HUMAN:WNT5A

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	WNT5A
Protein Name(s)	Protein Wnt-5a
External Links
UniProt	P41221
EMBL	L20861 AK290375 AK290869 CH471055 BC064694
CCDS	CCDS46850.1 CCDS58835.1
PIR	A48914
RefSeq	NP_001243034.1 NP_003383.2 XP_006713387.1
UniGene	Hs.643085
ProteinModelPortal	P41221
SMR	P41221
BioGrid	113311
DIP	DIP-29735N
IntAct	P41221
STRING	9606.ENSP00000264634
DMDM	212276478
MaxQB	P41221
PaxDb	P41221
PRIDE	P41221
DNASU	7474
Ensembl	ENST00000264634 ENST00000474267 ENST00000497027
GeneID	7474
KEGG	hsa:7474
UCSC	uc003dhm.3
CTD	7474
GeneCards	GC03M055474
HGNC	HGNC:12784
MIM	164975 180700
neXtProt	NX_P41221
Orphanet	3107
PharmGKB	PA37385
eggNOG	NOG284879
GeneTree	ENSGT00760000118943
HOVERGEN	HBG001595
InParanoid	P41221
KO	K00444
OMA	IVERCHC
OrthoDB	EOG7C8GJ8
PhylomeDB	P41221
TreeFam	TF105310
Reactome	REACT_163710 REACT_172581 REACT_172599 REACT_172631 REACT_172638 REACT_172761 REACT_18372 REACT_200643 REACT_200777
SignaLink	P41221
ChiTaRS	WNT5A
GeneWiki	WNT5A
GenomeRNAi	7474
NextBio	29276
PRO	PR:P41221
Proteomes	UP000005640
Bgee	P41221
CleanEx	HS_WNT5A
ExpressionAtlas	P41221
Genevestigator	P41221
GO	GO:0009986 GO:0030669 GO:0005788 GO:0005576 GO:0005615 GO:0070062 GO:0005796 GO:0005886 GO:0005578 GO:0005109 GO:0048018 GO:0005115 GO:0003700 GO:0044212 GO:0007257 GO:0000187 GO:0032148 GO:0001667 GO:0008595 GO:0007411 GO:0060070 GO:0051216 GO:0045165 GO:0034613 GO:0071277 GO:0071346 GO:0071222 GO:0071300 GO:0071560 GO:0060067 GO:0090103 GO:0060029 GO:0071542 GO:0042733 GO:0048706 GO:0060750 GO:0001837 GO:0001736 GO:0060324 GO:0048806 GO:0001947 GO:0071425 GO:0007442 GO:0048850 GO:0030216 GO:0060599 GO:0002088 GO:0030324 GO:0008584 GO:0060744 GO:0060638 GO:0007494 GO:0050919 GO:0043066 GO:0048843 GO:0030514 GO:0090090 GO:0050680 GO:0045599 GO:0040037 GO:0072201 GO:0060686 GO:0051964 GO:0045892 GO:0001843 GO:0030182 GO:0038031 GO:0021891 GO:0003408 GO:0060021 GO:0061350 GO:0061349 GO:0090179 GO:0061347 GO:0061354 GO:0061348 GO:0045766 GO:0061036 GO:2000049 GO:0030825 GO:0045080 GO:0002741 GO:0010595 GO:0001938 GO:0048146 GO:0050729 GO:0032729 GO:0050718 GO:0032755 GO:2000484 GO:0043032 GO:0060907 GO:0045836 GO:0002053 GO:0010976 GO:0051092 GO:0045778 GO:0033138 GO:0010800 GO:0045732 GO:0090037 GO:0060760 GO:0010820 GO:0070245 GO:0045944 GO:0045893 GO:0060340 GO:0036342 GO:0090009 GO:0006468 GO:0060762 GO:0010033 GO:0001756 GO:0003323 GO:0060157 GO:0060065 GO:0060068 GO:0016055 GO:0007223 GO:0042060
InterPro	IPR005817 IPR026538 IPR018161
PANTHER	PTHR12027 PTHR12027:SF33
Pfam	PF00110
PRINTS	PR01349
SMART	SM00097
PROSITE	PS00246

