:0072709 GO:0043525 GO:0006950 GO:0051403
InterPro	IPR011009 IPR000719 IPR002290 IPR008271
Pfam	PF00069
SMART	SM00220
SUPFAM	SSF56112
PROSITE	PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14733	P	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14733	P	Seeded From UniProt	complete
enables	GO:0016909	SAP kinase activity	PMID:9405446^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	PMID:9405446^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	PMID:11959862^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8K4T5	F	Seeded From UniProt	complete
involved_in	GO:0007257	activation of JUN kinase activity	PMID:11959862^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0046330	positive regulation of JNK cascade	PMID:9405446^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071347	cellular response to interleukin-1	PMID:9405446^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:9891090^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:9891090^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0008545	JUN kinase kinase activity	PMID:9405446^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0000287	magnesium ion binding	PMID:9405446^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0032147	activation of protein kinase activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1919399 PANTHER:PTN000684825 RGD:727905 UniProtKB:Q7RTN6 UniProtKB:Q9C0K7	P	Seeded From UniProt	complete
involved_in	GO:0031098	stress-activated protein kinase signaling cascade	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000684825 UniProtKB:A0A1D8PKE2 UniProtKB:A0A1D8PM87	P	Seeded From UniProt	complete
involved_in	GO:0023014	signal transduction by protein phosphorylation	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000684825 TAIR:locus:2205523 UniProtKB:Q9UEW8	P	Seeded From UniProt	complete
enables	GO:0008545	JUN kinase kinase activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001220492 RGD:1560043	F	Seeded From UniProt	complete
involved_in	GO:0007257	activation of JUN kinase activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001220492 RGD:1560043	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0023083 FB:FBgn0025743 FB:FBgn0267698 MGI:MGI:1339975 MGI:MGI:1344404 MGI:MGI:1346867 MGI:MGI:1346875 MGI:MGI:1891638 MGI:MGI:1928487 MGI:MGI:1929004 PANTHER:PTN000684825 PomBase:SPAC1F3.02c PomBase:SPBC17F3.02 PomBase:SPBC1D7.05 PomBase:SPBC409.07c PomBase:SPBC543.07 RGD:3780 RGD:620966 RGD:621643 SGD:S000000999 SGD:S000002318 SGD:S000002931 SGD:S000003664 SGD:S000004354 SGD:S000005757 SGD:S000006061 TAIR:locus:2017662 TAIR:locus:2074835 TAIR:locus:2087130 TAIR:locus:2170578 UniProtKB:A0A0B4KGS4 UniProtKB:O00506 UniProtKB:O95819 UniProtKB:Q13043 UniProtKB:Q13153 UniProtKB:Q13177 UniProtKB:Q13188 UniProtKB:Q57Y61 UniProtKB:Q7RTN6 UniProtKB:Q8N4C8 UniProtKB:Q96PY6 UniProtKB:Q9C0K7 UniProtKB:Q9H2G2 UniProtKB:Q9P289 UniProtKB:Q9S7U9 UniProtKB:Q9UKE5 UniProtKB:Q9Y4K4 UniProtKB:Q9Y6E0 UniProtKB:Q9Y6R4 WB:WBGene00002177 WB:WBGene00002201 WB:WBGene00003368 WB:WBGene00013355 dictyBase:DDB_G0284181 dictyBase:DDB_G0286359	C	Seeded From UniProt	complete
enables	GO:0004708	MAP kinase kinase activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0261524 MGI:MGI:1346866 MGI:MGI:1346868 PANTHER:PTN000684494 PomBase:SPAC1D4.13 PomBase:SPBC409.07c RGD:1307040 RGD:1560043 RGD:61888 RGD:620666 RGD:70495 SGD:S000002318 SGD:S000003664 TAIR:locus:2017662 TAIR:locus:2120855 TAIR:locus:2164981 TAIR:locus:2170578 TAIR:locus:2206885 UniProtKB:A0A1D8PKE2 UniProtKB:O14733 UniProtKB:P36507 UniProtKB:P52564 UniProtKB:Q02750 UniProtKB:Q5BEU9 UniProtKB:Q9S7U9 WB:WBGene00003185 WB:WBGene00003186 WB:WBGene00004758 dictyBase:DDB_G0269152	F	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0023083 FB:FBgn0025743 FB:FBgn0031030 FB:FBgn0035001 FB:FBgn0261456 FB:FBgn0267698 MGI:MGI:1344404 MGI:MGI:1346882 MGI:MGI:1349394 MGI:MGI:1355329 MGI:MGI:1858416 MGI:MGI:1917378 MGI:MGI:1920334 PANTHER:PTN000684825 PomBase:SPBC1604.14c PomBase:SPBC21.06c RGD:3250 RGD:3251 RGD:621643 RGD:708455 RGD:727905 SGD:S000005242 TAIR:locus:2035989 TAIR:locus:2045658 TAIR:locus:2080394 TAIR:locus:2116417 TAIR:locus:2133559 TAIR:locus:2174969 TAIR:locus:2205523 TAIR:locus:2206885 UniProtKB:A0A0B4KGS4 UniProtKB:C0H4N8 UniProtKB:O75914 UniProtKB:O94804 UniProtKB:O95747 UniProtKB:O95819 UniProtKB:O96013 UniProtKB:Q02750 UniProtKB:Q12851 UniProtKB:Q13043 UniProtKB:Q13153 UniProtKB:Q13177 UniProtKB:Q13188 UniProtKB:Q13233 UniProtKB:Q8IVH8 UniProtKB:Q8N4C8 UniProtKB:Q92918 UniProtKB:Q99558 UniProtKB:Q9H2G2 UniProtKB:Q9H2K8 UniProtKB:Q9UEW8 UniProtKB:Q9UKE5 UniProtKB:Q9UL54 UniProtKB:Q9Y4K4 UniProtKB:Q9Y6E0 WB:WBGene00013355 WB:WBGene00017472 dictyBase:DDB_G0276459 dictyBase:DDB_G0286359	F	Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0261524 MGI:MGI:1346866 MGI:MGI:1346868 MGI:MGI:1346870 PANTHER:PTN000684494 RGD:61890 RGD:70495 SGD:S000002318 SGD:S000003664 UniProtKB:P52564 UniProtKB:Q02750 WB:WBGene00003185 WB:WBGene00003368 WB:WBGene00004758 dictyBase:DDB_G0269152	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000671	regulation of motor neuron apoptotic process	PMID:25100604^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4948950	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904355	positive regulation of telomere capping	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14733	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14733	