HUMAN:MINK1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	MINK1 (ECO:0000312 with HGNC:HGNC:17565)
Protein Name(s)	Misshapen-like kinase 1 GCK family kinase MiNK MAPK/ERK kinase kinase kinase 6 MEK kinase kinase 6 MEKKK 6 Misshapen/NIK-related kinase Mitogen-activated protein kinase kinase kinase kinase 6
External Links
UniProt	Q8N4C8
EMBL	AB041926 AB035698 AY775058 AC233723 CH471108 CH471108 CH471108 CH471108 CH471108 BC034673
CCDS	CCDS45588.1 CCDS45589.1 CCDS45590.1
RefSeq	NP_001020108.1 NP_056531.1 NP_722549.2 NP_733763.1
UniGene	Hs.443417
ProteinModelPortal	Q8N4C8
SMR	Q8N4C8
BioGrid	119075
IntAct	Q8N4C8
STRING	9606.ENSP00000347427
BindingDB	Q8N4C8
ChEMBL	CHEMBL5518
GuidetoPHARMACOLOGY	2103
PhosphoSite	Q8N4C8
DMDM	296437370
MaxQB	Q8N4C8
PaxDb	Q8N4C8
PRIDE	Q8N4C8
DNASU	50488
GeneID	50488
KEGG	hsa:50488
UCSC	uc010vsk.2 uc010vsl.2 uc010vsm.2 uc010vsn.2
CTD	50488
GeneCards	GC17P004736
H-InvDB	HIX0013452
HGNC	HGNC:17565
HPA	HPA056296
MIM	609426
neXtProt	NX_Q8N4C8
PharmGKB	PA134910641
eggNOG	COG0515
GeneTree	ENSGT00760000118848
HOGENOM	HOG000290708
HOVERGEN	HBG036506
InParanoid	Q8N4C8
KO	K04413
OMA	GTQTPYG
OrthoDB	EOG73803V
PhylomeDB	Q8N4C8
TreeFam	TF105138
Reactome	REACT_169436
SignaLink	Q8N4C8
ChiTaRS	MINK1
GeneWiki	MINK1
GenomeRNAi	50488
NextBio	53052
PRO	PR:Q8N4C8
Proteomes	UP000005640
Bgee	Q8N4C8
CleanEx	HS_MINK1
ExpressionAtlas	Q8N4C8
Genevestigator	Q8N4C8
GO	GO:0030424 GO:0030054 GO:0005737 GO:0005829 GO:0030425 GO:0070062 GO:0005794 GO:0014069 GO:0045211 GO:0005524 GO:0004672 GO:0004674 GO:0005083 GO:0031532 GO:0048813 GO:0035556 GO:0007254 GO:0007275 GO:0045060 GO:0046330 GO:0046777 GO:0006468 GO:2000311 GO:0030334 GO:0022407 GO:0001952 GO:0006950 GO:0007268
InterPro	IPR001180 IPR011009 IPR000719 IPR017441 IPR002290 IPR008271
Pfam	PF00780 PF00069
SMART	SM00036 SM00220
SUPFAM	SSF56112
PROSITE	PS50219 PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0006468	protein phosphorylation	PMID:21690388^[1]	ECO:0000315			P		In figure 4A shows a western blot which shows that after OA treatment, cells with Msn overexpression exhibited higher levels of T312 phosphorylation	complete CACAO 6393
involved_in	GO:1900745	positive regulation of p38MAPK cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9JM52	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:21690388^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
NOT\|involved_in	GO:0030033	microvillus assembly	PMID:22797597^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19056867^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
involved_in	GO:2000311	regulation of AMPA receptor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:F1LP90	P		Seeded From UniProt	complete
involved_in	GO:0048813	dendrite morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:F1LP90	P		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	PMID:15469942^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046330	positive regulation of JNK cascade	PMID:15469942^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046330	positive regulation of JNK cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9JM52	P		Seeded From UniProt	complete
involved_in	GO:0031532	actin cytoskeleton reorganization	PMID:15469942^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030334	regulation of cell migration	PMID:15469942^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0022407	regulation of cell-cell adhesion	PMID:15469942^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9JM52	P		Seeded From UniProt	complete
involved_in	GO:0007268	chemical synaptic transmission	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:F1LP90	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9JM52	P		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:15469942^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:18930710^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9JM52	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:18930710^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21690388^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001952	regulation of cell-matrix adhesion	PMID:15469942^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048812	neuron projection morphogenesis	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000685430 WB:WBGene00003247	P		Seeded From UniProt	complete
involved_in	GO:0032147	activation of protein kinase activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1919399 PANTHER:PTN000684825 RGD:727905 UniProtKB:Q7RTN6 UniProtKB:Q9C0K7	P		Seeded From UniProt	complete
involved_in	GO:0031532	actin cytoskeleton reorganization	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001221023 UniProtKB:Q8N4C8	P		Seeded From UniProt	complete
involved_in	GO:0031098	stress-activated protein kinase signaling cascade	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000684825 UniProtKB:A0A1D8PKE2 UniProtKB:A0A1D8PM87	P		Seeded From UniProt	complete
involved_in	GO:0023014	signal transduction by protein phosphorylation	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000684825 TAIR:locus:2205523 UniProtKB:Q9UEW8	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0023083 FB:FBgn0025743 FB:FBgn0267698 MGI:MGI:1339975 MGI:MGI:1344404 MGI:MGI:1346867 MGI:MGI:1346875 MGI:MGI:1891638 MGI:MGI:1928487 MGI:MGI:1929004 PANTHER:PTN000684825 PomBase:SPAC1F3.02c PomBase:SPBC17F3.02 PomBase:SPBC1D7.05 PomBase:SPBC409.07c PomBase:SPBC543.07 RGD:3780 RGD:620966 RGD:621643 SGD:S000000999 SGD:S000002318 SGD:S000002931 SGD:S000003664 SGD:S000004354 SGD:S000005757 SGD:S000006061 TAIR:locus:2017662 TAIR:locus:2074835 TAIR:locus:2087130 TAIR:locus:2170578 UniProtKB:A0A0B4KGS4 UniProtKB:O00506 UniProtKB:O95819 UniProtKB:Q13043 UniProtKB:Q13153 UniProtKB:Q13177 UniProtKB:Q13188 UniProtKB:Q57Y61 UniProtKB:Q7RTN6 UniProtKB:Q8N4C8 UniProtKB:Q96PY6 UniProtKB:Q9C0K7 UniProtKB:Q9H2G2 UniProtKB:Q9P289 UniProtKB:Q9S7U9 UniProtKB:Q9UKE5 UniProtKB:Q9Y4K4 UniProtKB:Q9Y6E0 UniProtKB:Q9Y6R4 WB:WBGene00002177 WB:WBGene00002201 WB:WBGene00003368 WB:WBGene00013355 dictyBase:DDB_G0284181 dictyBase:DDB_G0286359	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0023083 FB:FBgn0025743 FB:FBgn0031030 FB:FBgn0035001 FB:FBgn0261456 FB:FBgn0267698 MGI:MGI:1344404 MGI:MGI:1346882 MGI:MGI:1349394 MGI:MGI:1355329 MGI:MGI:1858416 MGI:MGI:1917378 MGI:MGI:1920334 PANTHER:PTN000684825 PomBase:SPBC1604.14c PomBase:SPBC21.06c RGD:3250 RGD:3251 RGD:621643 RGD:708455 RGD:727905 SGD:S000005242 TAIR:locus:2035989 TAIR:locus:2045658 TAIR:locus:2080394 TAIR:locus:2116417 TAIR:locus:2133559 TAIR:locus:2174969 TAIR:locus:2205523 TAIR:locus:2206885 UniProtKB:A0A0B4KGS4 UniProtKB:C0H4N8 UniProtKB:O75914 UniProtKB:O94804 UniProtKB:O95747 UniProtKB:O95819 UniProtKB:O96013 UniProtKB:Q02750 UniProtKB:Q12851 UniProtKB:Q13043 UniProtKB:Q13153 UniProtKB:Q13177 UniProtKB:Q13188 UniProtKB:Q13233 UniProtKB:Q8IVH8 UniProtKB:Q8N4C8 UniProtKB:Q92918 UniProtKB:Q99558 UniProtKB:Q9H2G2 UniProtKB:Q9H2K8 UniProtKB:Q9UEW8 UniProtKB:Q9UKE5 UniProtKB:Q9UL54 UniProtKB:Q9Y4K4 UniProtKB:Q9Y6E0 WB:WBGene00013355 WB:WBGene00017472 dictyBase:DDB_G0276459 dictyBase:DDB_G0286359	F		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	CGD:CAL0000198103 PANTHER:PTN000685430	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	P		Seeded From UniProt	complete
involved_in	GO:0007254	JNK cascade	PMID:10708748^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:10708748^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-3225867	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003	C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0628	C		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333 UniProtKB-SubCell:SL-0132	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0283	C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0297	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0279	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Kaneko, S et al. (2011) Smad inhibition by the Ste20 kinase Misshapen. Proc. Natl. Acad. Sci. U.S.A. 108 11127-32 PubMed GONUTS page
↑ Gloerich, M et al. (2012) Rap2A links intestinal cell polarity to brush border formation. Nat. Cell Biol. 14 793-801 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Hu, Y et al. (2004) Identification and functional characterization of a novel human misshapen/Nck interacting kinase-related kinase, hMINK beta. J. Biol. Chem. 279 54387-97 PubMed GONUTS page
↑ ^5.0 ^5.1 Nonaka, H et al. (2008) MINK is a Rap2 effector for phosphorylation of the postsynaptic scaffold protein TANC1. Biochem. Biophys. Res. Commun. 377 573-8 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^7.0 ^7.1 Dan, I et al. (2000) Molecular cloning of MINK, a novel member of mammalian GCK family kinases, which is up-regulated during postnatal mouse cerebral development. FEBS Lett. 469 19-23 PubMed GONUTS page