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0090090	negative regulation of Wnt receptor signali...		ECO:0000316			P		Source: MGI	Missing: with/from, reference
	GO:0045732	positive regulation of protein catabolic pr...		ECO:0000316			P		Source: MGI	Missing: with/from, reference
	GO:1900020	positive regulation of protein kinase C activity	PMID:12086864^[1]	ECO:0000315			P		Fig. 4 A: Wnt5a increases PKC activity. PKC activity was strongly correlated to Wnt5a expression.	complete CACAO 6628
colocalizes_with	GO:0062023	collagen-containing extracellular matrix	PMID:28327460^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0002551)	Seeded From UniProt	complete
involved_in	GO:1904469	positive regulation of tumor necrosis factor secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P22725	P	regulates_o_occurs_in:(CL:0002609) has_regulation_target:(UniProtKB:P01375)	Seeded From UniProt	complete
involved_in	GO:0050718	positive regulation of interleukin-1 beta secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P22725	P	regulates_o_occurs_in:(CL:0002609)	Seeded From UniProt	complete
involved_in	GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P22725	P	regulates_o_occurs_in:(CL:0002609)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P22725	P	regulates_expression_of:(ENSEMBL:ENSG00000100906) regulates_o_occurs_in:(CL:0002609)\|regulates_expression_of(ENSEMBL:ENSG00000006062) regulates_o_occurs_in:(CL:0002609)	Seeded From UniProt	complete
involved_in	GO:0050727	regulation of inflammatory response	PMID:21857966^[3]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1901216	positive regulation of neuron death	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P22725	P	regulates_o_occurs_in:(CL:0002609)	Seeded From UniProt	complete
involved_in	GO:0150012	positive regulation of neuron projection arborization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P22725	P	occurs_in:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:0007223	Wnt signaling pathway, calcium modulating pathway	PMID:24431302^[4]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1904934	negative regulation of cell proliferation in midbrain	PMID:24431302^[4]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1904953	Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation	PMID:24431302^[4]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1900020	positive regulation of protein kinase C activity	PMID:12086864^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071425	hematopoietic stem cell proliferation	PMID:9787155^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060340	positive regulation of type I interferon-mediated signaling pathway	PMID:19399181^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060324	face development	PMID:19918918^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0062009	secondary palate development	PMID:18413325^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050729	positive regulation of inflammatory response	PMID:18174455^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050718	positive regulation of interleukin-1 beta secretion	PMID:18174455^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048806	genitalia development	PMID:19918918^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048706	embryonic skeletal system development	PMID:19918918^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0048018	receptor ligand activity	PMID:18174455^[9]	ECO:0000305	curator inference used in manual assertion	GO:0005109	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:18174455^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045778	positive regulation of ossification	PMID:20032469^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045599	negative regulation of fat cell differentiation	PMID:20032469^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043032	positive regulation of macrophage activation	PMID:18174455^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032755	positive regulation of interleukin-6 production	PMID:18174455^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032148	activation of protein kinase B activity	PMID:20034610^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045745	positive regulation of G protein-coupled receptor signaling pathway	PMID:19946729^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030216	keratinocyte differentiation	PMID:19399181^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	PMID:20034610^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007257	activation of JUN kinase activity	PMID:20032469^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007257	activation of JUN kinase activity	PMID:20034610^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007223	Wnt signaling pathway, calcium modulating pathway	PMID:19946729^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:20034610^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0003408	optic cup formation involved in camera-type eye development	PMID:16258938^[13]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9YGX6	P		Seeded From UniProt	complete
involved_in	GO:0002088	lens development in camera-type eye	PMID:16258938^[13]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9YGX6	P		Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	PMID:20034610^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090037	positive regulation of protein kinase C signaling	PMID:19099253^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072201	negative regulation of mesenchymal cell proliferation	PMID:19878652^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071560	cellular response to transforming growth factor beta stimulus	PMID:15040835^[16]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071346	cellular response to interferon-gamma	PMID:18174455^[9]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071300	cellular response to retinoic acid	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56706	P		Seeded From UniProt	complete
involved_in	GO:0071277	cellular response to calcium ion	PMID:18703641^[17]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	PMID:18174455^[9]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060907	positive regulation of macrophage cytokine production	PMID:18174455^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060760	positive regulation of response to cytokine stimulus	PMID:19399181^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:18287027^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048146	positive regulation of fibroblast proliferation	PMID:19251946^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:19847889^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:19277043^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	PMID:17035633^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045080	positive regulation of chemokine biosynthetic process	PMID:19520808^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:19847889^[20]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:19251946^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042060	wound healing	PMID:19878652^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034613	cellular protein localization	PMID:19177143^[24]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56706	P		Seeded From UniProt	complete
