MOUSE:TNFA

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Tnf (synonyms: Tnfa, Tnfsf2)
Protein Name(s)	Tumor necrosis factor Cachectin TNF-alpha Tumor necrosis factor ligand superfamily member 2 TNF-a Tumor necrosis factor, membrane form N-terminal fragment NTF Intracellular domain 1 ICD1 Intracellular domain 2 ICD2 C-domain 1 C-domain 2 Tumor necrosis factor, soluble form
External Links
UniProt	P06804
EMBL	M20155 M11731 M13049 X02611 M38296 Y00467 U06950 D84196 D84199 U68414 AF109719 AB039224 AB039225 AB039226 AB039227 AB039228 AB039229 AB039230 AB039231 AB039232
CCDS	CCDS28691.1
PIR	A22908
RefSeq	NP_001265530.1 NP_038721.1
UniGene	Mm.1293
PDB	2TNF
PDBsum	2TNF
ProteinModelPortal	P06804
SMR	P06804
BioGrid	204240
IntAct	P06804
ChEMBL	CHEMBL4984
PhosphoSite	P06804
PaxDb	P06804
PRIDE	P06804
Ensembl	ENSMUST00000025263 ENSMUST00000167924
GeneID	21926
KEGG	mmu:21926
UCSC	uc008cgr.1
CTD	7124
MGI	MGI:104798
eggNOG	NOG40413
GeneTree	ENSGT00530000062992
HOGENOM	HOG000048729
HOVERGEN	HBG012516
InParanoid	P06804
KO	K03156
OMA	PWYEPIY
OrthoDB	EOG7V4B0Q
PhylomeDB	P06804
TreeFam	TF332169
Reactome	REACT_252217 REACT_256171 REACT_27166
EvolutionaryTrace	P06804
NextBio	301508
PMAP-CutDB	P06804
PRO	PR:P06804
Proteomes	UP000000589
Bgee	P06804
CleanEx	MM_TNF
ExpressionAtlas	P06804
Genevestigator	P06804
GO	GO:0009897 GO:0005615 GO:0005887 GO:0005622 GO:0045121 GO:0001891 GO:0005886 GO:0055037 GO:0030141 GO:0005125 GO:0002020 GO:0044212 GO:0005164 GO:0006919 GO:0000187 GO:0000185 GO:0097190 GO:0019722 GO:0001775 GO:0008283 GO:0045123 GO:0071230 GO:0071222 GO:0071316 GO:0002439 GO:0006952 GO:0042742 GO:0050830 GO:0050966 GO:0048566 GO:0060664 GO:0030198 GO:0097191 GO:0008625 GO:0006006 GO:0006959 GO:0006954 GO:0008630 GO:0007254 GO:0050900 GO:0050901 GO:0031663 GO:0007275 GO:0097527 GO:0010693 GO:0061048 GO:0008285 GO:0002740 GO:2001240 GO:0046325 GO:0044130 GO:0032715 GO:0002037 GO:0050995 GO:0045662 GO:0045668 GO:0043242 GO:0000122 GO:0045071 GO:0009887 GO:0030316 GO:0045760 GO:0043065 GO:0060559 GO:0008284 GO:2000343 GO:0045080 GO:0002876 GO:0050715 GO:0031622 GO:0051798 GO:0034116 GO:0002925 GO:0043123 GO:0032729 GO:0032741 GO:0032755 GO:0045416 GO:0046330 GO:0043507 GO:0043406 GO:0051044 GO:0045840 GO:0043525 GO:0042346 GO:0051092 GO:0051533 GO:0045429 GO:0045672 GO:0033138 GO:0071803 GO:0043243 GO:0051897 GO:2000010 GO:0001934 GO:0048661 GO:0050806 GO:0045944 GO:0045893 GO:0045994 GO:0000060 GO:0043491 GO:0032800 GO:0060693 GO:0042127 GO:0051023 GO:0050796 GO:0045670 GO:0001932 GO:0050708 GO:2000377 GO:0014823 GO:0042493 GO:0051384 GO:1990268 GO:0001666 GO:0009314 GO:0009615 GO:0030730 GO:0003009 GO:0006927 GO:0033209
Gene3D	2.60.120.40
InterPro	IPR006053 IPR002959 IPR021184 IPR006052 IPR008983
Pfam	PF00229
PRINTS	PR01234 PR01235
SMART	SM00207
SUPFAM	SSF49842
PROSITE	PS00251 PS50049

