GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
HUMAN:TNFA
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | TNF (synonyms: TNFA, TNFSF2) | |
| Protein Name(s) | Tumor necrosis factor
Cachectin TNF-alpha Tumor necrosis factor ligand superfamily member 2 TNF-a Tumor necrosis factor, membrane form N-terminal fragment NTF Intracellular domain 1 ICD1 Intracellular domain 2 ICD2 C-domain 1 C-domain 2 Tumor necrosis factor, soluble form | |
| External Links | ||
| UniProt | P01375 | |
| EMBL | M16441 X02910 X01394 M10988 M26331 Z15026 Y14768 AF129756 BA000025 AB088112 AY066019 AY214167 BC028148 AF043342 AF098751 | |
| CCDS | CCDS4702.1 | |
| PIR | A93585 | |
| RefSeq | NP_000585.2 | |
| UniGene | Hs.241570 | |
| PDB | 1A8M 1TNF 2AZ5 2E7A 2TUN 2ZJC 2ZPX 3ALQ 3IT8 3L9J 3WD5 4G3Y 4TSV 5TSW | |
| PDBsum | 1A8M 1TNF 2AZ5 2E7A 2TUN 2ZJC 2ZPX 3ALQ 3IT8 3L9J 3WD5 4G3Y 4TSV 5TSW | |
| ProteinModelPortal | P01375 | |
| SMR | P01375 | |
| BioGrid | 112979 | |
| DIP | DIP-2895N | |
| IntAct | P01375 | |
| MINT | MINT-1131842 | |
| STRING | 9606.ENSP00000392858 | |
| BindingDB | P01375 | |
| ChEMBL | CHEMBL1825 | |
| DrugBank | DB00051 DB01427 DB08904 DB00608 DB01407 DB00668 DB00005 DB01296 DB06674 DB00065 DB08910 DB01411 DB00852 DB01041 | |
| GuidetoPHARMACOLOGY | 2635 | |
| PhosphoSite | P01375 | |
| UniCarbKB | P01375 | |
| DMDM | 135934 | |
| PaxDb | P01375 | |
| PRIDE | P01375 | |
| DNASU | 7124 | |
| Ensembl | ENST00000376122 ENST00000383496 ENST00000412275 ENST00000420425 ENST00000443707 ENST00000448781 ENST00000449264 | |
| GeneID | 7124 | |
| KEGG | hsa:7124 | |
| UCSC | uc003nui.4 | |
| CTD | 7124 | |
| GeneCards | GC06P031543 GC06Pj31530 GC06Pk31525 GC06Pl31582 GC06Pm31619 GC06Pn31533 GC06Po31533 | |
| H-InvDB | HIX0165948 | |
| HGNC | HGNC:11892 | |
| MIM | 191160 607507 610424 611162 | |
| neXtProt | NX_P01375 | |
| Orphanet | 40050 | |
| PharmGKB | PA435 | |
| eggNOG | NOG40413 | |
| HOGENOM | HOG000048729 | |
| HOVERGEN | HBG012516 | |
| InParanoid | P01375 | |
| KO | K03156 | |
| OMA | PWYEPIY | |
| OrthoDB | EOG7V4B0Q | |
| PhylomeDB | P01375 | |
| TreeFam | TF332169 | |
| Reactome | REACT_1432 REACT_27161 | |
| ChiTaRS | TNF | |
| EvolutionaryTrace | P01375 | |
| GeneWiki | Tumor_necrosis_factor-alpha | |
| GenomeRNAi | 7124 | |
| NextBio | 27879 | |
| PMAP-CutDB | P01375 | |
| PRO | PR:P01375 | |
| Proteomes | UP000005640 UP000005640 | |
| Bgee | P01375 | |
| CleanEx | HS_TNF | |
| ExpressionAtlas | P01375 | |
| Genevestigator | P01375 | |
| GO | GO:0009986 GO:0009897 GO:0005576 GO:0005615 GO:0005887 GO:0045121 GO:0001891 GO:0005886 GO:0055037 GO:0005125 GO:0042802 GO:0002020 GO:0044212 GO:0005164 GO:0006919 GO:0000187 GO:0000185 GO:0006915 GO:0097190 GO:0019722 GO:0001775 GO:0071230 GO:0071316 GO:0071407 GO:0002439 GO:0050830 GO:0050966 GO:0048566 GO:0060664 GO:0030198 GO:0097191 GO:0008625 GO:0006006 GO:0006959 GO:0006954 GO:0008630 GO:0007254 GO:0050901 GO:0031663 GO:0000165 GO:0097527 GO:0010693 GO:0061048 GO:0008285 GO:0002740 GO:2001240 GO:0045599 GO:0010629 GO:0046325 GO:0044130 GO:0032715 GO:0002037 GO:0050995 GO:0010888 GO:0045668 GO:0043242 GO:0000122 GO:0045892 GO:0045071 GO:0009887 GO:0030316 GO:0045760 GO:0043065 GO:0060559 GO:2000343 GO:0045080 GO:0032722 GO:0002876 GO:0043280 GO:0001819 GO:0050715 GO:0070374 GO:0031622 GO:0010628 GO:0051798 GO:0034116 GO:0002925 GO:0043123 GO:0032729 GO:0032741 GO:0032755 GO:0045416 GO:0043507 GO:0043406 GO:0051044 GO:0045840 GO:0071677 GO:0043525 GO:0042346 GO:0051092 GO:0051533 GO:0045429 GO:0045672 GO:0033138 GO:0071803 GO:0043068 GO:0031334 GO:0043243 GO:0051897 GO:2000010 GO:0001934 GO:0051222 GO:0051091 GO:0048661 GO:0050806 GO:0045944 GO:0045893 GO:0045994 GO:0060557 GO:0000060 GO:0043491 GO:0032800 GO:0060693 GO:0043122 GO:0051023 GO:0050796 GO:2000377 GO:0014823 GO:0042493 GO:0051384 GO:1990268 GO:0001666 GO:0009314 GO:0009651 GO:0009615 GO:0030730 GO:0003009 GO:0006927 GO:0033209 | |
| Gene3D | 2.60.120.40 | |
| InterPro | IPR006053 IPR002959 IPR021184 IPR006052 IPR008983 | |
| Pfam | PF00229 | |
| PRINTS | PR01234 PR01235 | |
| SMART | SM00207 | |
| SUPFAM | SSF49842 | |
| PROSITE | PS00251 PS50049 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:1903078 |
positive regulation of protein localization to plasma membrane |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0090197 |
positive regulation of chemokine secretion |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051897 |
positive regulation of protein kinase B signaling |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0050754 |
positive regulation of fractalkine biosynthetic process |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043123 |
positive regulation of I-kappaB kinase/NF-kappaB signaling |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0014068 |
positive regulation of phosphatidylinositol 3-kinase signaling |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006357 |
regulation of transcription by RNA polymerase II |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0050806 |
positive regulation of synaptic transmission |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
regulates_o_occurs_in:(CL:0002608) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051000 |
positive regulation of nitric-oxide synthase activity |
ECO:0000305 |
curator inference used in manual assertion |
GO:0010628 |
P |
|
Seeded From UniProt |
complete | |
|
involved_in |
GO:2000778 |
positive regulation of interleukin-6 secretion |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
regulates_o_occurs_in:(CL:2000043)|regulates_o_occurs_in:(CL:0000127) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051092 |
positive regulation of NF-kappaB transcription factor activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0046427 |
positive regulation of receptor signaling pathway via JAK-STAT |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045410 |
positive regulation of interleukin-6 biosynthetic process |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
regulates_o_occurs_in:(CL:2000043) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042531 |
positive regulation of tyrosine phosphorylation of STAT protein |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0033138 |
positive regulation of peptidyl-serine phosphorylation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010628 |
positive regulation of gene expression |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010628 |
positive regulation of gene expression |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010628 |
positive regulation of gene expression |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
RNAcentral:URS00001C770D_9606 |
P |
|
Seeded From UniProt |
complete | |
|
involved_in |
GO:0032755 |
positive regulation of interleukin-6 production |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
occurs_in:(CL:0002618) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010629 |
negative regulation of gene expression |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010628 |
positive regulation of gene expression |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045598 |
regulation of fat cell differentiation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043525 |
positive regulation of neuron apoptotic process |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
part_of:(GO:0001774) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001774 |
microglial cell activation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1903078 |
positive regulation of protein localization to plasma membrane |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0050807 |
