HUMAN:TRAF6

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	TRAF6 (synonyms: RNF85)
Protein Name(s)	TNF receptor-associated factor 6 E3 ubiquitin-protein ligase TRAF6 Interleukin-1 signal transducer RING finger protein 85
External Links
UniProt	Q9Y4K3
EMBL	U78798 AY228337 AK292978 AC009656 AC061999 CH471064 CH471064 CH471064 BC031052
CCDS	CCDS7901.1
PIR	S71821
RefSeq	NP_004611.1 NP_665802.1
UniGene	Hs.444172 Hs.591983
PDB	1LB4 1LB5 1LB6 2ECI 2JMD 3HCS 3HCT 3HCU
PDBsum	1LB4 1LB5 1LB6 2ECI 2JMD 3HCS 3HCT 3HCU
ProteinModelPortal	Q9Y4K3
SMR	Q9Y4K3
BioGrid	113041
DIP	DIP-27515N
IntAct	Q9Y4K3
MINT	MINT-88585
STRING	9606.ENSP00000316840
PhosphoSite	Q9Y4K3
DMDM	30580642
MaxQB	Q9Y4K3
PaxDb	Q9Y4K3
PRIDE	Q9Y4K3
DNASU	7189
Ensembl	ENST00000348124 ENST00000526995
GeneID	7189
KEGG	hsa:7189
UCSC	uc001mwq.2
CTD	7189
GeneCards	GC11M036467
HGNC	HGNC:12036
HPA	CAB004605 HPA019805 HPA020599
MIM	602355
neXtProt	NX_Q9Y4K3
Orphanet	1810
PharmGKB	PA36713
eggNOG	NOG289765
GeneTree	ENSGT00550000074359
HOGENOM	HOG000006625
HOVERGEN	HBG060248
InParanoid	Q9Y4K3
KO	K03175
OMA	NFQETIH
OrthoDB	EOG7966G5
PhylomeDB	Q9Y4K3
TreeFam	TF321154
Reactome	REACT_12555 REACT_13415 REACT_13443 REACT_13643 REACT_13696 REACT_163994 REACT_21281 REACT_21368 REACT_21399 REACT_22442 REACT_24918 REACT_24938 REACT_24969 REACT_25018 REACT_25024 REACT_25120 REACT_25222 REACT_25351 REACT_25354 REACT_25374 REACT_25380 REACT_27215 REACT_6788 REACT_75776
SignaLink	Q9Y4K3
UniPathway	UPA00143
ChiTaRS	TRAF6
EvolutionaryTrace	Q9Y4K3
GeneWiki	TRAF6
GenomeRNAi	7189
NextBio	28192
PRO	PR:Q9Y4K3
Proteomes	UP000005640
Bgee	Q9Y4K3
CleanEx	HS_TRAF6
Genevestigator	Q9Y4K3
GO	GO:0035631 GO:0005938 GO:0005737 GO:0009898 GO:0005829 GO:0010008 GO:0005811 GO:0005739 GO:0005730 GO:0005634 GO:0048471 GO:0005886 GO:0043234 GO:0042826 GO:0016874 GO:0031435 GO:0043422 GO:0019901 GO:0047485 GO:0004871 GO:0031996 GO:0005164 GO:0031624 GO:0031625 GO:0004842 GO:0008270 GO:0000187 GO:0007250 GO:0032147 GO:0019886 GO:0097190 GO:0045453 GO:0048468 GO:0071222 GO:0038095 GO:0007249 GO:0045087 GO:0070498 GO:0007254 GO:0031293 GO:0002755 GO:0002756 GO:0043011 GO:0043066 GO:0000122 GO:0045892 GO:0001843 GO:0048011 GO:0035872 GO:0070423 GO:0042475 GO:0001503 GO:0030316 GO:0043065 GO:0043123 GO:0045084 GO:0032743 GO:0045410 GO:0043507 GO:0031666 GO:0051092 GO:0045672 GO:0031398 GO:0051091 GO:0048661 GO:0050870 GO:0002726 GO:0042102 GO:0045944 GO:2000679 GO:0051865 GO:0006461 GO:0070534 GO:0000209 GO:0051023 GO:0070555 GO:0051403 GO:0050852 GO:0042088 GO:0034166 GO:0034134 GO:0034138 GO:0034142 GO:0034146 GO:0034162 GO:0002224 GO:0038123 GO:0038124 GO:0035666
Gene3D	3.30.40.10
InterPro	IPR002083 IPR012227 IPR008974 IPR027139 IPR001841 IPR013083 IPR017907 IPR001293
PANTHER	PTHR10131:SF52
Pfam	PF00917
PIRSF	PIRSF015614
SMART	SM00061 SM00184
SUPFAM	SSF49599
PROSITE	PS50144 PS00518 PS50089 PS50145

