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MOUSE:TRIB1
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Trib1 (ECO:0000312 with MGI:MGI:2443397) (synonyms: Trb1 (ECO:0000312 with MGI:MGI:2443397)) | |
| Protein Name(s) | Tribbles homolog 1
TRB-1 | |
| External Links | ||
| UniProt | Q8K4K4 | |
| EMBL | AF358866 AK028626 AK033358 AK040738 AK041212 AK080228 AK162876 BC006800 | |
| CCDS | CCDS27499.1 | |
| RefSeq | NP_653132.1 | |
| UniGene | Mm.40298 | |
| ProteinModelPortal | Q8K4K4 | |
| SMR | Q8K4K4 | |
| BioGrid | 229263 | |
| IntAct | Q8K4K4 | |
| PhosphoSite | Q8K4K4 | |
| PRIDE | Q8K4K4 | |
| Ensembl | ENSMUST00000067543 ENSMUST00000118228 | |
| GeneID | 211770 | |
| KEGG | mmu:211770 | |
| UCSC | uc007vxw.1 | |
| CTD | 10221 | |
| MGI | MGI:2443397 | |
| eggNOG | COG0515 | |
| GeneTree | ENSGT00760000119244 | |
| HOGENOM | HOG000231872 | |
| HOVERGEN | HBG067729 | |
| InParanoid | Q8K4K4 | |
| KO | K08814 | |
| OMA | AHCHQSA | |
| OrthoDB | EOG7RJPR4 | |
| PhylomeDB | Q8K4K4 | |
| TreeFam | TF329785 | |
| ChiTaRS | Trib1 | |
| NextBio | 373352 | |
| PRO | PR:Q8K4K4 | |
| Proteomes | UP000000589 | |
| Bgee | Q8K4K4 | |
| CleanEx | MM_TRIB1 | |
| Genevestigator | Q8K4K4 | |
| GO | GO:0005737 GO:0005634 GO:0004860 GO:0008134 GO:0016772 GO:0031625 GO:0055106 GO:0007254 GO:0031665 GO:0043433 GO:0014912 GO:0048662 GO:0032436 GO:0051443 GO:0043405 GO:0032496 | |
| InterPro | IPR011009 IPR000719 IPR024105 IPR024104 | |
| PANTHER | PTHR22961 PTHR22961:SF10 | |
| Pfam | PF00069 | |
| SUPFAM | SSF56112 | |
| PROSITE | PS50011 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0045645 |
positive regulation of eosinophil differentiation |
ECO:0000315 |
P |
Figure 2: Although the proportions of B cells, T cells, dendritic cells and Ly6ChighMac1+ inflammatory monocytes were not altered between wild-type and Trib1−/− splenocytes, F4/80+Mac1+ macrophages, which also expressed Mrc1 (also called MR), Arg1 and Fizz1 (also called Retnla), were markedly reduced and Siglec-F+CCR3+ eosinophils were absent in Trib1−/− spleens (Fig. 1a and Supplementary Figs 1 and 2). |
complete | |||||
| GO:0045659 |
negative regulation of neutrophil differentiation |
ECO:0000315 |
P |
Figure 2: Although the proportions of B cells, T cells, dendritic cells and Ly6ChighMac1+ inflammatory monocytes were not altered between wild-type and Trib1−/− splenocytes, F4/80+Mac1+ macrophages, which also expressed Mrc1 (also called MR), Arg1 and Fizz1 (also called Retnla), were markedly reduced and Siglec-F+CCR3+ eosinophils were absent in Trib1−/− spleens (Fig. 1a and Supplementary Figs 1 and 2). In contrast, the neutrophil population was increased in Trib1−/− spleens (Fig. 1a and Supplementary Fig. 3). |
complete | |||||
| GO:0045651 |
positive regulation of macrophage differentiation |
ECO:0000315 |
P |
Figure 2: Although the proportions of B cells, T cells, dendritic cells and Ly6ChighMac1+ inflammatory monocytes were not altered between wild-type and Trib1−/− splenocytes, F4/80+Mac1+ macrophages, which also expressed Mrc1 (also called MR), Arg1 and Fizz1 (also called Retnla), were markedly reduced and Siglec-F+CCR3+ eosinophils were absent in Trib1−/− spleens (Fig. 1a and Supplementary Figs 1 and 2). |
complete | |||||
|
involved_in |
GO:0045651 |
positive regulation of macrophage differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045659 |
negative regulation of neutrophil differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045645 |
positive regulation of eosinophil differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0055106 |
ubiquitin-protein transferase regulator activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051443 |
positive regulation of ubiquitin-protein transferase activity |
ECO:0000305 |
curator inference used in manual assertion |
GO:0032436 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043433 |
negative regulation of DNA-binding transcription factor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032496 |
response to lipopolysaccharide |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032436 |
positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0031625 |
ubiquitin protein ligase binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008134 |
transcription factor binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008134 |
transcription factor binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043405 |
regulation of MAP kinase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043405 |
regulation of MAP kinase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001121144 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032436 |
positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2145021 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0031434 |