regulation of synapse organization |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0050806 |
positive regulation of synaptic transmission |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060252 |
positive regulation of glial cell proliferation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
results_in_division_of:(CL:0000129)|results_in_division_of:(CL:0000127) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060252 |
positive regulation of glial cell proliferation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
results_in_division_of:(CL:0000127) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:2000351 |
regulation of endothelial cell apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
enables |
GO:0005164 |
tumor necrosis factor receptor binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001977) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045732 |
positive regulation of protein catabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_regulation_target:(UniProtKB:Q08353) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051092 |
positive regulation of NF-kappaB transcription factor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010628 |
positive regulation of gene expression |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010628 |
positive regulation of gene expression |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010628 |
positive regulation of gene expression |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045785 |
positive regulation of cell adhesion |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010628 |
positive regulation of gene expression |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1903140 |
regulation of establishment of endothelial barrier |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043065 |
positive regulation of apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010628 |
positive regulation of gene expression |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0072659 |
protein localization to plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0035509 |
negative regulation of myosin-light-chain-phosphatase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030866 |
cortical actin cytoskeleton organization |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1903347 |
negative regulation of bicellular tight junction assembly |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1901224 |
positive regulation of NIK/NF-kappaB signaling |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_regulation_target:(UniProtKB:P23396) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010628 |
positive regulation of gene expression |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1901671 |
positive regulation of superoxide dismutase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_regulation_target:(UniProtKB:P04179) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051092 |
positive regulation of NF-kappaB transcription factor activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
has_input:(UniProtKB:Q9HC29) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045860 |
positive regulation of protein kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_regulation_target:(UniProtKB:O14920) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051092 |
positive regulation of NF-kappaB transcription factor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051092 |
positive regulation of NF-kappaB transcription factor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050766 |
positive regulation of phagocytosis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010629 |
negative regulation of gene expression |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010628 |
positive regulation of gene expression |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010628 |
positive regulation of gene expression |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010628 |
positive regulation of gene expression |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1904999 |
positive regulation of leukocyte adhesion to arterial endothelial cell |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006954 |
inflammatory response |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
occurs_in:(CL:1000413) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1904996 |
positive regulation of leukocyte adhesion to vascular endothelial cell |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010629 |
negative regulation of gene expression |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010628 |
positive regulation of gene expression |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0048143 |
astrocyte activation |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0001774 |
microglial cell activation |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010628 |
positive regulation of gene expression |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:2000334 |
positive regulation of blood microparticle formation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_agent:(CL:0000071) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032757 |
positive regulation of interleukin-8 production |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
has_input:(UniProtKB:Q9HC29) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0048566 |
embryonic digestive tract development |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010628 |
positive regulation of gene expression |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_input:(UniProtKB:Q9H6S0) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:2001240 |
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2001240 |
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2000343 |
positive regulation of chemokine (C-X-C motif) ligand 2 production |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2000010 |
positive regulation of protein localization to cell surface |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_regulation_target:(UniProtKB:P16581) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0097527 |
necroptotic signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071803 |
positive regulation of podosome assembly |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071677 |
positive regulation of mononuclear cell migration |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0070374 |
positive regulation of ERK1 and ERK2 cascade |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060559 |
positive regulation of calcidiol 1-monooxygenase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060557 |
positive regulation of vitamin D biosynthetic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0055037 |
recycling endosome |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051384 |
response to glucocorticoid |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051222 |
positive regulation of protein transport |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
| GO:0010874 |
regulation of cholesterol efflux |
ECO:0000314 |
P |
Figure 1: Human macrophages were labeled with 3H-cholesterol. TNFa was added to the cell cultures in increasing doses. apoA-I or HDL were added. The figures show that cholesterol efflux decreased in a dose-dependent manner in cells treated with TNFa. |
complete | |||||
|
involved_in |
GO:0051092 |
positive regulation of NF-kappaB transcription factor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051092 |
positive regulation of NF-kappaB transcription factor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
| GO:0010468 |
regulation of gene expression |
ECO:0000314 |
P |
Figure 1A: Human macrophages were treated with increasing doses of TNFa. Using PCR, the levels of mRNA were measured. As the dose of mRNA increased, the level of ABCA1 mRNA decreased. |
complete | |||||
|
involved_in |
GO:0051091 |
positive regulation of DNA-binding transcription factor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051044 |
positive regulation of membrane protein ectodomain proteolysis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050995 |
negative regulation of lipid catabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050901 |
leukocyte tethering or rolling |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050796 |
regulation of insulin secretion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050715 |
positive regulation of cytokine secretion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0048661 |
positive regulation of smooth muscle cell proliferation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045672 |
positive regulation of osteoclast differentiation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045599 |
negative regulation of fat cell differentiation |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045429 |
positive regulation of nitric oxide biosynthetic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045416 |
positive regulation of interleukin-8 biosynthetic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0045121 |
membrane raft |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045080 |
positive regulation of chemokine biosynthetic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045071 |
negative regulation of viral genome replication |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043406 |
positive regulation of MAP kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043406 |
positive regulation of MAP kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
occurs_in:(CL:0002618) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043243 |
positive regulation of protein complex disassembly |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043123 |
positive regulation of I-kappaB kinase/NF-kappaB signaling |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043123 |
positive regulation of I-kappaB kinase/NF-kappaB signaling |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043122 |
regulation of I-kappaB kinase/NF-kappaB signaling |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1901224 |
positive regulation of NIK/NF-kappaB signaling |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0034116 |
positive regulation of heterotypic cell-cell adhesion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0034116 |
positive regulation of heterotypic cell-cell adhesion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0033209 |
tumor necrosis factor-mediated signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0033138 |
positive regulation of peptidyl-serine phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0033138 |
positive regulation of peptidyl-serine phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
occurs_in:(CL:0002618) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032800 |
receptor biosynthetic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032722 |
positive regulation of chemokine production |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032715 |
negative regulation of interleukin-6 production |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0031622 |
positive regulation of fever generation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0031334 |
positive regulation of protein complex assembly |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030730 |
sequestering of triglyceride |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010888 |
negative regulation of lipid storage |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0009986 |
cell surface |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0009897 |
external side of plasma membrane |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009615 |
response to virus |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008625 |
extrinsic apoptotic signaling pathway via death domain receptors |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008625 |
extrinsic apoptotic signaling pathway via death domain receptors |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008625 |
extrinsic apoptotic signaling pathway via death domain receptors |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006954 |
inflammatory response |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005164 |
tumor necrosis factor receptor binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005125 |
cytokine activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0002740 |
negative regulation of cytokine secretion involved in immune response |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0002439 |
chronic inflammatory response to antigenic stimulus |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0002020 |
protease binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0001934 |
positive regulation of protein phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0001891 |
phagocytic cup |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0001819 |
positive regulation of cytokine production |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000187 |
activation of MAPK activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000185 |
activation of MAPKKK activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0097527 |
necroptotic signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0097527 |
necroptotic signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0097527 |
necroptotic signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0097191 |
extrinsic apoptotic signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0097191 |
extrinsic apoptotic signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071407 |
cellular response to organic cyclic compound |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
occurs_in:(CL:1000742) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0071316 |
cellular response to nicotine |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0061048 |
negative regulation of branching involved in lung morphogenesis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051092 |
positive regulation of NF-kappaB transcription factor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051092 |
positive regulation of NF-kappaB transcription factor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_regulation_target:(UniProtKB:P24387) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0044212 |
transcription regulatory region DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043507 |
positive regulation of JUN kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043491 |
protein kinase B signaling |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(CL:1000742) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043406 |
positive regulation of MAP kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043280 |
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043243 |
positive regulation of protein complex disassembly |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043242 |
negative regulation of protein complex disassembly |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043068 |
positive regulation of programmed cell death |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043065 |
positive regulation of apoptotic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043065 |
positive regulation of apoptotic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043065 |
positive regulation of apoptotic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0031663 |
lipopolysaccharide-mediated signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
occurs_in:(CL:1000742) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010629 |
negative regulation of gene expression |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_regulation_target:(UniProtKB:Q60571) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0008625 |
extrinsic apoptotic signaling pathway via death domain receptors |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006954 |
inflammatory response |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
occurs_in:(CL:1000742) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006919 |
activation of cysteine-type endopeptidase activity involved in apoptotic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_input:(UniProtKB:P42574)|has_input:(UniProtKB:Q14790) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001934 |
positive regulation of protein phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0001934 |
positive regulation of protein phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000165 |
MAPK cascade |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(CL:1000742) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_regulation_target:(UniProtKB:P03372)|has_input(UniProtKB:P24387) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0070886 |
positive regulation of calcineurin-NFAT signaling cascade |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051092 |
positive regulation of NF-kappaB transcription factor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0005125 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0005125 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0005125 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:2000377 |
regulation of reactive oxygen species metabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1904707 |
positive regulation of vascular smooth muscle cell proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1903078 |
positive regulation of protein localization to plasma membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1901224 |
positive regulation of NIK/NF-kappaB signaling |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0097527 |
necroptotic signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0097191 |
extrinsic apoptotic signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0097190 |
apoptotic signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0072577 |
endothelial cell apoptotic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0071230 |
cellular response to amino acid stimulus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0071222 |
cellular response to lipopolysaccharide |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060693 |
regulation of branching involved in salivary gland morphogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060664 |
epithelial cell proliferation involved in salivary gland morphogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0055037 |
recycling endosome |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051897 |
positive regulation of protein kinase B signaling |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051798 |
positive regulation of hair follicle development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051023 |
regulation of immunoglobulin secretion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0050900 |
leukocyte migration |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0050830 |
defense response to Gram-positive bacterium |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0050807 |
regulation of synapse organization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0050806 |
positive regulation of synaptic transmission |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0050727 |
regulation of inflammatory response |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0050708 |
regulation of protein secretion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0046330 |
positive regulation of JNK cascade |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0046325 |
negative regulation of glucose import |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045994 |
positive regulation of translational initiation by iron |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045930 |
negative regulation of mitotic cell cycle |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045670 |
regulation of osteoclast differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045668 |
negative regulation of osteoblast differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045662 |
negative regulation of myoblast differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045123 |
cellular extravasation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0045121 |
membrane raft |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0044130 |
negative regulation of growth of symbiont in host |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043525 |
positive regulation of neuron apoptotic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043123 |
positive regulation of I-kappaB kinase/NF-kappaB signaling |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042742 |
defense response to bacterium |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042127 |
regulation of cell population proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0034116 |
positive regulation of heterotypic cell-cell adhesion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0033209 |
tumor necrosis factor-mediated signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032755 |
positive regulation of interleukin-6 production |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032729 |
positive regulation of interferon-gamma production |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0031622 |
positive regulation of fever generation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030316 |
osteoclast differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030198 |
extracellular matrix organization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010693 |
negative regulation of alkaline phosphatase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010629 |
negative regulation of gene expression |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010628 |
positive regulation of gene expression |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010033 |
response to organic substance |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0009897 |
external side of plasma membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0009887 |
animal organ morphogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0008630 |
intrinsic apoptotic signaling pathway in response to DNA damage |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0008625 |
extrinsic apoptotic signaling pathway via death domain receptors |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007275 |
multicellular organism development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007254 |
JNK cascade |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006959 |
humoral immune response |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006954 |
inflammatory response |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006952 |
defense response |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006919 |
activation of cysteine-type endopeptidase activity involved in apoptotic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006006 |
glucose metabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005164 |
tumor necrosis factor receptor binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005125 |
cytokine activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0002925 |
positive regulation of humoral immune response mediated by circulating immunoglobulin |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0002876 |
positive regulation of chronic inflammatory response to antigenic stimulus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0002020 |
protease binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001937 |
negative regulation of endothelial cell proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001932 |
regulation of protein phosphorylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0001891 |
phagocytic cup |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001774 |
microglial cell activation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P06804 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005164 |
tumor necrosis factor receptor binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006955 |
immune response |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0005125 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0005125 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0050890 |
cognition |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051966 |
regulation of synaptic transmission, glutamatergic |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1903978 |
regulation of microglial cell activation |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0150078 |
positive regulation of neuroinflammatory response |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0050768 |
negative regulation of neurogenesis |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
has_agent:(CL:0000129) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043123 |
positive regulation of I-kappaB kinase/NF-kappaB signaling |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2000778 |
positive regulation of interleukin-6 secretion |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0050729 |
positive regulation of inflammatory response |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009651 |
response to salt stress |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2000304 |
positive regulation of ceramide biosynthetic process |
Reactome:R-HSA-5626978 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0071550 |
death-inducing signaling complex assembly |
Reactome:R-HSA-5357786 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0033209 |
tumor necrosis factor-mediated signaling pathway |
Reactome:R-HSA-75893 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
P |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0019221 |
cytokine-mediated signaling pathway |
Reactome:R-HSA-6785807 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
P |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0010803 |
regulation of tumor necrosis factor-mediated signaling pathway |
Reactome:R-HSA-5357905 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007249 |
I-kappaB kinase/NF-kappaB signaling |
Reactome:R-HSA-5357956 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
Reactome:R-HSA-8863101 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
part_of |
GO:0005576 |
extracellular region |
Reactome:R-HSA-8863101 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005125 |
cytokine activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005125 |
cytokine activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
F |
part_of:(GO:0033209) |
Seeded From UniProt |
complete | |
|
part_of |
GO:0016020 |
membrane |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
part_of:(CL:0000129)|part_of:(CL:0000127)|part_of:(CL:0000540)|part_of:(UBERON:0001017) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0032991 |
protein-containing complex |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
|
Seeded From UniProt |
complete | |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Matsumoto, J et al. (2018) TNF-α-sensitive brain pericytes activate microglia by releasing IL-6 through cooperation between IκB-NFκB and JAK-STAT3 pathways. Brain Res. 1692 34-44 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Palmieri, D et al. (2014) TNFα induces the expression of genes associated with endothelial dysfunction through p38MAPK-mediated down-regulation of miR-149. Biochem. Biophys. Res. Commun. 443 246-51 PubMed GONUTS page
- ↑ Merrill, JE (1991) Effects of interleukin-1 and tumor necrosis factor-alpha on astrocytes, microglia, oligodendrocytes, and glial precursors in vitro. Dev. Neurosci. 13 130-7 PubMed GONUTS page
- ↑ Selmaj, KW et al. (1990) Proliferation of astrocytes in vitro in response to cytokines. A primary role for tumor necrosis factor. J. Immunol. 144 129-35 PubMed GONUTS page
- ↑ Eissner, G et al. (2000) Reverse signaling through transmembrane TNF confers resistance to lipopolysaccharide in human monocytes and macrophages. J. Immunol. 164 6193-8 PubMed GONUTS page
- ↑ Grell, M et al. (1998) The type 1 receptor (CD120a) is the high-affinity receptor for soluble tumor necrosis factor. Proc. Natl. Acad. Sci. U.S.A. 95 570-5 PubMed GONUTS page
- ↑ Khan, DA et al. (2011) Pro/anti-inflammatory cytokines in the pathogenesis of premature coronary artery disease. J. Interferon Cytokine Res. 31 561-7 PubMed GONUTS page
- ↑ Doceul, V et al. (2008) The Npro product of classical swine fever virus interacts with IkappaBalpha, the NF-kappaB inhibitor. J. Gen. Virol. 89 1881-9 PubMed GONUTS page
- ↑ Azad, AK et al. (2014) Coiled-coil domain containing 3 (CCDC3) represses tumor necrosis factor-α/nuclear factor κB-induced endothelial inflammation. Cell. Signal. 26 2793-800 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 10.3 Liu, RR et al. (2015) MicroRNA-141 regulates the expression level of ICAM-1 on endothelium to decrease myocardial ischemia-reperfusion injury. Am. J. Physiol. Heart Circ. Physiol. 309 H1303-13 PubMed GONUTS page
- ↑ Harder, J et al. (2001) Isolation and characterization of human beta -defensin-3, a novel human inducible peptide antibiotic. J. Biol. Chem. 276 5707-13 PubMed GONUTS page
- ↑ 12.0 12.1 Lacal, PM et al. (2013) Glucocorticoid-induced tumor necrosis factor receptor family-related ligand triggering upregulates vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 and promotes leukocyte adhesion. J. Pharmacol. Exp. Ther. 347 164-72 PubMed GONUTS page
- ↑ Gieseke, F et al. (2013) Proinflammatory stimuli induce galectin-9 in human mesenchymal stromal cells to suppress T-cell proliferation. Eur. J. Immunol. 43 2741-9 PubMed GONUTS page
- ↑ 14.0 14.1 14.2 14.3 14.4 Clark, PR et al. (2015) Tumor necrosis factor disrupts claudin-5 endothelial tight junction barriers in two distinct NF-κB-dependent phases. PLoS ONE 10 e0120075 PubMed GONUTS page
- ↑ Wang, GH et al. (1997) Bovine herpesvirus 4 BORFE2 protein inhibits Fas- and tumor necrosis factor receptor 1-induced apoptosis and contains death effector domains shared with other gamma-2 herpesviruses. J. Virol. 71 8928-32 PubMed GONUTS page
- ↑ McDonald, C et al. (2005) A role for Erbin in the regulation of Nod2-dependent NF-kappaB signaling. J. Biol. Chem. 280 40301-9 PubMed GONUTS page
