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DROME:JNK

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) bsk (synonyms: JNK)
Protein Name(s) Stress-activated protein kinase JNK

dJNK Protein basket

External Links
UniProt P92208
EMBL U50965
U50966
U49180
U49249
U73196
AE014134
AY122221
AY070865
RefSeq NP_001162930.1
NP_001162932.1
NP_723541.1
UniGene Dm.1448
PDB 4M3A
PDBsum 4M3A
ProteinModelPortal P92208
SMR P92208
BioGrid 69288
DIP DIP-17307N
IntAct P92208
MINT MINT-337077
PaxDb P92208
PRIDE P92208
EnsemblMetazoa FBtr0080087
FBtr0300982
FBtr0302378
GeneID 44801
KEGG dme:Dmel_CG5680
CTD 44801
FlyBase FBgn0000229
eggNOG COG0515
GeneTree ENSGT00550000074271
InParanoid P92208
KO K04440
OMA DCLFPAD
OrthoDB EOG7PCJGV
PhylomeDB P92208
BRENDA 2.7.11.24
Reactome REACT_181694
REACT_181712
REACT_202759
REACT_248330
REACT_254893
REACT_34513
SignaLink P92208
GenomeRNAi 44801
NextBio 837648
Proteomes UP000000803
Bgee P92208
ExpressionAtlas P92208
GO GO:0030424
GO:0005737
GO:0030425
GO:0005524
GO:0004705
GO:0004672
GO:0004674
GO:0019731
GO:0048675
GO:0007411
GO:0007298
GO:0071243
GO:0071276
GO:0034599
GO:0034614
GO:0048674
GO:0071907
GO:0046843
GO:0007391
GO:0048615
GO:0043652
GO:0001736
GO:0046529
GO:0048803
GO:0007254
GO:0007258
GO:0000165
GO:0035006
GO:0046844
GO:0043508
GO:0048666
GO:0048812
GO:0030707
GO:0010508
GO:0006468
GO:0009408
GO:0006979
GO:0016055
GO:0042060
GO:0035313
InterPro IPR011009
IPR003527
IPR008351
IPR000719
IPR002290
IPR008271
Pfam PF00069
PRINTS PR01772
SMART SM00220
SUPFAM SSF56112
PROSITE PS01351
PS50011
PS00108

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000165

MAPK cascade

PMID:10878576[1]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0000166

nucleotide binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

GO:0001736

establishment of planar polarity

PMID:12414186[2]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0004672

protein kinase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR002290
InterPro:IPR008271

F

Seeded From UniProt

complete

GO:0004672

protein kinase activity

PMID:9224720[3]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0723

F

Seeded From UniProt

complete

GO:0004674

protein serine/threonine kinase activity

PMID:10908587[4]

NAS: Non-traceable Author Statement

F

Seeded From UniProt

complete

GO:0004705

JUN kinase activity

PMID:10449347[5]

TAS: Traceable Author Statement

F

Seeded From UniProt

complete

GO:0004705

JUN kinase activity

PMID:10878576[1]

NAS: Non-traceable Author Statement

F

Seeded From UniProt

complete

GO:0004705

JUN kinase activity

PMID:11439243[6]

IMP: Inferred from Mutant Phenotype

F

Seeded From UniProt

complete

GO:0004705

JUN kinase activity

PMID:11825878[7]

TAS: Traceable Author Statement

F

Seeded From UniProt

complete

GO:0004705

JUN kinase activity

PMID:8946915[8]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0004705

JUN kinase activity

PMID:8946916[9]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0004705

JUN kinase activity

PMID:8946916[9]

ISS: Inferred from Sequence or Structural Similarity

HGNC:6886

F

Seeded From UniProt

complete

GO:0004707

MAP kinase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003527
InterPro:IPR008351

F

Seeded From UniProt

complete

GO:0004707

MAP kinase activity

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:2.7.11.24

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:11865058[10]

IPI: Inferred from Physical Interaction

FB:FBgn0044323

F

Seeded From UniProt

complete

GO:0005524

ATP binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR002290
InterPro:IPR003527
InterPro:IPR008351

F

Seeded From UniProt

complete

GO:0005524

ATP binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

GO:0006468

protein phosphorylation

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR002290
InterPro:IPR003527
InterPro:IPR008271
InterPro:IPR008351

P

Seeded From UniProt

complete

GO:0006468

protein phosphorylation

PMID:10449347[5]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0006468

protein phosphorylation

PMID:10908587[4]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0006979

response to oxidative stress

PMID:19627268[11]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007254

JNK cascade

PMID:10449347[5]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007254

JNK cascade

PMID:12147138[12]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007254

JNK cascade

PMID:8946915[8]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0007258

JUN phosphorylation

PMID:11439243[6]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007275

multicellular organismal development

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

GO:0007298

border follicle cell migration

PMID:17483425[13]

IGI: Inferred from Genetic Interaction

FB:FBgn0032006

P

Seeded From UniProt

complete

GO:0007391

dorsal closure

PMID:10449347[5]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007391

dorsal closure

PMID:12000787[14]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0007391

dorsal closure

PMID:12147138[12]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0007391

dorsal closure

PMID:9224720[3]