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:1901224	positive regulation of NIK/NF-kappaB signaling	PMID:25515214^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:2000044)	Seeded From UniProt	complete
involved_in	GO:0071345	cellular response to cytokine stimulus	PMID:25515214^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:2000044)	Seeded From UniProt	complete
involved_in	GO:0070534	protein K63-linked ubiquitination	PMID:21068390^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005164	tumor necrosis factor receptor binding	PMID:11728344^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9NP84	F		Seeded From UniProt	complete
involved_in	GO:2000679	positive regulation of transcription regulatory region DNA binding	PMID:11751921^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:12296995^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:11751921^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	PMID:12296995^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:11751921^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:11751921^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:22412986^[6]	ECO:0000303	author statement without traceable support used in manual assertion		P	has_regulation_target:(UniProtKB:P29460)	Seeded From UniProt	complete
involved_in	GO:0043507	positive regulation of JUN kinase activity	PMID:11751921^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0035631	CD40 receptor complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70196	C		Seeded From UniProt	complete
involved_in	GO:0031398	positive regulation of protein ubiquitination	PMID:22412986^[6]	ECO:0000303	author statement without traceable support used in manual assertion		P	has_regulation_target:(UniProtKB:Q13568)	Seeded From UniProt	complete
part_of	GO:0009898	cytoplasmic side of plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70196	C		Seeded From UniProt	complete
involved_in	GO:1904996	positive regulation of leukocyte adhesion to vascular endothelial cell	PMID:25515214^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_agent:(CL:0000084) has_agent:(CL:2000044) part_of:(GO:0071345)	Seeded From UniProt	complete
involved_in	GO:0070555	response to interleukin-1	PMID:17135271^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070534	protein K63-linked ubiquitination	PMID:17135271^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P0CG47	P		Seeded From UniProt	complete
involved_in	GO:0070534	protein K63-linked ubiquitination	PMID:19675569^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P0CG47	P		Seeded From UniProt	complete
involved_in	GO:0070534	protein K63-linked ubiquitination	PMID:19713527^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051865	protein autoubiquitination	PMID:18093978^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051865	protein autoubiquitination	PMID:17135271^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:11279055^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:16378096^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050852	T cell receptor signaling pathway	PMID:15125833^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0047485	protein N-terminus binding	PMID:14530355^[14]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8IUC6	F		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:18093978^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045672	positive regulation of osteoclast differentiation	PMID:17135271^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043507	positive regulation of JUN kinase activity	PMID:17135271^[7]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043422	protein kinase B binding	PMID:19713527^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9Y243	F		Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	PMID:17135271^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042826	histone deacetylase binding	PMID:18093978^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q13547	F		Seeded From UniProt	complete
involved_in	GO:0032743	positive regulation of interleukin-2 production	PMID:15125833^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032147	activation of protein kinase activity	PMID:17135271^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0031996	thioesterase binding	PMID:11279055^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q93009	F		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:11279055^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O94972	F		Seeded From UniProt	complete
