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HUMAN:NOD2

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) NOD2 (synonyms: CARD15, IBD1)
Protein Name(s) Nucleotide-binding oligomerization domain-containing protein 2

Caspase recruitment domain-containing protein 15 Inflammatory bowel disease protein 1

External Links
UniProt Q9HC29
EMBL AF178930
AF385089
AF385090
AJ303140
HQ204571
CCDS CCDS10746.1
RefSeq NP_001280486.1
NP_071445.1
XP_005256141.1
UniGene Hs.592072
ProteinModelPortal Q9HC29
SMR Q9HC29
BioGrid 122077
DIP DIP-41998N
IntAct Q9HC29
MINT MINT-151071
STRING 9606.ENSP00000300589
BindingDB Q9HC29
ChEMBL CHEMBL1293266
GuidetoPHARMACOLOGY 1763
PhosphoSite Q9HC29
DMDM 20137973
PaxDb Q9HC29
PRIDE Q9HC29
DNASU 64127
Ensembl ENST00000300589
GeneID 64127
KEGG hsa:64127
UCSC uc002egl.1
CTD 64127
GeneCards GC16P050729
HGNC HGNC:5331
HPA HPA041985
MIM 186580
266600
605956
609464
neXtProt NX_Q9HC29
Orphanet 117
90340
206
771
PharmGKB PA26074
eggNOG NOG248107
GeneTree ENSGT00710000106284
HOGENOM HOG000113814
HOVERGEN HBG050792
InParanoid Q9HC29
KO K10165
OMA NVGHLKL
OrthoDB EOG7P5T07
PhylomeDB Q9HC29
TreeFam TF352118
Reactome REACT_21281
REACT_21368
REACT_21399
REACT_22442
REACT_75776
SignaLink Q9HC29
GeneWiki NOD2
GenomeRNAi 64127
NextBio 35496989
PRO PR:Q9HC29
Proteomes UP000005640
Bgee Q9HC29
CleanEx HS_NOD2
ExpressionAtlas Q9HC29
Genevestigator Q9HC29
GO GO:0009986
GO:0005737
GO:0005856
GO:0005829
GO:0005886
GO:0043234
GO:0031982
GO:0005524
GO:0050700
GO:0019899
GO:0032500
GO:0042834
GO:0019901
GO:0000187
GO:0035419
GO:0071225
GO:0071407
GO:0071224
GO:0002367
GO:0006952
GO:0042742
GO:0050830
GO:0016045
GO:0009595
GO:0032498
GO:0002381
GO:0045087
GO:0002227
GO:0035556
GO:0007254
GO:0071608
GO:0030277
GO:0002755
GO:0002756
GO:0044130
GO:0002862
GO:0032689
GO:0032695
GO:0032701
GO:0032703
GO:2000110
GO:0032088
GO:0002710
GO:0034136
GO:0032720
GO:0035872
GO:0070431
GO:0070423
GO:0050871
GO:0006965
GO:0002606
GO:0002732
GO:0050679
GO:0070374
GO:0046645
GO:0002925
GO:0043123
GO:0032731
GO:0050718
GO:0032733
GO:0032735
GO:0032740
GO:0032755
GO:0046330
GO:0051092
GO:0051770
GO:0045747
GO:0051353
GO:0050731
GO:0050766
GO:0043552
GO:2000363
GO:0060585
GO:0031398
GO:0032874
GO:0045944
GO:0032760
GO:0002830
GO:0051259
GO:0050727
GO:0090022
GO:0043330
GO:0032496
GO:0032495
GO:0007584
GO:0051403
GO:0034166
GO:0034134
GO:0034138
GO:0034142
GO:0034146
GO:0034162
GO:0002224
GO:0038123
GO:0038124
GO:0035666
Gene3D 1.10.533.10
InterPro IPR001315
IPR011029
IPR001611
IPR007111
IPR027417
Pfam PF00619
SMART SM00114
SUPFAM SSF47986
SSF52540
PROSITE PS50209
PS51450
PS50837

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0071222

cellular response to lipopolysaccharide

PMID:27812135[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0071225

cellular response to muramyl dipeptide

PMID:27812135[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0044877

protein-containing complex binding

PMID:17337451[2]

