DROME:JNK

Species (Taxon ID)	Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s)	bsk (synonyms: JNK)
Protein Name(s)	Stress-activated protein kinase JNK dJNK Protein basket
External Links
UniProt	P92208
EMBL	U50965 U50966 U49180 U49249 U73196 AE014134 AY122221 AY070865
RefSeq	NP_001162930.1 NP_001162932.1 NP_723541.1
UniGene	Dm.1448
PDB	4M3A
PDBsum	4M3A
ProteinModelPortal	P92208
SMR	P92208
BioGrid	69288
DIP	DIP-17307N
IntAct	P92208
MINT	MINT-337077
PaxDb	P92208
PRIDE	P92208
EnsemblMetazoa	FBtr0080087 FBtr0300982 FBtr0302378
GeneID	44801
KEGG	dme:Dmel_CG5680
CTD	44801
FlyBase	FBgn0000229
eggNOG	COG0515
GeneTree	ENSGT00550000074271
InParanoid	P92208
KO	K04440
OMA	DCLFPAD
OrthoDB	EOG7PCJGV
PhylomeDB	P92208
BRENDA	2.7.11.24
Reactome	REACT_181694 REACT_181712 REACT_202759 REACT_248330 REACT_254893 REACT_34513
SignaLink	P92208
GenomeRNAi	44801
NextBio	837648
Proteomes	UP000000803
Bgee	P92208
ExpressionAtlas	P92208
GO	GO:0030424 GO:0005737 GO:0030425 GO:0005524 GO:0004705 GO:0004672 GO:0004674 GO:0019731 GO:0048675 GO:0007411 GO:0007298 GO:0071243 GO:0071276 GO:0034599 GO:0034614 GO:0048674 GO:0071907 GO:0046843 GO:0007391 GO:0048615 GO:0043652 GO:0001736 GO:0046529 GO:0048803 GO:0007254 GO:0007258 GO:0000165 GO:0035006 GO:0046844 GO:0043508 GO:0048666 GO:0048812 GO:0030707 GO:0010508 GO:0006468 GO:0009408 GO:0006979 GO:0016055 GO:0042060 GO:0035313
InterPro	IPR011009 IPR003527 IPR008351 IPR000719 IPR002290 IPR008271
Pfam	PF00069
PRINTS	PR01772
SMART	SM00220
SUPFAM	SSF56112
PROSITE	PS01351 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0007395	dorsal closure, spreading of leading edge cells	PMID:28628612^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:20379222^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q7K5M0)	Seeded From UniProt	complete
involved_in	GO:1903688	positive regulation of border follicle cell migration	PMID:18394891^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042060	wound healing	PMID:11784101^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007254	JNK cascade	PMID:8946915^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004705	JUN kinase activity	PMID:8946915^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0071310	cellular response to organic substance	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001172432 RGD:70500	P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:106908 MGI:MGI:1201387 MGI:MGI:1201408 MGI:MGI:1346865 PANTHER:PTN000622075 RGD:3046 RGD:70500 RGD:71050 UniProtKB:P78362 UniProtKB:Q16539 UniProtKB:Q96SB4 UniProtKB:Q9UPZ9 WB:WBGene00004055 WB:WBGene00004056	P		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1346861 PANTHER:PTN000622075 UniProtKB:A9T142	P		Seeded From UniProt	complete
involved_in	GO:0007254	JNK cascade	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000229 MGI:MGI:1346863 PANTHER:PTN001171982 RGD:3663	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0052703 FB:FBgn0267339 MGI:MGI:1201408 MGI:MGI:1346347 MGI:MGI:1346858 MGI:MGI:1346859 MGI:MGI:1346861 MGI:MGI:1346862 MGI:MGI:1346863 MGI:MGI:1346865 MGI:MGI:1354946 MGI:MGI:2444559 PANTHER:PTN000622075 PomBase:SPAC24B11.06c PomBase:SPBC119.08 PomBase:SPBC530.14c RGD:3046 RGD:621506 RGD:628847 RGD:70500 RGD:70975 RGD:71050 SGD:S000000112 SGD:S000004103 SGD:S000004829 TAIR:locus:2024887 TAIR:locus:2124943 UniProtKB:A9T142 UniProtKB:O77306 UniProtKB:P28482 UniProtKB:P78362 UniProtKB:Q10N20 UniProtKB:Q13164 UniProtKB:Q96SB4 WB:WBGene00002178 WB:WBGene00002187 WB:WBGene00003048 WB:WBGene00003401 WB:WBGene00004056 WB:WBGene00004057	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003256 FB:FBgn0015765 MGI:MGI:1201387 MGI:MGI:1201408 MGI:MGI:1336881 MGI:MGI:1346347 MGI:MGI:1346858 MGI:MGI:1346859 MGI:MGI:1346861 MGI:MGI:1346865 MGI:MGI:1354946 MGI:MGI:1934157 MGI:MGI:2444559 MGI:MGI:96913 