enables	GO:0031435	mitogen-activated protein kinase kinase kinase binding	PMID:10094049^[15]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O43318	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:19713527^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P31751	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:19713527^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P31749	F		Seeded From UniProt	complete
involved_in	GO:0007250	activation of NF-kappaB-inducing kinase activity	PMID:15125833^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:18093978^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005811	lipid droplet	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70196	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:18093978^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:16378096^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18093978^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	PMID:17135271^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	PMID:19713527^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	PMID:15125833^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0002726	positive regulation of T cell cytokine production	PMID:15125833^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000209	protein polyubiquitination	PMID:19675569^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000209	protein polyubiquitination	PMID:15125833^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:18093978^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070534	protein K63-linked ubiquitination	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108072 PANTHER:PTN000805706 UniProtKB:Q9Y4K3	P		Seeded From UniProt	complete
involved_in	GO:0070498	interleukin-1-mediated signaling pathway	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108072 PANTHER:PTN002562173 RGD:1306853	P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108072 PANTHER:PTN000805706 UniProtKB:Q9Y4K3	P		Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108072 PANTHER:PTN000805706 UniProtKB:Q9Y4K3	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101835 MGI:MGI:107548 MGI:MGI:108041 MGI:MGI:108072 PANTHER:PTN000805648 RGD:1306853 RGD:1310457 UniProtKB:Q12933 UniProtKB:Q9Y4K3	C		Seeded From UniProt	complete
enables	GO:0005164	tumor necrosis factor receptor binding	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000805706 UniProtKB:Q9Y4K3	F		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108072 PANTHER:PTN000805706 UniProtKB:Q9Y4K3	F		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	PMID:17135271^[7]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	PMID:15361868^[17]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	PMID:23776175^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051865	protein autoubiquitination	PMID:23776175^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:23776175^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0031624	ubiquitin conjugating enzyme binding	PMID:23776175^[18]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:27107012^[19]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9Y4K3	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:25416956^[20]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9Y4K3	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:22493164^[21]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9Y4K3	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:21988832^[22]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9Y4K3	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:19465916^[23]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9Y4K3	F		Seeded From UniProt	complete
involved_in	GO:0070498	interleukin-1-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B5DF45 ensembl:ENSRNOP00000006148	P		Seeded From UniProt	complete
involved_in	GO:0048661	positive regulation of smooth muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B5DF45 ensembl:ENSRNOP00000006148	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B5DF45 ensembl:ENSRNOP00000006148	C		Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B5DF45 ensembl:ENSRNOP00000006148	P		Seeded From UniProt	complete
involved_in	GO:0007254	JNK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B5DF45 ensembl:ENSRNOP00000006148	P		Seeded From UniProt	complete
involved_in	GO:0070534	protein K63-linked ubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70196 ensembl:ENSMUSP00000004949	P		Seeded From UniProt	complete