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0001774	microglial cell activation	PMID:22950459^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043525	positive regulation of neuron apoptotic process	PMID:22950459^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	part_of:(GO:0001774)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:18941241^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000129) regulates_expression_of:(ENSEMBL:ENSMUSG00000002944)\|regulates_o_occurs_in(CL:0000129) regulates_expression_of:(ENSEMBL:ENSMUSG00000056999)	Seeded From UniProt	complete
involved_in	GO:0050807	regulation of synapse organization	PMID:16547515^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(UBERON:0002421) occurs_in:(UBERON:0002421) occurs_in:(CL:0000125) regulates_o_occurs_in:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:0050806	positive regulation of synaptic transmission	PMID:16547515^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(UBERON:0002421) occurs_in:(UBERON:0002421) occurs_in:(CL:0000125) regulates_o_occurs_in:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:1903078	positive regulation of protein localization to plasma membrane	PMID:16547515^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0002608) has_regulation_target:(UniProtKB:P23818) has_target_end_location:(GO:0097060) occurs_in:(CL:0000125)	Seeded From UniProt	complete
involved_in	GO:0034116	positive regulation of heterotypic cell-cell adhesion	PMID:26808574^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072577	endothelial cell apoptotic process	PMID:26808574^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045930	negative regulation of mitotic cell cycle	PMID:26808574^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1904707	positive regulation of vascular smooth muscle cell proliferation	PMID:26808574^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001937	negative regulation of endothelial cell proliferation	PMID:26808574^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
part_of	GO:0055037	recycling endosome	PMID:16282525^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045668	negative regulation of osteoblast differentiation	PMID:21689636^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	PMID:17010968^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1901224	positive regulation of NIK/NF-kappaB signaling	PMID:21689636^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031622	positive regulation of fever generation	PMID:19940926^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010693	negative regulation of alkaline phosphatase activity	PMID:21689636^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:16282525^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0002020	protease binding	PMID:12135759^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q05910	F		Seeded From UniProt	complete
part_of	GO:0001891	phagocytic cup	PMID:16282525^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:21689636^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q91V88)\|has_regulation_target:(UniProtKB:P09242)	Seeded From UniProt	complete
involved_in	GO:0097527	necroptotic signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
involved_in	GO:0051798	positive regulation of hair follicle development	PMID:16702408^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043507	positive regulation of JUN kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
involved_in	GO:0043406	positive regulation of MAP kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
involved_in	GO:0043243	positive regulation of protein complex disassembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
involved_in	GO:0043242	negative regulation of protein complex disassembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:9305915^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:19404405^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:98259)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17670746^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3876	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	PMID:12761567^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045860	positive regulation of protein kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045840	positive regulation of mitotic nuclear division	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3876	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045785	positive regulation of cell adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045760	positive regulation of action potential	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3876	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045732	positive regulation of protein catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045672	positive regulation of osteoclast differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045670	regulation of osteoclast differentiation	PMID:12490655^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045662	negative regulation of myoblast differentiation	PMID:23844157^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045599	negative regulation of fat cell differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3876	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045429	positive regulation of nitric oxide biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045416	positive regulation of interleukin-8 biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045410	positive regulation of interleukin-6 biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3876	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045123	cellular extravasation	PMID:10528208^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045080	positive regulation of chemokine biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045071	negative regulation of viral genome replication	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0044130	negative regulation of growth of symbiont in host	PMID:9834074^[18]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:104797	P	regulates_o_occurs_in:(EMAPA:17373)\|regulates_o_occurs_in:(EMAPA:16846)\|regulates_o_occurs_in:(EMAPA:19205)\|regulates_o_occurs_in:(EMAPA:35126)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043525	positive regulation of neuron apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3876	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043507	positive regulation of JUN kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043491	protein kinase B signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043406	positive regulation of MAP kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043243	positive regulation of protein complex disassembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043242	negative regulation of protein complex disassembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	PMID:16260493^[19]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1346877	P	regulates_o_occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	PMID:22089168^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	PMID:16260493^[19]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	PMID:12867038^[21]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000624)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3876	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043068	positive regulation of programmed cell death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043065	positive regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043065	positive regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3876	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3876	C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042742	defense response to bacterium	PMID:10899905^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3876	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042311	vasodilation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3876	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042127	regulation of cell population proliferation	PMID:11799106^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042127	regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3876	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035509	negative regulation of myosin-light-chain-phosphatase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034138	toll-like receptor 3 signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3876	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034116	positive regulation of heterotypic cell-cell adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033209	tumor necrosis factor-mediated signaling pathway	PMID:3898078^[24]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033209	tumor necrosis factor-mediated signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033138	positive regulation of peptidyl-serine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033138	positive regulation of peptidyl-serine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3876	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032800	