ECO:0000353

physical interaction evidence used in manual assertion

ComplexPortal:CPX-1870

F

Seeded From UniProt

complete

involved_in

GO:0043406

positive regulation of MAP kinase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8K3Z0

P

part_of:(GO:0045089)

Seeded From UniProt

complete

enables

GO:0019901

protein kinase binding

PMID:25891078[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O75385

F

Seeded From UniProt

complete

involved_in

GO:1902523

positive regulation of protein K63-linked ubiquitination

PMID:25891078[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_input:(UniProtKB:A1A4Y4)

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:24790089[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0051092

positive regulation of NF-kappaB transcription factor activity

PMID:16203728[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

part_of:(GO:0032495)

Seeded From UniProt

complete

part_of

GO:0016323

basolateral plasma membrane

PMID:16203728[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0030544

Hsp70 protein binding

PMID:24790089[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P0DMV9

F

occurs_in:(CL:0011108)

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:25093298[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:1901224

positive regulation of NIK/NF-kappaB signaling

PMID:25093298[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

happens_during:(GO:0071224)

Seeded From UniProt

complete

involved_in

GO:0071225

cellular response to muramyl dipeptide

PMID:25093298[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:25093298[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0030544

Hsp70 protein binding

PMID:24790089[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P0DMV8

F

occurs_in:(CL:0011108)

Seeded From UniProt

complete

enables

GO:0019901

protein kinase binding

PMID:24790089[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O43353

F

Seeded From UniProt

complete

involved_in

GO:0032495

response to muramyl dipeptide

PMID:24790089[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(CL:0011108)

Seeded From UniProt

complete

involved_in

GO:0051092

positive regulation of NF-kappaB transcription factor activity

PMID:24790089[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0051879

Hsp90 protein binding

PMID:24790089[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003779

actin binding

PMID:24790089[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0002374

cytokine secretion involved in immune response

PMID:20441518[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1900017

positive regulation of cytokine production involved in inflammatory response

PMID:24671169[8]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030277

maintenance of gastrointestinal epithelium

PMID:17058067[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032757

positive regulation of interleukin-8 production

PMID:24790089[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:2000363

positive regulation of prostaglandin-E synthase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8K3Z0

P

Seeded From UniProt

complete

involved_in

GO:2000110

negative regulation of macrophage apoptotic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8K3Z0

P

Seeded From UniProt

complete

involved_in

GO:0070374

positive regulation of ERK1 and ERK2 cascade

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8K3Z0

P

Seeded From UniProt

complete

involved_in

GO:0060585

positive regulation of prostaglandin-endoperoxide synthase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8K3Z0

P

Seeded From UniProt

complete

involved_in

GO:0051770

positive regulation of nitric-oxide synthase biosynthetic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8K3Z0

P

Seeded From UniProt

complete

involved_in

GO:0051353

positive regulation of oxidoreductase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8K3Z0

P

Seeded From UniProt

complete

involved_in

GO:0050871

positive regulation of B cell activation

PMID:20844241[10]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050727

regulation of inflammatory response

PMID:11385577[11]

ECO:0000305

curator inference used in manual assertion

GO:0051092

P

Seeded From UniProt

complete

involved_in

GO:0050679

positive regulation of epithelial cell proliferation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8K3Z0

P

Seeded From UniProt

complete

involved_in

GO:0046645

positive regulation of gamma-delta T cell activation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q6E804

P

Seeded From UniProt

complete

involved_in

GO:0045747

positive regulation of Notch signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8K3Z0

P

Seeded From UniProt

complete

involved_in

GO:0043552

positive regulation of phosphatidylinositol 3-kinase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8K3Z0

P

Seeded From UniProt

complete

involved_in

GO:0032760

positive regulation of tumor necrosis factor production

PMID:21040358[12]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032755

positive regulation of interleukin-6 production

PMID:16414084[13]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032733

positive regulation of interleukin-10 production

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8K3Z0

P

Seeded From UniProt

complete

involved_in

GO:0032731

positive regulation of interleukin-1 beta production

PMID:21040358[12]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032495

response to muramyl dipeptide

PMID:16414084[13]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0002830

positive regulation of type 2 immune response

PMID:21172192[14]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0002606

positive regulation of dendritic cell antigen processing and presentation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8K3Z0

