HUMAN:NOD2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	NOD2 (synonyms: CARD15, IBD1)
Protein Name(s)	Nucleotide-binding oligomerization domain-containing protein 2 Caspase recruitment domain-containing protein 15 Inflammatory bowel disease protein 1
External Links
UniProt	Q9HC29
EMBL	AF178930 AF385089 AF385090 AJ303140 HQ204571
CCDS	CCDS10746.1
RefSeq	NP_001280486.1 NP_071445.1 XP_005256141.1
UniGene	Hs.592072
ProteinModelPortal	Q9HC29
SMR	Q9HC29
BioGrid	122077
DIP	DIP-41998N
IntAct	Q9HC29
MINT	MINT-151071
STRING	9606.ENSP00000300589
BindingDB	Q9HC29
ChEMBL	CHEMBL1293266
GuidetoPHARMACOLOGY	1763
PhosphoSite	Q9HC29
DMDM	20137973
PaxDb	Q9HC29
PRIDE	Q9HC29
DNASU	64127
Ensembl	ENST00000300589
GeneID	64127
KEGG	hsa:64127
UCSC	uc002egl.1
CTD	64127
GeneCards	GC16P050729
HGNC	HGNC:5331
HPA	HPA041985
MIM	186580 266600 605956 609464
neXtProt	NX_Q9HC29
Orphanet	117 90340 206 771
PharmGKB	PA26074
eggNOG	NOG248107
GeneTree	ENSGT00710000106284
HOGENOM	HOG000113814
HOVERGEN	HBG050792
InParanoid	Q9HC29
KO	K10165
OMA	NVGHLKL
OrthoDB	EOG7P5T07
PhylomeDB	Q9HC29
TreeFam	TF352118
Reactome	REACT_21281 REACT_21368 REACT_21399 REACT_22442 REACT_75776
SignaLink	Q9HC29
GeneWiki	NOD2
GenomeRNAi	64127
NextBio	35496989
PRO	PR:Q9HC29
Proteomes	UP000005640
Bgee	Q9HC29
CleanEx	HS_NOD2
ExpressionAtlas	Q9HC29
Genevestigator	Q9HC29
GO	GO:0009986 GO:0005737 GO:0005856 GO:0005829 GO:0005886 GO:0043234 GO:0031982 GO:0005524 GO:0050700 GO:0019899 GO:0032500 GO:0042834 GO:0019901 GO:0000187 GO:0035419 GO:0071225 GO:0071407 GO:0071224 GO:0002367 GO:0006952 GO:0042742 GO:0050830 GO:0016045 GO:0009595 GO:0032498 GO:0002381 GO:0045087 GO:0002227 GO:0035556 GO:0007254 GO:0071608 GO:0030277 GO:0002755 GO:0002756 GO:0044130 GO:0002862 GO:0032689 GO:0032695 GO:0032701 GO:0032703 GO:2000110 GO:0032088 GO:0002710 GO:0034136 GO:0032720 GO:0035872 GO:0070431 GO:0070423 GO:0050871 GO:0006965 GO:0002606 GO:0002732 GO:0050679 GO:0070374 GO:0046645 GO:0002925 GO:0043123 GO:0032731 GO:0050718 GO:0032733 GO:0032735 GO:0032740 GO:0032755 GO:0046330 GO:0051092 GO:0051770 GO:0045747 GO:0051353 GO:0050731 GO:0050766 GO:0043552 GO:2000363 GO:0060585 GO:0031398 GO:0032874 GO:0045944 GO:0032760 GO:0002830 GO:0051259 GO:0050727 GO:0090022 GO:0043330 GO:0032496 GO:0032495 GO:0007584 GO:0051403 GO:0034166 GO:0034134 GO:0034138 GO:0034142 GO:0034146 GO:0034162 GO:0002224 GO:0038123 GO:0038124 GO:0035666
Gene3D	1.10.533.10
InterPro	IPR001315 IPR011029 IPR001611 IPR007111 IPR027417
Pfam	PF00619
SMART	SM00114
SUPFAM	SSF47986 SSF52540
PROSITE	PS50209 PS51450 PS50837

