DROME:M3K7

Species (Taxon ID)	Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s)	Tak1
Protein Name(s)	Mitogen-activated protein kinase kinase kinase 7 TGF-beta-activated kinase 1 dTAK1
External Links
UniProt	Q9V3Q6
EMBL	AF199466 AE014298 AY051953
RefSeq	NP_524080.1
UniGene	Dm.6425
ProteinModelPortal	Q9V3Q6
SMR	Q9V3Q6
BioGrid	64981
MINT	MINT-1613430
STRING	7227.FBpp0077011
PaxDb	Q9V3Q6
PRIDE	Q9V3Q6
EnsemblMetazoa	FBtr0077319
GeneID	39659
KEGG	dme:Dmel_CG18492
CTD	39659
FlyBase	FBgn0026323
eggNOG	COG0515
GeneTree	ENSGT00760000118807
InParanoid	Q9V3Q6
KO	K04427
OMA	HMAKEYL
OrthoDB	EOG7RBZ8D
PhylomeDB	Q9V3Q6
Reactome	REACT_181694 REACT_184321 REACT_257192
SignaLink	Q9V3Q6
GenomeRNAi	39659
NextBio	814736
Proteomes	UP000000803
Bgee	Q9V3Q6
GO	GO:0005524 GO:0004706 GO:0004709 GO:0046872 GO:0004672 GO:0031625 GO:0007256 GO:0006915 GO:0071222 GO:0048749 GO:0050829 GO:0051607 GO:0007391 GO:0007249 GO:0006955 GO:0045087 GO:0007254 GO:0048802 GO:0016318 GO:0006963 GO:0006964 GO:0046330 GO:0006468 GO:0010506
InterPro	IPR011009 IPR000719 IPR017441 IPR001245 IPR008271
Pfam	PF07714
PRINTS	PR00109
SUPFAM	SSF56112
PROSITE	PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0010628	positive regulation of gene expression	PMID:25737837^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q7K5M0)	Seeded From UniProt	complete
involved_in	GO:0007256	activation of JNKK activity	PMID:14519762^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007249	I-kappaB kinase/NF-kappaB signaling	PMID:14519762^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006955	immune response	PMID:14519762^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004706	JUN kinase kinase kinase activity	PMID:14519762^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:24429281^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0010506	regulation of autophagy	PMID:23532117^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050829	defense response to Gram-negative bacterium	PMID:22549468^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	PMID:19829691^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061057	peptidoglycan recognition protein signaling pathway	PMID:19497884^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006964	positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria	PMID:17343912^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050829	defense response to Gram-negative bacterium	PMID:17129215^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0030695	P		Seeded From UniProt	complete
involved_in	GO:0050829	defense response to Gram-negative bacterium	PMID:16894030^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:16179944^[11]	ECO:0000353	physical interaction evidence used in manual assertion	FB:FBgn0040294	F		Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	PMID:16451733^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046330	positive regulation of JNK cascade	PMID:16451733^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016318	ommatidial rotation	PMID:11287182^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048802	notum morphogenesis	PMID:11287182^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:10908587^[14]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:10908587^[14]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:10757786^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0011706	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:10757786^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0015946	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:10757786^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0003997	P		Seeded From UniProt	complete
involved_in	GO:0007391	dorsal closure	PMID:10757786^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048749	compound eye development	PMID:10757786^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004709	MAP kinase kinase kinase activity	PMID:10757786^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007254	JNK cascade	PMID:10757786^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0010303	P		Seeded From UniProt	complete
involved_in	GO:0007254	JNK cascade	PMID:10757786^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0000229	P		Seeded From UniProt	complete
