MOUSE:M3K5

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Map3k5 (synonyms: Ask1, Mekk5)
Protein Name(s)	Mitogen-activated protein kinase kinase kinase 5 Apoptosis signal-regulating kinase 1 ASK-1 MAPK/ERK kinase kinase 5 MEK kinase 5 MEKK 5
External Links
UniProt	O35099
EMBL	AB006787 BC116627 BC133697
CCDS	CCDS35857.1
PIR	JC5778
RefSeq	NP_032606.4
UniGene	Mm.6595
ProteinModelPortal	O35099
SMR	O35099
BioGrid	204961
DIP	DIP-38055N
IntAct	O35099
MINT	MINT-151480
STRING	10090.ENSMUSP00000093485
PhosphoSite	O35099
MaxQB	O35099
PaxDb	O35099
PRIDE	O35099
Ensembl	ENSMUST00000095806
GeneID	26408
KEGG	mmu:26408
UCSC	uc007enm.2
CTD	4217
MGI	MGI:1346876
eggNOG	COG0515
GeneTree	ENSGT00760000119077
HOGENOM	HOG000293286
HOVERGEN	HBG006305
InParanoid	O35099
KO	K04426
OMA	TELHCKK
OrthoDB	EOG7WDN1P
TreeFam	TF105115
BRENDA	2.7.12.2
Reactome	REACT_188970
ChiTaRS	Map3k5
NextBio	304389
PRO	PR:O35099
Proteomes	UP000000589
Bgee	O35099
CleanEx	MM_MAP3K5
ExpressionAtlas	O35099
Genevestigator	O35099
GO	GO:0005783 GO:1902911 GO:0005524 GO:0008656 GO:0000287 GO:0004709 GO:0042803 GO:0019901 GO:0000187 GO:0070301 GO:1902170 GO:0045087 GO:0008631 GO:0007254 GO:0000165 GO:0043065 GO:1901216 GO:0097300 GO:0010941 GO:0002931
InterPro	IPR025136 IPR011009 IPR000719 IPR017441 IPR013761 IPR002290 IPR008271
Pfam	PF13281 PF00069
SMART	SM00220
SUPFAM	SSF47769 SSF56112
PROSITE	PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0045663	positive regulation of myoblast differentiation	PMID:22337877^[1]	ECO:0000314			P		Fig. 3	complete CACAO 3800
	GO:0038066	p38MAPK cascade	PMID:22337877^[1]	ECO:0000270			P		Fig. 4	complete CACAO 3811
involved_in	GO:1901216	positive regulation of neuron death	PMID:12050113^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	PMID:12050113^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046330	positive regulation of JNK cascade	PMID:12050113^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0034976)	Seeded From UniProt	complete
involved_in	GO:0034976	response to endoplasmic reticulum stress	PMID:12050113^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038066	p38MAPK cascade	PMID:22337877^[1]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045663	positive regulation of myoblast differentiation	PMID:22337877^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:18948261^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99683	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:18948261^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q61846	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99683	F		Seeded From UniProt	complete
enables	GO:0004709	MAP kinase kinase kinase activity	PMID:18948261^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000287	magnesium ion binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99683	F		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99683	P		Seeded From UniProt	complete
involved_in	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1346876 PANTHER:PTN000684887 UniProtKB:Q99683	P		Seeded From UniProt	complete
enables	GO:0004709	MAP kinase kinase kinase activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1346876 PANTHER:PTN000684847 RGD:1306565 UniProtKB:O95382 UniProtKB:Q99683	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000172316 UniProtKB:Q99683	F		Seeded From UniProt	complete
involved_in	GO:0000186	activation of MAPKK activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000684847 UniProtKB:Q99683	P		Seeded From UniProt	complete
part_of	GO:1990604	IRE1-TRAF2-ASK1 complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99683	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904707	positive regulation of vascular smooth muscle cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1306565	P		Seeded From UniProt	complete
part_of	GO:1902911	protein kinase complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99683	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902170	cellular response to reactive nitrogen species	PMID:18007661^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901216	positive regulation of neuron death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99683	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900745	positive regulation of p38MAPK cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1306565	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097300	programmed necrotic cell death	PMID:18007661^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070301	cellular response to hydrogen peroxide	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99683	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051403	stress-activated MAPK cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99683	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99683	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043507	positive regulation of JUN kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99683	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043507	positive regulation of JUN kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1306565	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99683	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043065	positive regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99683	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99683	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99683	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034976	response to endoplasmic reticulum stress	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99683	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034198	cellular response to amino acid starvation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99683	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99683	C		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99683	F		Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99683	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010941	regulation of cell death	PMID:19451227^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109484	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010666	positive regulation of cardiac muscle cell apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1306565	P		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1306565	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	PMID:18948261^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99683	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007254	JNK cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99683	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99683	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1306565	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1306565	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99683	F		Seeded From UniProt	complete
enables	GO:0004709	MAP kinase kinase kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99683	F		Seeded From UniProt	complete
enables	GO:0004709	MAP kinase kinase kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1306565	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99683	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1306565	P		Seeded From UniProt	complete
