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PMID:23914732
| Citation |
Ma, AZ, Zhang, Q and Song, ZY (2013) TNFa alter cholesterol metabolism in human macrophages via PKC-θ-dependent pathway. BMC Biochem. 14:20 |
|---|---|
| Abstract |
Studies have shown that inflammation promoted atherosclerotic progression; however, it remains unclear whether inflammation promoted atherosclerotic progression properties by altering cholesterol metabolism in human macrophages. In the present study, we evaluated a potential mechanism of inflammation on atherogenic effects. We evaluated the ability of TNFa to affect Reverse cholesterol transport (RCT) and cholesterol uptake and its mechanism(s) of action in human macrophages. |
| Links |
PubMed PMC3751201 Online version:10.1186/1471-2091-14-20 |
| Keywords |
ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters/genetics; ATP-Binding Cassette Transporters/metabolism; Antigens, CD36/genetics; Antigens, CD36/metabolism; Cells, Cultured; Cholesterol/metabolism; Down-Regulation/drug effects; Humans; Isoenzymes/antagonists & inhibitors; Isoenzymes/genetics; Isoenzymes/metabolism; Macrophages/cytology; Macrophages/drug effects; Macrophages/metabolism; Orphan Nuclear Receptors/antagonists & inhibitors; Orphan Nuclear Receptors/genetics; Orphan Nuclear Receptors/metabolism; Protein Kinase C/antagonists & inhibitors; Protein Kinase C/genetics; Protein Kinase C/metabolism; RNA Interference; RNA, Messenger/metabolism; RNA, Small Interfering/metabolism; Scavenger Receptors, Class A/genetics; Scavenger Receptors, Class A/metabolism; Tumor Necrosis Factor-alpha/pharmacology |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0010874: regulation of cholesterol efflux |
ECO:0000314: |
P |
Figure 1: Human macrophages were labeled with 3H-cholesterol. TNFa was added to the cell cultures in increasing doses. apoA-I or HDL were added. The figures show that cholesterol efflux decreased in a dose-dependent manner in cells treated with TNFa. |
complete | ||||
| GO:0010468: regulation of gene expression |
ECO:0000314: |
P |
Figure 1A: Human macrophages were treated with increasing doses of TNFa. Using PCR, the levels of mRNA were measured. As the dose of mRNA increased, the level of ABCA1 mRNA decreased. |
complete | ||||
See also
References
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