enables	GO:0000287	magnesium ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017421	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0004709	MAP kinase kinase kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017421	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008271	P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017421	P		Seeded From UniProt	complete
enables	GO:0004709	MAP kinase kinase kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.11.25	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-DME-209320 Reactome:R-DME-209289 Reactome:R-DME-209240 Reactome:R-DME-209188	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	Reactome:R-DME-209320	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006963	positive regulation of antibacterial peptide biosynthetic process	PMID:15032585^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004709	MAP kinase kinase kinase activity	PMID:15032585^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	PMID:12728280^[17]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007391	dorsal closure	PMID:12147138^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Srivastava, A & Dong, Q (2015) Regulation of a serine protease homolog by the JNK pathway during thoracic development of Drosophila melanogaster. FEBS Open Bio 5 117-23 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Silverman, N et al. (2003) Immune activation of NF-kappaB and JNK requires Drosophila TAK1. J. Biol. Chem. 278 48928-34 PubMed GONUTS page
↑ Stronach, B et al. (2014) Domain specificity of MAP3K family members, MLK and Tak1, for JNK signaling in Drosophila. Genetics 197 497-513 PubMed GONUTS page
↑ Shin, JH et al. (2013) TAK1 regulates autophagic cell death by suppressing the phosphorylation of p70 S6 kinase 1. Sci Rep 3 1561 PubMed GONUTS page
↑ Meinander, A et al. (2012) Ubiquitylation of the initiator caspase DREDD is required for innate immune signalling. EMBO J. 31 2770-83 PubMed GONUTS page
↑ Costa, A et al. (2009) The Imd pathway is involved in antiviral immune responses in Drosophila. PLoS ONE 4 e7436 PubMed GONUTS page
↑ Ertürk-Hasdemir, D et al. (2009) Two roles for the Drosophila IKK complex in the activation of Relish and the induction of antimicrobial peptide genes. Proc. Natl. Acad. Sci. U.S.A. 106 9779-84 PubMed GONUTS page
↑ Valanne, S et al. (2007) Iap2 is required for a sustained response in the Drosophila Imd pathway. Dev. Comp. Immunol. 31 991-1001 PubMed GONUTS page
↑ Libert, S et al. (2006) Trade-offs between longevity and pathogen resistance in Drosophila melanogaster are mediated by NFkappaB signaling. Aging Cell 5 533-43 PubMed GONUTS page
↑ Leulier, F et al. (2006) The Drosophila inhibitor of apoptosis protein DIAP2 functions in innate immunity and is essential to resist gram-negative bacterial infection. Mol. Cell. Biol. 26 7821-31 PubMed GONUTS page
↑ Tsuda, M et al. (2005) The RING-finger scaffold protein Plenty of SH3s targets TAK1 to control immunity signalling in Drosophila. EMBO Rep. 6 1082-7 PubMed GONUTS page
↑ ^12.0 ^12.1 Ryabinina, OP et al. (2006) D-MEKK1, the Drosophila orthologue of mammalian MEKK4/MTK1, and Hemipterous/D-MKK7 mediate the activation of D-JNK by cadmium and arsenite in Schneider cells. BMC Cell Biol. 7 7 PubMed GONUTS page
↑ ^13.0 ^13.1 Mihaly, J et al. (2001) The role of the Drosophila TAK homologue dTAK during development. Mech. Dev. 102 67-79 PubMed GONUTS page
↑ ^14.0 ^14.1 Morrison, DK et al. (2000) Protein kinases and phosphatases in the Drosophila genome. J. Cell Biol. 150 F57-62 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 ^15.4 ^15.5 ^15.6 ^15.7 Takatsu, Y et al. (2000) TAK1 participates in c-Jun N-terminal kinase signaling during Drosophila development. Mol. Cell. Biol. 20 3015-26 PubMed GONUTS page
↑ ^16.0 ^16.1 Brennan, CA & Anderson, KV (2004) Drosophila: the genetics of innate immune recognition and response. Annu. Rev. Immunol. 22 457-83 PubMed GONUTS page
↑ Kurz, CL & Ewbank, JJ (2003) Caenorhabditis elegans: an emerging genetic model for the study of innate immunity. Nat. Rev. Genet. 4 380-90 PubMed GONUTS page
↑ Harden, N (2002) Signaling pathways directing the movement and fusion of epithelial sheets: lessons from dorsal closure in Drosophila. Differentiation 70 181-203 PubMed GONUTS page