receptor biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032757	positive regulation of interleukin-8 production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032755	positive regulation of interleukin-6 production	PMID:11894098^[25]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032741	positive regulation of interleukin-18 production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3876	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032729	positive regulation of interferon-gamma production	PMID:9834074^[18]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:104797	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032722	positive regulation of chemokine production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032715	negative regulation of interleukin-6 production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032496	response to lipopolysaccharide	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3876	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031663	lipopolysaccharide-mediated signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031642	negative regulation of myelination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3876	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031334	positive regulation of protein complex assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030866	cortical actin cytoskeleton organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030730	sequestering of triglyceride	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030316	osteoclast differentiation	PMID:15485831^[26]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1100089 MGI:MGI:99484	P	occurs_in:(EMAPA:16846) results_in_acquisition_of_features_of:(CL:0000092)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030198	extracellular matrix organization	PMID:15381731^[27]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019722	calcium-mediated signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3876	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3876	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010629	negative regulation of gene expression	PMID:26427354^[28]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000136) has_regulation_target:(MGI:MGI:2675492)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010629	negative regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3876	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010033	response to organic substance	PMID:17475835^[29]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:21606376^[30]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3876	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009887	animal organ morphogenesis	PMID:8879212^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2149024	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009615	response to virus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	PMID:17242187^[32]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	PMID:20080598^[33]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1929004	P	regulates_o_occurs_in:(CL:0000182)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	PMID:20080598^[33]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1928487	P	regulates_o_occurs_in:(CL:0000182)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	PMID:12431371^[34]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1096330	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3876	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007275	multicellular organism development	PMID:9368616^[35]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1860953	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007254	JNK cascade	PMID:17015619^[36]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1341850	P	occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007165	signal transduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3876	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006959	humoral immune response	PMID:8879212^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2149024	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006954	inflammatory response	PMID:21148126^[37]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2687194 MGI:MGI:893592	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006954	inflammatory response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006952	defense response	PMID:9223320^[38]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1860250	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006952	defense response	PMID:8395024^[39]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1861040	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:16183742^[40]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006915	apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3876	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3876	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006006	glucose metabolic process	PMID:12068289^[41]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:15155767^[42]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17544) part_of:(CL:0000117)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3876	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:25084278^[43]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:24740015^[44]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:23892723^[45]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:18997793^[46]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:18261938^[47]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000235)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:17693256^[48]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:16275384^[49]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:35770)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:16239543^[50]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16894)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:16236719^[51]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:15843532^[52]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:1577194^[53]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:15220916^[54]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:14764707^[55]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:12872135^[56]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:12855817^[57]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:11894098^[25]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:11728336^[58]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:11168643^[59]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:10899905^[22]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000235)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:10549626^[60]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:10545106^[61]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:35690)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3876	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	C		Seeded From UniProt	complete
enables	GO:0005164	tumor necrosis factor receptor binding	PMID:1645445^[62]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P25118 UniProtKB:P25119	F		Seeded From UniProt	complete
enables	GO:0005164	tumor necrosis factor receptor binding	PMID:11588035^[63]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0000037)	Seeded From UniProt	complete
enables	GO:0005164	tumor necrosis factor receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	F		Seeded From UniProt	complete
enables	GO:0005164	tumor necrosis factor receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3876	F		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:11894098^[25]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0000057)	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:11588035^[63]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0000037)	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002925	positive regulation of humoral immune response mediated by circulating immunoglobulin	PMID:9834074^[18]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:104797	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002876	positive regulation of chronic inflammatory response to antigenic stimulus	PMID:9834074^[18]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:104797	P	regulates_o_has_participant:(EMAPA:16405)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002740	negative regulation of cytokine secretion involved in immune response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002439	chronic inflammatory response to antigenic stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002037	negative regulation of L-glutamate import across plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3876	P		Seeded From UniProt	complete
