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HUMAN:IRAK2

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) IRAK2
Protein Name(s) Interleukin-1 receptor-associated kinase-like 2

IRAK-2

External Links
UniProt O43187
EMBL AJ496794
AK299033
BC125184
AF026273
CCDS CCDS33697.1
RefSeq NP_001561.3
UniGene Hs.449207
PDB 3MOP
PDBsum 3MOP
ProteinModelPortal O43187
SMR O43187
BioGrid 109865
DIP DIP-31800N
IntAct O43187
MINT MINT-97184
STRING 9606.ENSP00000256458
PhosphoSite O43187
MaxQB O43187
PaxDb O43187
PeptideAtlas O43187
PRIDE O43187
DNASU 3656
Ensembl ENST00000256458
GeneID 3656
KEGG hsa:3656
UCSC uc003bve.1
CTD 3656
GeneCards GC03P010206
HGNC HGNC:6113
HPA CAB013483
MIM 603304
neXtProt NX_O43187
PharmGKB PA29913
eggNOG COG0515
GeneTree ENSGT00530000063073
HOGENOM HOG000113102
HOVERGEN HBG052145
InParanoid O43187
KO K04731
OMA LSEWDWM
OrthoDB EOG747PHP
PhylomeDB O43187
TreeFam TF328924
BRENDA 2.7.10.2
Reactome REACT_21281
REACT_21368
REACT_21399
REACT_22442
REACT_25018
REACT_25024
REACT_25222
REACT_25380
REACT_27215
REACT_6788
REACT_75776
SignaLink O43187
EvolutionaryTrace O43187
GeneWiki IRAK2
GenomeRNAi 3656
NextBio 14303
PRO PR:O43187
Proteomes UP000005640
Bgee O43187
CleanEx HS_IRAK2
Genevestigator O43187
GO GO:0005829
GO:0010008
GO:0005886
GO:0005524
GO:0046982
GO:0042803
GO:0004672
GO:0000187
GO:0007249
GO:0006954
GO:0045087
GO:0070498
GO:0007254
GO:0031663
GO:0002755
GO:0002756
GO:0032088
GO:0035872
GO:0070423
GO:0051092
GO:0006468
GO:0001959
GO:0070555
GO:0051403
GO:0034166
GO:0034134
GO:0034138
GO:0034142
GO:0034146
GO:0034162
GO:0002224
GO:0038123
GO:0038124
GO:0035666
Gene3D 1.10.533.10
InterPro IPR011029
IPR000488
IPR011009
IPR000719
Pfam PF00531
PF00069
SUPFAM SSF47986
SSF56112
PROSITE PS50011

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0070555

response to interleukin-1

PMID:10383454[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0070498

interleukin-1-mediated signaling pathway

PMID:10383454[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051092

positive regulation of NF-kappaB transcription factor activity

PMID:10383454[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

PMID:10383454[1]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P51617

F

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

PMID:10383454[1]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9Y616

F

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

PMID:10383454[1]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O43187

F

Seeded From UniProt

complete

involved_in

GO:0032088

negative regulation of NF-kappaB transcription factor activity

PMID:10383454[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001959

regulation of cytokine-mediated signaling pathway

PMID:10383454[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0070498

interleukin-1-mediated signaling pathway

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:107420
MGI:MGI:1921164
PANTHER:PTN001563216
UniProtKB:O43187
UniProtKB:P51617
UniProtKB:Q9Y616

P

Seeded From UniProt

complete

involved_in

GO:0051092

positive regulation of NF-kappaB transcription factor activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:107420
MGI:MGI:1921164
MGI:MGI:2429603
PANTHER:PTN001563216
UniProtKB:O43187
UniProtKB:P51617
UniProtKB:Q9Y616

P

Seeded From UniProt

complete

involved_in

GO:0035556

intracellular signal transduction

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1194498
PANTHER:PTN000784925
UniProtKB:Q8TF76

P

Seeded From UniProt

complete

involved_in

GO:0019221

cytokine-mediated signaling pathway

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:107420
MGI:MGI:1921164
MGI:MGI:2182474
PANTHER:PTN000701353
RGD:1305303
RGD:1563841

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003882
PANTHER:PTN000701353

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003882
FB:FBgn0010441
MGI:MGI:1921164
PANTHER:PTN000784925
TAIR:locus:2012340
UniProtKB:Q9Y616

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1194498
MGI:MGI:1921164
PANTHER:PTN000784925
TAIR:locus:2012340
UniProtKB:P51617
UniProtKB:Q8TF76
UniProtKB:Q9Y616