involved_in	GO:0070498	interleukin-1-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70196 ensembl:ENSMUSP00000004949	P		Seeded From UniProt	complete
enables	GO:0061630	ubiquitin protein ligase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70196 ensembl:ENSMUSP00000004949	F		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70196 ensembl:ENSMUSP00000004949	P		Seeded From UniProt	complete
involved_in	GO:0051023	regulation of immunoglobulin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70196 ensembl:ENSMUSP00000004949	P		Seeded From UniProt	complete
involved_in	GO:0048468	cell development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70196 ensembl:ENSMUSP00000004949	P		Seeded From UniProt	complete
involved_in	GO:0046849	bone remodeling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70196 ensembl:ENSMUSP00000004949	P		Seeded From UniProt	complete
involved_in	GO:0045453	bone resorption	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70196 ensembl:ENSMUSP00000004949	P		Seeded From UniProt	complete
involved_in	GO:0045410	positive regulation of interleukin-6 biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70196 ensembl:ENSMUSP00000004949	P		Seeded From UniProt	complete
involved_in	GO:0045084	positive regulation of interleukin-12 biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70196 ensembl:ENSMUSP00000004949	P		Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70196 ensembl:ENSMUSP00000004949	P		Seeded From UniProt	complete
involved_in	GO:0043011	myeloid dendritic cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70196 ensembl:ENSMUSP00000004949	P		Seeded From UniProt	complete
involved_in	GO:0042475	odontogenesis of dentin-containing tooth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70196 ensembl:ENSMUSP00000004949	P		Seeded From UniProt	complete
involved_in	GO:0042102	positive regulation of T cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70196 ensembl:ENSMUSP00000004949	P		Seeded From UniProt	complete
involved_in	GO:0042088	T-helper 1 type immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70196 ensembl:ENSMUSP00000004949	P		Seeded From UniProt	complete
part_of	GO:0035631	CD40 receptor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70196 ensembl:ENSMUSP00000004949	C		Seeded From UniProt	complete
involved_in	GO:0031666	positive regulation of lipopolysaccharide-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70196 ensembl:ENSMUSP00000004949	P		Seeded From UniProt	complete
involved_in	GO:0030316	osteoclast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70196 ensembl:ENSMUSP00000004949	P		Seeded From UniProt	complete
involved_in	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70196 ensembl:ENSMUSP00000004949	P		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70196 ensembl:ENSMUSP00000004949	P		Seeded From UniProt	complete
part_of	GO:0009898	cytoplasmic side of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70196 ensembl:ENSMUSP00000004949	C		Seeded From UniProt	complete
involved_in	GO:0009887	animal organ morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70196 ensembl:ENSMUSP00000004949	P		Seeded From UniProt	complete
involved_in	GO:0007249	I-kappaB kinase/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70196 ensembl:ENSMUSP00000004949	P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70196 ensembl:ENSMUSP00000004949	P		Seeded From UniProt	complete
involved_in	GO:0006955	immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70196 ensembl:ENSMUSP00000004949	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70196 ensembl:ENSMUSP00000004949	C		Seeded From UniProt	complete
part_of	GO:0005811	lipid droplet	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70196 ensembl:ENSMUSP00000004949	C		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70196 ensembl:ENSMUSP00000004949	F		Seeded From UniProt	complete
involved_in	GO:0001843	neural tube closure	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70196 ensembl:ENSMUSP00000004949	P		Seeded From UniProt	complete
involved_in	GO:0001503	ossification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70196 ensembl:ENSMUSP00000004949	P		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027139 InterPro:IPR037309	F		Seeded From UniProt	complete
enables	GO:0005164	tumor necrosis factor receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027139 InterPro:IPR037309	F		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012227	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001293 InterPro:IPR012227	F		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027139 InterPro:IPR037309	P		Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012227	P		Seeded From UniProt	complete