enables	GO:0000287	magnesium ion binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99683	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000187	activation of MAPK activity	PMID:15767678^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000186	activation of MAPKK activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99683	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000165	MAPK cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99683	P		Seeded From UniProt	complete
involved_in	GO:1904707	positive regulation of vascular smooth muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZZH6 ensembl:ENSRNOP00000051338	P		Seeded From UniProt	complete
involved_in	GO:1900745	positive regulation of p38MAPK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZZH6 ensembl:ENSRNOP00000051338	P		Seeded From UniProt	complete
involved_in	GO:0072577	endothelial cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZZH6 ensembl:ENSRNOP00000051338	P		Seeded From UniProt	complete
involved_in	GO:0071356	cellular response to tumor necrosis factor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZZH6 ensembl:ENSRNOP00000051338	P		Seeded From UniProt	complete
involved_in	GO:0043507	positive regulation of JUN kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZZH6 ensembl:ENSRNOP00000051338	P		Seeded From UniProt	complete
involved_in	GO:0042060	wound healing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZZH6 ensembl:ENSRNOP00000051338	P		Seeded From UniProt	complete
involved_in	GO:0034976	response to endoplasmic reticulum stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZZH6 ensembl:ENSRNOP00000051338	P		Seeded From UniProt	complete
involved_in	GO:0010666	positive regulation of cardiac muscle cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZZH6 ensembl:ENSRNOP00000051338	P		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZZH6 ensembl:ENSRNOP00000051338	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZZH6 ensembl:ENSRNOP00000051338	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZZH6 ensembl:ENSRNOP00000051338	C		Seeded From UniProt	complete
enables	GO:0004709	MAP kinase kinase kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZZH6 ensembl:ENSRNOP00000051338	F		Seeded From UniProt	complete
involved_in	GO:0002931	response to ischemia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZZH6 ensembl:ENSRNOP00000051338	P		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZZH6 ensembl:ENSRNOP00000051338	P		Seeded From UniProt	complete
part_of	GO:1990604	IRE1-TRAF2-ASK1 complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99683 ensembl:ENSP00000351908	C		Seeded From UniProt	complete
part_of	GO:1902911	protein kinase complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99683 ensembl:ENSP00000351908	C		Seeded From UniProt	complete
involved_in	GO:1901216	positive regulation of neuron death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99683 ensembl:ENSP00000351908	P		Seeded From UniProt	complete
involved_in	GO:0070301	cellular response to hydrogen peroxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99683 ensembl:ENSP00000351908	P		Seeded From UniProt	complete
involved_in	GO:0051403	stress-activated MAPK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99683 ensembl:ENSP00000351908	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99683 ensembl:ENSP00000351908	P		Seeded From UniProt	complete
involved_in	GO:0043507	positive regulation of JUN kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99683 ensembl:ENSP00000351908	P		Seeded From UniProt	complete
involved_in	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99683 ensembl:ENSP00000351908	P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99683 ensembl:ENSP00000351908	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99683 ensembl:ENSP00000351908	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99683 ensembl:ENSP00000351908	F		Seeded From UniProt	complete
involved_in	GO:0034976	response to endoplasmic reticulum stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99683 ensembl:ENSP00000351908	P		Seeded From UniProt	complete
involved_in	GO:0034198	cellular response to amino acid starvation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99683 ensembl:ENSP00000351908	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99683 ensembl:ENSP00000351908	C		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99683 ensembl:ENSP00000351908	F		Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99683 ensembl:ENSP00000351908	F		Seeded From UniProt	complete
involved_in	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99683 ensembl:ENSP00000351908	P		Seeded From UniProt	complete
involved_in	GO:0007254	JNK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99683 ensembl:ENSP00000351908	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99683 ensembl:ENSP00000351908	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99683 ensembl:ENSP00000351908	F		Seeded From UniProt	complete
enables	GO:0004709	MAP kinase kinase kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99683 ensembl:ENSP00000351908	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99683 ensembl:ENSP00000351908	F		Seeded From UniProt	complete
enables	GO:0000287	magnesium ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99683 ensembl:ENSP00000351908	F		Seeded From UniProt	complete
involved_in	GO:0000186	activation of MAPKK activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99683 ensembl:ENSP00000351908	P		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99683 ensembl:ENSP00000351908	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	P		Seeded From UniProt	complete
enables	GO:0004709	MAP kinase kinase kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.11.25	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256 UniProtKB-SubCell:SL-0095	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Tran, P et al. (2012) TGF-β-activated kinase 1 (TAK1) and apoptosis signal-regulating kinase 1 (ASK1) interact with the promyogenic receptor Cdo to promote myogenic differentiation via activation of p38MAPK pathway. J. Biol. Chem. 287 11602-15 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Nishitoh, H et al. (2002) ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats. Genes Dev. 16 1345-55 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Jung, H et al. (2008) Murine protein serine/threonine kinase 38 activates apoptosis signal-regulating kinase 1 via Thr 838 phosphorylation. J. Biol. Chem. 283 34541-53 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^5.0 ^5.1 Wu, YT et al. (2008) Signaling pathways from membrane lipid rafts to JNK1 activation in reactive nitrogen species-induced non-apoptotic cell death. Cell Death Differ. 15 386-97 PubMed GONUTS page
↑ Zhou, J et al. (2009) Serine 58 of 14-3-3zeta is a molecular switch regulating ASK1 and oxidant stress-induced cell death. Mol. Cell. Biol. 29 4167-76 PubMed GONUTS page
↑ Kelkar, N et al. (2005) Role of the JIP4 scaffold protein in the regulation of mitogen-activated protein kinase signaling pathways. Mol. Cell. Biol. 25 2733-43 PubMed GONUTS page

