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DROME:M3K7

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) Tak1
Protein Name(s) Mitogen-activated protein kinase kinase kinase 7

TGF-beta-activated kinase 1 dTAK1

External Links
UniProt Q9V3Q6
EMBL AF199466
AE014298
AY051953
RefSeq NP_524080.1
UniGene Dm.6425
ProteinModelPortal Q9V3Q6
SMR Q9V3Q6
BioGrid 64981
MINT MINT-1613430
STRING 7227.FBpp0077011
PaxDb Q9V3Q6
PRIDE Q9V3Q6
EnsemblMetazoa FBtr0077319
GeneID 39659
KEGG dme:Dmel_CG18492
CTD 39659
FlyBase FBgn0026323
eggNOG COG0515
GeneTree ENSGT00760000118807
InParanoid Q9V3Q6
KO K04427
OMA HMAKEYL
OrthoDB EOG7RBZ8D
PhylomeDB Q9V3Q6
Reactome REACT_181694
REACT_184321
REACT_257192
SignaLink Q9V3Q6
GenomeRNAi 39659
NextBio 814736
Proteomes UP000000803
Bgee Q9V3Q6
GO GO:0005524
GO:0004706
GO:0004709
GO:0046872
GO:0004672
GO:0031625
GO:0007256
GO:0006915
GO:0071222
GO:0048749
GO:0050829
GO:0051607
GO:0007391
GO:0007249
GO:0006955
GO:0045087
GO:0007254
GO:0048802
GO:0016318
GO:0006963
GO:0006964
GO:0046330
GO:0006468
GO:0010506
InterPro IPR011009
IPR000719
IPR017441
IPR001245
IPR008271
Pfam PF07714
PRINTS PR00109
SUPFAM SSF56112
PROSITE PS00107
PS50011
PS00108

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000166

nucleotide binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

GO:0002376

immune system process

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0391

P

Seeded From UniProt

complete

GO:0004672

protein kinase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR001245
InterPro:IPR008271

F

Seeded From UniProt

complete

GO:0004672

protein kinase activity

PMID:10908587[1]

NAS: Non-traceable Author Statement

F

Seeded From UniProt

complete

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0723

F

Seeded From UniProt

complete

GO:0004706

JUN kinase kinase kinase activity

PMID:14519762[2]

IMP: Inferred from Mutant Phenotype

F

Seeded From UniProt

complete

GO:0004709

MAP kinase kinase kinase activity

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:2.7.11.25

F

Seeded From UniProt

complete

GO:0004709

MAP kinase kinase kinase activity

PMID:10757786[3]

ISS: Inferred from Sequence or Structural Similarity

RefSeq:NP_663305

F

Seeded From UniProt

complete

GO:0004709

MAP kinase kinase kinase activity

PMID:15032585[4]

TAS: Traceable Author Statement

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:23532117[5]

IPI: Inferred from Physical Interaction

FB:FBgn0015806

F

Seeded From UniProt

complete

GO:0005524

ATP binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR017441

F

Seeded From UniProt

complete

GO:0005524

ATP binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

GO:0005575

cellular_component

GO_REF:0000015

ND: No biological Data available

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:24429281[6]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0006468

protein phosphorylation

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR001245
InterPro:IPR008271

P

Seeded From UniProt

complete

GO:0006468

protein phosphorylation

PMID:10908587[1]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0006915

apoptotic process

PMID:10757786[3]

IGI: Inferred from Genetic Interaction

FB:FBgn0003997

P

Seeded From UniProt

complete

GO:0006915

apoptotic process

PMID:10757786[3]

IGI: Inferred from Genetic Interaction

FB:FBgn0011706

P

Seeded From UniProt

complete

GO:0006915

apoptotic process

PMID:10757786[3]

IGI: Inferred from Genetic Interaction

FB:FBgn0015946

P

Seeded From UniProt

complete

GO:0006955

immune response

PMID:14519762[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0006955

immune response

PMID:15199954[7]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0006963

positive regulation of antibacterial peptide biosynthetic process

PMID:15032585[4]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0006964

positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria

PMID:17343912[8]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007249

I-kappaB kinase/NF-kappaB signaling

PMID:14519762[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007254

JNK cascade

PMID:10757786[3]

IGI: Inferred from Genetic Interaction

FB:FBgn0000229

P

Seeded From UniProt

complete

GO:0007254

JNK cascade

PMID:10757786[3]