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0071222	cellular response to lipopolysaccharide	PMID:27812135^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071225	cellular response to muramyl dipeptide	PMID:27812135^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	PMID:17337451^[2]	ECO:0000353	physical interaction evidence used in manual assertion	ComplexPortal:CPX-1870	F		Seeded From UniProt	complete
involved_in	GO:0043406	positive regulation of MAP kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8K3Z0	P	part_of:(GO:0045089)	Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:25891078^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O75385	F		Seeded From UniProt	complete
involved_in	GO:1902523	positive regulation of protein K63-linked ubiquitination	PMID:25891078^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(UniProtKB:A1A4Y4)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:24790089^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:16203728^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0032495)	Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	PMID:16203728^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0030544	Hsp70 protein binding	PMID:24790089^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P0DMV9	F	occurs_in:(CL:0011108)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:25093298^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1901224	positive regulation of NIK/NF-kappaB signaling	PMID:25093298^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(GO:0071224)	Seeded From UniProt	complete
involved_in	GO:0071225	cellular response to muramyl dipeptide	PMID:25093298^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:25093298^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0030544	Hsp70 protein binding	PMID:24790089^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P0DMV8	F	occurs_in:(CL:0011108)	Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:24790089^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O43353	F		Seeded From UniProt	complete
involved_in	GO:0032495	response to muramyl dipeptide	PMID:24790089^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0011108)	Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:24790089^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(GO:0032495) occurs_in:(CL:0011108)\|happens_during(GO:0071356)	Seeded From UniProt	complete
enables	GO:0051879	Hsp90 protein binding	PMID:24790089^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003779	actin binding	PMID:24790089^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:1900017	positive regulation of cytokine production involved in inflammatory response	PMID:24671169^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030277	maintenance of gastrointestinal epithelium	PMID:17058067^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032757	positive regulation of interleukin-8 production	PMID:24790089^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(GO:0032495) occurs_in:(CL:0011108)\|happens_during(GO:0071356)	Seeded From UniProt	complete
involved_in	GO:2000363	positive regulation of prostaglandin-E synthase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8K3Z0	P		Seeded From UniProt	complete
involved_in	GO:2000110	negative regulation of macrophage apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8K3Z0	P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8K3Z0	P		Seeded From UniProt	complete
involved_in	GO:0060585	positive regulation of prostaglandin-endoperoxide synthase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8K3Z0	P		Seeded From UniProt	complete
involved_in	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8K3Z0	P		Seeded From UniProt	complete
involved_in	GO:0051353	positive regulation of oxidoreductase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8K3Z0	P		Seeded From UniProt	complete
involved_in	GO:0050871	positive regulation of B cell activation	PMID:20844241^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050727	regulation of inflammatory response	PMID:11385577^[10]	ECO:0000305	curator inference used in manual assertion	GO:0051092	P		Seeded From UniProt	complete
involved_in	GO:0050679	positive regulation of epithelial cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8K3Z0	P		Seeded From UniProt	complete
involved_in	GO:0046645	positive regulation of gamma-delta T cell activation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6E804	P		Seeded From UniProt	complete
involved_in	GO:0045747	positive regulation of Notch signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8K3Z0	P		Seeded From UniProt	complete
involved_in	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8K3Z0	P		Seeded From UniProt	complete