involved_in	GO:0021891	olfactory bulb interneuron development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P22725	P		Seeded From UniProt	complete
involved_in	GO:0010976	positive regulation of neuron projection development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P22725	P		Seeded From UniProt	complete
involved_in	GO:0010820	positive regulation of T cell chemotaxis	PMID:19520808^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010595	positive regulation of endothelial cell migration	PMID:17986384^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010595	positive regulation of endothelial cell migration	PMID:17035633^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010033	response to organic substance	PMID:17486081^[26]	ECO:0000270	expression pattern evidence used in manual assertion		P	has_input:(CHEBI:50131)	Seeded From UniProt	complete
involved_in	GO:0008584	male gonad development	PMID:17848411^[27]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P22725	P	occurs_in:(CL:0000700) occurs_in:(UBERON:0001891)	Seeded From UniProt	complete
involved_in	GO:0007223	Wnt signaling pathway, calcium modulating pathway	PMID:17986384^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:19048125^[28]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:18703641^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005115	receptor tyrosine kinase-like orphan receptor binding	PMID:18287027^[18]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q01973	F		Seeded From UniProt	complete
enables	GO:0005109	frizzled binding	PMID:18174455^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q13467	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:19847889^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0002741	positive regulation of cytokine secretion involved in immune response	PMID:18174455^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001938	positive regulation of endothelial cell proliferation	PMID:17986384^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001837	epithelial to mesenchymal transition	PMID:12841867^[29]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0099566	regulation of postsynaptic cytosolic calcium ion concentration	PMID:27402827^[30]	ECO:0006063	over expression analysis evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0099566	regulation of postsynaptic cytosolic calcium ion concentration	PMID:27402827^[30]	ECO:0005589	confocal microscopy evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0099175	regulation of postsynapse organization	PMID:27402827^[30]	ECO:0006063	over expression analysis evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0099175	regulation of postsynapse organization	PMID:27402827^[30]	ECO:0005589	confocal microscopy evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:27402827^[30]	ECO:0006063	over expression analysis evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:18986540^[31]	ECO:0006063	over expression analysis evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:27402827^[30]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:18986540^[31]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0050807	regulation of synapse organization	PMID:18986540^[31]	ECO:0006063	over expression analysis evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0050807	regulation of synapse organization	PMID:18986540^[31]	ECO:0005589	confocal microscopy evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0045165	cell fate commitment	PMID:21873635^[32]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98957 PANTHER:PTN000246517 UniProtKB:P49339 ZFIN:ZDB-GENE-980526-332	P		Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	PMID:21873635^[32]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000246517 RGD:69250 UniProtKB:P56706 UniProtKB:Q98SN7	P		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	PMID:21873635^[32]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010194 MGI:MGI:108061 MGI:MGI:1197020 MGI:MGI:98953 MGI:MGI:98954 MGI:MGI:98956 MGI:MGI:98958 MGI:MGI:98960 MGI:MGI:98961 MGI:MGI:98962 PANTHER:PTN000246517 UniProtKB:P41221 UniProtKB:Q98SN7 WB:WBGene00000858 WB:WBGene00003029 ZFIN:ZDB-GENE-980526-332	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[32]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004009 MGI:MGI:98956 MGI:MGI:98957 PANTHER:PTN000246517 RGD:1311441 RGD:69250 UniProtKB:P41221 UniProtKB:P56704 UniProtKB:P56705 UniProtKB:Q2LMP1 UniProtKB:Q9UBV4 UniProtKB:Q9YGX6	C		Seeded From UniProt	complete
enables	GO:0005109	frizzled binding	PMID:21873635^[32]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004009 FB:FBgn0004360 FB:FBgn0010453 FB:FBgn0038134 MGI:MGI:98956 MGI:MGI:98957 MGI:MGI:98958 MGI:MGI:98961 MGI:MGI:98962 PANTHER:PTN000246517 RGD:69079 UniProtKB:P09544 UniProtKB:P41221 UniProtKB:P56703 UniProtKB:Q98SN7	F		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:12952940^[33]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P25054	P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:12952940^[33]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:O43255	P		Seeded From UniProt	complete
involved_in	GO:0045732	positive regulation of protein catabolic process	PMID:12952940^[33]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P25054	P		Seeded From UniProt	complete
involved_in	GO:0045732	positive regulation of protein catabolic process	PMID:12952940^[33]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:O43255	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0048018	P		Seeded From UniProt	complete
part_of	GO:0098794	postsynapse	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0099566	C		Seeded From UniProt	complete
part_of	GO:0098794	postsynapse	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0099566	C		Seeded From UniProt	complete
involved_in	GO:2000484	positive regulation of interleukin-8 secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:2000052	positive regulation of non-canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:2000049	positive regulation of cell-cell adhesion mediated by cadherin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:1904953	Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:1904948	midbrain dopaminergic neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:1904938	planar cell polarity pathway involved in axon guidance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:1904934	negative regulation of cell proliferation in midbrain	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:1904469	positive regulation of tumor necrosis factor secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:1903827	regulation of cellular protein localization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