PANTHER:PTN000622075 PomBase:SPAC24B11.06c PomBase:SPAC31G5.09c PomBase:SPBC119.08 PomBase:SPBC530.14c RGD:3046 RGD:3663 RGD:621505 RGD:621506 RGD:628675 RGD:628847 RGD:70496 RGD:70500 SGD:S000000112 SGD:S000001072 SGD:S000003272 SGD:S000003642 SGD:S000004103 TAIR:locus:2024887 TAIR:locus:2124943 UniProtKB:A9T142 UniProtKB:O77306 UniProtKB:P20794 UniProtKB:P28482 UniProtKB:P45983 UniProtKB:P78362 UniProtKB:Q10N20 UniProtKB:Q13164 UniProtKB:Q5AZN7 UniProtKB:Q8GYQ5 UniProtKB:Q96SB4 UniProtKB:Q9LV37 UniProtKB:Q9P419 WB:WBGene00002178 WB:WBGene00003048 WB:WBGene00003401 WB:WBGene00004055 WB:WBGene00004057 dictyBase:DDB_G0283903 dictyBase:DDB_G0286353	C		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015765 FB:FBgn0024846 FB:FBgn0267339 MGI:MGI:1346858 MGI:MGI:1346859 MGI:MGI:1346865 MGI:MGI:1354946 PANTHER:PTN001172432 PomBase:SPAC31G5.09c PomBase:SPBC119.08 RGD:1309340 RGD:3045 RGD:3046 RGD:621505 RGD:70496 RGD:70500 RGD:70975 SGD:S000000112 SGD:S000003272 SGD:S000006258 UniProtKB:A0A1D8PFT5 UniProtKB:A0A1D8PT38 UniProtKB:O15264 UniProtKB:P27361 UniProtKB:Q15759 UniProtKB:Q16539 WB:WBGene00003401 WB:WBGene00004055 WB:WBGene00004056 dictyBase:DDB_G0286353	F		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	CGD:CAL0000183747 FB:FBgn0015765 FB:FBgn0024846 FB:FBgn0267339 MGI:MGI:1346858 MGI:MGI:1346859 MGI:MGI:1346865 MGI:MGI:1354946 PANTHER:PTN002372889 PomBase:SPAC31G5.09c PomBase:SPBC119.08 RGD:1309340 RGD:3045 RGD:3046 RGD:621505 RGD:70496 RGD:70500 RGD:70975 SGD:S000000112 SGD:S000003272 SGD:S000006258 UniProtKB:A0A1D8PFT5 UniProtKB:A0A1D8PT38 UniProtKB:O15264 UniProtKB:P27361 UniProtKB:Q15759 UniProtKB:Q16539 WB:WBGene00003401 WB:WBGene00004055 WB:WBGene00004056 dictyBase:DDB_G0286353	F		Seeded From UniProt	complete
enables	GO:0004705	JUN kinase activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000229 MGI:MGI:1346863 PANTHER:PTN001171982 RGD:3663 WB:WBGene00002178 WB:WBGene00002187	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:10908587^[7]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	PMID:10878576^[8]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004705	JUN kinase activity	PMID:10878576^[8]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:9224720^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007391	dorsal closure	PMID:9224720^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0001291	P		Seeded From UniProt	complete
involved_in	GO:0019731	antibacterial humoral response	PMID:8946915^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004705	JUN kinase activity	PMID:8946916^[10]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(FB:FBgn0001291)	Seeded From UniProt	complete
involved_in	GO:1904801	positive regulation of neuron remodeling	PMID:26586184^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:26586184^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0016319	mushroom body development	PMID:26586184^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	PMID:25160612^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007616	long-term memory	PMID:23063437^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0030600	P		Seeded From UniProt	complete
involved_in	GO:0043652	engulfment of apoptotic cell	PMID:22992958^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035006	melanization defense response	PMID:21664581^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0002707	P		Seeded From UniProt	complete