IGI: Inferred from Genetic Interaction

FB:FBgn0001291

P

Seeded From UniProt

complete

GO:0007411

axon guidance

PMID:18516287[15]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007411

axon guidance

PMID:25160612[16]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0009408

response to heat

PMID:19627268[11]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0010508

positive regulation of autophagy

PMID:19540338[17]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016055

Wnt signaling pathway

PMID:12231350[18]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0016301

kinase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

GO:0016310

phosphorylation

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

GO:0016740

transferase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

GO:0019731

antibacterial humoral response

PMID:8946915[8]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0030424

axon

PMID:20035736[19]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0030425

dendrite

PMID:20035736[19]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0030707

ovarian follicle cell development

PMID:16542414[20]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0034599

cellular response to oxidative stress

PMID:19540338[17]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0034614

cellular response to reactive oxygen species

PMID:16451733[21]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0035006

melanization defense response

PMID:17356067[22]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0035006

melanization defense response

PMID:21664581[23]

IGI: Inferred from Genetic Interaction

FB:FBgn0002707

P

Seeded From UniProt

complete

GO:0035313

wound healing, spreading of epidermal cells

PMID:15269788[24]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0042060

wound healing

PMID:11784101[25]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0042060

wound healing

PMID:15766749[26]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0043508

negative regulation of JUN kinase activity

PMID:16150723[27]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0043652

engulfment of apoptotic cell

PMID:22992958[28]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0046529

imaginal disc fusion, thorax closure

PMID:14585960[29]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0046843

dorsal appendage formation

PMID:11543614[30]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0046844

micropyle formation

PMID:11543614[30]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0048615

embryonic anterior midgut (ectodermal) morphogenesis

PMID:17915206[31]

IGI: Inferred from Genetic Interaction

FB:FBgn0243512

P

Seeded From UniProt

complete

GO:0048666

neuron development

PMID:20035736[19]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0048674

collateral sprouting of injured axon

PMID:20921142[32]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0048675

axon extension

PMID:17032066[33]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0048803

imaginal disc-derived male genitalia morphogenesis

PMID:21389055[34]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0048812

neuron projection morphogenesis

PMID:20035736[19]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0071243

cellular response to arsenic-containing substance

PMID:16451733[21]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0071276

cellular response to cadmium ion

PMID:16451733[21]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0071907

determination of digestive tract left/right asymmetry

PMID:17915206[31]