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051973	positive regulation of telomerase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14733	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051403	stress-activated MAPK cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14733	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051403	stress-activated MAPK cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1560043	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14733	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043525	positive regulation of neuron apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1560043	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034612	response to tumor necrosis factor	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14733	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032212	positive regulation of telomere maintenance via telomerase	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14733	P	Seeded From UniProt	complete
enables	GO:0031435	mitogen-activated protein kinase kinase kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1560043	F	Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14733	F	Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14733	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009611	response to wounding	PMID:25100604^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4948950	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009411	response to UV	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14733	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009408	response to heat	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14733	P	Seeded From UniProt	complete
enables	GO:0008545	JUN kinase kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1560043	F	Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1560043	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007257	activation of JUN kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1560043	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007254	JNK cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1560043	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006970	response to osmotic stress	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14733	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006970	response to osmotic stress	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1560043	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1560043	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1560043	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1560043	C	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1560043	F	Seeded From UniProt	complete
enables	GO:0004708	MAP kinase kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14733	F	Seeded From UniProt	complete
enables	GO:0004708	MAP kinase kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1560043	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1560043	P	Seeded From UniProt	complete
enables	GO:0000287	magnesium ion binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14733	F	Seeded From UniProt	complete
enables	GO:0000287	magnesium ion binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1560043	F	Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004713	P	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719	F	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	P	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F	Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0829	F	Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Yao, Z et al. (1997) Activation of stress-activated protein kinases/c-Jun N-terminal protein kinases (SAPKs/JNKs) by a novel mitogen-activated protein kinase kinase. J. Biol. Chem. 272 32378-83 PubMed GONUTS page
↑ ^2.0 ^2.1 Zama, T et al. (2002) Scaffold role of a mitogen-activated protein kinase phosphatase, SKRP1, for the JNK signaling pathway. J. Biol. Chem. 277 23919-26 PubMed GONUTS page
↑ ^3.0 ^3.1 Tournier, C et al. (1999) The MKK7 gene encodes a group of c-Jun NH2-terminal kinase kinases. Mol. Cell. Biol. 19 1569-81 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^5.0 ^5.1 Itoh, T et al. (2014) ZPK/DLK and MKK4 form the critical gateway to axotomy-induced motoneuron death in neonates. J. Neurosci. 34 10729-42 PubMed GONUTS page

[PMID:9405446-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Yao, Z et al. (1997) Activation of stress-activated protein kinases/c-Jun N-terminal protein kinases (SAPKs/JNKs) by a novel mitogen-activated protein kinase kinase. J. Biol. Chem. 272 32378-83 PubMed GONUTS page

[PMID:11959862-2] 2.0 ^2.1 Zama, T et al. (2002) Scaffold role of a mitogen-activated protein kinase phosphatase, SKRP1, for the JNK signaling pathway. J. Biol. Chem. 277 23919-26 PubMed GONUTS page

[PMID:9891090-3] 3.0 ^3.1 Tournier, C et al. (1999) The MKK7 gene encodes a group of c-Jun NH2-terminal kinase kinases. Mol. Cell. Biol. 19 1569-81 PubMed GONUTS page

[PMID:21873635-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:25100604-5] 5.0 ^5.1 Itoh, T et al. (2014) ZPK/DLK and MKK4 form the critical gateway to axotomy-induced motoneuron death in neonates. J. Neurosci. 34 10729-42 PubMed GONUTS page

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MOUSE:MP2K7

Contents

Annotations

Notes

References

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