involved_in	GO:0048803	imaginal disc-derived male genitalia morphogenesis	PMID:21389055^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048674	collateral sprouting of injured axon	PMID:20921142^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	PMID:18516287^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:20035736^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0048666	neuron development	PMID:20035736^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:20035736^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0048812	neuron projection morphogenesis	PMID:20035736^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010508	positive regulation of autophagy	PMID:19540338^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034599	cellular response to oxidative stress	PMID:19540338^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
NOT\|involved_in	GO:0009267	cellular response to starvation	PMID:19540338^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	PMID:19627268^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009408	response to heat	PMID:19627268^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903688	positive regulation of border follicle cell migration	PMID:17483425^[22]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0032006	P		Seeded From UniProt	complete
involved_in	GO:0048615	embryonic anterior midgut (ectodermal) morphogenesis	PMID:17915206^[23]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0243512	P		Seeded From UniProt	complete
involved_in	GO:0071907	determination of digestive tract left/right asymmetry	PMID:17915206^[23]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0243512	P		Seeded From UniProt	complete
involved_in	GO:0035006	melanization defense response	PMID:17356067^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048675	axon extension	PMID:17032066^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030707	ovarian follicle cell development	PMID:16542414^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071276	cellular response to cadmium ion	PMID:16451733^[27]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071243	cellular response to arsenic-containing substance	PMID:16451733^[27]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034614	cellular response to reactive oxygen species	PMID:16451733^[27]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043508	negative regulation of JUN kinase activity	PMID:16150723^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042060	wound healing	PMID:15766749^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035313	wound healing, spreading of epidermal cells	PMID:15269788^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046529	imaginal disc fusion, thorax closure	PMID:14585960^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001736	establishment of planar polarity	PMID:12414186^[32]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007391	dorsal closure	PMID:12147138^[33]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046844	chorion micropyle formation	PMID:11543614^[34]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046843	dorsal appendage formation	PMID:11543614^[34]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004705	JUN kinase activity	PMID:11439243^[35]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007258	JUN phosphorylation	PMID:11439243^[35]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:10908587^[7]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048010	vascular endothelial growth factor receptor signaling pathway	PMID:15457211^[36]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046529	imaginal disc fusion, thorax closure	PMID:15457211^[36]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007254	JNK cascade	PMID:15457211^[36]	ECO:0000314	direct assay evidence used in manual assertion		P	part_of:(GO:0048010)	Seeded From UniProt	complete
involved_in	GO:0007254	JNK cascade	PMID:8946916^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007391	dorsal closure	PMID:8946916^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003527 InterPro:IPR008351	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR003527 InterPro:IPR008351	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR003527 InterPro:IPR008271 InterPro:IPR008351	P		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.11.24	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-DME-209302 Reactome:R-DME-209298 Reactome:R-DME-209199 Reactome:R-DME-209183 Reactome:R-DME-209157	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-DME-209381 Reactome:R-DME-209330 Reactome:R-DME-209193	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	Reactome:R-DME-209199	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:10449347^[37]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007391	dorsal closure	PMID:10449347^[37]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004705	JUN kinase activity	PMID:10449347^[37] PMID:11825878^[38]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007254	JNK cascade	PMID:12147138^[33]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Kushnir, T et al. (2017) Novel interplay between JNK and Egfr signaling in Drosophila dorsal closure. PLoS Genet. 13 e1006860 PubMed GONUTS page
↑ Sorrosal, G et al. (2010) Scarface, a secreted serine protease-like protein, regulates polarized localization of laminin A at the basement membrane of the Drosophila embryo. EMBO Rep. 11 373-9 PubMed GONUTS page
↑ Melani, M et al. (2008) Regulation of cell adhesion and collective cell migration by hindsight and its human homolog RREB1. Curr. Biol. 18 532-7 PubMed GONUTS page
↑ Rämet, M et al. (2002) JNK signaling pathway is required for efficient wound healing in Drosophila. Dev. Biol. 241 145-56 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Sluss, HK et al. (1996) A JNK signal transduction pathway that mediates morphogenesis and an immune response in Drosophila. Genes Dev. 10 2745-58 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 ^6.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^7.0 ^7.1 Morrison, DK et al. (2000) Protein kinases and phosphatases in the Drosophila genome. J. Cell Biol. 150 F57-62 PubMed GONUTS page
↑ ^8.0 ^8.1 Martín-Blanco, E (2000) p38 MAPK signalling cascades: ancient roles and new functions. Bioessays 22 637-45 PubMed GONUTS page
↑ ^9.0 ^9.1 Riesgo-Escovar, JR & Hafen, E (1997) Drosophila Jun kinase regulates expression of decapentaplegic via the ETS-domain protein Aop and the AP-1 transcription factor DJun during dorsal closure. Genes Dev. 11 1717-27 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Riesgo-Escovar, JR et al. (1996) The Drosophila Jun-N-terminal kinase is required for cell morphogenesis but not for DJun-dependent cell fate specification in the eye. Genes Dev. 10 2759-68 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Bornstein, B et al. (2015) Developmental Axon Pruning Requires Destabilization of Cell Adhesion by JNK Signaling. Neuron 88 926-940 PubMed GONUTS page
↑ Soares, L et al. (2014) Axon injury and regeneration in the adult Drosophila. Sci Rep 4 6199 PubMed GONUTS page
↑ Huang, C et al. (2012) A permissive role of mushroom body α/β core neurons in long-term memory consolidation in Drosophila. Curr. Biol. 22 1981-9 PubMed GONUTS page
↑ Etchegaray, JI et al. (2012) Draper acts through the JNK pathway to control synchronous engulfment of dying germline cells by follicular epithelial cells. Development 139 4029-39 PubMed GONUTS page
↑ Karpac, J et al. (2011) Dynamic coordination of innate immune signaling and insulin signaling regulates systemic responses to localized DNA damage. Dev. Cell 20 841-54 PubMed GONUTS page
↑ Kuranaga, E et al. (2011) Apoptosis controls the speed of looping morphogenesis in Drosophila male terminalia. Development 138 1493-9 PubMed GONUTS page
↑ Xiong, X et al. (2010) Protein turnover of the Wallenda/DLK kinase regulates a retrograde response to axonal injury. J. Cell Biol. 191 211-23 PubMed GONUTS page
↑ Berger, J et al. (2008) Systematic identification of genes that regulate neuronal wiring in the Drosophila visual system. PLoS Genet. 4 e1000085 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 Rallis, A et al. (2010) Signal strength and signal duration define two distinct aspects of JNK-regulated axon stability. Dev. Biol. 339 65-77 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 Wu, H et al. () JNK protects Drosophila from oxidative stress by trancriptionally activating autophagy. Mech. Dev. 126 624-37 PubMed GONUTS page
↑ ^21.0 ^21.1 Karpac, J et al. (2009) JNK signaling in insulin-producing cells is required for adaptive responses to stress in Drosophila. Aging Cell 8 288-95 PubMed GONUTS page
↑ Mathieu, J et al. (2007) A sensitized PiggyBac-based screen for regulators of border cell migration in Drosophila. Genetics 176 1579-90 PubMed GONUTS page
↑ ^23.0 ^23.1 Taniguchi, K et al. (2007) D-JNK signaling in visceral muscle cells controls the laterality of the Drosophila gut. Dev. Biol. 311 251-63 PubMed GONUTS page
↑ Bidla, G et al. (2007) Crystal cell rupture after injury in Drosophila requires the JNK pathway, small GTPases and the TNF homolog Eiger. J. Cell. Sci. 120 1209-15 PubMed GONUTS page
↑ Srahna, M et al. (2006) A signaling network for patterning of neuronal connectivity in the Drosophila brain. PLoS Biol. 4 e348 PubMed GONUTS page
↑ Jordan, KC et al. (2006) Notch signaling through tramtrack bypasses the mitosis promoting activity of the JNK pathway in the mitotic-to-endocycle transition of Drosophila follicle cells. BMC Dev. Biol. 6 16 PubMed GONUTS page
↑ ^27.0 ^27.1 ^27.2 Ryabinina, OP et al. (2006) D-MEKK1, the Drosophila orthologue of mammalian MEKK4/MTK1, and Hemipterous/D-MKK7 mediate the activation of D-JNK by cadmium and arsenite in Schneider cells. BMC Cell Biol. 7 7 PubMed GONUTS page
↑ Uhlirova, M et al. (2005) Non-cell-autonomous induction of tissue overgrowth by JNK/Ras cooperation in a Drosophila tumor model. Proc. Natl. Acad. Sci. U.S.A. 102 13123-8 PubMed GONUTS page
↑ Bosch, M et al. (2005) JNK signaling pathway required for wound healing in regenerating Drosophila wing imaginal discs. Dev. Biol. 280 73-86 PubMed GONUTS page
↑ Galko, MJ & Krasnow, MA (2004) Cellular and genetic analysis of wound healing in Drosophila larvae. PLoS Biol. 2 E239 PubMed GONUTS page
↑ Cha, GH et al. (2003) Discrete functions of TRAF1 and TRAF2 in Drosophila melanogaster mediated by c-Jun N-terminal kinase and NF-kappaB-dependent signaling pathways. Mol. Cell. Biol. 23 7982-91 PubMed GONUTS page
↑ Mlodzik, M (2002) Planar cell polarization: do the same mechanisms regulate Drosophila tissue polarity and vertebrate gastrulation? Trends Genet. 18 564-71 PubMed GONUTS page
↑ ^33.0 ^33.1 Harden, N (2002) Signaling pathways directing the movement and fusion of epithelial sheets: lessons from dorsal closure in Drosophila. Differentiation 70 181-203 PubMed GONUTS page
↑ ^34.0 ^34.1 Suzanne, M et al. (2001) The Drosophila JNK pathway controls the morphogenesis of the egg dorsal appendages and micropyle. Dev. Biol. 237 282-94 PubMed GONUTS page
↑ ^35.0 ^35.1 Botella, JA et al. (2001) The Drosophila cell shape regulator c-Jun N-terminal kinase also functions as a stress-activated protein kinase. Insect Biochem. Mol. Biol. 31 839-47 PubMed GONUTS page
↑ ^36.0 ^36.1 ^36.2 Ishimaru, S et al. (2004) PVR plays a critical role via JNK activation in thorax closure during Drosophila metamorphosis. EMBO J. 23 3984-94 PubMed GONUTS page
↑ ^37.0 ^37.1 ^37.2 Noselli, S & Agnès, F (1999) Roles of the JNK signaling pathway in Drosophila morphogenesis. Curr. Opin. Genet. Dev. 9 466-72 PubMed GONUTS page
↑ Stronach, B & Perrimon, N (2002) Activation of the JNK pathway during dorsal closure in Drosophila requires the mixed lineage kinase, slipper. Genes Dev. 16 377-87 PubMed GONUTS page