mitogen-activated protein kinase kinase binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001121144 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0028978 |
C |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0048662 |
negative regulation of smooth muscle cell proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0043433 |
negative regulation of DNA-binding transcription factor activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0043405 |
regulation of MAP kinase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0032496 |
response to lipopolysaccharide |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0031665 |
negative regulation of lipopolysaccharide-mediated signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0031434 |
mitogen-activated protein kinase kinase binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0014912 |
negative regulation of smooth muscle cell migration |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008134 |
transcription factor binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0007254 |
JNK cascade |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0006469 |
negative regulation of protein kinase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004860 |
protein kinase inhibitor activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0048662 |
negative regulation of smooth muscle cell proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96RU8 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043433 |
negative regulation of DNA-binding transcription factor activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96RU8 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043405 |
regulation of MAP kinase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96RU8 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032496 |
response to lipopolysaccharide |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96RU8 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0031665 |
negative regulation of lipopolysaccharide-mediated signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96RU8 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0031434 |
mitogen-activated protein kinase kinase binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96RU8 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0014912 |
negative regulation of smooth muscle cell migration |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96RU8 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008134 |
transcription factor binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96RU8 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006469 |
negative regulation of protein kinase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96RU8 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96RU8 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96RU8 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004860 |
protein kinase inhibitor activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96RU8 |
F |
Seeded From UniProt |
complete | ||
|
NOT|involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
NOT|enables |
GO:0005524 |
ATP binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
NOT|enables |
GO:0004672 |
protein kinase activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004860 |
protein kinase inhibitor activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Satoh, T et al. (2013) Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages. Nature 495 524-8 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 Dedhia, PH et al. (2010) Differential ability of Tribbles family members to promote degradation of C/EBPalpha and induce acute myelogenous leukemia. Blood 116 1321-8 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Yamamoto, M et al. (2007) Enhanced TLR-mediated NF-IL6 dependent gene expression by Trib1 deficiency. J. Exp. Med. 204 2233-9 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
g
m
n
- GO:0006469 ! negative regulation of protein kinase activity
- GO:0014912 ! negative regulation of smooth muscle cell migration
- GO:0045659 ! negative regulation of neutrophil differentiation
- GO:0031665 ! negative regulation of lipopolysaccharide-mediated signaling pathway
- GO:0048662 ! negative regulation of smooth muscle cell proliferation
- GO:0043433 ! negative regulation of DNA-binding transcription factor activity
- GO:0005634 ! nucleus
p
- GO:0045645 ! positive regulation of eosinophil differentiation
- GO:0051443 ! positive regulation of ubiquitin-protein transferase activity
- GO:0032436 ! positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- GO:0045651 ! positive regulation of macrophage differentiation
- GO:0004672 ! protein kinase activity
- GO:0004860 ! protein kinase inhibitor activity
- GO:0006468 ! protein phosphorylation
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