enables	GO:0002020	protease binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001932	regulation of protein phosphorylation	PMID:24349514^[64]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001932	regulation of protein phosphorylation	PMID:15169905^[65]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001819	positive regulation of cytokine production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001775	cell activation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3876	P		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3876	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000187	activation of MAPK activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000185	activation of MAPKKK activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000165	MAPK cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:9305915^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:1618860^[66]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000778	positive regulation of interleukin-6 secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3876	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000377	regulation of reactive oxygen species metabolic process	PMID:21052097^[67]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000351	regulation of endothelial cell apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000343	positive regulation of chemokine (C-X-C motif) ligand 2 production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000334	positive regulation of blood microparticle formation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000010	positive regulation of protein localization to cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904999	positive regulation of leukocyte adhesion to arterial endothelial cell	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904996	positive regulation of leukocyte adhesion to vascular endothelial cell	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903347	negative regulation of bicellular tight junction assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903140	regulation of establishment of endothelial barrier	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903078	positive regulation of protein localization to plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3876	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901671	positive regulation of superoxide dismutase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901224	positive regulation of NIK/NF-kappaB signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097527	necroptotic signaling pathway	PMID:22037414^[68]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1261423 MGI:MGI:1921506	P	occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097527	necroptotic signaling pathway	PMID:21368763^[69]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1261423 MGI:MGI:1336166 MGI:MGI:2154952	P	occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097527	necroptotic signaling pathway	PMID:21052097^[67]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:108212 MGI:MGI:1197009 MGI:MGI:1346877	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097527	necroptotic signaling pathway	PMID:21052097^[67]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:108212 MGI:MGI:1197009	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097527	necroptotic signaling pathway	PMID:19498109^[70]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:108212 MGI:MGI:2154952	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097527	necroptotic signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097191	extrinsic apoptotic signaling pathway	PMID:22089168^[20]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:104798 MGI:MGI:1261423	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097191	extrinsic apoptotic signaling pathway	PMID:19498109^[70]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:108212	P	occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097191	extrinsic apoptotic signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097190	apoptotic signaling pathway	PMID:8208546^[71]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097190	apoptotic signaling pathway	PMID:15629131^[72]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090197	positive regulation of chemokine secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3876	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072659	protein localization to plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071803	positive regulation of podosome assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071407	cellular response to organic cyclic compound	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071316	cellular response to nicotine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071230	cellular response to amino acid stimulus	PMID:20548288^[73]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:16846)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071222	cellular response to lipopolysaccharide	PMID:23610142^[74]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071222	cellular response to lipopolysaccharide	PMID:21606371^[75]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071222	cellular response to lipopolysaccharide	PMID:20060382^[76]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071222	cellular response to lipopolysaccharide	PMID:19047410^[77]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070886	positive regulation of calcineurin-NFAT signaling cascade	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061048	negative regulation of branching involved in lung morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060693	regulation of branching involved in salivary gland morphogenesis	PMID:11241200^[78]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060693	regulation of branching involved in salivary gland morphogenesis	PMID:11241200^[78]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060664	epithelial cell proliferation involved in salivary gland morphogenesis	PMID:11241200^[78]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060559	positive regulation of calcidiol 1-monooxygenase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060557	positive regulation of vitamin D biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060252	positive regulation of glial cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051897	positive regulation of protein kinase B signaling	PMID:20080598^[33]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(EMAPA:16846) regulates_o_occurs_in:(CL:0000182)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051897	positive regulation of protein kinase B signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3876	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051384	response to glucocorticoid	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051222	positive regulation of protein transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051222	positive regulation of protein transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3876	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:15790681^[79]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3876	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051091	positive regulation of DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051044	positive regulation of membrane protein ectodomain proteolysis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051023	regulation of immunoglobulin secretion	PMID:12958312^[80]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050995	negative regulation of lipid catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050966	detection of mechanical stimulus involved in sensory perception of pain	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3876	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050901	leukocyte tethering or rolling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050900	leukocyte migration	PMID:15034066^[81]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050830	defense response to Gram-positive bacterium	PMID:9834074^[18]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:104797	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050806	positive regulation of synaptic transmission	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3876	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050796	regulation of insulin secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050766	positive regulation of phagocytosis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050754	positive regulation of fractalkine biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3876	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050729	positive regulation of inflammatory response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3876	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050727	regulation of inflammatory response	PMID:24349514^[64]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050715	positive regulation of cytokine secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050708	regulation of protein secretion	PMID:19293336^[82]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000136)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048661	positive regulation of smooth muscle cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01375	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3876	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046330	positive regulation of JNK cascade	PMID:16260493^[19]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1346877	P	regulates_o_occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046330	positive regulation of JNK cascade	PMID:20080598^[33]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(EMAPA:16846) regulates_o_occurs_in:(CL:0000182)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046330	positive regulation of JNK cascade	PMID:16260493^[19]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046325	negative regulation of glucose import	PMID:12068289^[41]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046325	negative regulation of glucose import	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3876	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045994	positive regulation of translational initiation by iron	PMID:11588035^[63]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000037)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:18025219^[83]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:107656	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:2000351	regulation of endothelial cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:2000343	positive regulation of chemokine (C-X-C motif) ligand 2 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:2000334	positive regulation of blood microparticle formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:2000010	positive regulation of protein localization to cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:1904999	positive regulation of leukocyte adhesion to arterial endothelial cell	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:1904996	positive regulation of leukocyte adhesion to vascular endothelial cell	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:1903347	negative regulation of bicellular tight junction assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:1903140	regulation of establishment of endothelial barrier	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:1901671	positive regulation of superoxide dismutase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:1901224	positive regulation of NIK/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0097527	necroptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0097191	extrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0072659	protein localization to plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0071803	positive regulation of podosome assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0071407	cellular response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0071316	cellular response to nicotine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0070886	positive regulation of calcineurin-NFAT signaling cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0061048	negative regulation of branching involved in lung morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0060559	positive regulation of calcidiol 1-monooxygenase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0060557	positive regulation of vitamin D biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0060252	positive regulation of glial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0051384	response to glucocorticoid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0051222	positive regulation of protein transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0051044	positive regulation of membrane protein ectodomain proteolysis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0050995	negative regulation of lipid catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0050901	leukocyte tethering or rolling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0050796	regulation of insulin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0050766	positive regulation of phagocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0050715	positive regulation of cytokine secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0048661	positive regulation of smooth muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0048566	embryonic digestive tract development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0045860	positive regulation of protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0045785	positive regulation of cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0045732	positive regulation of protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0045672	positive regulation of osteoclast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0045429	positive regulation of nitric oxide biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0045416	positive regulation of interleukin-8 biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	C		Seeded From UniProt	complete
involved_in	GO:0045080	positive regulation of chemokine biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0045071	negative regulation of viral genome replication	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	F		Seeded From UniProt	complete
involved_in	GO:0043507	positive regulation of JUN kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0043491	protein kinase B signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0043406	positive regulation of MAP kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0043243	positive regulation of protein complex disassembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0043242	negative regulation of protein complex disassembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0043068	positive regulation of programmed cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	F		Seeded From UniProt	complete
involved_in	GO:0035509	negative regulation of myosin-light-chain-phosphatase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0034116	positive regulation of heterotypic cell-cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0033209	tumor necrosis factor-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0033138	positive regulation of peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0032800	receptor biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0032757	positive regulation of interleukin-8 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0032755	positive regulation of interleukin-6 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0032722	positive regulation of chemokine production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0032715	negative regulation of interleukin-6 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0031663	lipopolysaccharide-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0031334	positive regulation of protein complex assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0030866	cortical actin cytoskeleton organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0030730	sequestering of triglyceride	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	C		Seeded From UniProt	complete
involved_in	GO:0009615	response to virus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	C		Seeded From UniProt	complete
enables	GO:0005164	tumor necrosis factor receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	F		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	F		Seeded From UniProt	complete
involved_in	GO:0002740	negative regulation of cytokine secretion involved in immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0002439	chronic inflammatory response to antigenic stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
enables	GO:0002020	protease binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	F		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0001819	positive regulation of cytokine production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0000185	activation of MAPKKK activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01375 ensembl:ENSP00000398698	P		Seeded From UniProt	complete
enables	GO:0005164	tumor necrosis factor receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002959 InterPro:IPR006052 InterPro:IPR006053	F		Seeded From UniProt	complete
involved_in	GO:0006955	immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002959 InterPro:IPR006052 InterPro:IPR006053	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002959 InterPro:IPR006052 InterPro:IPR006053	C		Seeded From UniProt	complete
part_of	GO:0030141	secretory granule	PMID:8879212^[31]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	PMID:8171322^[84]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006954	inflammatory response	PMID:8387893^[85] PMID:8171322^[84]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:8879212^[31]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005164	tumor necrosis factor receptor binding	PMID:9565643^[86] PMID:9368616^[35] PMID:9256477^[87] PMID:9223320^[38] PMID:8395024^[39] PMID:8387893^[85] PMID:8171322^[84]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	F		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

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↑ Shimizu, E et al. (2008) IL-4-induced selective clearance of oligomeric beta-amyloid peptide(1-42) by rat primary type 2 microglia. J. Immunol. 181 6503-13 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Stellwagen, D & Malenka, RC (2006) Synaptic scaling mediated by glial TNF-alpha. Nature 440 1054-9 PubMed GONUTS page
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↑ Tellier, E et al. (2006) The shedding activity of ADAM17 is sequestered in lipid rafts. Exp. Cell Res. 312 3969-80 PubMed GONUTS page
↑ Hanada, R et al. (2009) Central control of fever and female body temperature by RANKL/RANK. Nature 462 505-9 PubMed GONUTS page
↑ Amour, A et al. (2002) The enzymatic activity of ADAM8 and ADAM9 is not regulated by TIMPs. FEBS Lett. 524 154-8 PubMed GONUTS page
↑ Tong, X & Coulombe, PA (2006) Keratin 17 modulates hair follicle cycling in a TNFalpha-dependent fashion. Genes Dev. 20 1353-64 PubMed GONUTS page
↑ ^11.0 ^11.1 Hadri, KE et al. (1997) Differential regulation by tumor necrosis factor-alpha of beta1-, beta2-, and beta3-adrenoreceptor gene expression in 3T3-F442A adipocytes. J. Biol. Chem. 272 24514-21 PubMed GONUTS page
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↑ Yao, D et al. (2007) High glucose increases angiopoietin-2 transcription in microvascular endothelial cells through methylglyoxal modification of mSin3A. J. Biol. Chem. 282 31038-45 PubMed GONUTS page
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↑ Alimzhanov, MB et al. (1997) Abnormal development of secondary lymphoid tissues in lymphotoxin beta-deficient mice. Proc. Natl. Acad. Sci. U.S.A. 94 9302-7 PubMed GONUTS page