involved_in	GO:0032760	positive regulation of tumor necrosis factor production	PMID:21040358^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032755	positive regulation of interleukin-6 production	PMID:16414084^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032733	positive regulation of interleukin-10 production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8K3Z0	P		Seeded From UniProt	complete
involved_in	GO:0032731	positive regulation of interleukin-1 beta production	PMID:21040358^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032495	response to muramyl dipeptide	PMID:16414084^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002830	positive regulation of type 2 immune response	PMID:21172192^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002606	positive regulation of dendritic cell antigen processing and presentation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8K3Z0	P		Seeded From UniProt	complete
involved_in	GO:0050718	positive regulation of interleukin-1 beta secretion	PMID:15107016^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042834	peptidoglycan binding	PMID:15998797^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0042742	defense response to bacterium	PMID:15653568^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:15653568^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0032500	muramyl dipeptide binding	PMID:15998797^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0032498	detection of muramyl dipeptide	PMID:15998797^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032495	response to muramyl dipeptide	PMID:15998797^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0031982	vesicle	PMID:15998797^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0016045	detection of bacterium	PMID:15653568^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:15998797^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:15998797^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0071225	cellular response to muramyl dipeptide	PMID:21887730^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070431	nucleotide-binding oligomerization domain containing 2 signaling pathway	PMID:23806334^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:21887730^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:11385577^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0050700	CARD domain binding	PMID:11087742^[19]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O43353	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21887730^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	PMID:23806334^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	PMID:17690884^[20]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:21887730^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	PMID:11087742^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032740	positive regulation of interleukin-17 production	PMID:17919942^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0031982	vesicle	PMID:21887730^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:15075345^[22]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O43318	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:15753091^[23]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9P0J0	F		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:16714539^[24]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	PMID:21887730^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21887730^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0002367	cytokine production involved in immune response	PMID:16260731^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	PMID:21873635^[26]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2429397 PANTHER:PTN000648064 UniProtKB:Q9HC29	P		Seeded From UniProt	complete
involved_in	GO:0042742	defense response to bacterium	PMID:21873635^[26]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000648064 UniProtKB:Q9HC29	P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:21873635^[26]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000716087 UniProtKB:Q9HC29 UniProtKB:Q9Y239	P		Seeded From UniProt	complete
involved_in	GO:0032495	response to muramyl dipeptide	PMID:21873635^[26]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2429397 PANTHER:PTN000648064 RGD:1306368 UniProtKB:Q6E804 UniProtKB:Q9HC29	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[26]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000648064 UniProtKB:Q9HC29	C		Seeded From UniProt	complete
colocalizes_with	GO:0005737	cytoplasm	PMID:21873635^[26]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000716087 RGD:1306368 UniProtKB:Q7RTR2 UniProtKB:Q86WI3 UniProtKB:Q9HC29 UniProtKB:Q9Y239 ZFIN:ZDB-GENE-061108-4	C		Seeded From UniProt	complete