P

Seeded From UniProt

complete

involved_in

GO:0050718

positive regulation of interleukin-1 beta secretion

PMID:15107016[15]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0042834

peptidoglycan binding

PMID:15998797[16]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0042742

defense response to bacterium

PMID:15653568[17]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035556

intracellular signal transduction

PMID:15653568[17]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0032500

muramyl dipeptide binding

PMID:15998797[16]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0032498

detection of muramyl dipeptide

PMID:15998797[16]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032495

response to muramyl dipeptide

PMID:15998797[16]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0031982

vesicle

PMID:15998797[16]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0016045

detection of bacterium

PMID:15653568[17]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:15998797[16]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:15998797[16]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0071225

cellular response to muramyl dipeptide

PMID:21887730[18]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0070431

nucleotide-binding oligomerization domain containing 2 signaling pathway

PMID:23806334[19]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051092

positive regulation of NF-kappaB transcription factor activity

PMID:21887730[18]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051092

positive regulation of NF-kappaB transcription factor activity

PMID:11385577[11]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0050700

CARD domain binding

PMID:11087742[20]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O43353

F

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:21887730[18]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045087

innate immune response

PMID:23806334[19]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045087

innate immune response

PMID:17690884[21]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

PMID:21887730[18]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

PMID:11087742[20]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032740

positive regulation of interleukin-17 production

PMID:17919942[22]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0031982

vesicle

PMID:21887730[18]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0019901

protein kinase binding

PMID:15075345[23]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O43318

F

Seeded From UniProt

complete

enables

GO:0019899

enzyme binding

PMID:15753091[24]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9P0J0

F

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

PMID:16714539[25]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

PMID:21887730[18]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21887730[18]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0002367

cytokine production involved in immune response

PMID:16260731[26]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

PMID:21873635[27]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2429397
PANTHER:PTN000648064
UniProtKB:Q9HC29

P

Seeded From UniProt

complete

involved_in

GO:0042742

defense response to bacterium

PMID:21873635[27]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000648064
UniProtKB:Q9HC29

P

Seeded From UniProt

complete

involved_in

GO:0035556

intracellular signal transduction

PMID:21873635[27]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000716087
UniProtKB:Q9HC29
UniProtKB:Q9Y239

P

Seeded From UniProt

complete

involved_in

GO:0032495

response to muramyl dipeptide

PMID:21873635[27]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2429397
PANTHER:PTN000648064
RGD:1306368
UniProtKB:Q6E804
UniProtKB:Q9HC29

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21873635[27]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000648064
UniProtKB:Q9HC29

C

Seeded From UniProt

complete

colocalizes_with

GO:0005737

cytoplasm

PMID:21873635[27]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000716087
RGD:1306368
UniProtKB:Q7RTR2
UniProtKB:Q86WI3
UniProtKB:Q9HC29
UniProtKB:Q9Y239
ZFIN:ZDB-GENE-061108-4

C

Seeded From UniProt

complete

involved_in

GO:0070431

nucleotide-binding oligomerization domain containing 2 signaling pathway

PMID:12527755[28]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051092

positive regulation of NF-kappaB transcription factor activity

PMID:12527755[28]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046330

positive regulation of JNK cascade

PMID:17187069[29]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

PMID:12527755[28]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032874

positive regulation of stress-activated MAPK cascade

PMID:17187069[29]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032760

positive regulation of tumor necrosis factor production

PMID:17187069[29]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032498

detection of muramyl dipeptide

PMID:12527755[28]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0050718

positive regulation of interleukin-1 beta secretion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q80SY9
ensembl:ENSMUSP00000113773

P

Seeded From UniProt

complete

involved_in

GO:0032495

response to muramyl dipeptide

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q80SY9
ensembl:ENSMUSP00000113773

P

Seeded From UniProt

complete

involved_in

GO:0071407

cellular response to organic cyclic compound

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:A0A0G2K4Z7
ensembl:ENSRNOP00000073236

P

Seeded From UniProt

complete

involved_in

GO:0071224

cellular response to peptidoglycan

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:A0A0G2K4Z7
ensembl:ENSRNOP00000073236