[PMID:28628612-1] Kushnir, T et al. (2017) Novel interplay between JNK and Egfr signaling in Drosophila dorsal closure. PLoS Genet. 13 e1006860 PubMed GONUTS page

[PMID:20379222-2] Sorrosal, G et al. (2010) Scarface, a secreted serine protease-like protein, regulates polarized localization of laminin A at the basement membrane of the Drosophila embryo. EMBO Rep. 11 373-9 PubMed GONUTS page

[PMID:18394891-3] Melani, M et al. (2008) Regulation of cell adhesion and collective cell migration by hindsight and its human homolog RREB1. Curr. Biol. 18 532-7 PubMed GONUTS page

[PMID:11784101-4] Rämet, M et al. (2002) JNK signaling pathway is required for efficient wound healing in Drosophila. Dev. Biol. 241 145-56 PubMed GONUTS page

[PMID:8946915-5] 5.0 ^5.1 ^5.2 Sluss, HK et al. (1996) A JNK signal transduction pathway that mediates morphogenesis and an immune response in Drosophila. Genes Dev. 10 2745-58 PubMed GONUTS page

[PMID:21873635-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 ^6.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:10908587-7] 7.0 ^7.1 Morrison, DK et al. (2000) Protein kinases and phosphatases in the Drosophila genome. J. Cell Biol. 150 F57-62 PubMed GONUTS page

[PMID:10878576-8] 8.0 ^8.1 Martín-Blanco, E (2000) p38 MAPK signalling cascades: ancient roles and new functions. Bioessays 22 637-45 PubMed GONUTS page

[PMID:9224720-9] 9.0 ^9.1 Riesgo-Escovar, JR & Hafen, E (1997) Drosophila Jun kinase regulates expression of decapentaplegic via the ETS-domain protein Aop and the AP-1 transcription factor DJun during dorsal closure. Genes Dev. 11 1717-27 PubMed GONUTS page

[PMID:8946916-10] 10.0 ^10.1 ^10.2 Riesgo-Escovar, JR et al. (1996) The Drosophila Jun-N-terminal kinase is required for cell morphogenesis but not for DJun-dependent cell fate specification in the eye. Genes Dev. 10 2759-68 PubMed GONUTS page

[PMID:26586184-11] 11.0 ^11.1 ^11.2 Bornstein, B et al. (2015) Developmental Axon Pruning Requires Destabilization of Cell Adhesion by JNK Signaling. Neuron 88 926-940 PubMed GONUTS page

[PMID:25160612-12] Soares, L et al. (2014) Axon injury and regeneration in the adult Drosophila. Sci Rep 4 6199 PubMed GONUTS page

[PMID:23063437-13] Huang, C et al. (2012) A permissive role of mushroom body α/β core neurons in long-term memory consolidation in Drosophila. Curr. Biol. 22 1981-9 PubMed GONUTS page

[PMID:22992958-14] Etchegaray, JI et al. (2012) Draper acts through the JNK pathway to control synchronous engulfment of dying germline cells by follicular epithelial cells. Development 139 4029-39 PubMed GONUTS page

[PMID:21664581-15] Karpac, J et al. (2011) Dynamic coordination of innate immune signaling and insulin signaling regulates systemic responses to localized DNA damage. Dev. Cell 20 841-54 PubMed GONUTS page

[PMID:21389055-16] Kuranaga, E et al. (2011) Apoptosis controls the speed of looping morphogenesis in Drosophila male terminalia. Development 138 1493-9 PubMed GONUTS page

[PMID:20921142-17] Xiong, X et al. (2010) Protein turnover of the Wallenda/DLK kinase regulates a retrograde response to axonal injury. J. Cell Biol. 191 211-23 PubMed GONUTS page

[PMID:18516287-18] Berger, J et al. (2008) Systematic identification of genes that regulate neuronal wiring in the Drosophila visual system. PLoS Genet. 4 e1000085 PubMed GONUTS page

[PMID:20035736-19] 19.0 ^19.1 ^19.2 ^19.3 Rallis, A et al. (2010) Signal strength and signal duration define two distinct aspects of JNK-regulated axon stability. Dev. Biol. 339 65-77 PubMed GONUTS page

[PMID:19540338-20] 20.0 ^20.1 ^20.2 Wu, H et al. () JNK protects Drosophila from oxidative stress by trancriptionally activating autophagy. Mech. Dev. 126 624-37 PubMed GONUTS page

[PMID:19627268-21] 21.0 ^21.1 Karpac, J et al. (2009) JNK signaling in insulin-producing cells is required for adaptive responses to stress in Drosophila. Aging Cell 8 288-95 PubMed GONUTS page

[PMID:17483425-22] Mathieu, J et al. (2007) A sensitized PiggyBac-based screen for regulators of border cell migration in Drosophila. Genetics 176 1579-90 PubMed GONUTS page