- ↑ Gao, X et al. (2009) Bacterial effector binding to ribosomal protein s3 subverts NF-kappaB function. PLoS Pathog. 5 e1000708 PubMed GONUTS page
- ↑ 18.0 18.1 18.2 Li, S et al. (2014) MicroRNA-19b functions as potential anti-thrombotic protector in patients with unstable angina by targeting tissue factor. J. Mol. Cell. Cardiol. 75 49-57 PubMed GONUTS page
- ↑ Zhang, X et al. (2012) MicroRNA-21 modulates the levels of reactive oxygen species by targeting SOD3 and TNFα. Cancer Res. 72 4707-13 PubMed GONUTS page
- ↑ 20.0 20.1 Mohanan, V & Grimes, CL (2014) The molecular chaperone HSP70 binds to and stabilizes NOD2, an important protein involved in Crohn disease. J. Biol. Chem. 289 18987-98 PubMed GONUTS page
- ↑ 21.0 21.1 Park, KJ et al. (2002) Nonstructural 5A protein of hepatitis C virus modulates tumor necrosis factor alpha-stimulated nuclear factor kappa B activation. J. Biol. Chem. 277 13122-8 PubMed GONUTS page
- ↑ Chung, YM et al. (2001) Hepatitis C virus core protein potentiates TNF-alpha-induced NF-kappaB activation through TRAF2-IKKbeta-dependent pathway. Biochem. Biophys. Res. Commun. 284 15-9 PubMed GONUTS page
- ↑ Oviedo-Boyso, J et al. (2008) Internalization of Staphylococcus aureus by bovine endothelial cells is associated with the activity state of NF-kappaB and modulated by the pro-inflammatory cytokines TNF-alpha and IL-1beta. Scand. J. Immunol. 67 169-76 PubMed GONUTS page
- ↑ 24.0 24.1 24.2 24.3 24.4 24.5 Fang, Y & Davies, PF (2012) Site-specific microRNA-92a regulation of Kruppel-like factors 4 and 2 in atherosusceptible endothelium. Arterioscler. Thromb. Vasc. Biol. 32 979-87 PubMed GONUTS page
- ↑ 25.0 25.1 25.2 Gu, Y et al. () Role of TNF in mast cell neuroinflammation and pain. J. Biol. Regul. Homeost. Agents 29 787-91 PubMed GONUTS page
- ↑ Maheshwari, A et al. (2011) TGF-β2 suppresses macrophage cytokine production and mucosal inflammatory responses in the developing intestine. Gastroenterology 140 242-53 PubMed GONUTS page
- ↑ Morohashi, K et al. (2011) Cyclosporin A associated helicase-like protein facilitates the association of hepatitis C virus RNA polymerase with its cellular cyclophilin B. PLoS ONE 6 e18285 PubMed GONUTS page
- ↑ Scheuerer, B et al. (2000) The CXC-chemokine platelet factor 4 promotes monocyte survival and induces monocyte differentiation into macrophages. Blood 95 1158-66 PubMed GONUTS page
- ↑ 29.0 29.1 29.2 29.3 29.4 29.5 29.6 29.7 29.8 Madge, LA & Pober, JS (2000) A phosphatidylinositol 3-kinase/Akt pathway, activated by tumor necrosis factor or interleukin-1, inhibits apoptosis but does not activate NFkappaB in human endothelial cells. J. Biol. Chem. 275 15458-65 PubMed GONUTS page
- ↑ 30.0 30.1 30.2 30.3 30.4 Ohnesorge, N et al. (2010) Erk5 activation elicits a vasoprotective endothelial phenotype via induction of Kruppel-like factor 4 (KLF4). J. Biol. Chem. 285 26199-210 PubMed GONUTS page
- ↑ Upton, PD et al. (2009) Bone morphogenetic protein (BMP) and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase-1 in human pulmonary artery endothelial cells. J. Biol. Chem. 284 15794-804 PubMed GONUTS page
- ↑ Holler, N et al. (2000) Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule. Nat. Immunol. 1 489-95 PubMed GONUTS page
- ↑ Johansson, MW et al. (2004) Eosinophils adhere to vascular cell adhesion molecule-1 via podosomes. Am. J. Respir. Cell Mol. Biol. 31 413-22 PubMed GONUTS page
- ↑ 34.0 34.1 Bramlage, CP et al. () The role of bone morphogenetic protein-5 (BMP-5) in human nephrosclerosis. J. Nephrol. 24 647-55 PubMed GONUTS page
- ↑ Guerrini, MM et al. (2008) Human osteoclast-poor osteopetrosis with hypogammaglobulinemia due to TNFRSF11A (RANK) mutations. Am. J. Hum. Genet. 83 64-76 PubMed GONUTS page
- ↑ 36.0 36.1 Pryke, AM et al. (1990) Tumor necrosis factor-alpha induces vitamin D-1-hydroxylase activity in normal human alveolar macrophages. J. Cell. Physiol. 142 652-6 PubMed GONUTS page
- ↑ 37.0 37.1 37.2 37.3 37.4 37.5 Franchimont, D et al. (1999) Tumor necrosis factor alpha decreases, and interleukin-10 increases, the sensitivity of human monocytes to dexamethasone: potential regulation of the glucocorticoid receptor. J. Clin. Endocrinol. Metab. 84 2834-9 PubMed GONUTS page
- ↑ 38.0 38.1 38.2 Zhang, H et al. (2004) AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation. J. Biol. Chem. 279 44955-65 PubMed GONUTS page
- ↑ 39.0 39.1 Ma, AZ et al. (2013) TNFa alter cholesterol metabolism in human macrophages via PKC-θ-dependent pathway. BMC Biochem. 14 20 PubMed GONUTS page
- ↑ Wesche, H et al. (1999) IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family. J. Biol. Chem. 274 19403-10 PubMed GONUTS page
- ↑ Schramme, A et al. (2008) The role of CXCL16 and its processing metalloproteinases ADAM10 and ADAM17 in the proliferation and migration of human mesangial cells. Biochem. Biophys. Res. Commun. 370 311-6 PubMed GONUTS page
- ↑ 42.0 42.1 Persson, J et al. (2008) Interleukin-1beta and tumour necrosis factor-alpha impede neutral lipid turnover in macrophage-derived foam cells. BMC Immunol. 9 70 PubMed GONUTS page
- ↑ Luu, NT et al. (2000) Differential ability of exogenous chemotactic agents to disrupt transendothelial migration of flowing neutrophils. J. Immunol. 164 5961-9 PubMed GONUTS page
- ↑ 44.0 44.1 Corbett, JA et al. (1993) Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans. Proc. Natl. Acad. Sci. U.S.A. 90 1731-5 PubMed GONUTS page
- ↑ Zhang, HS & Wang, SQ (2006) Ginsenoside Rg1 inhibits tumor necrosis factor-alpha (TNF-alpha)-induced human arterial smooth muscle cells (HASMCs) proliferation. J. Cell. Biochem. 98 1471-81 PubMed GONUTS page
- ↑ 46.0 46.1 46.2 46.3 Steed, PM et al. (2003) Inactivation of TNF signaling by rationally designed dominant-negative TNF variants. Science 301 1895-8 PubMed GONUTS page
- ↑ Yago, T et al. (2007) IL-23 induces human osteoclastogenesis via IL-17 in vitro, and anti-IL-23 antibody attenuates collagen-induced arthritis in rats. Arthritis Res. Ther. 9 R96 PubMed GONUTS page
- ↑ 48.0 48.1 Gustafson, B & Smith, U (2006) Cytokines promote Wnt signaling and inflammation and impair the normal differentiation and lipid accumulation in 3T3-L1 preadipocytes. J. Biol. Chem. 281 9507-16 PubMed GONUTS page
- ↑ Tellier, E et al. (2006) The shedding activity of ADAM17 is sequestered in lipid rafts. Exp. Cell Res. 312 3969-80 PubMed GONUTS page
- ↑ 50.0 50.1 50.2 50.3 Lane, BR et al. (1999) TNF-alpha inhibits HIV-1 replication in peripheral blood monocytes and alveolar macrophages by inducing the production of RANTES and decreasing C-C chemokine receptor 5 (CCR5) expression. J. Immunol. 163 3653-61 PubMed GONUTS page
- ↑ 51.0 51.1 51.2 Zhang, R et al. (2003) AIP1 mediates TNF-alpha-induced ASK1 activation by facilitating dissociation of ASK1 from its inhibitor 14-3-3. J. Clin. Invest. 111 1933-43 PubMed GONUTS page
- ↑ 52.0 52.1 Evans, IM et al. (2008) Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase. Cell. Signal. 20 1375-84 PubMed GONUTS page
- ↑ 53.0 53.1 53.2 Hohensinner, PJ et al. (2007) Macrophage colony stimulating factor expression in human cardiac cells is upregulated by tumor necrosis factor-alpha via an NF-kappaB dependent mechanism. J. Thromb. Haemost. 5 2520-8 PubMed GONUTS page
- ↑ Ouchi, N et al. () Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin. Circulation 100 2473-6 PubMed GONUTS page
- ↑ 55.0 55.1 55.2 55.3 55.4 55.5 55.6 Zhang, H et al. (2007) RIP1-mediated AIP1 phosphorylation at a 14-3-3-binding site is critical for tumor necrosis factor-induced ASK1-JNK/p38 activation. J. Biol. Chem. 282 14788-96 PubMed GONUTS page