IGI: Inferred from Genetic Interaction

FB:FBgn0010303

P

Seeded From UniProt

complete

GO:0007256

activation of JNKK activity

PMID:14519762[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007391

dorsal closure

PMID:10757786[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007391

dorsal closure

PMID:12147138[9]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0010506

regulation of autophagy

PMID:23532117[5]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016301

kinase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

GO:0016310

phosphorylation

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

GO:0016318

ommatidial rotation

PMID:11287182[10]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016740

transferase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

GO:0031625

ubiquitin protein ligase binding

PMID:16179944[11]

IPI: Inferred from Physical Interaction

FB:FBgn0040294

F

Seeded From UniProt

complete

GO:0045087

innate immune response

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0399

P

Seeded From UniProt

complete

GO:0045087

innate immune response

PMID:12728280[12]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0046330

positive regulation of JNK cascade

PMID:16451733[13]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0046872

metal ion binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

GO:0048749

compound eye development

PMID:10757786[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0048802

notum morphogenesis

PMID:11287182[10]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0050829

defense response to Gram-negative bacterium

PMID:16894030[14]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0050829

defense response to Gram-negative bacterium

PMID:17129215[15]

IGI: Inferred from Genetic Interaction

FB:FBgn0030695

P

Seeded From UniProt

complete

GO:0050829

defense response to Gram-negative bacterium

PMID:22549468[16]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0051607

defense response to virus

PMID:19829691[17]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0071222

cellular response to lipopolysaccharide

PMID:16451733[13]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Morrison, DK et al. (2000) Protein kinases and phosphatases in the Drosophila genome. J. Cell Biol. 150 F57-62 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 Silverman, N et al. (2003) Immune activation of NF-kappaB and JNK requires Drosophila TAK1. J. Biol. Chem. 278 48928-34 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 Takatsu, Y et al. (2000) TAK1 participates in c-Jun N-terminal kinase signaling during Drosophila development. Mol. Cell. Biol. 20 3015-26 PubMed GONUTS page
  4. 4.0 4.1 Brennan, CA & Anderson, KV (2004) Drosophila: the genetics of innate immune recognition and response. Annu. Rev. Immunol. 22 457-83 PubMed GONUTS page
  5. 5.0 5.1 Shin, JH et al. (2013) TAK1 regulates autophagic cell death by suppressing the phosphorylation of p70 S6 kinase 1. Sci Rep 3 1561 PubMed GONUTS page
  6. Stronach, B et al. (2014) Domain specificity of MAP3K family members, MLK and Tak1, for JNK signaling in Drosophila. Genetics 197 497-513 PubMed GONUTS page
  7. Leclerc, V & Reichhart, JM (2004) The immune response of Drosophila melanogaster. Immunol. Rev. 198 59-71 PubMed GONUTS page
  8. Valanne, S et al. (2007) Iap2 is required for a sustained response in the Drosophila Imd pathway. Dev. Comp. Immunol. 31 991-1001 PubMed GONUTS page
  9. Harden, N (2002) Signaling pathways directing the movement and fusion of epithelial sheets: lessons from dorsal closure in Drosophila. Differentiation 70 181-203 PubMed GONUTS page
  10. 10.0 10.1 Mihaly, J et al. (2001) The role of the Drosophila TAK homologue dTAK during development. Mech. Dev. 102 67-79 PubMed GONUTS page
  11. Tsuda, M et al. (2005) The RING-finger scaffold protein Plenty of SH3s targets TAK1 to control immunity signalling in Drosophila. EMBO Rep. 6 1082-7 PubMed GONUTS page
  12. Kurz, CL & Ewbank, JJ (2003) Caenorhabditis elegans: an emerging genetic model for the study of innate immunity. Nat. Rev. Genet. 4 380-90 PubMed GONUTS page
  13. 13.0 13.1 Ryabinina, OP et al. (2006) D-MEKK1, the Drosophila orthologue of mammalian MEKK4/MTK1, and Hemipterous/D-MKK7 mediate the activation of D-JNK by cadmium and arsenite in Schneider cells. BMC Cell Biol. 7 7 PubMed GONUTS page
  14. Leulier, F et al. (2006) The Drosophila inhibitor of apoptosis protein DIAP2 functions in innate immunity and is essential to resist gram-negative bacterial infection. Mol. Cell. Biol. 26 7821-31 PubMed GONUTS page
  15. Libert, S et al. (2006) Trade-offs between longevity and pathogen resistance in Drosophila melanogaster are mediated by NFkappaB signaling. Aging Cell 5 533-43 PubMed GONUTS page
  16. Meinander, A et al. (2012) Ubiquitylation of the initiator caspase DREDD is required for innate immune signalling. EMBO J. 31 2770-83 PubMed GONUTS page
  17. Costa, A et al. (2009) The Imd pathway is involved in antiviral immune responses in Drosophila. PLoS ONE 4 e7436 PubMed GONUTS page