[PMID:22337877-1] 1.0 ^1.1 ^1.2 ^1.3 Tran, P et al. (2012) TGF-β-activated kinase 1 (TAK1) and apoptosis signal-regulating kinase 1 (ASK1) interact with the promyogenic receptor Cdo to promote myogenic differentiation via activation of p38MAPK pathway. J. Biol. Chem. 287 11602-15 PubMed GONUTS page

[PMID:12050113-2] 2.0 ^2.1 ^2.2 ^2.3 Nishitoh, H et al. (2002) ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats. Genes Dev. 16 1345-55 PubMed GONUTS page

[PMID:18948261-3] 3.0 ^3.1 ^3.2 ^3.3 Jung, H et al. (2008) Murine protein serine/threonine kinase 38 activates apoptosis signal-regulating kinase 1 via Thr 838 phosphorylation. J. Biol. Chem. 283 34541-53 PubMed GONUTS page

[PMID:21873635-4] 4.0 ^4.1 ^4.2 ^4.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:18007661-5] 5.0 ^5.1 Wu, YT et al. (2008) Signaling pathways from membrane lipid rafts to JNK1 activation in reactive nitrogen species-induced non-apoptotic cell death. Cell Death Differ. 15 386-97 PubMed GONUTS page

[PMID:19451227-6] Zhou, J et al. (2009) Serine 58 of 14-3-3zeta is a molecular switch regulating ASK1 and oxidant stress-induced cell death. Mol. Cell. Biol. 29 4167-76 PubMed GONUTS page

[PMID:15767678-7] Kelkar, N et al. (2005) Role of the JIP4 scaffold protein in the regulation of mitogen-activated protein kinase signaling pathways. Mol. Cell. Biol. 25 2733-43 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

MOUSE:M3K5

Contents

Annotations

Notes

References

a

c

e

g

i

j

k

m

n

o

p

r

s

t

v

w

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools