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DROME:JIP1

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) Aplip1 (synonyms: SP512)
Protein Name(s) JNK-interacting protein 1

JIP-1 APP-like-interacting protein 1 APLIP1 Protein eye developmental SP512

External Links
UniProt Q9W0K0
EMBL AF220194
AF231037
AE014296
AE014296
AY051495
BT001795
RefSeq NP_728573.1
NP_728574.1
UniGene Dm.4584
ProteinModelPortal Q9W0K0
SMR Q9W0K0
BioGrid 72744
DIP DIP-20311N
IntAct Q9W0K0
MINT MINT-839312
EnsemblMetazoa FBtr0072627
GeneID 53472
KEGG dme:Dmel_CG1200
CTD 53472
FlyBase FBgn0040281
eggNOG NOG266073
GeneTree ENSGT00390000003908
InParanoid Q9W0K0
OMA FYSLIPN
OrthoDB EOG74J97M
PhylomeDB Q9W0K0
SignaLink Q9W0K0
GenomeRNAi 53472
NextBio 841215
PRO PR:Q9W0K0
Proteomes UP000000803
Bgee Q9W0K0
GO GO:0005737
GO:0042802
GO:0019894
GO:0005078
GO:0019901
GO:0048490
GO:0019896
GO:0007254
GO:0048812
GO:0009967
GO:0046328
GO:2000331
GO:0048491
Gene3D 2.30.29.30
InterPro IPR011993
IPR006020
IPR001452
Pfam PF00640
PF14604
SMART SM00462
SM00326
SUPFAM SSF50044
PROSITE PS01179
PS50002

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005078

MAP-kinase scaffold activity

PMID:11912189[1]

IPI: Inferred from Physical Interaction

UniProtKB:Q23977

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:11912189[1]

IPI: Inferred from Physical Interaction

FB:FBgn0000108

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:11912189[1]

IPI: Inferred from Physical Interaction

UniProtKB:P14599

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:11912189[1]

IPI: Inferred from Physical Interaction

UniProtKB:Q23977

F

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

GO:0007254

JNK cascade

PMID:11912189[1]

ISA: Inferred from Sequence Alignment

MGI:MGI:1309464

P

Seeded From UniProt

complete

GO:0007254

JNK cascade

PMID:11912189[1]

ISA: Inferred from Sequence Alignment

MGI:MGI:1926555

P

Seeded From UniProt

complete

GO:0007275

multicellular organismal development

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

GO:0009967

positive regulation of signal transduction

PMID:11912189[1]

IPI: Inferred from Physical Interaction

UniProtKB:Q23977

P

Seeded From UniProt

complete

GO:0019894

kinesin binding

PMID:11912189[1]

IPI: Inferred from Physical Interaction

FB:FBgn0010235

F

Seeded From UniProt

complete

GO:0019894

kinesin binding

PMID:11912189[1]

IPI: Inferred from Physical Interaction

UniProtKB:P46824

F

Seeded From UniProt

complete

GO:0019894

kinesin binding

PMID:16332540[2]

IPI: Inferred from Physical Interaction

FB:FBgn0010235

F

Seeded From UniProt

complete

GO:0019896

axon transport of mitochondrion

PMID:16332540[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0019901

protein kinase binding

PMID:11912189[1]

IPI: Inferred from Physical Interaction

FB:FBgn0010303

F

Seeded From UniProt

complete

GO:0019901

protein kinase binding

PMID:11912189[1]

IPI: Inferred from Physical Interaction

UniProtKB:Q23977

F

Seeded From UniProt

complete

GO:0030424

axon

PMID:16332540[2]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0042802

identical protein binding

PMID:11912189[1]

IPI: Inferred from Physical Interaction

UniProtKB:Q9W0K0

F

Seeded From UniProt

complete

GO:0046328

regulation of JNK cascade

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q9WVI9

P

Seeded From UniProt

complete

GO:0046328

regulation of JNK cascade

PMID:11912189[1]

IPI: Inferred from Physical Interaction

FB:FBgn0010303

P

Seeded From UniProt

complete

GO:0048490

anterograde synaptic vesicle transport

PMID:16332540[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0048491

retrograde synaptic vesicle transport

PMID:16332540[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0048812

neuron projection morphogenesis

PMID:18604272[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:2000331

regulation of terminal button organization

PMID:23904612[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

NOT

GO:0008432

JUN kinase binding

PMID:11912189[1]

IPI: Inferred from Physical Interaction

FB:FBgn0000229

F

Seeded From UniProt

complete

NOT

GO:0008432

JUN kinase binding

PMID:11912189[1]

ISA: Inferred from Sequence Alignment

MGI:MGI:1309464

F

Seeded From UniProt

complete

NOT

GO:0008432

JUN kinase binding

PMID:11912189[1]

ISA: Inferred from Sequence Alignment

MGI:MGI:1926555

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 1.14 1.15 Taru, H et al. (2002) Interaction of Alzheimer's beta -amyloid precursor family proteins with scaffold proteins of the JNK signaling cascade. J. Biol. Chem. 277 20070-8 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 Horiuchi, D et al. (2005) APLIP1, a kinesin binding JIP-1/JNK scaffold protein, influences the axonal transport of both vesicles and mitochondria in Drosophila. Curr. Biol. 15 2137-41 PubMed GONUTS page
  3. Sepp, KJ et al. (2008) Identification of neural outgrowth genes using genome-wide RNAi. PLoS Genet. 4 e1000111 PubMed GONUTS page
  4. Klinedinst, S et al. (2013) Independent pathways downstream of the Wnd/DLK MAPKKK regulate synaptic structure, axonal transport, and injury signaling. J. Neurosci. 33 12764-78 PubMed GONUTS page