MOUSE:MK08

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Mapk8 (synonyms: Jnk1, Prkm8)
Protein Name(s)	Mitogen-activated protein kinase 8 MAP kinase 8 MAPK 8 Stress-activated protein kinase JNK1 c-Jun N-terminal kinase 1
External Links
UniProt	Q91Y86
EMBL	AB005663
CCDS	CCDS36869.1
RefSeq	NP_057909.1
UniGene	Mm.21495
ProteinModelPortal	Q91Y86
SMR	Q91Y86
BioGrid	204971
IntAct	Q91Y86
MINT	MINT-1204569
STRING	10090.ENSMUSP00000022504
BindingDB	Q91Y86
ChEMBL	CHEMBL1795174
PhosphoSite	Q91Y86
MaxQB	Q91Y86
PaxDb	Q91Y86
PRIDE	Q91Y86
Ensembl	ENSMUST00000111945
GeneID	26419
KEGG	mmu:26419
UCSC	uc007szt.3
CTD	5599
MGI	MGI:1346861
eggNOG	COG0515
GeneTree	ENSGT00550000074271
HOGENOM	HOG000233024
HOVERGEN	HBG014652
InParanoid	Q91Y86
KO	K04440
OrthoDB	EOG7PCJGV
PhylomeDB	Q91Y86
TreeFam	TF105100
BRENDA	2.7.11.24
Reactome	REACT_188530 REACT_188970 REACT_202271 REACT_204811 REACT_204812 REACT_209641 REACT_229508 REACT_243212
NextBio	304433
PRO	PR:Q91Y86
Proteomes	UP000000589
Bgee	Q91Y86
CleanEx	MM_MAPK8
ExpressionAtlas	Q91Y86
Genevestigator	Q91Y86
GO	GO:0005737 GO:0005829 GO:0005739 GO:0005634 GO:0005524 GO:0035033 GO:0004705 GO:0016301 GO:0070301 GO:0071222 GO:0071260 GO:0071732 GO:0048263 GO:0007254 GO:0007258 GO:0043066 GO:0032091 GO:0001503 GO:0018105 GO:0018107 GO:2001235 GO:0090045 GO:2000017 GO:0010628 GO:0097300 GO:0006468 GO:0010468 GO:0032880 GO:0046686 GO:0009411
InterPro	IPR011009 IPR003527 IPR008351 IPR000719 IPR002290 IPR008271
Pfam	PF00069
PRINTS	PR01772
SMART	SM00220
SUPFAM	SSF56112
PROSITE	PS01351 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0001764	neuron migration	PMID:21297631^[1]	ECO:0000315			P		Figure 2E, JNK1 deficient neurons migrate faster than wild type neurons, as 3 times as many JNK deficient cells had migrated. Figure 7E supports this, showing that JNK deficient cells migrate at a faster speed in a time lapse study. JNK1 is involved in migration of neurons.	complete CACAO 4638
	GO:0048813	dendrite morphogenesis	PMID:16000625^[2]	ECO:0000315			P		Figure 4 shows that inhibition of JNK1 results in shorter and more numerous dendritic processes. Figures 7 and 8 support JNK1 involvement in the development of the shape and size of the dendritic processes by pictures and analyzation of the dendrites.	complete CACAO 4643
	GO:0004708	MAP kinase kinase activity	PMID:12689591^[3]	ECO:0000315			F		Figure 5B shows that JNK1 efficiently phosphorylates MAP and 5D shows that it is specific. At low concentrations, JNK1 is a predominant MAP2 kinase. In Figure 6A, JNK1 deficient mice displayed 3 fold lower labelling of MAP2 and in 6B MAP2 polypeptides are significantly lowered in JNK1 deficient mice. JNK1 is an important MAP2 kinase.	complete CACAO 4653
part_of	GO:0097441	basal dendrite	PMID:22683681^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		C	exists_during:(GO:0006468)	Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:22683681^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		C	exists_during:(GO:0006468)	Seeded From UniProt	complete
involved_in	GO:0031398	positive regulation of protein ubiquitination	PMID:29153991^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1901485	positive regulation of transcription factor catabolic process	PMID:29153991^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:29153991^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:29153991^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004712	protein serine/threonine/tyrosine kinase activity	PMID:29153991^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0048813	dendrite morphogenesis	PMID:16000625^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001764	neuron migration	PMID:21297631^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042752	regulation of circadian rhythm	PMID:22441692^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:22441692^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007254	JNK cascade	PMID:10811224^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004705	JUN kinase activity	PMID:10811224^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0071310	cellular response to organic substance	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001172432 RGD:70500	P		Seeded From UniProt	complete
involved_in	GO:0048666	neuron development	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000622286 RGD:621506 RGD:628847	P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001171983 RGD:621506 RGD:628847	P		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000622286 RGD:628847	C		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:106908 MGI:MGI:1201387 MGI:MGI:1201408 MGI:MGI:1346865 PANTHER:PTN000622075 RGD:3046 RGD:70500 RGD:71050 UniProtKB:P78362 UniProtKB:Q16539 UniProtKB:Q96SB4 UniProtKB:Q9UPZ9 WB:WBGene00004055 WB:WBGene00004056	P		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1346861 PANTHER:PTN000622075 UniProtKB:A9T142	P		Seeded From UniProt	complete
involved_in	GO:0009612	response to mechanical stimulus	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001171983 RGD:628847	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0052703 FB:FBgn0267339 MGI:MGI:1201408 MGI:MGI:1346347 MGI:MGI:1346858 MGI:MGI:1346859 MGI:MGI:1346861 MGI:MGI:1346862 MGI:MGI:1346863 MGI:MGI:1346865 MGI:MGI:1354946 MGI:MGI:2444559 PANTHER:PTN000622075 PomBase:SPAC24B11.06c PomBase:SPBC119.08 PomBase:SPBC530.14c RGD:3046 RGD:621506 RGD:628847 RGD:70500 RGD:70975 RGD:71050 SGD:S000000112 SGD:S000004103 SGD:S000004829 TAIR:locus:2024887 TAIR:locus:2124943 UniProtKB:A9T142 UniProtKB:O77306 UniProtKB:P28482 UniProtKB:P78362 UniProtKB:Q10N20 UniProtKB:Q13164 UniProtKB:Q96SB4 WB:WBGene00002178 WB:WBGene00002187 WB:WBGene00003048 WB:WBGene00003401 WB:WBGene00004056 WB:WBGene00004057	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003256 FB:FBgn0015765 MGI:MGI:1201387 MGI:MGI:1201408 MGI:MGI:1336881 MGI:MGI:1346347 MGI:MGI:1346858 MGI:MGI:1346859 MGI:MGI:1346861 MGI:MGI:1346865 MGI:MGI:1354946 MGI:MGI:1934157 MGI:MGI:2444559 MGI:MGI:96913 PANTHER:PTN000622075 PomBase:SPAC24B11.06c PomBase:SPAC31G5.09c PomBase:SPBC119.08 PomBase:SPBC530.14c RGD:3046 RGD:3663 RGD:621505 RGD:621506 RGD:628675 RGD:628847 RGD:70496 RGD:70500 SGD:S000000112 SGD:S000001072 SGD:S000003272 SGD:S000003642 SGD:S000004103 TAIR:locus:2024887 TAIR:locus:2124943 UniProtKB:A9T142 UniProtKB:O77306 UniProtKB:P20794 UniProtKB:P28482 UniProtKB:P45983 UniProtKB:P78362 UniProtKB:Q10N20 UniProtKB:Q13164 UniProtKB:Q5AZN7 UniProtKB:Q8GYQ5 UniProtKB:Q96SB4 UniProtKB:Q9LV37 UniProtKB:Q9P419 WB:WBGene00002178 WB:WBGene00003048 WB:WBGene00003401 WB:WBGene00004055 WB:WBGene00004057 dictyBase:DDB_G0283903 dictyBase:DDB_G0286353	C		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015765 FB:FBgn0024846 FB:FBgn0267339 MGI:MGI:1346858 MGI:MGI:1346859 MGI:MGI:1346865 MGI:MGI:1354946 PANTHER:PTN001172432 PomBase:SPAC31G5.09c PomBase:SPBC119.08 RGD:1309340 RGD:3045 RGD:3046 RGD:621505 RGD:70496 RGD:70500 RGD:70975 SGD:S000000112 SGD:S000003272 SGD:S000006258 UniProtKB:A0A1D8PFT5 UniProtKB:A0A1D8PT38 UniProtKB:O15264 UniProtKB:P27361 UniProtKB:Q15759 UniProtKB:Q16539 WB:WBGene00003401 WB:WBGene00004055 WB:WBGene00004056 dictyBase:DDB_G0286353	F		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	CGD:CAL0000183747 FB:FBgn0015765 FB:FBgn0024846 FB:FBgn0267339 MGI:MGI:1346858 MGI:MGI:1346859 MGI:MGI:1346865 MGI:MGI:1354946 PANTHER:PTN002372889 PomBase:SPAC31G5.09c PomBase:SPBC119.08 RGD:1309340 RGD:3045 RGD:3046 RGD:621505 RGD:70496 RGD:70500 RGD:70975 SGD:S000000112 SGD:S000003272 SGD:S000006258 UniProtKB:A0A1D8PFT5 UniProtKB:A0A1D8PT38 UniProtKB:O15264 UniProtKB:P27361 UniProtKB:Q15759 UniProtKB:Q16539 WB:WBGene00003401 WB:WBGene00004055 WB:WBGene00004056 dictyBase:DDB_G0286353	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001235	positive regulation of apoptotic signaling pathway	PMID:16458303^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1346862	P	regulates_o_occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001224	positive regulation of neuron migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621506	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000017	positive regulation of determination of dorsal identity	PMID:18316368^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902595	regulation of DNA replication origin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P45983	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097300	programmed necrotic cell death	PMID:18007661^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097150	neuronal stem cell population maintenance	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49185	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097050	type B pancreatic cell apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621506	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090045	positive regulation of deacetylase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P45983	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071803	positive regulation of podosome assembly	PMID:24127566^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071732	cellular response to nitric oxide	PMID:18007661^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071276	cellular response to cadmium ion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P45983	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071222	cellular response to lipopolysaccharide	PMID:23776175^[13]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P45983	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070301	cellular response to hydrogen peroxide	PMID:20808772^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061833	protein localization to tricellular tight junction	PMID:24889144^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(MGI:MGI:1927471) has_input:(MGI:MGI:2446166)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051403	stress-activated MAPK cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P45983	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051247	positive regulation of protein metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P45983	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048263	determination of dorsal identity	PMID:17681137^[16]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9DGD9	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046686	response to cadmium ion	PMID:16458303^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1346862	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046605	regulation of centrosome cycle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621506	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045740	positive regulation of DNA replication	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621506	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045664	regulation of neuron differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621506	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043525	positive regulation of neuron apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621506	P		Seeded From UniProt	complete
part_of	GO:0043204	perikaryon	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621506	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621506	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P45983	P		Seeded From UniProt	complete
enables	GO:0042826	histone deacetylase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P45983	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042542	response to hydrogen peroxide	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621506	P		Seeded From UniProt	complete