involved_in	GO:0070431	nucleotide-binding oligomerization domain containing 2 signaling pathway	PMID:12527755^[27]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:12527755^[27]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046330	positive regulation of JNK cascade	PMID:17187069^[28]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	PMID:12527755^[27]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032874	positive regulation of stress-activated MAPK cascade	PMID:17187069^[28]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032760	positive regulation of tumor necrosis factor production	PMID:17187069^[28]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032498	detection of muramyl dipeptide	PMID:12527755^[27]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0050718	positive regulation of interleukin-1 beta secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80SY9 ensembl:ENSMUSP00000113773	P		Seeded From UniProt	complete
involved_in	GO:0032495	response to muramyl dipeptide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80SY9 ensembl:ENSMUSP00000113773	P		Seeded From UniProt	complete
involved_in	GO:0071407	cellular response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K4Z7 ensembl:ENSRNOP00000073236	P		Seeded From UniProt	complete
involved_in	GO:0071224	cellular response to peptidoglycan	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K4Z7 ensembl:ENSRNOP00000073236	P		Seeded From UniProt	complete
enables	GO:0032500	muramyl dipeptide binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K4Z7 ensembl:ENSRNOP00000073236	F		Seeded From UniProt	complete
involved_in	GO:0032495	response to muramyl dipeptide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K4Z7 ensembl:ENSRNOP00000073236	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K4Z7 ensembl:ENSRNOP00000073236	P		Seeded From UniProt	complete
involved_in	GO:0007584	response to nutrient	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K4Z7 ensembl:ENSRNOP00000073236	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K4Z7 ensembl:ENSRNOP00000073236	C		Seeded From UniProt	complete
involved_in	GO:0002732	positive regulation of dendritic cell cytokine production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K4Z7 ensembl:ENSRNOP00000073236	P		Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001315	P		Seeded From UniProt	complete
involved_in	GO:0051259	protein complex oligomerization	PMID:15967716^[29]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009595	detection of biotic stimulus	PMID:15967716^[29]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006952	defense response	PMID:15967716^[29]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:15967716^[29]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0070498	interleukin-1-mediated signaling pathway	Reactome:R-HSA-9020702	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070423	nucleotide-binding oligomerization domain containing signaling pathway	Reactome:R-HSA-168638	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	Reactome:R-HSA-445989	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007254	JNK cascade	Reactome:R-HSA-450321	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-741411 Reactome:R-HSA-741386 Reactome:R-HSA-708349 Reactome:R-HSA-706479 Reactome:R-HSA-688985 Reactome:R-HSA-688137 Reactome:R-HSA-688136 Reactome:R-HSA-622415 Reactome:R-HSA-450346 Reactome:R-HSA-450337 Reactome:R-HSA-168412 Reactome:R-HSA-168405 Reactome:R-HSA-168184	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	Reactome:R-HSA-450302	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496 UniProtKB-SubCell:SL-0173	C		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0026	C		Seeded From UniProt	complete
	GO:0002720	positive regulation of cytokine production involved in immune response	PMID:20441518^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Figure 5. Effectiveness of NOD2 to produce cytokines as an immune response to Borrelia burgdorferi shown through experimentation of stimulated PBMCs.	complete CACAO 6508
	GO:1900017	positive regulation of cytokine production involved in inflammatory response	PMID:24671169^[7]	ECO:0000314			P		The results from figure 4 show how the overexpression of NOD2 restricts HCMV replication and induces antiviral and pro-inflammatory cytokines. These results show for the first time that NOD2 plays a significant role in HCMV replication and may provide a model for studies of HCMV recognition by the host cell and HCMV colitis in Crohn's disease	complete CACAO 10066
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Thiébaut, R et al. (2016) Characterization and Genetic Analyses of New Genes Coding for NOD2 Interacting Proteins. PLoS ONE 11 e0165420 PubMed GONUTS page
↑ da Silva Correia, J et al. (2007) The subunit CSN6 of the COP9 signalosome is cleaved during apoptosis. J. Biol. Chem. 282 12557-65 PubMed GONUTS page