enables	GO:1902379	chemoattractant activity involved in axon guidance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	F		Seeded From UniProt	complete
involved_in	GO:1901216	positive regulation of neuron death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0150012	positive regulation of neuron projection arborization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0097325	melanocyte proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0090630	activation of GTPase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0090179	planar cell polarity pathway involved in neural tube closure	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0090103	cochlea morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0090009	primitive streak formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0071542	dopaminergic neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0071425	hematopoietic stem cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0071219	cellular response to molecule of bacterial origin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0070245	positive regulation of thymocyte apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0061354	planar cell polarity pathway involved in pericardium morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0061350	planar cell polarity pathway involved in cardiac muscle tissue morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0061349	planar cell polarity pathway involved in cardiac right atrium morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0061348	planar cell polarity pathway involved in ventricular septum morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0061347	planar cell polarity pathway involved in outflow tract morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0061053	somite development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0061036	positive regulation of cartilage development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0060809	mesodermal to mesenchymal transition involved in gastrulation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0060775	planar cell polarity pathway involved in gastrula mediolateral intercalation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0060762	regulation of branching involved in mammary gland duct morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0060750	epithelial cell proliferation involved in mammary gland duct elongation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0060744	mammary gland branching involved in thelarche	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0060686	negative regulation of prostatic bud formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0060638	mesenchymal-epithelial cell signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0060606	tube closure	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0060599	lateral sprouting involved in mammary gland duct morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0060157	urinary bladder development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0060071	Wnt signaling pathway, planar cell polarity pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0060068	vagina development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0060067	cervix development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0060065	uterus development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0060029	convergent extension involved in organogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0060028	convergent extension involved in axis elongation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0060026	convergent extension	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0051964	negative regulation of synapse assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0051885	positive regulation of timing of anagen	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0050919	negative chemotaxis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0050718	positive regulation of interleukin-1 beta secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0050680	negative regulation of epithelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0050679	positive regulation of epithelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0048850	hypophysis morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0048843	negative regulation of axon extension involved in axon guidance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0048812	neuron projection morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0048570	notochord morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0048546	digestive tract morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0048341	paraxial mesoderm formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0048022	negative regulation of melanin biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0046546	development of primary male sexual characteristics	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0046330	positive regulation of JNK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0045860	positive regulation of protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0045836	positive regulation of meiotic nuclear division	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0045807	positive regulation of endocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0045198	establishment of epithelial cell apical/basal polarity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0043547	positive regulation of GTPase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0043507	positive regulation of JUN kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0042733	embryonic digit morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0042472	inner ear morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0038031	non-canonical Wnt signaling pathway via JNK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0036518	chemorepulsion of dopaminergic neuron axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0036517	chemoattraction of serotonergic neuron axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0036342	post-anal tail morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0035567	non-canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0035108	limb morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0034613	cellular protein localization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0033138	positive regulation of peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0032880	regulation of protein localization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0032755	positive regulation of interleukin-6 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0032729	positive regulation of interferon-gamma production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0032092	positive regulation of protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