enables	GO:0035033	histone deacetylase regulator activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P45983	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034614	cellular response to reactive oxygen species	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P45983	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034352	positive regulation of glial cell apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621506	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034198	cellular response to amino acid starvation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P45983	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032880	regulation of protein localization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P45983	P		Seeded From UniProt	complete
part_of	GO:0032839	dendrite cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621506	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032091	negative regulation of protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P45983	P		Seeded From UniProt	complete
part_of	GO:0031982	vesicle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621506	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031281	positive regulation of cyclase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P45983	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031175	neuron projection development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621506	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031116	positive regulation of microtubule polymerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621506	P		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621506	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030335	positive regulation of cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621506	P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P45983	F		Seeded From UniProt	complete
enables	GO:0019894	kinesin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621506	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018107	peptidyl-threonine phosphorylation	PMID:14967141^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2384141	P	occurs_in:(CL:0000057) has_participant:(MGI:MGI:1096330)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018107	peptidyl-threonine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P45983	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018105	peptidyl-serine phosphorylation	PMID:24889144^[15]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(PR:000049783) has_output:(PR:000049782)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018105	peptidyl-serine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P45983	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	PMID:15767678^[18]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	PMID:15483136^[19]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	PMID:12808090^[20]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010666	positive regulation of cardiac muscle cell apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621506	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P45983	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010468	regulation of gene expression	PMID:19289495^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009411	response to UV	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P45983	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009408	response to heat	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621506	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007258	JUN phosphorylation	PMID:14967141^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2384141	P	occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007258	JUN phosphorylation	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P45983	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007254	JNK cascade	PMID:17681137^[16]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9DGD9	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007254	JNK cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P45983	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007165	signal transduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621506	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006970	response to osmotic stress	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621506	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006954	inflammatory response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621506	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	PMID:24889144^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	PMID:15767678^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P45983	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621506	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:11884367^[22]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16105)	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:11884367^[22]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16105)	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621506	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:24127566^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:15030387^[23]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621506	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:24127566^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15483136^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15030387^[23]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P45983	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621506	C		Seeded From UniProt	complete
enables	GO:0004705	JUN kinase activity	PMID:19289495^[21]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004705	JUN kinase activity	PMID:15579909^[24]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004705	JUN kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P45983	F		Seeded From UniProt	complete
enables	GO:0004705	JUN kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621506	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:24889144^[15]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(PR:000049783) has_output:(PR:000049782)	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:24127566^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P45983	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:24889144^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0002102	podosome	PMID:24127566^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002052	positive regulation of neuroblast proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621506	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001503	ossification	PMID:15820682^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031063	regulation of histone deacetylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0035033	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003527 InterPro:IPR008351	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR003527 InterPro:IPR008351	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR003527 InterPro:IPR008271 InterPro:IPR008351	P		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.11.24	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-MMU-205060	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0048511	rhythmic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0090	P		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Westerlund, N et al. (2011) Phosphorylation of SCG10/stathmin-2 determines multipolar stage exit and neuronal migration rate. Nat. Neurosci. 14 305-13 PubMed GONUTS page
↑ ^2.0 ^2.1 Björkblom, B et al. (2005) Constitutively active cytoplasmic c-Jun N-terminal kinase 1 is a dominant regulator of dendritic architecture: role of microtubule-associated protein 2 as an effector. J. Neurosci. 25 6350-61 PubMed GONUTS page
↑ Chang, L et al. (2003) JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins. Dev. Cell 4 521-33 PubMed GONUTS page
↑ ^4.0 ^4.1 de Anda, FC et al. (2012) Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex. Nat. Neurosci. 15 1022-31 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Bae, KB et al. (2017) Serine 347 Phosphorylation by JNKs Negatively Regulates OCT4 Protein Stability in Mouse Embryonic Stem Cells. Stem Cell Reports 9 2050-2064 PubMed GONUTS page
↑ ^6.0 ^6.1 Yoshitane, H et al. (2012) JNK regulates the photic response of the mammalian circadian clock. EMBO Rep. 13 455-61 PubMed GONUTS page
↑ ^7.0 ^7.1 Dong, C et al. (2000) JNK is required for effector T-cell function but not for T-cell activation. Nature 405 91-4 PubMed GONUTS page
↑ ^8.00 ^8.01 ^8.02 ^8.03 ^8.04 ^8.05 ^8.06 ^8.07 ^8.08 ^8.09 ^8.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^9.0 ^9.1 Papadakis, ES et al. (2006) The regulation of Bax by c-Jun N-terminal protein kinase (JNK) is a prerequisite to the mitochondrial-induced apoptotic pathway. FEBS Lett. 580 1320-6 PubMed GONUTS page
↑ Lu, Z et al. (2008) Protein encoded by the Axin(Fu) allele effectively down-regulates Wnt signaling but exerts a dominant negative effect on c-Jun N-terminal kinase signaling. J. Biol. Chem. 283 13132-9 PubMed GONUTS page
↑ ^11.0 ^11.1 Wu, YT et al. (2008) Signaling pathways from membrane lipid rafts to JNK1 activation in reactive nitrogen species-induced non-apoptotic cell death. Cell Death Differ. 15 386-97 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 Pan, YR et al. (2013) Phosphorylation of moesin by Jun N-terminal kinase is important for podosome rosette formation in Src-transformed fibroblasts. J. Cell. Sci. 126 5670-80 PubMed GONUTS page
↑ Dauphinee, SM et al. (2013) SASH1 is a scaffold molecule in endothelial TLR4 signaling. J. Immunol. 191 892-901 PubMed GONUTS page
↑ Negishi, M et al. (2010) A novel zinc finger protein Zfp277 mediates transcriptional repression of the Ink4a/arf locus through polycomb repressive complex 1. PLoS ONE 5 e12373 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 ^15.4 Nakatsu, D et al. (2014) JNK1/2-dependent phosphorylation of angulin-1/LSR is required for the exclusive localization of angulin-1/LSR and tricellulin at tricellular contacts in EpH4 epithelial sheet. Genes Cells 19 565-81 PubMed GONUTS page
↑ ^16.0 ^16.1 Rui, Y et al. (2007) A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida. Dev. Cell 13 268-82 PubMed GONUTS page
↑ ^17.0 ^17.1 Yu, C et al. (2004) JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD. Mol. Cell 13 329-40 PubMed GONUTS page
↑ ^18.0 ^18.1 Kelkar, N et al. (2005) Role of the JIP4 scaffold protein in the regulation of mitogen-activated protein kinase signaling pathways. Mol. Cell. Biol. 25 2733-43 PubMed GONUTS page
↑ ^19.0 ^19.1 Lee, AF et al. (2004) Evidence that DeltaNp73 promotes neuronal survival by p53-dependent and p53-independent mechanisms. J. Neurosci. 24 9174-84 PubMed GONUTS page
↑ Holgado-Madruga, M & Wong, AJ (2003) Gab1 is an integrator of cell death versus cell survival signals in oxidative stress. Mol. Cell. Biol. 23 4471-84 PubMed GONUTS page
↑ ^21.0 ^21.1 Abell, AN et al. (2009) Trophoblast stem cell maintenance by fibroblast growth factor 4 requires MEKK4 activation of Jun N-terminal kinase. Mol. Cell. Biol. 29 2748-61 PubMed GONUTS page
↑ ^22.0 ^22.1 Baines, CP et al. (2002) Mitochondrial PKCepsilon and MAPK form signaling modules in the murine heart: enhanced mitochondrial PKCepsilon-MAPK interactions and differential MAPK activation in PKCepsilon-induced cardioprotection. Circ. Res. 90 390-7 PubMed GONUTS page
↑ ^23.0 ^23.1 Robert, K et al. (2004) The neuronal SAPK/JNK pathway is altered in a murine model of hyperhomocysteinemia. J. Neurochem. 89 33-43 PubMed GONUTS page
↑ Luo, W et al. (2005) Axin contains three separable domains that confer intramolecular, homodimeric, and heterodimeric interactions involved in distinct functions. J. Biol. Chem. 280 5054-60 PubMed GONUTS page
↑ Yamashita, M et al. (2005) Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation. Cell 121 101-13 PubMed GONUTS page

[PMID:21297631-1] 1.0 ^1.1 Westerlund, N et al. (2011) Phosphorylation of SCG10/stathmin-2 determines multipolar stage exit and neuronal migration rate. Nat. Neurosci. 14 305-13 PubMed GONUTS page

[PMID:16000625-2] 2.0 ^2.1 Björkblom, B et al. (2005) Constitutively active cytoplasmic c-Jun N-terminal kinase 1 is a dominant regulator of dendritic architecture: role of microtubule-associated protein 2 as an effector. J. Neurosci. 25 6350-61 PubMed GONUTS page

[PMID:12689591-3] Chang, L et al. (2003) JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins. Dev. Cell 4 521-33 PubMed GONUTS page

[PMID:22683681-4] 4.0 ^4.1 de Anda, FC et al. (2012) Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex. Nat. Neurosci. 15 1022-31 PubMed GONUTS page

[PMID:29153991-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Bae, KB et al. (2017) Serine 347 Phosphorylation by JNKs Negatively Regulates OCT4 Protein Stability in Mouse Embryonic Stem Cells. Stem Cell Reports 9 2050-2064 PubMed GONUTS page

[PMID:22441692-6] 6.0 ^6.1 Yoshitane, H et al. (2012) JNK regulates the photic response of the mammalian circadian clock. EMBO Rep. 13 455-61 PubMed GONUTS page

[PMID:10811224-7] 7.0 ^7.1 Dong, C et al. (2000) JNK is required for effector T-cell function but not for T-cell activation. Nature 405 91-4 PubMed GONUTS page

[PMID:21873635-8] 8.00 ^8.01 ^8.02 ^8.03 ^8.04 ^8.05 ^8.06 ^8.07 ^8.08 ^8.09 ^8.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:16458303-9] 9.0 ^9.1 Papadakis, ES et al. (2006) The regulation of Bax by c-Jun N-terminal protein kinase (JNK) is a prerequisite to the mitochondrial-induced apoptotic pathway. FEBS Lett. 580 1320-6 PubMed GONUTS page

[PMID:18316368-10] Lu, Z et al. (2008) Protein encoded by the Axin(Fu) allele effectively down-regulates Wnt signaling but exerts a dominant negative effect on c-Jun N-terminal kinase signaling. J. Biol. Chem. 283 13132-9 PubMed GONUTS page

[PMID:18007661-11] 11.0 ^11.1 Wu, YT et al. (2008) Signaling pathways from membrane lipid rafts to JNK1 activation in reactive nitrogen species-induced non-apoptotic cell death. Cell Death Differ. 15 386-97 PubMed GONUTS page

[PMID:24127566-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 Pan, YR et al. (2013) Phosphorylation of moesin by Jun N-terminal kinase is important for podosome rosette formation in Src-transformed fibroblasts. J. Cell. Sci. 126 5670-80 PubMed GONUTS page

[PMID:23776175-13] Dauphinee, SM et al. (2013) SASH1 is a scaffold molecule in endothelial TLR4 signaling. J. Immunol. 191 892-901 PubMed GONUTS page

[PMID:20808772-14] Negishi, M et al. (2010) A novel zinc finger protein Zfp277 mediates transcriptional repression of the Ink4a/arf locus through polycomb repressive complex 1. PLoS ONE 5 e12373 PubMed GONUTS page

[PMID:24889144-15] 15.0 ^15.1 ^15.2 ^15.3 ^15.4 Nakatsu, D et al. (2014) JNK1/2-dependent phosphorylation of angulin-1/LSR is required for the exclusive localization of angulin-1/LSR and tricellulin at tricellular contacts in EpH4 epithelial sheet. Genes Cells 19 565-81 PubMed GONUTS page

[PMID:17681137-16] 16.0 ^16.1 Rui, Y et al. (2007) A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida. Dev. Cell 13 268-82 PubMed GONUTS page

[PMID:14967141-17] 17.0 ^17.1 Yu, C et al. (2004) JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD. Mol. Cell 13 329-40 PubMed GONUTS page

[PMID:15767678-18] 18.0 ^18.1 Kelkar, N et al. (2005) Role of the JIP4 scaffold protein in the regulation of mitogen-activated protein kinase signaling pathways. Mol. Cell. Biol. 25 2733-43 PubMed GONUTS page

[PMID:15483136-19] 19.0 ^19.1 Lee, AF et al. (2004) Evidence that DeltaNp73 promotes neuronal survival by p53-dependent and p53-independent mechanisms. J. Neurosci. 24 9174-84 PubMed GONUTS page

[PMID:12808090-20] Holgado-Madruga, M & Wong, AJ (2003) Gab1 is an integrator of cell death versus cell survival signals in oxidative stress. Mol. Cell. Biol. 23 4471-84 PubMed GONUTS page

[PMID:19289495-21] 21.0 ^21.1 Abell, AN et al. (2009) Trophoblast stem cell maintenance by fibroblast growth factor 4 requires MEKK4 activation of Jun N-terminal kinase. Mol. Cell. Biol. 29 2748-61 PubMed GONUTS page

[PMID:11884367-22] 22.0 ^22.1 Baines, CP et al. (2002) Mitochondrial PKCepsilon and MAPK form signaling modules in the murine heart: enhanced mitochondrial PKCepsilon-MAPK interactions and differential MAPK activation in PKCepsilon-induced cardioprotection. Circ. Res. 90 390-7 PubMed GONUTS page

[PMID:15030387-23] 23.0 ^23.1 Robert, K et al. (2004) The neuronal SAPK/JNK pathway is altered in a murine model of hyperhomocysteinemia. J. Neurochem. 89 33-43 PubMed GONUTS page

[PMID:15579909-24] Luo, W et al. (2005) Axin contains three separable domains that confer intramolecular, homodimeric, and heterodimeric interactions involved in distinct functions. J. Biol. Chem. 280 5054-60 PubMed GONUTS page

[PMID:15820682-25] Yamashita, M et al. (2005) Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation. Cell 121 101-13 PubMed GONUTS page

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