name: extrinsic apoptotic signaling pathway via death domain receptors
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def: "A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with a ligand binding to a death domain receptor on the cell surface, and ends when the execution phase of apoptosis is triggered." [GOC:mah, GOC:mtg_apoptosis]
comment: Gene products that may be annotated to this term include: 1) ligands such as FASL; 2) receptors such as FAS/CD95 (though care should be taken because FAS can also act as a non-apoptotic signal transducer); 3) signaling molecules such as FADD (FAS-associated protein with a death domain), cIAPs (cellular inhibitor of apoptosis proteins), c-FLIPs and caspases 8 and 10. Examples are TWEAK (TNF12) and FN14 (TNFRSF12A) (UniProt symbols O43508 and Q9NP84) in PMID:21525013.
synonym: "death receptor-mediated apoptosis" NARROW 
synonym: "induction of apoptosis via death domain receptors" RELATED 
synonym: "induction of apoptosis via death receptors" EXACT [GOC:mah]
is_a: GO:0097191 ! extrinsic apoptotic signaling pathway
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