involved_in	GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR037309	P		Seeded From UniProt	complete
involved_in	GO:0051865	protein autoubiquitination	PMID:16378096^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070498	interleukin-1-mediated signaling pathway	Reactome:R-HSA-9020702	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070423	nucleotide-binding oligomerization domain containing signaling pathway	Reactome:R-HSA-168638	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	Reactome:R-HSA-445989	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050852	T cell receptor signaling pathway	Reactome:R-HSA-202403	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	Reactome:R-HSA-937039	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	Reactome:R-HSA-193639	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	Reactome:R-HSA-205043	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038095	Fc-epsilon receptor signaling pathway	Reactome:R-HSA-2454202	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034162	toll-like receptor 9 signaling pathway	Reactome:R-HSA-168138	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031293	membrane protein intracellular domain proteolysis	Reactome:R-HSA-193692	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016579	protein deubiquitination	Reactome:R-HSA-5688426	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0010008	endosome membrane	Reactome:R-HSA-975188 Reactome:R-HSA-975185 Reactome:R-HSA-975147 Reactome:R-HSA-975142 Reactome:R-HSA-975139 Reactome:R-HSA-975122 Reactome:R-HSA-975119 Reactome:R-HSA-975118 Reactome:R-HSA-975111 Reactome:R-HSA-975106 Reactome:R-HSA-975103 Reactome:R-HSA-975100 Reactome:R-HSA-975097 Reactome:R-HSA-9628444 Reactome:R-HSA-847070 Reactome:R-HSA-450358 Reactome:R-HSA-450259 Reactome:R-HSA-177694 Reactome:R-HSA-177692 Reactome:R-HSA-177690	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007254	JNK cascade	Reactome:R-HSA-450321	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007249	I-kappaB kinase/NF-kappaB signaling	Reactome:R-HSA-937072 Reactome:R-HSA-9014325	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-975879 Reactome:R-HSA-975857 Reactome:R-HSA-937050 Reactome:R-HSA-937044 Reactome:R-HSA-937034 Reactome:R-HSA-936991 Reactome:R-HSA-936986 Reactome:R-HSA-936963 Reactome:R-HSA-936960 Reactome:R-HSA-936942 Reactome:R-HSA-2262777 Reactome:R-HSA-2262775 Reactome:R-HSA-166363 Reactome:R-HSA-166362	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-975857 Reactome:R-HSA-975185 Reactome:R-HSA-975111 Reactome:R-HSA-937075 Reactome:R-HSA-937050 Reactome:R-HSA-937032 Reactome:R-HSA-936985 Reactome:R-HSA-936963 Reactome:R-HSA-936952 Reactome:R-HSA-936951 Reactome:R-HSA-936947 Reactome:R-HSA-933538 Reactome:R-HSA-933537 Reactome:R-HSA-933530 Reactome:R-HSA-933527 Reactome:R-HSA-933525 Reactome:R-HSA-918230 Reactome:R-HSA-8948018 Reactome:R-HSA-8948015 Reactome:R-HSA-8869506 Reactome:R-HSA-8869456 Reactome:R-HSA-847070 Reactome:R-HSA-741386 Reactome:R-HSA-5696627 Reactome:R-HSA-5690870 Reactome:R-HSA-5690843 Reactome:R-HSA-5607759 Reactome:R-HSA-5607757 Reactome:R-HSA-5607756 Reactome:R-HSA-5607751 Reactome:R-HSA-5607747 Reactome:R-HSA-5607742 Reactome:R-HSA-5607732 Reactome:R-HSA-507719 Reactome:R-HSA-450358 Reactome:R-HSA-450346 Reactome:R-HSA-450337 Reactome:R-HSA-450187 Reactome:R-HSA-450173 Reactome:R-HSA-446894 Reactome:R-HSA-446877 Reactome:R-HSA-446870 Reactome:R-HSA-446862 Reactome:R-HSA-2730904 Reactome:R-HSA-2730903 Reactome:R-HSA-2730900 Reactome:R-HSA-2730876 Reactome:R-HSA-2730864 Reactome:R-HSA-2730861 Reactome:R-HSA-2262777 Reactome:R-HSA-209566 Reactome:R-HSA-205118 Reactome:R-HSA-205112 Reactome:R-HSA-202534 Reactome:R-HSA-202510 Reactome:R-HSA-202500 Reactome:R-HSA-202472 Reactome:R-HSA-202453 Reactome:R-HSA-193705 Reactome:R-HSA-193703 Reactome:R-HSA-193700 Reactome:R-HSA-193695 Reactome:R-HSA-193694 Reactome:R-HSA-193684 Reactome:R-HSA-193669 Reactome:R-HSA-193665 Reactome:R-HSA-193641 Reactome:R-HSA-177694 Reactome:R-HSA-168184 Reactome:R-HSA-166869 Reactome:R-HSA-166363	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	Reactome:R-HSA-975147 Reactome:R-HSA-936986 Reactome:R-HSA-936942 Reactome:R-HSA-450358 Reactome:R-HSA-446877 Reactome:R-HSA-2730904 Reactome:R-HSA-202534 Reactome:R-HSA-202453	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	Reactome:R-HSA-975871 Reactome:R-HSA-166058	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002224	toll-like receptor signaling pathway	Reactome:R-HSA-168181	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002223	stimulatory C-type lectin receptor signaling pathway	Reactome:R-HSA-5621481	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	Reactome:R-HSA-450302	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0001503	ossification	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0892	P		Seeded From UniProt	complete
