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Category:GO:0048010 ! vascular endothelial growth factor receptor signaling pathway
name: vascular endothelial growth factor receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor (VEGFR) on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling]
comment: In GO, a gene product with 'vascular endothelial growth factor-activated receptor activity ; GO:0005021' necessarily binds VEGF to transduce a signal. In contrast, the VEGFR refers to PR:000001971. To represent cross-talk between ligands and receptors, signaling pathways in GO are starting to be named after the receptor and/or the signal. GO:0048010 is for annotation of any pathway in which a ligand (VEGF or an alternative growth factor) binds and activates a VEGFR (PR:000001971). For annotation of signaling pathways where a VEGF binds to a cell surface receptor (VEGFR, PDGFR etc.), consider 'vascular endothelial growth factor signaling pathway ; GO:0038084'.
synonym: "VEGF receptor signaling pathway" EXACT []
synonym: "VEGF receptor signalling pathway" EXACT []
synonym: "VEGFR signaling pathway" EXACT []
is_a: GO:0007169 ! cell surface receptor protein tyrosine kinase signaling pathway
AmiGO
<GOterm>GO:0048010</GOterm>
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This category has the following 8 subcategories, out of 8 total.