[PMID:17915206-23] 23.0 ^23.1 Taniguchi, K et al. (2007) D-JNK signaling in visceral muscle cells controls the laterality of the Drosophila gut. Dev. Biol. 311 251-63 PubMed GONUTS page

[PMID:17356067-24] Bidla, G et al. (2007) Crystal cell rupture after injury in Drosophila requires the JNK pathway, small GTPases and the TNF homolog Eiger. J. Cell. Sci. 120 1209-15 PubMed GONUTS page

[PMID:17032066-25] Srahna, M et al. (2006) A signaling network for patterning of neuronal connectivity in the Drosophila brain. PLoS Biol. 4 e348 PubMed GONUTS page

[PMID:16542414-26] Jordan, KC et al. (2006) Notch signaling through tramtrack bypasses the mitosis promoting activity of the JNK pathway in the mitotic-to-endocycle transition of Drosophila follicle cells. BMC Dev. Biol. 6 16 PubMed GONUTS page

[PMID:16451733-27] 27.0 ^27.1 ^27.2 Ryabinina, OP et al. (2006) D-MEKK1, the Drosophila orthologue of mammalian MEKK4/MTK1, and Hemipterous/D-MKK7 mediate the activation of D-JNK by cadmium and arsenite in Schneider cells. BMC Cell Biol. 7 7 PubMed GONUTS page

[PMID:16150723-28] Uhlirova, M et al. (2005) Non-cell-autonomous induction of tissue overgrowth by JNK/Ras cooperation in a Drosophila tumor model. Proc. Natl. Acad. Sci. U.S.A. 102 13123-8 PubMed GONUTS page

[PMID:15766749-29] Bosch, M et al. (2005) JNK signaling pathway required for wound healing in regenerating Drosophila wing imaginal discs. Dev. Biol. 280 73-86 PubMed GONUTS page

[PMID:15269788-30] Galko, MJ & Krasnow, MA (2004) Cellular and genetic analysis of wound healing in Drosophila larvae. PLoS Biol. 2 E239 PubMed GONUTS page

[PMID:14585960-31] Cha, GH et al. (2003) Discrete functions of TRAF1 and TRAF2 in Drosophila melanogaster mediated by c-Jun N-terminal kinase and NF-kappaB-dependent signaling pathways. Mol. Cell. Biol. 23 7982-91 PubMed GONUTS page

[PMID:12414186-32] Mlodzik, M (2002) Planar cell polarization: do the same mechanisms regulate Drosophila tissue polarity and vertebrate gastrulation? Trends Genet. 18 564-71 PubMed GONUTS page

[PMID:12147138-33] 33.0 ^33.1 Harden, N (2002) Signaling pathways directing the movement and fusion of epithelial sheets: lessons from dorsal closure in Drosophila. Differentiation 70 181-203 PubMed GONUTS page

[PMID:11543614-34] 34.0 ^34.1 Suzanne, M et al. (2001) The Drosophila JNK pathway controls the morphogenesis of the egg dorsal appendages and micropyle. Dev. Biol. 237 282-94 PubMed GONUTS page

[PMID:11439243-35] 35.0 ^35.1 Botella, JA et al. (2001) The Drosophila cell shape regulator c-Jun N-terminal kinase also functions as a stress-activated protein kinase. Insect Biochem. Mol. Biol. 31 839-47 PubMed GONUTS page

[PMID:15457211-36] 36.0 ^36.1 ^36.2 Ishimaru, S et al. (2004) PVR plays a critical role via JNK activation in thorax closure during Drosophila metamorphosis. EMBO J. 23 3984-94 PubMed GONUTS page

[PMID:10449347-37] 37.0 ^37.1 ^37.2 Noselli, S & Agnès, F (1999) Roles of the JNK signaling pathway in Drosophila morphogenesis. Curr. Opin. Genet. Dev. 9 466-72 PubMed GONUTS page

[PMID:11825878-38] Stronach, B & Perrimon, N (2002) Activation of the JNK pathway during dorsal closure in Drosophila requires the mixed lineage kinase, slipper. Genes Dev. 16 377-87 PubMed GONUTS page

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