part_of	GO:0005811	lipid droplet	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0551 UniProtKB-SubCell:SL-0154	C		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0138	C		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00143	P		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Wu, D et al. (2015) Brain endothelial miR-146a negatively modulates T-cell adhesion through repressing multiple targets to inhibit NF-κB activation. J. Cereb. Blood Flow Metab. 35 412-23 PubMed GONUTS page
↑ Rong, J et al. (2011) Bifunctional apoptosis regulator (BAR), an endoplasmic reticulum (ER)-associated E3 ubiquitin ligase, modulates BI-1 protein stability and function in ER Stress. J. Biol. Chem. 286 1453-63 PubMed GONUTS page
↑ Wiley, SR et al. (2001) A novel TNF receptor family member binds TWEAK and is implicated in angiogenesis. Immunity 15 837-46 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Shin, JN et al. (2002) A novel zinc finger protein that inhibits osteoclastogenesis and the function of tumor necrosis factor receptor-associated factor 6. J. Biol. Chem. 277 8346-53 PubMed GONUTS page
↑ ^5.0 ^5.1 Lee, SW et al. (2002) TAK1-dependent activation of AP-1 and c-Jun N-terminal kinase by receptor activator of NF-kappaB. J. Biochem. Mol. Biol. 35 371-6 PubMed GONUTS page
↑ ^6.0 ^6.1 Chang Foreman, HC et al. (2012) Activation of interferon regulatory factor 5 by site specific phosphorylation. PLoS ONE 7 e33098 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 ^7.8 Lamothe, B et al. (2007) Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation. J. Biol. Chem. 282 4102-12 PubMed GONUTS page
↑ ^8.0 ^8.1 Xia, ZP et al. (2009) Direct activation of protein kinases by unanchored polyubiquitin chains. Nature 461 114-9 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 Yang, WL et al. (2009) The E3 ligase TRAF6 regulates Akt ubiquitination and activation. Science 325 1134-8 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 Pham, LV et al. (2008) Nuclear tumor necrosis factor receptor-associated factor 6 in lymphoid cells negatively regulates c-Myb-mediated transactivation through small ubiquitin-related modifier-1 modification. J. Biol. Chem. 283 5081-9 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Zapata, JM et al. (2001) A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains. J. Biol. Chem. 276 24242-52 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Wang, Y et al. (2006) Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling. Nat. Immunol. 7 139-47 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 Sun, L et al. (2004) The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes. Mol. Cell 14 289-301 PubMed GONUTS page
↑ Sato, S et al. (2003) Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling. J. Immunol. 171 4304-10 PubMed GONUTS page
↑ Ninomiya-Tsuji, J et al. (1999) The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway. Nature 398 252-6 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 ^16.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Kawai, T et al. (2004) Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. Nat. Immunol. 5 1061-8 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 ^18.3 Dauphinee, SM et al. (2013) SASH1 is a scaffold molecule in endothelial TLR4 signaling. J. Immunol. 191 892-901 PubMed GONUTS page
↑ Yachie, N et al. (2016) Pooled-matrix protein interaction screens using Barcode Fusion Genetics. Mol. Syst. Biol. 12 863 PubMed GONUTS page
↑ Rolland, T et al. (2014) A proteome-scale map of the human interactome network. Cell 159 1212-26 PubMed GONUTS page
↑ Woodsmith, J et al. (2012) Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks. Mol. Cell Proteomics 11 M111.016162 PubMed GONUTS page
↑ Wang, J et al. (2011) Toward an understanding of the protein interaction network of the human liver. Mol. Syst. Biol. 7 536 PubMed GONUTS page
↑ Yin, Q et al. (2009) E2 interaction and dimerization in the crystal structure of TRAF6. Nat. Struct. Mol. Biol. 16 658-66 PubMed GONUTS page

