GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:16282525
| Citation |
Murray, RZ, Kay, JG, Sangermani, DG and Stow, JL (2005) A role for the phagosome in cytokine secretion. Science 310:1492-5 |
|---|---|
| Abstract |
Membrane traffic in activated macrophages is required for two critical events in innate immunity: proinflammatory cytokine secretion and phagocytosis of pathogens. We found a joint trafficking pathway linking both actions, which may economize membrane transport and augment the immune response. Tumor necrosis factor alpha (TNFalpha) is trafficked from the Golgi to the recycling endosome (RE), where vesicle-associated membrane protein 3 mediates its delivery to the cell surface at the site of phagocytic cup formation. Fusion of the RE at the cup simultaneously allows rapid release of TNFalpha and expands the membrane for phagocytosis. |
| Links |
PubMed Online version:10.1126/science.1120225 |
| Keywords |
Animals; Candida albicans/immunology; Cell Line; Cell Membrane/metabolism; Cytoplasmic Vesicles/metabolism; Endosomes/metabolism; Interferon-gamma/metabolism; Macrophage Activation; Macrophages/immunology; Macrophages/secretion; Mice; Phagocytosis; Phagosomes/physiology; Qa-SNARE Proteins/metabolism; Tumor Necrosis Factor-alpha/secretion; Vesicle-Associated Membrane Protein 3/physiology; rab GTP-Binding Proteins/biosynthesis |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| edit table |
See also
References
See Help:References for how to manage references in GONUTS.