[PMID:22950459-1] 1.0 ^1.1 Zhang, L et al. (2012) The microRNA miR-181c controls microglia-mediated neuronal apoptosis by suppressing tumor necrosis factor. J Neuroinflammation 9 211 PubMed GONUTS page

[PMID:18941241-2] Shimizu, E et al. (2008) IL-4-induced selective clearance of oligomeric beta-amyloid peptide(1-42) by rat primary type 2 microglia. J. Immunol. 181 6503-13 PubMed GONUTS page

[PMID:16547515-3] 3.0 ^3.1 ^3.2 Stellwagen, D & Malenka, RC (2006) Synaptic scaling mediated by glial TNF-alpha. Nature 440 1054-9 PubMed GONUTS page

[PMID:26808574-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Verma, SK et al. (2016) IL-10 Accelerates Re-Endothelialization and Inhibits Post-Injury Intimal Hyperplasia following Carotid Artery Denudation. PLoS ONE 11 e0147615 PubMed GONUTS page

[PMID:16282525-5] 5.0 ^5.1 ^5.2 Murray, RZ et al. (2005) A role for the phagosome in cytokine secretion. Science 310 1492-5 PubMed GONUTS page

[PMID:21689636-6] 6.0 ^6.1 ^6.2 ^6.3 Tsukasaki, M et al. (2011) Expression of POEM, a positive regulator of osteoblast differentiation, is suppressed by TNF-α. Biochem. Biophys. Res. Commun. 410 766-70 PubMed GONUTS page

[PMID:17010968-7] Tellier, E et al. (2006) The shedding activity of ADAM17 is sequestered in lipid rafts. Exp. Cell Res. 312 3969-80 PubMed GONUTS page

[PMID:19940926-8] Hanada, R et al. (2009) Central control of fever and female body temperature by RANKL/RANK. Nature 462 505-9 PubMed GONUTS page

[PMID:12135759-9] Amour, A et al. (2002) The enzymatic activity of ADAM8 and ADAM9 is not regulated by TIMPs. FEBS Lett. 524 154-8 PubMed GONUTS page

[PMID:16702408-10] Tong, X & Coulombe, PA (2006) Keratin 17 modulates hair follicle cycling in a TNFalpha-dependent fashion. Genes Dev. 20 1353-64 PubMed GONUTS page

[PMID:9305915-11] 11.0 ^11.1 Hadri, KE et al. (1997) Differential regulation by tumor necrosis factor-alpha of beta1-, beta2-, and beta3-adrenoreceptor gene expression in 3T3-F442A adipocytes. J. Biol. Chem. 272 24514-21 PubMed GONUTS page

[PMID:19404405-12] Esteban, V et al. (2009) Angiotensin-(1-7) and the g protein-coupled receptor MAS are key players in renal inflammation. PLoS ONE 4 e5406 PubMed GONUTS page

[PMID:17670746-13] Yao, D et al. (2007) High glucose increases angiopoietin-2 transcription in microvascular endothelial cells through methylglyoxal modification of mSin3A. J. Biol. Chem. 282 31038-45 PubMed GONUTS page

[PMID:12761567-14] Abrantes, EF et al. (2003) Identification, structural characterization, and tissue distribution of Tsg-5: a new TNF-stimulated gene. Genes Immun. 4 298-311 PubMed GONUTS page

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