- ↑ 56.0 56.1 56.2 56.3 Hiraoka, Y et al. (2008) Ectodomain shedding of TNF-alpha is enhanced by nardilysin via activation of ADAM proteases. Biochem. Biophys. Res. Commun. 370 154-8 PubMed GONUTS page
- ↑ Lin, Y et al. (1999) Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis. Genes Dev. 13 2514-26 PubMed GONUTS page
- ↑ Rushworth, SA & MacEwan, DJ (2008) HO-1 underlies resistance of AML cells to TNF-induced apoptosis. Blood 111 3793-801 PubMed GONUTS page
- ↑ Marmenout, A et al. (1985) Molecular cloning and expression of human tumor necrosis factor and comparison with mouse tumor necrosis factor. Eur. J. Biochem. 152 515-22 PubMed GONUTS page
- ↑ Fourie, AM et al. (2003) Catalytic activity of ADAM8, ADAM15, and MDC-L (ADAM28) on synthetic peptide substrates and in ectodomain cleavage of CD23. J. Biol. Chem. 278 30469-77 PubMed GONUTS page
- ↑ Li, J et al. (2012) The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis. Cell 150 339-50 PubMed GONUTS page
- ↑ Sun, L et al. (2012) Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell 148 213-27 PubMed GONUTS page
- ↑ Wang, Z et al. (2012) The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways. Cell 148 228-43 PubMed GONUTS page
- ↑ 64.0 64.1 Al-Zoubi, AM et al. (2001) Contrasting effects of IG20 and its splice isoforms, MADD and DENN-SV, on tumor necrosis factor alpha-induced apoptosis and activation of caspase-8 and -3. J. Biol. Chem. 276 47202-11 PubMed GONUTS page
- ↑ 65.0 65.1 65.2 Zheng, L et al. (2006) Competitive control of independent programs of tumor necrosis factor receptor-induced cell death by TRADD and RIP1. Mol. Cell. Biol. 26 3505-13 PubMed GONUTS page
- ↑ 66.0 66.1 66.2 66.3 66.4 Wu, F et al. (2011) Inhibitory effects of honokiol on lipopolysaccharide-induced cellular responses and signaling events in human renal mesangial cells. Eur. J. Pharmacol. 654 117-21 PubMed GONUTS page
- ↑ 67.0 67.1 Zhang, J et al. (2009) Nicotine induces resistance to chemotherapy by modulating mitochondrial signaling in lung cancer. Am. J. Respir. Cell Mol. Biol. 40 135-46 PubMed GONUTS page
- ↑ 68.0 68.1 68.2 68.3 Zhu, NL et al. (2007) TNF-alpha represses transcription of human Bone Morphogenetic Protein-4 in lung epithelial cells. Gene 393 70-80 PubMed GONUTS page
- ↑ Yeh, PY et al. (2006) A pathway for tumor necrosis factor-alpha-induced Bcl10 nuclear translocation. Bcl10 is up-regulated by NF-kappaB and phosphorylated by Akt1 and then complexes with Bcl3 to enter the nucleus. J. Biol. Chem. 281 167-75 PubMed GONUTS page
- ↑ 70.0 70.1 70.2 van de Stolpe, A et al. (2004) Estrogen receptor (ER)-mediated transcriptional regulation of the human corticotropin-releasing hormone-binding protein promoter: differential effects of ERalpha and ERbeta. Mol. Endocrinol. 18 2908-23 PubMed GONUTS page
- ↑ Afonso, V et al. (2006) Tumor necrosis factor-alpha down-regulates human Cu/Zn superoxide dismutase 1 promoter via JNK/AP-1 signaling pathway. Free Radic. Biol. Med. 41 709-21 PubMed GONUTS page
- ↑ 72.0 72.1 72.2 Shankar, SL et al. (2006) Gas6/Axl signaling activates the phosphatidylinositol 3-kinase/Akt1 survival pathway to protect oligodendrocytes from tumor necrosis factor alpha-induced apoptosis. J. Neurosci. 26 5638-48 PubMed GONUTS page
- ↑ Löder, S et al. (2012) RIP1 is required for IAP inhibitor-mediated sensitization of childhood acute leukemia cells to chemotherapy-induced apoptosis. Leukemia 26 1020-9 PubMed GONUTS page
- ↑ 74.0 74.1 Yan, Y et al. (2006) NFAT3 is specifically required for TNF-alpha-induced cyclooxygenase-2 (COX-2) expression and transformation of Cl41 cells. J. Cell. Sci. 119 2985-94 PubMed GONUTS page
- ↑ Bettelli, E et al. (2005) Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells. Proc. Natl. Acad. Sci. U.S.A. 102 5138-43 PubMed GONUTS page
- ↑ Schröder, NW et al. (2003) Lipoteichoic acid (LTA) of Streptococcus pneumoniae and Staphylococcus aureus activates immune cells via Toll-like receptor (TLR)-2, lipopolysaccharide-binding protein (LBP), and CD14, whereas TLR-4 and MD-2 are not involved. J. Biol. Chem. 278 15587-94 PubMed GONUTS page
- ↑ Stephens, JM & Pekala, PH (1992) Transcriptional repression of the C/EBP-alpha and GLUT4 genes in 3T3-L1 adipocytes by tumor necrosis factor-alpha. Regulations is coordinate and independent of protein synthesis. J. Biol. Chem. 267 13580-4 PubMed GONUTS page
- ↑ Jones, EY et al. (1989) Structure of tumour necrosis factor. Nature 338 225-8 PubMed GONUTS page
- ↑ Etemadi, N et al. (2013) Lymphotoxin α induces apoptosis, necroptosis and inflammatory signals with the same potency as tumour necrosis factor. FEBS J. 280 5283-97 PubMed GONUTS page
- ↑ Yang, Z et al. (2009) Crystal structure of TNFalpha complexed with a poxvirus MHC-related TNF binding protein. Nat. Struct. Mol. Biol. 16 1189-91 PubMed GONUTS page
- ↑ 81.0 81.1 81.2 81.3 Belarbi, K et al. (2012) TNF-α protein synthesis inhibitor restores neuronal function and reverses cognitive deficits induced by chronic neuroinflammation. J Neuroinflammation 9 23 PubMed GONUTS page
- ↑ Bachstetter, AD et al. (2011) Fractalkine and CX 3 CR1 regulate hippocampal neurogenesis in adult and aged rats. Neurobiol. Aging 32 2030-44 PubMed GONUTS page
- ↑ 83.0 83.1 83.2 83.3 83.4 83.5 83.6 83.7 83.8 Olmos, G & Lladó, J (2014) Tumor necrosis factor alpha: a link between neuroinflammation and excitotoxicity. Mediators Inflamm. 2014 861231 PubMed GONUTS page
a
c
- GO:0007249 ! canonical NF-kappaB signal transduction
- Catarrhini
- GO:0045123 ! cellular extravasation
- GO:0071316 ! cellular response to nicotine
- GO:0071230 ! cellular response to amino acid stimulus
- GO:0071222 ! cellular response to lipopolysaccharide
- GO:0009986 ! cell surface
- Chordata
- GO:0002439 ! chronic inflammatory response to antigenic stimulus
- GO:0050890 ! cognition
- GO:0030866 ! cortical actin cytoskeleton organization
- Craniata
- GO:0019221 ! cytokine-mediated signaling pathway
- GO:0005125 ! cytokine activity
d
e
- GO:0048566 ! embryonic digestive tract development
- GO:0072577 ! endothelial cell apoptotic process
- GO:0060664 ! epithelial cell proliferation involved in salivary gland morphogenesis
- Euarchontoglires
- Eukaryota
- Euteleostomi
- Eutheria
- GO:0009897 ! external side of plasma membrane
- GO:0030198 ! extracellular matrix organization
- GO:0005615 ! extracellular space
- GO:0005576 ! extracellular region
- GO:0008625 ! extrinsic apoptotic signaling pathway via death domain receptors
- GO:0097191 ! extrinsic apoptotic signaling pathway
i
- GO:0042802 ! identical protein binding
- GO:0006955 ! immune response
- GO:0006954 ! inflammatory response
- GO:0016021 ! integral component of membrane
- GO:0005887 ! integral component of plasma membrane
- GO:0042226 ! interleukin-6 biosynthetic process
- GO:0072604 ! interleukin-6 secretion
- GO:0008630 ! intrinsic apoptotic signaling pathway in response to DNA damage
l
m
n
- GO:0097527 ! necroptotic signaling pathway
- GO:0010693 ! negative regulation of alkaline phosphatase activity
- GO:0032715 ! negative regulation of interleukin-6 production
- GO:0010629 ! negative regulation of gene expression
- GO:0045662 ! negative regulation of myoblast differentiation
- GO:0010888 ! negative regulation of lipid storage
- GO:1903347 ! negative regulation of bicellular tight junction assembly
- GO:0002740 ! negative regulation of cytokine secretion involved in immune response
- GO:0045668 ! negative regulation of osteoblast differentiation
- GO:0045930 ! negative regulation of mitotic cell cycle
- GO:0046325 ! negative regulation of D-glucose import
- GO:0061048 ! negative regulation of branching involved in lung morphogenesis
