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PMID:1752215

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Citation

Merrill, JE (1991) Effects of interleukin-1 and tumor necrosis factor-alpha on astrocytes, microglia, oligodendrocytes, and glial precursors in vitro. Dev. Neurosci. 13:130-7

Abstract

Microglia and astrocytes undergo proliferative and differentiative changes in vivo after trauma or diseases such as multiple sclerosis (MS). Oligodendrocytes are destroyed in lesions in MS. Interleukin-1 (IL1) and tumor necrosis factor-alpha (TNF alpha) are involved in inflammation of the central nervous system and are elevated in MS. We have investigated the changes in cell morphology and cell number induced by IL1 and TNF alpha in purified and mixed populations of primary rat brain microglia, astrocytes, oligodendrocytes, and glial precursors. Depending on the target population, proliferation, differentiation, or inhibition of cultured cells was observed. The data also suggest that interactions among cell populations occur and support the hypothesis that IL1 and TNF alpha effects may be indirect, possibly through induction of other factors.

Links

PubMed

Keywords

Animals; Astrocytes/drug effects; Biological Markers; Brain/cytology; Cell Differentiation/drug effects; Cell Division/drug effects; Cells, Cultured; Culture Media, Serum-Free/pharmacology; Indomethacin/pharmacology; Interleukin-1/pharmacology; Neuroglia/drug effects; Oligodendroglia/drug effects; Rats; Recombinant Proteins/pharmacology; Stem Cells/drug effects; Tumor Necrosis Factor-alpha/pharmacology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:TNFA

involved_in

GO:0060252: positive regulation of glial cell proliferation

ECO:0000316: genetic interaction evidence used in manual assertion

UniProtKB:P01584

P

  • results_in_division_of:(CL:0000129)|results_in_division_of:(CL:0000127)

Seeded From UniProt

complete

HUMAN:IL1B

involved_in

GO:0060252: positive regulation of glial cell proliferation

ECO:0000316: genetic interaction evidence used in manual assertion

UniProtKB:P01375

P

  • results_in_division_of:(CL:0000129)|results_in_division_of:(CL:0000127)

Seeded From UniProt

complete

HUMAN:TNFA

involved_in

GO:0060252: positive regulation of glial cell proliferation

ECO:0000316: genetic interaction evidence used in manual assertion

UniProtKB:P01584

P

results_in_division_of:(CL:0000129)|results_in_division_of:(CL:0000127)

Seeded From UniProt

complete

HUMAN:IL1B

involved_in

GO:0060252: positive regulation of glial cell proliferation

ECO:0000316: genetic interaction evidence used in manual assertion

UniProtKB:P01375

P

results_in_division_of:(CL:0000129)|results_in_division_of:(CL:0000127)

Seeded From UniProt

complete


See also

References

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