↑ ^3.0 ^3.1 Chauhan, S et al. (2015) IRGM governs the core autophagy machinery to conduct antimicrobial defense. Mol. Cell 58 507-21 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 Mohanan, V & Grimes, CL (2014) The molecular chaperone HSP70 binds to and stabilizes NOD2, an important protein involved in Crohn disease. J. Biol. Chem. 289 18987-98 PubMed GONUTS page
↑ ^5.0 ^5.1 McDonald, C et al. (2005) A role for Erbin in the regulation of Nod2-dependent NF-kappaB signaling. J. Biol. Chem. 280 40301-9 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Parkhouse, R et al. (2014) Blau syndrome polymorphisms in NOD2 identify nucleotide hydrolysis and helical domain 1 as signalling regulators. FEBS Lett. 588 3382-9 PubMed GONUTS page
↑ ^7.0 ^7.1 Kapoor, A et al. (2014) Activation of nucleotide oligomerization domain 2 (NOD2) by human cytomegalovirus initiates innate immune responses and restricts virus replication. PLoS ONE 9 e92704 PubMed GONUTS page
↑ Moehle, C et al. (2006) Aberrant intestinal expression and allelic variants of mucin genes associated with inflammatory bowel disease. J. Mol. Med. 84 1055-66 PubMed GONUTS page
↑ Petterson, T et al. (2011) Effects of NOD-like receptors in human B lymphocytes and crosstalk between NOD1/NOD2 and Toll-like receptors. J. Leukoc. Biol. 89 177-87 PubMed GONUTS page
↑ ^10.0 ^10.1 Ogura, Y et al. (2001) A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 411 603-6 PubMed GONUTS page
↑ ^11.0 ^11.1 Brooks, MN et al. (2011) NOD2 controls the nature of the inflammatory response and subsequent fate of Mycobacterium tuberculosis and M. bovis BCG in human macrophages. Cell. Microbiol. 13 402-18 PubMed GONUTS page
↑ ^12.0 ^12.1 Davey, MP et al. (2006) Human endothelial cells express NOD2/CARD15 and increase IL-6 secretion in response to muramyl dipeptide. Microvasc. Res. 71 103-7 PubMed GONUTS page
↑ Butler, M et al. (2007) NOD2 activity modulates the phenotype of LPS-stimulated dendritic cells to promote the development of T-helper type 2-like lymphocytes - Possible implications for NOD2-associated Crohn's disease. J Crohns Colitis 1 106-15 PubMed GONUTS page
↑ Damiano, JS et al. (2004) Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses. Biochem. J. 381 213-9 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 ^15.4 ^15.5 ^15.6 Barnich, N et al. (2005) Membrane recruitment of NOD2 in intestinal epithelial cells is essential for nuclear factor-{kappa}B activation in muramyl dipeptide recognition. J. Cell Biol. 170 21-6 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 Opitz, B et al. (2005) Nod1-mediated endothelial cell activation by Chlamydophila pneumoniae. Circ. Res. 96 319-26 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 ^17.4 ^17.5 ^17.6 Zhao, Y et al. (2012) Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1. Inflamm. Bowel Dis. 18 603-12 PubMed GONUTS page
↑ ^18.0 ^18.1 Fiil, BK et al. (2013) OTULIN restricts Met1-linked ubiquitination to control innate immune signaling. Mol. Cell 50 818-30 PubMed GONUTS page
↑ ^19.0 ^19.1 Ogura, Y et al. (2001) Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB. J. Biol. Chem. 276 4812-8 PubMed GONUTS page
↑ Tattoli, I et al. (2007) The Nodosome: Nod1 and Nod2 control bacterial infections and inflammation. Semin Immunopathol 29 289-301 PubMed GONUTS page
↑ van Beelen, AJ et al. (2007) Stimulation of the intracellular bacterial sensor NOD2 programs dendritic cells to promote interleukin-17 production in human memory T cells. Immunity 27 660-9 PubMed GONUTS page
↑ Chen, CM et al. (2004) Reciprocal cross-talk between Nod2 and TAK1 signaling pathways. J. Biol. Chem. 279 25876-82 PubMed GONUTS page
↑ Barnich, N et al. (2005) GRIM-19 interacts with nucleotide oligomerization domain 2 and serves as downstream effector of anti-bacterial function in intestinal epithelial cells. J. Biol. Chem. 280 19021-6 PubMed GONUTS page
↑ Kufer, TA et al. (2006) Role for erbin in bacterial activation of Nod2. Infect. Immun. 74 3115-24 PubMed GONUTS page
↑ Netea, MG et al. (2005) IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1beta and IL-6 production through a caspase 1-dependent mechanism. Proc. Natl. Acad. Sci. U.S.A. 102 16309-14 PubMed GONUTS page
↑ ^26.0 ^26.1 ^26.2 ^26.3 ^26.4 ^26.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^27.0 ^27.1 ^27.2 ^27.3 Girardin, SE et al. (2003) Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J. Biol. Chem. 278 8869-72 PubMed GONUTS page
↑ ^28.0 ^28.1 ^28.2 Hsu, YM et al. (2007) The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens. Nat. Immunol. 8 198-205 PubMed GONUTS page
↑ ^29.0 ^29.1 ^29.2 ^29.3 Martinon, F & Tschopp, J (2005) NLRs join TLRs as innate sensors of pathogens. Trends Immunol. 26 447-54 PubMed GONUTS page
↑ Oosting, M et al. (2010) Recognition of Borrelia burgdorferi by NOD2 is central for the induction of an inflammatory reaction. J. Infect. Dis. 201 1849-58 PubMed GONUTS page