[PMID:21690388-1] 1.0 ^1.1 ^1.2 Kaneko, S et al. (2011) Smad inhibition by the Ste20 kinase Misshapen. Proc. Natl. Acad. Sci. U.S.A. 108 11127-32 PubMed GONUTS page

[PMID:22797597-2] Gloerich, M et al. (2012) Rap2A links intestinal cell polarity to brush border formation. Nat. Cell Biol. 14 793-801 PubMed GONUTS page

[PMID:19056867-3] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:15469942-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Hu, Y et al. (2004) Identification and functional characterization of a novel human misshapen/Nck interacting kinase-related kinase, hMINK beta. J. Biol. Chem. 279 54387-97 PubMed GONUTS page

[PMID:18930710-5] 5.0 ^5.1 Nonaka, H et al. (2008) MINK is a Rap2 effector for phosphorylation of the postsynaptic scaffold protein TANC1. Biochem. Biophys. Res. Commun. 377 573-8 PubMed GONUTS page

[PMID:21873635-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:10708748-7] 7.0 ^7.1 Dan, I et al. (2000) Molecular cloning of MINK, a novel member of mammalian GCK family kinases, which is up-regulated during postnatal mouse cerebral development. FEBS Lett. 469 19-23 PubMed GONUTS page

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HUMAN:MINK1

Contents

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