GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

PMID:19399181

From GONUTS
Jump to: navigation, search
Citation

Romanowska, M, Evans, A, Kellock, D, Bray, SE, McLean, K, Donandt, S and Foerster, J (2009) Wnt5a exhibits layer-specific expression in adult skin, is upregulated in psoriasis, and synergizes with type 1 interferon. PLoS ONE 4:e5354

Abstract

Wnt5a is a member of the wingless-type patterning regulators important in pre-natal development. The expression and distribution of Wnt5a and its receptors frizzled (fzd) 3 and fzd 5 in adult human skin have not been comprehensively studied to date.

Links

PubMed PMC2670517 Online version:10.1371/journal.pone.0005354

Keywords

Adult; Amyloid beta-Protein Precursor/biosynthesis; Cells, Cultured; Frizzled Receptors/genetics; Frizzled Receptors/metabolism; Gene Expression; Humans; Interferon Type I/genetics; Interferon Type I/metabolism; Interferon Type I/pharmacology; Keratinocytes/drug effects; Keratinocytes/metabolism; Protease Nexins; Proto-Oncogene Proteins/genetics; Proto-Oncogene Proteins/metabolism; Psoriasis/genetics; Psoriasis/metabolism; Psoriasis/pathology; Receptors, Cell Surface/biosynthesis; Recombinant Proteins; Skin/anatomy & histology; Skin/drug effects; Skin/metabolism; Tissue Distribution; Transfection; Ubiquitins/biosynthesis; Up-Regulation; Wnt Proteins/genetics; Wnt Proteins/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:WNT5A

involved_in

GO:0060760: positive regulation of response to cytokine stimulus

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:WNT5A

involved_in

GO:0030216: keratinocyte differentiation

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:WNT5A

involved_in

GO:0060340: positive regulation of type I interferon-mediated signaling pathway

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

See Help:References for how to manage references in GONUTS.