[PMID:27812135-1] 1.0 ^1.1 Thiébaut, R et al. (2016) Characterization and Genetic Analyses of New Genes Coding for NOD2 Interacting Proteins. PLoS ONE 11 e0165420 PubMed GONUTS page

[PMID:17337451-2] Silva Correia, J et al. (2007) The subunit CSN6 of the COP9 signalosome is cleaved during apoptosis. J. Biol. Chem. 282 12557-65 PubMed GONUTS page

[PMID:25891078-3] 3.0 ^3.1 Chauhan, S et al. (2015) IRGM governs the core autophagy machinery to conduct antimicrobial defense. Mol. Cell 58 507-21 PubMed GONUTS page

[PMID:24790089-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 Mohanan, V & Grimes, CL (2014) The molecular chaperone HSP70 binds to and stabilizes NOD2, an important protein involved in Crohn disease. J. Biol. Chem. 289 18987-98 PubMed GONUTS page

[PMID:16203728-5] 5.0 ^5.1 McDonald, C et al. (2005) A role for Erbin in the regulation of Nod2-dependent NF-kappaB signaling. J. Biol. Chem. 280 40301-9 PubMed GONUTS page

[PMID:25093298-6] 6.0 ^6.1 ^6.2 ^6.3 Parkhouse, R et al. (2014) Blau syndrome polymorphisms in NOD2 identify nucleotide hydrolysis and helical domain 1 as signalling regulators. FEBS Lett. 588 3382-9 PubMed GONUTS page

[PMID:24671169-7] 7.0 ^7.1 Kapoor, A et al. (2014) Activation of nucleotide oligomerization domain 2 (NOD2) by human cytomegalovirus initiates innate immune responses and restricts virus replication. PLoS ONE 9 e92704 PubMed GONUTS page

[PMID:17058067-8] Moehle, C et al. (2006) Aberrant intestinal expression and allelic variants of mucin genes associated with inflammatory bowel disease. J. Mol. Med. 84 1055-66 PubMed GONUTS page

[PMID:20844241-9] Petterson, T et al. (2011) Effects of NOD-like receptors in human B lymphocytes and crosstalk between NOD1/NOD2 and Toll-like receptors. J. Leukoc. Biol. 89 177-87 PubMed GONUTS page

[PMID:11385577-10] 10.0 ^10.1 Ogura, Y et al. (2001) A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 411 603-6 PubMed GONUTS page

[PMID:21040358-11] 11.0 ^11.1 Brooks, MN et al. (2011) NOD2 controls the nature of the inflammatory response and subsequent fate of Mycobacterium tuberculosis and M. bovis BCG in human macrophages. Cell. Microbiol. 13 402-18 PubMed GONUTS page

[PMID:16414084-12] 12.0 ^12.1 Davey, MP et al. (2006) Human endothelial cells express NOD2/CARD15 and increase IL-6 secretion in response to muramyl dipeptide. Microvasc. Res. 71 103-7 PubMed GONUTS page

[PMID:21172192-13] Butler, M et al. (2007) NOD2 activity modulates the phenotype of LPS-stimulated dendritic cells to promote the development of T-helper type 2-like lymphocytes - Possible implications for NOD2-associated Crohn's disease. J Crohns Colitis 1 106-15 PubMed GONUTS page