[PMID:25737837-1] Srivastava, A & Dong, Q (2015) Regulation of a serine protease homolog by the JNK pathway during thoracic development of Drosophila melanogaster. FEBS Open Bio 5 117-23 PubMed GONUTS page

[PMID:14519762-2] 2.0 ^2.1 ^2.2 ^2.3 Silverman, N et al. (2003) Immune activation of NF-kappaB and JNK requires Drosophila TAK1. J. Biol. Chem. 278 48928-34 PubMed GONUTS page

[PMID:24429281-3] Stronach, B et al. (2014) Domain specificity of MAP3K family members, MLK and Tak1, for JNK signaling in Drosophila. Genetics 197 497-513 PubMed GONUTS page

[PMID:23532117-4] Shin, JH et al. (2013) TAK1 regulates autophagic cell death by suppressing the phosphorylation of p70 S6 kinase 1. Sci Rep 3 1561 PubMed GONUTS page

[PMID:22549468-5] Meinander, A et al. (2012) Ubiquitylation of the initiator caspase DREDD is required for innate immune signalling. EMBO J. 31 2770-83 PubMed GONUTS page

[PMID:19829691-6] Costa, A et al. (2009) The Imd pathway is involved in antiviral immune responses in Drosophila. PLoS ONE 4 e7436 PubMed GONUTS page

[PMID:19497884-7] Ertürk-Hasdemir, D et al. (2009) Two roles for the Drosophila IKK complex in the activation of Relish and the induction of antimicrobial peptide genes. Proc. Natl. Acad. Sci. U.S.A. 106 9779-84 PubMed GONUTS page

[PMID:17343912-8] Valanne, S et al. (2007) Iap2 is required for a sustained response in the Drosophila Imd pathway. Dev. Comp. Immunol. 31 991-1001 PubMed GONUTS page

[PMID:17129215-9] Libert, S et al. (2006) Trade-offs between longevity and pathogen resistance in Drosophila melanogaster are mediated by NFkappaB signaling. Aging Cell 5 533-43 PubMed GONUTS page

[PMID:16894030-10] Leulier, F et al. (2006) The Drosophila inhibitor of apoptosis protein DIAP2 functions in innate immunity and is essential to resist gram-negative bacterial infection. Mol. Cell. Biol. 26 7821-31 PubMed GONUTS page

[PMID:16179944-11] Tsuda, M et al. (2005) The RING-finger scaffold protein Plenty of SH3s targets TAK1 to control immunity signalling in Drosophila. EMBO Rep. 6 1082-7 PubMed GONUTS page

[PMID:16451733-12] 12.0 ^12.1 Ryabinina, OP et al. (2006) D-MEKK1, the Drosophila orthologue of mammalian MEKK4/MTK1, and Hemipterous/D-MKK7 mediate the activation of D-JNK by cadmium and arsenite in Schneider cells. BMC Cell Biol. 7 7 PubMed GONUTS page

[PMID:11287182-13] 13.0 ^13.1 Mihaly, J et al. (2001) The role of the Drosophila TAK homologue dTAK during development. Mech. Dev. 102 67-79 PubMed GONUTS page

[PMID:10908587-14] 14.0 ^14.1 Morrison, DK et al. (2000) Protein kinases and phosphatases in the Drosophila genome. J. Cell Biol. 150 F57-62 PubMed GONUTS page

[PMID:10757786-15] 15.0 ^15.1 ^15.2 ^15.3 ^15.4 ^15.5 ^15.6 ^15.7 Takatsu, Y et al. (2000) TAK1 participates in c-Jun N-terminal kinase signaling during Drosophila development. Mol. Cell. Biol. 20 3015-26 PubMed GONUTS page

[PMID:15032585-16] 16.0 ^16.1 Brennan, CA & Anderson, KV (2004) Drosophila: the genetics of innate immune recognition and response. Annu. Rev. Immunol. 22 457-83 PubMed GONUTS page

[PMID:12728280-17] Kurz, CL & Ewbank, JJ (2003) Caenorhabditis elegans: an emerging genetic model for the study of innate immunity. Nat. Rev. Genet. 4 380-90 PubMed GONUTS page

[PMID:12147138-18] Harden, N (2002) Signaling pathways directing the movement and fusion of epithelial sheets: lessons from dorsal closure in Drosophila. Differentiation 70 181-203 PubMed GONUTS page

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DROME:M3K7

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Annotations

Notes

References

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