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PMID:10708748
| Citation |
Dan, I, Watanabe, NM, Kobayashi, T, Yamashita-Suzuki, K, Fukagaya, Y, Kajikawa, E, Kimura, WK, Nakashima, TM, Matsumoto, K, Ninomiya-Tsuji, J and Kusumi, A (2000) Molecular cloning of MINK, a novel member of mammalian GCK family kinases, which is up-regulated during postnatal mouse cerebral development. FEBS Lett. 469:19-23 |
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| Abstract |
A new germinal center kinase (GCK) family kinase, Misshapen/NIKs-related kinase (MINK), has been cloned and its expression has been characterized in several tissues and various developmental stages of the mouse brain. MINK encodes a 1300 amino acid polypeptide, consisting of an N-terminal kinase domain, a proline-rich intermediate region, and a C-terminal GCK homology region. The expression of MINK is up-regulated during the postnatal development of the mouse brain. MINK activates the cJun N-terminal kinase and the p38 pathways. |
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| Keywords |
Amino Acid Sequence; Animals; Brain/enzymology; Brain/growth & development; Cell Line; Cloning, Molecular; Enzyme Activation; Gene Expression Regulation, Developmental; Mice; Mitogen-Activated Protein Kinases/genetics; Mitogen-Activated Protein Kinases/metabolism; Molecular Sequence Data; Nerve Tissue Proteins/chemistry; Nerve Tissue Proteins/genetics; Phylogeny; Protein-Serine-Threonine Kinases/chemistry; Protein-Serine-Threonine Kinases/genetics; RNA, Messenger/metabolism; Signal Transduction; Transfection; Up-Regulation |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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