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PMID:20875417

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Citation

Maheshwari, A, Kelly, DR, Nicola, T, Ambalavanan, N, Jain, SK, Murphy-Ullrich, J, Athar, M, Shimamura, M, Bhandari, V, Aprahamian, C, Dimmitt, RA, Serra, R and Ohls, RK (2011) TGF-β2 suppresses macrophage cytokine production and mucosal inflammatory responses in the developing intestine. Gastroenterology 140:242-53

Abstract

Premature neonates are predisposed to necrotizing enterocolitis (NEC), an idiopathic, inflammatory bowel necrosis. We investigated whether NEC occurs in the preterm intestine due to incomplete noninflammatory differentiation of intestinal macrophages, which increases the risk of a severe mucosal inflammatory response to bacterial products.

Links

PubMed PMC3008335 Online version:10.1053/j.gastro.2010.09.043

Keywords

Adult; Animals; Cells, Cultured; Chemotaxis, Leukocyte; Cytokines/metabolism; Enterocolitis, Necrotizing/immunology; Humans; Infant, Newborn; Intestines/growth & development; Intestines/immunology; Lipopolysaccharides/metabolism; Macrophage Activation; Macrophages/metabolism; Mice; Mice, Transgenic; NF-kappa B/metabolism; Neutrophils/metabolism; Transforming Growth Factor beta2/metabolism; Transforming Growth Factor beta2/pharmacology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:TGFB3

involved_in

GO:0010936: negative regulation of macrophage cytokine production

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:TGFB2

involved_in

GO:0010936: negative regulation of macrophage cytokine production

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:TGFB2

involved_in

GO:0048566: embryonic digestive tract development

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:TNFA

involved_in

GO:0048566: embryonic digestive tract development

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:TGFB1

involved_in

GO:0010936: negative regulation of macrophage cytokine production

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:IL8

involved_in

GO:0048566: embryonic digestive tract development

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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