part_of	GO:0031012	extracellular matrix	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	C		Seeded From UniProt	complete
involved_in	GO:0030901	midbrain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0030514	negative regulation of BMP signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0030326	embryonic limb morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0030324	lung development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0022008	neurogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0021915	neural tube development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0021891	olfactory bulb interneuron development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	F		Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0010976	positive regulation of neuron projection development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0010800	positive regulation of peptidyl-threonine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	C		Seeded From UniProt	complete
involved_in	GO:0009952	anterior/posterior pattern specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0008595	anterior/posterior axis specification, embryo	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0008584	male gonad development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0007494	midgut development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0007442	hindgut morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0007409	axonogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0007368	determination of left/right symmetry	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0007254	JNK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0007223	Wnt signaling pathway, calcium modulating pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	F		Seeded From UniProt	complete
enables	GO:0005109	frizzled binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	F		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	F		Seeded From UniProt	complete
involved_in	GO:0003402	planar cell polarity pathway involved in axis elongation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0003401	axis elongation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0003344	pericardium morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0003323	type B pancreatic cell development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0002053	positive regulation of mesenchymal cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0002009	morphogenesis of an epithelium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0001947	heart looping	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0001843	neural tube closure	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0001819	positive regulation of cytokine production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0001756	somitogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0001736	establishment of planar polarity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
involved_in	GO:0001667	ameboidal-type cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22725 ensembl:ENSMUSP00000064878	P		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005817	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005817	C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005817	P		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005817	P		Seeded From UniProt	complete
enables	GO:0005109	frizzled binding	PMID:25424568^[34]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	has_input:(UniProtKB:Q9ULV1)	Seeded From UniProt	complete
enables	GO:0005543	phospholipid binding	PMID:25424568^[34]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	occurs_in:(GO:0005886)	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:25424568^[34] Reactome:R-HSA-5323545 Reactome:R-HSA-5140747 Reactome:R-HSA-5140741 Reactome:R-HSA-5099899 Reactome:R-HSA-5099886 Reactome:R-HSA-3247843	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	adjacent_to:(GO:0005886)	Seeded From UniProt	complete
involved_in	GO:0099054	presynapse assembly	PMID:24449494^[35]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035567	non-canonical Wnt signaling pathway	PMID:24449494^[35]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	part_of:(GO:0099068) occurs_in:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:1904862	inhibitory synapse assembly	PMID:24449494^[35]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1904861	excitatory synapse assembly	PMID:24449494^[35]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902474	positive regulation of protein localization to synapse	PMID:24449494^[35]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	part_of:(GO:0007416)	Seeded From UniProt	complete
involved_in	GO:0099068	postsynapse assembly	PMID:24449494^[35]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060071	Wnt signaling pathway, planar cell polarity pathway	PMID:24431302^[4] Reactome:R-HSA-4086400	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	occurs_in:(CL:0000700)	Seeded From UniProt	complete
involved_in	GO:1904955	planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation	PMID:22988876^[36]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	Reactome:R-HSA-8868661 Reactome:R-HSA-8868651 Reactome:R-HSA-8868648 Reactome:R-HSA-8868236 Reactome:R-HSA-8868230 Reactome:R-HSA-8868072 Reactome:R-HSA-8868071 Reactome:R-HSA-8867756 Reactome:R-HSA-8867754 Reactome:R-HSA-8866283 Reactome:R-HSA-8866269 Reactome:R-HSA-5138459 Reactome:R-HSA-5138441 Reactome:R-HSA-5138433 Reactome:R-HSA-5138432 Reactome:R-HSA-5099899 Reactome:R-HSA-3781941	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0061024	membrane organization	Reactome:R-HSA-199991	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030669	clathrin-coated endocytic vesicle membrane	Reactome:R-HSA-5140747 Reactome:R-HSA-5138459	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030666	endocytic vesicle membrane	Reactome:R-HSA-3781943 Reactome:R-HSA-3781941	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030665	clathrin-coated vesicle membrane	Reactome:R-HSA-8871194 Reactome:R-HSA-8871193 Reactome:R-HSA-8869438 Reactome:R-HSA-8868661 Reactome:R-HSA-8868660 Reactome:R-HSA-8868659 Reactome:R-HSA-8868658	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	Reactome:R-HSA-195721	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-3781943 Reactome:R-HSA-3247844 Reactome:R-HSA-3247843	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005796	Golgi lumen	Reactome:R-HSA-3247844 Reactome:R-HSA-3247840 Reactome:R-HSA-3247837	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005788	endoplasmic reticulum lumen	Reactome:R-HSA-3247837	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0879	P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
involved_in	GO:0051216	cartilage development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0891	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Weeraratna, AT et al. (2002) Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma. Cancer Cell 1 279-88 PubMed GONUTS page
↑ Ragelle, H et al. (2017) Comprehensive proteomic characterization of stem cell-derived extracellular matrices. Biomaterials 128 147-159 PubMed GONUTS page
↑ Li, B et al. (2011) WNT5A signaling contributes to Aβ-induced neuroinflammation and neurotoxicity. PLoS ONE 6 e22920 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Arenas, E (2014) Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease. J Mol Cell Biol 6 42-53 PubMed GONUTS page
↑ Van Den Berg, DJ et al. (1998) Role of members of the Wnt gene family in human hematopoiesis. Blood 92 3189-202 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Romanowska, M et al. (2009) Wnt5a exhibits layer-specific expression in adult skin, is upregulated in psoriasis, and synergizes with type 1 interferon. PLoS ONE 4 e5354 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Person, AD et al. (2010) WNT5A mutations in patients with autosomal dominant Robinow syndrome. Dev. Dyn. 239 327-37 PubMed GONUTS page
↑ Chiquet, BT et al. (2008) Variation in WNT genes is associated with non-syndromic cleft lip with or without cleft palate. Hum. Mol. Genet. 17 2212-8 PubMed GONUTS page
↑ ^9.00 ^9.01 ^9.02 ^9.03 ^9.04 ^9.05 ^9.06 ^9.07 ^9.08 ^9.09 ^9.10 Pereira, C et al. (2008) Wnt5A/CaMKII signaling contributes to the inflammatory response of macrophages and is a target for the antiinflammatory action of activated protein C and interleukin-10. Arterioscler. Thromb. Vasc. Biol. 28 504-10 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Bilkovski, R et al. (2010) Role of WNT-5a in the determination of human mesenchymal stem cells into preadipocytes. J. Biol. Chem. 285 6170-8 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 Peng, L et al. (2010) Expression of Wnt5a in tooth germs and the related signal transduction analysis. Arch. Oral Biol. 55 108-14 PubMed GONUTS page
↑ ^12.0 ^12.1 Bazhin, AV et al. (2010) cGMP-phosphodiesterase 6, transducin and Wnt5a/Frizzled-2-signaling control cGMP and Ca(2+) homeostasis in melanoma cells. Cell. Mol. Life Sci. 67 817-28 PubMed GONUTS page
↑ ^13.0 ^13.1 Fokina, VM & Frolova, EI (2006) Expression patterns of Wnt genes during development of an anterior part of the chicken eye. Dev. Dyn. 235 496-505 PubMed GONUTS page
↑ Dissanayake, SK & Weeraratna, AT (2008) Detecting PKC phosphorylation as part of the Wnt/calcium pathway in cutaneous melanoma. Methods Mol. Biol. 468 157-72 PubMed GONUTS page
↑ ^15.0 ^15.1 Peng, L et al. (2009) WNT5A inhibits human dental papilla cell proliferation and migration. Biochem. Biophys. Res. Commun. 390 1072-8 PubMed GONUTS page
↑ Zhou, S et al. (2004) Cooperation between TGF-beta and Wnt pathways during chondrocyte and adipocyte differentiation of human marrow stromal cells. J. Bone Miner. Res. 19 463-70 PubMed GONUTS page
↑ ^17.0 ^17.1 Pacheco, II & Macleod, RJ (2008) CaSR stimulates secretion of Wnt5a from colonic myofibroblasts to stimulate CDX2 and sucrase-isomaltase using Ror2 on intestinal epithelia. Am. J. Physiol. Gastrointest. Liver Physiol. 295 G748-59 PubMed GONUTS page
↑ ^18.0 ^18.1 Fukuda, T et al. (2008) Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal antigen and receptor for Wnt5a. Proc. Natl. Acad. Sci. U.S.A. 105 3047-52 PubMed GONUTS page
↑ ^19.0 ^19.1 Vuga, LJ et al. (2009) WNT5A is a regulator of fibroblast proliferation and resistance to apoptosis. Am. J. Respir. Cell Mol. Biol. 41 583-9 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 Pizzatti, L et al. (2010) SUZ12 is a candidate target of the non-canonical WNT pathway in the progression of chronic myeloid leukemia. Genes Chromosomes Cancer 49 107-18 PubMed GONUTS page
↑ Kawano, Y et al. (2009) Secreted Frizzled-related protein-1 is a negative regulator of androgen receptor activity in prostate cancer. Br. J. Cancer 100 1165-74 PubMed GONUTS page
↑ ^22.0 ^22.1 Masckauchán, TN et al. (2006) Wnt5a signaling induces proliferation and survival of endothelial cells in vitro and expression of MMP-1 and Tie-2. Mol. Biol. Cell 17 5163-72 PubMed GONUTS page
↑ ^23.0 ^23.1 Ghosh, MC et al. (2009) Activation of Wnt5A signaling is required for CXC chemokine ligand 12-mediated T-cell migration. Blood 114 1366-73 PubMed GONUTS page
↑ O'Connell, MP et al. (2009) Wnt5A activates the calpain-mediated cleavage of filamin A. J. Invest. Dermatol. 129 1782-9 PubMed GONUTS page
↑ ^25.0 ^25.1 ^25.2 Cheng, CW et al. (2008) Wnt5a-mediated non-canonical Wnt signalling regulates human endothelial cell proliferation and migration. Biochem. Biophys. Res. Commun. 365 285-90 PubMed GONUTS page
↑ Wang, Q et al. (2007) Hypomethylation of WNT5A, CRIP1 and S100P in prostate cancer. Oncogene 26 6560-5 PubMed GONUTS page
↑ O'Shaughnessy, PJ et al. (2007) Developmental changes in human fetal testicular cell numbers and messenger ribonucleic acid levels during the second trimester. J. Clin. Endocrinol. Metab. 92 4792-801 PubMed GONUTS page
↑ Tamimi, Y et al. (2008) WNT5A is regulated by PAX2 and may be involved in blastemal predominant Wilms tumorigenesis. Neoplasia 10 1470-80 PubMed GONUTS page
↑ Taki, M et al. (2003) Down-regulation of Wnt-4 and up-regulation of Wnt-5a expression by epithelial-mesenchymal transition in human squamous carcinoma cells. Cancer Sci. 94 593-7 PubMed GONUTS page
↑ ^30.0 ^30.1 ^30.2 ^30.3 ^30.4 ^30.5 Ramírez, VT et al. (2016) Wnt-5a/Frizzled9 Receptor Signaling through the Gαo-Gβγ Complex Regulates Dendritic Spine Formation. J. Biol. Chem. 291 19092-107 PubMed GONUTS page
↑ ^31.0 ^31.1 ^31.2 ^31.3 Davis, EK et al. (2008) Wnts acting through canonical and noncanonical signaling pathways exert opposite effects on hippocampal synapse formation. Neural Dev 3 32 PubMed GONUTS page
↑ ^32.0 ^32.1 ^32.2 ^32.3 ^32.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^33.0 ^33.1 ^33.2 ^33.3 Topol, L et al. (2003) Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation. J. Cell Biol. 162 899-908 PubMed GONUTS page
↑ ^34.0 ^34.1 ^34.2 Bian, WJ et al. (2015) A novel Wnt5a-Frizzled4 signaling pathway mediates activity-independent dendrite morphogenesis via the distal PDZ motif of Frizzled 4. Dev Neurobiol 75 805-22 PubMed GONUTS page
↑ ^35.0 ^35.1 ^35.2 ^35.3 ^35.4 ^35.5 Purro, SA et al. (2014) Dysfunction of Wnt signaling and synaptic disassembly in neurodegenerative diseases. J Mol Cell Biol 6 75-80 PubMed GONUTS page
↑ Berwick, DC & Harvey, K (2012) The importance of Wnt signalling for neurodegeneration in Parkinson's disease. Biochem. Soc. Trans. 40 1123-8 PubMed GONUTS page

[PMID:12086864-1] 1.0 ^1.1 Weeraratna, AT et al. (2002) Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma. Cancer Cell 1 279-88 PubMed GONUTS page

[PMID:28327460-2] Ragelle, H et al. (2017) Comprehensive proteomic characterization of stem cell-derived extracellular matrices. Biomaterials 128 147-159 PubMed GONUTS page

[PMID:21857966-3] Li, B et al. (2011) WNT5A signaling contributes to Aβ-induced neuroinflammation and neurotoxicity. PLoS ONE 6 e22920 PubMed GONUTS page

[PMID:24431302-4] 4.0 ^4.1 ^4.2 ^4.3 Arenas, E (2014) Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease. J Mol Cell Biol 6 42-53 PubMed GONUTS page

[PMID:9787155-5] Van Den Berg, DJ et al. (1998) Role of members of the Wnt gene family in human hematopoiesis. Blood 92 3189-202 PubMed GONUTS page

[PMID:19399181-6] 6.0 ^6.1 ^6.2 Romanowska, M et al. (2009) Wnt5a exhibits layer-specific expression in adult skin, is upregulated in psoriasis, and synergizes with type 1 interferon. PLoS ONE 4 e5354 PubMed GONUTS page

[PMID:19918918-7] 7.0 ^7.1 ^7.2 Person, AD et al. (2010) WNT5A mutations in patients with autosomal dominant Robinow syndrome. Dev. Dyn. 239 327-37 PubMed GONUTS page

[PMID:18413325-8] Chiquet, BT et al. (2008) Variation in WNT genes is associated with non-syndromic cleft lip with or without cleft palate. Hum. Mol. Genet. 17 2212-8 PubMed GONUTS page

[PMID:18174455-9] 9.00 ^9.01 ^9.02 ^9.03 ^9.04 ^9.05 ^9.06 ^9.07 ^9.08 ^9.09 ^9.10 Pereira, C et al. (2008) Wnt5A/CaMKII signaling contributes to the inflammatory response of macrophages and is a target for the antiinflammatory action of activated protein C and interleukin-10. Arterioscler. Thromb. Vasc. Biol. 28 504-10 PubMed GONUTS page

[PMID:20032469-10] 10.0 ^10.1 ^10.2 Bilkovski, R et al. (2010) Role of WNT-5a in the determination of human mesenchymal stem cells into preadipocytes. J. Biol. Chem. 285 6170-8 PubMed GONUTS page

[PMID:20034610-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 Peng, L et al. (2010) Expression of Wnt5a in tooth germs and the related signal transduction analysis. Arch. Oral Biol. 55 108-14 PubMed GONUTS page

[PMID:19946729-12] 12.0 ^12.1 Bazhin, AV et al. (2010) cGMP-phosphodiesterase 6, transducin and Wnt5a/Frizzled-2-signaling control cGMP and Ca(2+) homeostasis in melanoma cells. Cell. Mol. Life Sci. 67 817-28 PubMed GONUTS page

[PMID:16258938-13] 13.0 ^13.1 Fokina, VM & Frolova, EI (2006) Expression patterns of Wnt genes during development of an anterior part of the chicken eye. Dev. Dyn. 235 496-505 PubMed GONUTS page

[PMID:19099253-14] Dissanayake, SK & Weeraratna, AT (2008) Detecting PKC phosphorylation as part of the Wnt/calcium pathway in cutaneous melanoma. Methods Mol. Biol. 468 157-72 PubMed GONUTS page

[PMID:19878652-15] 15.0 ^15.1 Peng, L et al. (2009) WNT5A inhibits human dental papilla cell proliferation and migration. Biochem. Biophys. Res. Commun. 390 1072-8 PubMed GONUTS page

[PMID:15040835-16] Zhou, S et al. (2004) Cooperation between TGF-beta and Wnt pathways during chondrocyte and adipocyte differentiation of human marrow stromal cells. J. Bone Miner. Res. 19 463-70 PubMed GONUTS page

[PMID:18703641-17] 17.0 ^17.1 Pacheco, II & Macleod, RJ (2008) CaSR stimulates secretion of Wnt5a from colonic myofibroblasts to stimulate CDX2 and sucrase-isomaltase using Ror2 on intestinal epithelia. Am. J. Physiol. Gastrointest. Liver Physiol. 295 G748-59 PubMed GONUTS page

[PMID:18287027-18] 18.0 ^18.1 Fukuda, T et al. (2008) Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal antigen and receptor for Wnt5a. Proc. Natl. Acad. Sci. U.S.A. 105 3047-52 PubMed GONUTS page

[PMID:19251946-19] 19.0 ^19.1 Vuga, LJ et al. (2009) WNT5A is a regulator of fibroblast proliferation and resistance to apoptosis. Am. J. Respir. Cell Mol. Biol. 41 583-9 PubMed GONUTS page

[PMID:19847889-20] 20.0 ^20.1 ^20.2 Pizzatti, L et al. (2010) SUZ12 is a candidate target of the non-canonical WNT pathway in the progression of chronic myeloid leukemia. Genes Chromosomes Cancer 49 107-18 PubMed GONUTS page

[PMID:19277043-21] Kawano, Y et al. (2009) Secreted Frizzled-related protein-1 is a negative regulator of androgen receptor activity in prostate cancer. Br. J. Cancer 100 1165-74 PubMed GONUTS page

[PMID:17035633-22] 22.0 ^22.1 Masckauchán, TN et al. (2006) Wnt5a signaling induces proliferation and survival of endothelial cells in vitro and expression of MMP-1 and Tie-2. Mol. Biol. Cell 17 5163-72 PubMed GONUTS page

[PMID:19520808-23] 23.0 ^23.1 Ghosh, MC et al. (2009) Activation of Wnt5A signaling is required for CXC chemokine ligand 12-mediated T-cell migration. Blood 114 1366-73 PubMed GONUTS page

[PMID:19177143-24] O'Connell, MP et al. (2009) Wnt5A activates the calpain-mediated cleavage of filamin A. J. Invest. Dermatol. 129 1782-9 PubMed GONUTS page

[PMID:17986384-25] 25.0 ^25.1 ^25.2 Cheng, CW et al. (2008) Wnt5a-mediated non-canonical Wnt signalling regulates human endothelial cell proliferation and migration. Biochem. Biophys. Res. Commun. 365 285-90 PubMed GONUTS page

[PMID:17486081-26] Wang, Q et al. (2007) Hypomethylation of WNT5A, CRIP1 and S100P in prostate cancer. Oncogene 26 6560-5 PubMed GONUTS page

[PMID:17848411-27] O'Shaughnessy, PJ et al. (2007) Developmental changes in human fetal testicular cell numbers and messenger ribonucleic acid levels during the second trimester. J. Clin. Endocrinol. Metab. 92 4792-801 PubMed GONUTS page

[PMID:19048125-28] Tamimi, Y et al. (2008) WNT5A is regulated by PAX2 and may be involved in blastemal predominant Wilms tumorigenesis. Neoplasia 10 1470-80 PubMed GONUTS page

[PMID:12841867-29] Taki, M et al. (2003) Down-regulation of Wnt-4 and up-regulation of Wnt-5a expression by epithelial-mesenchymal transition in human squamous carcinoma cells. Cancer Sci. 94 593-7 PubMed GONUTS page

[PMID:27402827-30] 30.0 ^30.1 ^30.2 ^30.3 ^30.4 ^30.5 Ramírez, VT et al. (2016) Wnt-5a/Frizzled9 Receptor Signaling through the Gαo-Gβγ Complex Regulates Dendritic Spine Formation. J. Biol. Chem. 291 19092-107 PubMed GONUTS page

[PMID:18986540-31] 31.0 ^31.1 ^31.2 ^31.3 Davis, EK et al. (2008) Wnts acting through canonical and noncanonical signaling pathways exert opposite effects on hippocampal synapse formation. Neural Dev 3 32 PubMed GONUTS page

[PMID:21873635-32] 32.0 ^32.1 ^32.2 ^32.3 ^32.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:12952940-33] 33.0 ^33.1 ^33.2 ^33.3 Topol, L et al. (2003) Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation. J. Cell Biol. 162 899-908 PubMed GONUTS page

[PMID:25424568-34] 34.0 ^34.1 ^34.2 Bian, WJ et al. (2015) A novel Wnt5a-Frizzled4 signaling pathway mediates activity-independent dendrite morphogenesis via the distal PDZ motif of Frizzled 4. Dev Neurobiol 75 805-22 PubMed GONUTS page

[PMID:24449494-35] 35.0 ^35.1 ^35.2 ^35.3 ^35.4 ^35.5 Purro, SA et al. (2014) Dysfunction of Wnt signaling and synaptic disassembly in neurodegenerative diseases. J Mol Cell Biol 6 75-80 PubMed GONUTS page

[PMID:22988876-36] Berwick, DC & Harvey, K (2012) The importance of Wnt signalling for neurodegeneration in Parkinson's disease. Biochem. Soc. Trans. 40 1123-8 PubMed GONUTS page

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