C

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1194498
MGI:MGI:1921164
PANTHER:PTN000784925
UniProtKB:P51617
UniProtKB:Q9NWZ3
UniProtKB:Q9Y616

F

Seeded From UniProt

complete

involved_in

GO:0051092

positive regulation of NF-kappaB transcription factor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8CFA1
ensembl:ENSMUSP00000055073

P

Seeded From UniProt

complete

involved_in

GO:0043433

negative regulation of DNA-binding transcription factor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8CFA1
ensembl:ENSMUSP00000055073

P

Seeded From UniProt

complete

involved_in

GO:0031663

lipopolysaccharide-mediated signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8CFA1
ensembl:ENSMUSP00000055073

P

Seeded From UniProt

complete

involved_in

GO:0001959

regulation of cytokine-mediated signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR033611

P

Seeded From UniProt

complete

involved_in

GO:0002755

MyD88-dependent toll-like receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR033611

P

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719

F

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719

P

Seeded From UniProt

complete

involved_in

GO:0006954

inflammatory response

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR033611

P

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000488

P

Seeded From UniProt

complete

involved_in

GO:0007249

I-kappaB kinase/NF-kappaB signaling

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR033611

P

Seeded From UniProt

complete

involved_in

GO:0070498

interleukin-1-mediated signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR033611

P

Seeded From UniProt

complete

involved_in

GO:0007249

I-kappaB kinase/NF-kappaB signaling

PMID:9374458[3]
Reactome:R-HSA-937072

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

involved_in

GO:0006954

inflammatory response

PMID:9374458[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

PMID:9374458[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0002755

MyD88-dependent toll-like receptor signaling pathway

PMID:10383454[1]
Reactome:R-HSA-975871
Reactome:R-HSA-166058

ECO:0000304

author statement supported by traceable reference used in manual assertion



P

Seeded From UniProt

complete

involved_in

GO:0070498

interleukin-1-mediated signaling pathway

Reactome:R-HSA-9020702

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0070423

nucleotide-binding oligomerization domain containing signaling pathway

Reactome:R-HSA-168638

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051092

positive regulation of NF-kappaB transcription factor activity

Reactome:R-HSA-445989

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0034162

toll-like receptor 9 signaling pathway

Reactome:R-HSA-168138

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0010008

endosome membrane

Reactome:R-HSA-975185
Reactome:R-HSA-975160
Reactome:R-HSA-975147
Reactome:R-HSA-975115
Reactome:R-HSA-975111
Reactome:R-HSA-975103
Reactome:R-HSA-975100
Reactome:R-HSA-975097
Reactome:R-HSA-450358

ECO:0000304

author statement supported by traceable reference used in manual assertion









C

Seeded From UniProt

complete

involved_in

GO:0007254

JNK cascade

Reactome:R-HSA-450321

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-975879
Reactome:R-HSA-975861
Reactome:R-HSA-975857
Reactome:R-HSA-975852
Reactome:R-HSA-937059
Reactome:R-HSA-936991
Reactome:R-HSA-936986
Reactome:R-HSA-936963
Reactome:R-HSA-936960
Reactome:R-HSA-936942
Reactome:R-HSA-2262777
Reactome:R-HSA-2262775
Reactome:R-HSA-166091

ECO:0000304

author statement supported by traceable reference used in manual assertion













C

Seeded From UniProt

complete

GO:0007165

signal transduction

PMID:23724040[4]

ECO:0000314

P

Figure 6 suggests IRAK2 regulates expression of UPR signaling protein.

complete
CACAO 9210

part_of

GO:0005829

cytosol

Reactome:R-HSA-975852
Reactome:R-HSA-975115
Reactome:R-HSA-450346
Reactome:R-HSA-450337
Reactome:R-HSA-446684
Reactome:R-HSA-168184
Reactome:R-HSA-166091

ECO:0000304

author statement supported by traceable reference used in manual assertion







C

Seeded From UniProt

complete

involved_in

GO:0002224

toll-like receptor signaling pathway

Reactome:R-HSA-168181

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000187

activation of MAPK activity

Reactome:R-HSA-450302

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Wesche, H et al. (1999) IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family. J. Biol. Chem. 274 19403-10 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Muzio, M et al. (1997) IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Science 278 1612-5 PubMed GONUTS page
  4. ↑ Benosman, S et al. (2013) Interleukin-1 receptor-associated kinase-2 (IRAK2) is a critical mediator of endoplasmic reticulum (ER) stress signaling. PLoS ONE 8 e64256 PubMed GONUTS page
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