[PMID:25515214-1] 1.0 ^1.1 ^1.2 Wu, D et al. (2015) Brain endothelial miR-146a negatively modulates T-cell adhesion through repressing multiple targets to inhibit NF-κB activation. J. Cereb. Blood Flow Metab. 35 412-23 PubMed GONUTS page

[PMID:21068390-2] Rong, J et al. (2011) Bifunctional apoptosis regulator (BAR), an endoplasmic reticulum (ER)-associated E3 ubiquitin ligase, modulates BI-1 protein stability and function in ER Stress. J. Biol. Chem. 286 1453-63 PubMed GONUTS page

[PMID:11728344-3] Wiley, SR et al. (2001) A novel TNF receptor family member binds TWEAK and is implicated in angiogenesis. Immunity 15 837-46 PubMed GONUTS page

[PMID:11751921-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Shin, JN et al. (2002) A novel zinc finger protein that inhibits osteoclastogenesis and the function of tumor necrosis factor receptor-associated factor 6. J. Biol. Chem. 277 8346-53 PubMed GONUTS page

[PMID:12296995-5] 5.0 ^5.1 Lee, SW et al. (2002) TAK1-dependent activation of AP-1 and c-Jun N-terminal kinase by receptor activator of NF-kappaB. J. Biochem. Mol. Biol. 35 371-6 PubMed GONUTS page

[PMID:22412986-6] 6.0 ^6.1 Chang Foreman, HC et al. (2012) Activation of interferon regulatory factor 5 by site specific phosphorylation. PLoS ONE 7 e33098 PubMed GONUTS page

[PMID:17135271-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 ^7.8 Lamothe, B et al. (2007) Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation. J. Biol. Chem. 282 4102-12 PubMed GONUTS page

[PMID:19675569-8] 8.0 ^8.1 Xia, ZP et al. (2009) Direct activation of protein kinases by unanchored polyubiquitin chains. Nature 461 114-9 PubMed GONUTS page

[PMID:19713527-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 Yang, WL et al. (2009) The E3 ligase TRAF6 regulates Akt ubiquitination and activation. Science 325 1134-8 PubMed GONUTS page

[PMID:18093978-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 Pham, LV et al. (2008) Nuclear tumor necrosis factor receptor-associated factor 6 in lymphoid cells negatively regulates c-Myb-mediated transactivation through small ubiquitin-related modifier-1 modification. J. Biol. Chem. 283 5081-9 PubMed GONUTS page

[PMID:11279055-11] 11.0 ^11.1 ^11.2 Zapata, JM et al. (2001) A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains. J. Biol. Chem. 276 24242-52 PubMed GONUTS page

[PMID:16378096-12] 12.0 ^12.1 ^12.2 Wang, Y et al. (2006) Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling. Nat. Immunol. 7 139-47 PubMed GONUTS page

[PMID:15125833-13] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 Sun, L et al. (2004) The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes. Mol. Cell 14 289-301 PubMed GONUTS page

[PMID:14530355-14] Sato, S et al. (2003) Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling. J. Immunol. 171 4304-10 PubMed GONUTS page

[PMID:10094049-15] Ninomiya-Tsuji, J et al. (1999) The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway. Nature 398 252-6 PubMed GONUTS page

[PMID:21873635-16] 16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 ^16.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:15361868-17] Kawai, T et al. (2004) Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. Nat. Immunol. 5 1061-8 PubMed GONUTS page

[PMID:23776175-18] 18.0 ^18.1 ^18.2 ^18.3 Dauphinee, SM et al. (2013) SASH1 is a scaffold molecule in endothelial TLR4 signaling. J. Immunol. 191 892-901 PubMed GONUTS page

[PMID:27107012-19] Yachie, N et al. (2016) Pooled-matrix protein interaction screens using Barcode Fusion Genetics. Mol. Syst. Biol. 12 863 PubMed GONUTS page

[PMID:25416956-20] Rolland, T et al. (2014) A proteome-scale map of the human interactome network. Cell 159 1212-26 PubMed GONUTS page

[PMID:22493164-21] Woodsmith, J et al. (2012) Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks. Mol. Cell Proteomics 11 M111.016162 PubMed GONUTS page

[PMID:21988832-22] Wang, J et al. (2011) Toward an understanding of the protein interaction network of the human liver. Mol. Syst. Biol. 7 536 PubMed GONUTS page

[PMID:19465916-23] Yin, Q et al. (2009) E2 interaction and dimerization in the crystal structure of TRAF6. Nat. Struct. Mol. Biol. 16 658-66 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

[19]

[20]

[21]

[22]

[23]

HUMAN:TRAF6

Contents

Annotations

Notes

References

a

b

c

d

e

f

h

i

j

l

m

n

o

p

r

s

t

u

v

z

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools