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PMID:22988876

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Citation

Berwick, DC and Harvey, K (2012) The importance of Wnt signalling for neurodegeneration in Parkinson's disease. Biochem. Soc. Trans. 40:1123-8

Abstract

PD (Parkinson's disease) is a devastating progressive motor disorder with no available cure. Over the last two decades, an increasing number of genetic defects have been found that cause familial and idiopathic forms of PD. In parallel, the importance of Wnt signalling pathways for the healthy functioning of the adult brain and the dysregulation of these pathways in neurodegenerative disease has become apparent. Cell biological functions disrupted in PD are partially controlled by Wnt signalling pathways and proteins encoded by PARK genes have been shown to modify Wnt signalling. This suggests the prospect of targeting Wnt signalling pathways to modify PD progression.

Links

PubMed Online version:10.1042/BST20120122

Keywords

Animals; Dopaminergic Neurons/metabolism; Dopaminergic Neurons/pathology; Humans; Parkinson Disease/genetics; Parkinson Disease/metabolism; Parkinson Disease/pathology; Wnt Signaling Pathway

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:WNT7A

involved_in

GO:0036465: synaptic vesicle recycling

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:PRKN

involved_in

GO:0045732: positive regulation of protein catabolic process

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:PRKN

involved_in

GO:0090090: negative regulation of canonical Wnt signaling pathway

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:LRP5

part_of

GO:1990851: Wnt-Frizzled-LRP5/6 complex

ECO:0000304: author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

HUMAN:LRP6

part_of

GO:1990851: Wnt-Frizzled-LRP5/6 complex

ECO:0000304: author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

HUMAN:LRP6

enables

GO:0017147: Wnt-protein binding

ECO:0000304: author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

HUMAN:LRP6

involved_in

GO:0060070: canonical Wnt signaling pathway

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:LRP6

involved_in

GO:1904948: midbrain dopaminergic neuron differentiation

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:DKK1

enables

GO:0039706: co-receptor binding

ECO:0000304: author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

HUMAN:NR4A2

enables

GO:0008013: beta-catenin binding

ECO:0000304: author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

HUMAN:NR4A2

involved_in

GO:0000122: negative regulation of transcription by RNA polymerase II

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

  • has_input:(UniProtKB:P37840)

Seeded From UniProt

complete

HUMAN:NR4A2

involved_in

GO:1904948: midbrain dopaminergic neuron differentiation

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:GSK3B

enables

GO:0004672: protein kinase activity

ECO:0000304: author statement supported by traceable reference used in manual assertion

F

  • has_input:(UniProtKB:P10636)

Seeded From UniProt

complete

HUMAN:WNT3A

involved_in

GO:0036465: synaptic vesicle recycling

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:APOE

involved_in

GO:0090090: negative regulation of canonical Wnt signaling pathway

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:WNT1

involved_in

GO:1904954: canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:WNT3A

involved_in

GO:1904953: Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:WNT3A

involved_in

GO:0036465: synaptic vesicle recycling

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

occurs_at:(GO:0098793)

Seeded From UniProt

complete

HUMAN:WNT5A

involved_in

GO:1904955: planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:WNT7A

involved_in

GO:0036465: synaptic vesicle recycling

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

occurs_at:(GO:0098793)

Seeded From UniProt

complete

HUMAN:PRKN2

involved_in

GO:0045732: positive regulation of protein catabolic process

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

  • has_regulation_target:(UniProtKB:P35222)
  • part_of:(GO:0090090)

Seeded From UniProt

complete

HUMAN:PRKN2

involved_in

GO:0090090: negative regulation of canonical Wnt signaling pathway

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:GSK3B

enables

GO:0004672: protein kinase activity

ECO:0000304: author statement supported by traceable reference used in manual assertion



F

Seeded From UniProt

complete

HUMAN:DKK1

enables

GO:0039706: co-receptor binding

ECO:0000304: author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

HUMAN:LRRK2

involved_in

GO:0060828: regulation of canonical Wnt signaling pathway

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:LRP5

enables

GO:0017147: Wnt-protein binding

ECO:0000304: author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

Notes

See also

References

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