- GO:0045892 ! negative regulation of DNA-templated transcription
- GO:0043242 ! negative regulation of protein-containing complex disassembly
- GO:0045071 ! negative regulation of viral genome replication
- GO:0000122 ! negative regulation of transcription by RNA polymerase II
- GO:0050768 ! negative regulation of neurogenesis
- GO:0045599 ! negative regulation of fat cell differentiation
- GO:0001937 ! negative regulation of endothelial cell proliferation
- GO:2001240 ! negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
- GO:0050995 ! negative regulation of lipid catabolic process
o
- GO:0000187 ! obsolete activation of MAPK activity
- GO:0006919 ! obsolete activation of cysteine-type endopeptidase activity involved in apoptotic process
- GO:0000185 ! obsolete activation of MAPKKK activity
- GO:0071407 ! obsolete cellular response to organic cyclic compound
- GO:0035509 ! obsolete negative regulation of myosin-light-chain-phosphatase activity
- GO:0044130 ! obsolete negative regulation of growth of symbiont in host
- GO:0014068 ! obsolete positive regulation of phosphatidylinositol 3-kinase signaling
- GO:0043280 ! obsolete positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
- GO:0032800 ! obsolete receptor biosynthetic process
- GO:0010033 ! obsolete response to organic substance
- GO:0030316 ! osteoclast differentiation
p
- GO:0001891 ! phagocytic cup
- GO:0043491 ! phosphatidylinositol 3-kinase/protein kinase B signal transduction
- GO:0005886 ! plasma membrane
- GO:0050754 ! positive regulation of fractalkine biosynthetic process
- GO:0060252 ! positive regulation of glial cell proliferation
- GO:0045994 ! positive regulation of translational initiation by iron
- GO:0045732 ! positive regulation of protein catabolic process
- GO:0051897 ! positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
- GO:0043123 ! positive regulation of canonical NF-kappaB signal transduction
- GO:0090197 ! positive regulation of chemokine secretion
- GO:0045944 ! positive regulation of transcription by RNA polymerase II
- GO:0046330 ! positive regulation of JNK cascade
- GO:0051798 ! positive regulation of hair follicle development
- GO:0002876 ! positive regulation of chronic inflammatory response to antigenic stimulus
- GO:2000778 ! positive regulation of interleukin-6 secretion
- GO:0050806 ! positive regulation of synaptic transmission
- GO:0150078 ! positive regulation of neuroinflammatory response
- GO:0002925 ! positive regulation of humoral immune response mediated by circulating immunoglobulin
- GO:0042531 ! positive regulation of tyrosine phosphorylation of STAT protein
- GO:0033138 ! positive regulation of peptidyl-serine phosphorylation
- GO:0032755 ! positive regulation of interleukin-6 production
- GO:0045410 ! positive regulation of interleukin-6 biosynthetic process
- GO:1904707 ! positive regulation of vascular associated smooth muscle cell proliferation
- GO:0050729 ! positive regulation of inflammatory response
- GO:0051000 ! positive regulation of nitric-oxide synthase activity
- GO:2000304 ! positive regulation of ceramide biosynthetic process
- GO:0032729 ! positive regulation of type II interferon production
- GO:0043525 ! positive regulation of neuron apoptotic process
- GO:0046427 ! positive regulation of receptor signaling pathway via JAK-STAT
- GO:0051092 ! positive regulation of NF-kappaB transcription factor activity
- GO:0010628 ! positive regulation of gene expression
- GO:0045785 ! positive regulation of cell adhesion
- GO:1904996 ! positive regulation of leukocyte adhesion to vascular endothelial cell
- GO:1903078 ! positive regulation of protein localization to plasma membrane
- GO:0051044 ! positive regulation of membrane protein ectodomain proteolysis
- GO:0032722 ! positive regulation of chemokine production
- GO:0034116 ! positive regulation of heterotypic cell-cell adhesion
- GO:0045860 ! positive regulation of protein kinase activity
- GO:0043243 ! positive regulation of protein-containing complex disassembly
- GO:0045080 ! positive regulation of chemokine biosynthetic process
- GO:0045416 ! positive regulation of interleukin-8 biosynthetic process
- GO:0045429 ! positive regulation of nitric oxide biosynthetic process
- GO:0045672 ! positive regulation of osteoclast differentiation
- GO:0045893 ! positive regulation of DNA-templated transcription
- GO:0048661 ! positive regulation of smooth muscle cell proliferation
- GO:0050715 ! positive regulation of cytokine secretion
- GO:0051091 ! positive regulation of DNA-binding transcription factor activity
- GO:0031334 ! positive regulation of protein-containing complex assembly
- GO:0051222 ! positive regulation of protein transport
- GO:0060557 ! positive regulation of vitamin D biosynthetic process
- GO:0060559 ! positive regulation of calcidiol 1-monooxygenase activity
- GO:0070374 ! positive regulation of ERK1 and ERK2 cascade
- GO:0071677 ! positive regulation of mononuclear cell migration
- GO:0071803 ! positive regulation of podosome assembly
- GO:2000010 ! positive regulation of protein localization to cell surface
- GO:2000343 ! positive regulation of chemokine (C-X-C motif) ligand 2 production
- GO:0050766 ! positive regulation of phagocytosis
- GO:0032757 ! positive regulation of interleukin-8 production
- GO:2000334 ! positive regulation of blood microparticle formation
- GO:0031622 ! positive regulation of fever generation
- GO:0043406 ! positive regulation of MAP kinase activity
- GO:0043507 ! positive regulation of JUN kinase activity
- GO:1901671 ! positive regulation of superoxide dismutase activity
- GO:0070886 ! positive regulation of calcineurin-NFAT signaling cascade
- GO:1901224 ! positive regulation of non-canonical NF-kappaB signal transduction
- GO:1904999 ! positive regulation of leukocyte adhesion to arterial endothelial cell
- GO:0043068 ! positive regulation of programmed cell death
- GO:0043065 ! positive regulation of apoptotic process
- GO:0001819 ! positive regulation of cytokine production
- GO:0001934 ! positive regulation of protein phosphorylation
- Primates
- GO:0002020 ! protease binding
- GO:0032991 ! protein-containing complex
- GO:0072659 ! protein localization to plasma membrane
r
- GO:0055037 ! recycling endosome
- GO:0010874 ! regulation of cholesterol efflux
- GO:2000351 ! regulation of endothelial cell apoptotic process
- GO:0050807 ! regulation of synapse organization
- GO:0006357 ! regulation of transcription by RNA polymerase II
- GO:0050727 ! regulation of inflammatory response
- GO:0051023 ! regulation of immunoglobulin secretion
- GO:0050708 ! regulation of protein secretion
- GO:0010803 ! regulation of tumor necrosis factor-mediated signaling pathway
- GO:2000377 ! regulation of reactive oxygen species metabolic process
- GO:0010468 ! regulation of gene expression
- GO:0045598 ! regulation of fat cell differentiation
- GO:1903140 ! regulation of establishment of endothelial barrier
- GO:0060693 ! regulation of branching involved in salivary gland morphogenesis
- GO:1903978 ! regulation of microglial cell activation
- GO:0051966 ! regulation of synaptic transmission, glutamatergic
- GO:0045670 ! regulation of osteoclast differentiation
- GO:0001932 ! regulation of protein phosphorylation
- GO:0010469 ! regulation of signaling receptor activity
- GO:0043122 ! regulation of canonical NF-kappaB signal transduction
- GO:0042127 ! regulation of cell population proliferation
- GO:0050796 ! regulation of insulin secretion
- GO:0009651 ! response to salt stress
- GO:0051384 ! response to glucocorticoid
- GO:0009615 ! response to virus
t