[PMID:15107016-14] Damiano, JS et al. (2004) Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses. Biochem. J. 381 213-9 PubMed GONUTS page

[PMID:15998797-15] 15.0 ^15.1 ^15.2 ^15.3 ^15.4 ^15.5 ^15.6 Barnich, N et al. (2005) Membrane recruitment of NOD2 in intestinal epithelial cells is essential for nuclear factor-{kappa}B activation in muramyl dipeptide recognition. J. Cell Biol. 170 21-6 PubMed GONUTS page

[PMID:15653568-16] 16.0 ^16.1 ^16.2 Opitz, B et al. (2005) Nod1-mediated endothelial cell activation by Chlamydophila pneumoniae. Circ. Res. 96 319-26 PubMed GONUTS page

[PMID:21887730-17] 17.0 ^17.1 ^17.2 ^17.3 ^17.4 ^17.5 ^17.6 Zhao, Y et al. (2012) Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1. Inflamm. Bowel Dis. 18 603-12 PubMed GONUTS page

[PMID:23806334-18] 18.0 ^18.1 Fiil, BK et al. (2013) OTULIN restricts Met1-linked ubiquitination to control innate immune signaling. Mol. Cell 50 818-30 PubMed GONUTS page

[PMID:11087742-19] 19.0 ^19.1 Ogura, Y et al. (2001) Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB. J. Biol. Chem. 276 4812-8 PubMed GONUTS page

[PMID:17690884-20] Tattoli, I et al. (2007) The Nodosome: Nod1 and Nod2 control bacterial infections and inflammation. Semin Immunopathol 29 289-301 PubMed GONUTS page

[PMID:17919942-21] van Beelen, AJ et al. (2007) Stimulation of the intracellular bacterial sensor NOD2 programs dendritic cells to promote interleukin-17 production in human memory T cells. Immunity 27 660-9 PubMed GONUTS page

[PMID:15075345-22] Chen, CM et al. (2004) Reciprocal cross-talk between Nod2 and TAK1 signaling pathways. J. Biol. Chem. 279 25876-82 PubMed GONUTS page

[PMID:15753091-23] Barnich, N et al. (2005) GRIM-19 interacts with nucleotide oligomerization domain 2 and serves as downstream effector of anti-bacterial function in intestinal epithelial cells. J. Biol. Chem. 280 19021-6 PubMed GONUTS page

[PMID:16714539-24] Kufer, TA et al. (2006) Role for erbin in bacterial activation of Nod2. Infect. Immun. 74 3115-24 PubMed GONUTS page

[PMID:16260731-25] Netea, MG et al. (2005) IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1beta and IL-6 production through a caspase 1-dependent mechanism. Proc. Natl. Acad. Sci. U.S.A. 102 16309-14 PubMed GONUTS page

[PMID:21873635-26] 26.0 ^26.1 ^26.2 ^26.3 ^26.4 ^26.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:12527755-27] 27.0 ^27.1 ^27.2 ^27.3 Girardin, SE et al. (2003) Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J. Biol. Chem. 278 8869-72 PubMed GONUTS page

[PMID:17187069-28] 28.0 ^28.1 ^28.2 Hsu, YM et al. (2007) The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens. Nat. Immunol. 8 198-205 PubMed GONUTS page

[PMID:15967716-29] 29.0 ^29.1 ^29.2 ^29.3 Martinon, F & Tschopp, J (2005) NLRs join TLRs as innate sensors of pathogens. Trends Immunol. 26 447-54 PubMed GONUTS page

[PMID:20441518-30] Oosting, M et al. (2010) Recognition of Borrelia burgdorferi by NOD2 is central for the induction of an inflammatory reaction. J. Infect. Dis. 201 1849-58 PubMed GONUTS page

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HUMAN:NOD2

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