GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

PMID:12839624

From GONUTS
Jump to: navigation, search
Citation

Oishi, I, Suzuki, H, Onishi, N, Takada, R, Kani, S, Ohkawara, B, Koshida, I, Suzuki, K, Yamada, G, Schwabe, GC, Mundlos, S, Shibuya, H, Takada, S and Minami, Y (2003) The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway. Genes Cells 8:645-54

Abstract

Ror2 is an orphan receptor, belonging to the Ror family of receptor tyrosine kinases. Although Ror2 has been shown to play crucial roles in developmental morphogenesis, the precise signalling events that Ror2 mediates remain elusive. Since Ror2 possesses an extracellular cysteine-rich domain (CRD) that resembles the Wnt-binding sites of the Frizzled (Fz) proteins, it is conceivable that Ror2 interacts with members of the Wnt family.

Links

PubMed

Keywords

Animals; Blotting, Western; Enzyme Activation; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Mice; Mitogen-Activated Protein Kinase Kinases/genetics; Mitogen-Activated Protein Kinase Kinases/metabolism; Mitogen-Activated Protein Kinase Kinases/physiology; Phenotype; Precipitin Tests; Proto-Oncogene Proteins/genetics; Proto-Oncogene Proteins/metabolism; Proto-Oncogene Proteins/physiology; Receptor Protein-Tyrosine Kinases/physiology; Receptor Tyrosine Kinase-like Orphan Receptors; Signal Transduction/physiology; Wnt Proteins

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:WNT5A

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

PR:Q9Z138

F

Seeded From UniProt

complete

MOUSE:FZD2

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

PR:Q9Z138

F

Seeded From UniProt

complete

MOUSE:FZD2

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q9Z138

F

Seeded From UniProt

complete

MOUSE:ROR2

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

PR:P22725
PR:Q9JIP6

F

Seeded From UniProt

complete

MOUSE:ROR2

acts_upstream_of_or_within

GO:0007254: JNK cascade

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:ROR2

acts_upstream_of_or_within

GO:0007223: Wnt signaling pathway, calcium modulating pathway

ECO:0000353: physical interaction evidence used in manual assertion

PR:P22725
PR:Q9JIP6

P

Seeded From UniProt

complete

MOUSE:ROR2

enables

GO:0005109: frizzled binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q9JIP6

F

Seeded From UniProt

complete

MOUSE:WNT5A

acts_upstream_of_or_within

GO:0007254: JNK cascade

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

See Help:References for how to manage references in GONUTS.