Category:GO:0007249 ! canonical NF-kappaB signal transduction

name: canonical NF-kappaB signal transduction
namespace: biological_process
def: "An intracellular signaling cassette characterized by the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB, also known as the canonical NF-kappaB signaling cascade. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. The canonical NF-kappaB pathway is mainly stimulated by proinflammatory cytokines such as IL-1beta, tumor necrosis factor (TNF)-alpha, antigen ligands, and toll-like receptors (TLRs)." [GOC:bf, PMID:12773372, PMID:34659217]
synonym: "canonical NF-kappaB signaling cascade" EXACT [GOC:bf]
synonym: "I-kappaB kinase/NF-kappaB cascade" EXACT [GOC:signaling]
synonym: "I-kappaB kinase/NF-kappaB signal transduction" EXACT [GOC:signaling]
synonym: "I-kappaB kinase/NF-kappaB signaling" EXACT []
synonym: "NF-kappaB cascade" BROAD []
synonym: "p50-dependent NF-kappaB signaling" RELATED [PMID:18292232]
is_a: GO:0141124 ! intracellular signaling cassette

AmiGO <GOterm>GO:0007249</GOterm>
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