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PMID:17681137
| Citation |
Rui, Y, Xu, Z, Xiong, B, Cao, Y, Lin, S, Zhang, M, Chan, SC, Luo, W, Han, Y, Lu, Z, Ye, Z, Zhou, HM, Han, J, Meng, A and Lin, SC (2007) A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida. Dev. Cell 13:268-82 |
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| Abstract |
Axin is a scaffold protein that controls multiple important pathways, including the canonical Wnt pathway and JNK signaling. Here we have identified an Axin-interacting protein, Aida, which blocks Axin-mediated JNK activation by disrupting Axin homodimerization. During investigation of in vivo functions of Axin/JNK signaling and aida in development, it was found that Axin, besides ventralizing activity by facilitating beta-catenin degradation, possesses a dorsalizing activity that is mediated by Axin-induced JNK activation. This dorsalizing activity is repressed when aida is overexpressed in zebrafish embryos. Whereas Aida-MO injection leads to dorsalized embryos, JNK-MO and MKK4-MO can ventralize embryos. The anti-dorsalization activity of aida is conferred by its ability to block Axin-mediated JNK activity. We further demonstrate that dorsoventral patterning regulated by Axin/JNK signaling is independent of maternal or zygotic Wnt signaling. We have thus identified a dorsalization pathway that is exerted by Axin/JNK signaling and its inhibitor Aida during vertebrate embryogenesis. |
| Links |
PubMed Online version:10.1016/j.devcel.2007.07.006 |
| Keywords |
Animals; Axin Protein; Body Patterning/drug effects; COS Cells; Carrier Proteins/metabolism; Cell Line; Cercopithecus aethiops; Dimerization; Embryo, Nonmammalian/cytology; Embryo, Nonmammalian/drug effects; Embryo, Nonmammalian/embryology; Embryo, Nonmammalian/enzymology; Enzyme Activation/drug effects; Humans; JNK Mitogen-Activated Protein Kinases/metabolism; MAP Kinase Signaling System/drug effects; Mice; Oligonucleotides, Antisense/pharmacology; Phenotype; Protein Binding/drug effects; Repressor Proteins/chemistry; Repressor Proteins/metabolism; Wnt Proteins/metabolism; Zebrafish/embryology; Zebrafish/metabolism; Zebrafish Proteins/metabolism; beta Catenin/metabolism |
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Significance
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