P

Seeded From UniProt

complete

enables

GO:0032500

muramyl dipeptide binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:A0A0G2K4Z7
ensembl:ENSRNOP00000073236

F

Seeded From UniProt

complete

involved_in

GO:0032495

response to muramyl dipeptide

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:A0A0G2K4Z7
ensembl:ENSRNOP00000073236

P

Seeded From UniProt

complete

involved_in

GO:0008284

positive regulation of cell population proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:A0A0G2K4Z7
ensembl:ENSRNOP00000073236

P

Seeded From UniProt

complete

involved_in

GO:0007584

response to nutrient

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:A0A0G2K4Z7
ensembl:ENSRNOP00000073236

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:A0A0G2K4Z7
ensembl:ENSRNOP00000073236

C

Seeded From UniProt

complete

involved_in

GO:0002732

positive regulation of dendritic cell cytokine production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:A0A0G2K4Z7
ensembl:ENSRNOP00000073236

P

Seeded From UniProt

complete

involved_in

GO:0042981

regulation of apoptotic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001315

P

Seeded From UniProt

complete

involved_in

GO:0051259

protein complex oligomerization

PMID:15967716[30]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009595

detection of biotic stimulus

PMID:15967716[30]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006952

defense response

PMID:15967716[30]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:15967716[30]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0070498

interleukin-1-mediated signaling pathway

Reactome:R-HSA-9020702

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0070423

nucleotide-binding oligomerization domain containing signaling pathway

Reactome:R-HSA-168638

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051092

positive regulation of NF-kappaB transcription factor activity

Reactome:R-HSA-445989

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007254

JNK cascade

Reactome:R-HSA-450321

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-741411
Reactome:R-HSA-741386
Reactome:R-HSA-708349
Reactome:R-HSA-706479
Reactome:R-HSA-688985
Reactome:R-HSA-688137
Reactome:R-HSA-688136
Reactome:R-HSA-622415
Reactome:R-HSA-450346
Reactome:R-HSA-450337
Reactome:R-HSA-168412
Reactome:R-HSA-168405
Reactome:R-HSA-168184

ECO:0000304

author statement supported by traceable reference used in manual assertion













C

Seeded From UniProt

complete

involved_in

GO:0000187

activation of MAPK activity

Reactome:R-HSA-450302

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045087

innate immune response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0399

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472
UniProtKB-SubCell:SL-0162

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0496
UniProtKB-SubCell:SL-0173

C

Seeded From UniProt

complete

involved_in

GO:0002376

immune system process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0391

P

Seeded From UniProt

complete

part_of

GO:0016323

basolateral plasma membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0026

C

Seeded From UniProt

complete

GO:0002374

cytokine secretion involved in immune response

PMID:20441518[7]

ECO:0000315

P

Figure 5. Effectiveness of NOD2 to produce cytokines as an immune response to Borrelia burgdorferi shown through experimentation of stimulated PBMCs.

complete
CACAO 6508

GO:1900017

positive regulation of cytokine production involved in inflammatory response

PMID:24671169[8]

ECO:0000314

P

The results from figure 4 show how the overexpression of NOD2 restricts HCMV replication and induces antiviral and pro-inflammatory cytokines. These results show for the first time that NOD2 plays a significant role in HCMV replication and may provide a model for studies of HCMV recognition by the host cell and HCMV colitis in Crohn's disease

complete
CACAO 10066

Notes


References

See Help:References for how to manage references in GONUTS.

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  2. da Silva Correia, J et al. (2007) The subunit CSN6 of the COP9 signalosome is cleaved during apoptosis. J. Biol. Chem. 282 12557-65 PubMed GONUTS page
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  9. Moehle, C et al. (2006) Aberrant intestinal expression and allelic variants of mucin genes associated with inflammatory bowel disease. J. Mol. Med. 84 1055-66 PubMed GONUTS page
  10. Petterson, T et al. (2011) Effects of NOD-like receptors in human B lymphocytes and crosstalk between NOD1/NOD2 and Toll-like receptors. J. Leukoc. Biol. 89 177-87 PubMed GONUTS page
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  15. Damiano, JS et al. (2004) Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses. Biochem. J. 381 213-9 PubMed GONUTS page
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