IGI: Inferred from Genetic Interaction

FB:FBgn0243512

P

Seeded From UniProt

complete

GO:1903688

positive regulation of border follicle cell migration

PMID:18394891[35]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

NOT

GO:0009267

cellular response to starvation

PMID:19540338[17]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Martín-Blanco, E (2000) p38 MAPK signalling cascades: ancient roles and new functions. Bioessays 22 637-45 PubMed GONUTS page
  2. Mlodzik, M (2002) Planar cell polarization: do the same mechanisms regulate Drosophila tissue polarity and vertebrate gastrulation? Trends Genet. 18 564-71 PubMed GONUTS page
  3. 3.0 3.1 Riesgo-Escovar, JR & Hafen, E (1997) Drosophila Jun kinase regulates expression of decapentaplegic via the ETS-domain protein Aop and the AP-1 transcription factor DJun during dorsal closure. Genes Dev. 11 1717-27 PubMed GONUTS page
  4. 4.0 4.1 Morrison, DK et al. (2000) Protein kinases and phosphatases in the Drosophila genome. J. Cell Biol. 150 F57-62 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 Noselli, S & Agnès, F (1999) Roles of the JNK signaling pathway in Drosophila morphogenesis. Curr. Opin. Genet. Dev. 9 466-72 PubMed GONUTS page
  6. 6.0 6.1 Botella, JA et al. (2001) The Drosophila cell shape regulator c-Jun N-terminal kinase also functions as a stress-activated protein kinase. Insect Biochem. Mol. Biol. 31 839-47 PubMed GONUTS page
  7. Stronach, B & Perrimon, N (2002) Activation of the JNK pathway during dorsal closure in Drosophila requires the mixed lineage kinase, slipper. Genes Dev. 16 377-87 PubMed GONUTS page
  8. 8.0 8.1 8.2 Sluss, HK et al. (1996) A JNK signal transduction pathway that mediates morphogenesis and an immune response in Drosophila. Genes Dev. 10 2745-58 PubMed GONUTS page
  9. 9.0 9.1 Riesgo-Escovar, JR et al. (1996) The Drosophila Jun-N-terminal kinase is required for cell morphogenesis but not for DJun-dependent cell fate specification in the eye. Genes Dev. 10 2759-68 PubMed GONUTS page
  10. Chen, HW et al. (2002) CKA, a novel multidomain protein, regulates the JUN N-terminal kinase signal transduction pathway in Drosophila. Mol. Cell. Biol. 22 1792-803 PubMed GONUTS page
  11. 11.0 11.1 Karpac, J et al. (2009) JNK signaling in insulin-producing cells is required for adaptive responses to stress in Drosophila. Aging Cell 8 288-95 PubMed GONUTS page
  12. 12.0 12.1 Harden, N (2002) Signaling pathways directing the movement and fusion of epithelial sheets: lessons from dorsal closure in Drosophila. Differentiation 70 181-203 PubMed GONUTS page
  13. Mathieu, J et al. (2007) A sensitized PiggyBac-based screen for regulators of border cell migration in Drosophila. Genetics 176 1579-90 PubMed GONUTS page
  14. Van Aelst, L & Symons, M (2002) Role of Rho family GTPases in epithelial morphogenesis. Genes Dev. 16 1032-54 PubMed GONUTS page
  15. Berger, J et al. (2008) Systematic identification of genes that regulate neuronal wiring in the Drosophila visual system. PLoS Genet. 4 e1000085 PubMed GONUTS page
  16. Soares, L et al. (2014) Axon injury and regeneration in the adult Drosophila. Sci Rep 4 6199 PubMed GONUTS page
  17. 17.0 17.1 17.2 Wu, H et al. () JNK protects Drosophila from oxidative stress by trancriptionally activating autophagy. Mech. Dev. 126 624-37 PubMed GONUTS page
  18. Wedlich, D (2002) The polarising role of cell adhesion molecules in early development. Curr. Opin. Cell Biol. 14 563-8 PubMed GONUTS page
  19. 19.0 19.1 19.2 19.3 Rallis, A et al. (2010) Signal strength and signal duration define two distinct aspects of JNK-regulated axon stability. Dev. Biol. 339 65-77 PubMed GONUTS page
  20. Jordan, KC et al. (2006) Notch signaling through tramtrack bypasses the mitosis promoting activity of the JNK pathway in the mitotic-to-endocycle transition of Drosophila follicle cells. BMC Dev. Biol. 6 16 PubMed GONUTS page
  21. 21.0 21.1 21.2 Ryabinina, OP et al. (2006) D-MEKK1, the Drosophila orthologue of mammalian MEKK4/MTK1, and Hemipterous/D-MKK7 mediate the activation of D-JNK by cadmium and arsenite in Schneider cells. BMC Cell Biol. 7 7 PubMed GONUTS page
  22. Bidla, G et al. (2007) Crystal cell rupture after injury in Drosophila requires the JNK pathway, small GTPases and the TNF homolog Eiger. J. Cell. Sci. 120 1209-15 PubMed GONUTS page
  23. Karpac, J et al. (2011) Dynamic coordination of innate immune signaling and insulin signaling regulates systemic responses to localized DNA damage. Dev. Cell 20 841-54 PubMed GONUTS page
  24. Galko, MJ & Krasnow, MA (2004) Cellular and genetic analysis of wound healing in Drosophila larvae. PLoS Biol. 2 E239 PubMed GONUTS page
  25. Rämet, M et al. (2002) JNK signaling pathway is required for efficient wound healing in Drosophila. Dev. Biol. 241 145-56 PubMed GONUTS page
  26. Bosch, M et al. (2005) JNK signaling pathway required for wound healing in regenerating Drosophila wing imaginal discs. Dev. Biol. 280 73-86 PubMed GONUTS page
  27. Uhlirova, M et al. (2005) Non-cell-autonomous induction of tissue overgrowth by JNK/Ras cooperation in a Drosophila tumor model. Proc. Natl. Acad. Sci. U.S.A. 102 13123-8 PubMed GONUTS page
  28. Etchegaray, JI et al. (2012) Draper acts through the JNK pathway to control synchronous engulfment of dying germline cells by follicular epithelial cells. Development 139 4029-39 PubMed GONUTS page
  29. Cha, GH et al. (2003) Discrete functions of TRAF1 and TRAF2 in Drosophila melanogaster mediated by c-Jun N-terminal kinase and NF-kappaB-dependent signaling pathways. Mol. Cell. Biol. 23 7982-91 PubMed GONUTS page
  30. 30.0 30.1 Suzanne, M et al. (2001) The Drosophila JNK pathway controls the morphogenesis of the egg dorsal appendages and micropyle. Dev. Biol. 237 282-94 PubMed GONUTS page
  31. 31.0 31.1 Taniguchi, K et al. (2007) D-JNK signaling in visceral muscle cells controls the laterality of the Drosophila gut. Dev. Biol. 311 251-63 PubMed GONUTS page
  32. Xiong, X et al. (2010) Protein turnover of the Wallenda/DLK kinase regulates a retrograde response to axonal injury. J. Cell Biol. 191 211-23 PubMed GONUTS page
  33. Srahna, M et al. (2006) A signaling network for patterning of neuronal connectivity in the Drosophila brain. PLoS Biol. 4 e348 PubMed GONUTS page
  34. Kuranaga, E et al. (2011) Apoptosis controls the speed of looping morphogenesis in Drosophila male terminalia. Development 138 1493-9 PubMed GONUTS page
  35. Melani, M et al. (2008) Regulation of cell adhesion and collective cell migration by hindsight and its human homolog RREB1. Curr. Biol. 18 532-7 PubMed GONUTS page