RAT:MK08

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Mapk8 (synonyms: Jnk1, Prkm8)
Protein Name(s)	Mitogen-activated protein kinase 8 MAP kinase 8 MAPK 8 SAPK gamma Stress-activated protein kinase JNK1 c-Jun N-terminal kinase 1 p54 gamma
External Links
UniProt	P49185
EMBL	L27129
PIR	S43970
RefSeq	NP_446281.2
UniGene	Rn.4090
ProteinModelPortal	P49185
SMR	P49185
IntAct	P49185
MINT	MINT-1500743
STRING	10116.ENSRNOP00000027338
BindingDB	P49185
ChEMBL	CHEMBL5718
PhosphoSite	P49185
PaxDb	P49185
PRIDE	P49185
GeneID	116554
KEGG	rno:116554
UCSC	RGD:621506
CTD	5599
RGD	621506
eggNOG	COG0515
HOGENOM	HOG000233024
HOVERGEN	HBG014652
InParanoid	P49185
KO	K04440
PhylomeDB	P49185
BRENDA	2.7.11.24
Reactome	REACT_258144
Proteomes	UP000002494
Genevestigator	P49185
GO	GO:0030424 GO:0005737 GO:0005829 GO:0032839 GO:0005739 GO:0005634 GO:0043204 GO:0031982 GO:0005524 GO:0004705 GO:0006954 GO:0007254 GO:0007258 GO:0043066 GO:0031175 GO:0043065 GO:0030335 GO:0045740 GO:0031116 GO:0006355 GO:0009408 GO:0042542 GO:0006970 GO:0048545 GO:0007165
InterPro	IPR011009 IPR003527 IPR008351 IPR000719 IPR002290 IPR008271
Pfam	PF00069
PRINTS	PR01772
SMART	SM00220
SUPFAM	SSF56112
PROSITE	PS01351 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0097050	type B pancreatic cell apoptotic process	PMID:24475223^[1]	ECO:0000315			P	Figure 2	complete CACAO 9361
involved_in	GO:0097050	type B pancreatic cell apoptotic process	PMID:24475223^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042752	regulation of circadian rhythm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q91Y86	P	Seeded From UniProt	complete
involved_in	GO:0007254	JNK cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q91Y86	P	Seeded From UniProt	complete
enables	GO:0004705	JUN kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q91Y86	F	Seeded From UniProt	complete
involved_in	GO:2001224	positive regulation of neuron migration	PMID:24388750^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1904646	cellular response to amyloid-beta	PMID:12534344^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071347	cellular response to interleukin-1	PMID:9513050^[4]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048666	neuron development	PMID:17568197^[5]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048545	response to steroid hormone	PMID:14512437^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0046605	regulation of centrosome cycle	PMID:24388750^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045740	positive regulation of DNA replication	PMID:9487126^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045664	regulation of neuron differentiation	PMID:24388750^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043525	positive regulation of neuron apoptotic process	PMID:12534344^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0043204	perikaryon	PMID:9714150^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:15309413^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:16699462^[10]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042542	response to hydrogen peroxide	PMID:14707549^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0034352	positive regulation of glial cell apoptotic process	PMID:14997384^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0034349	glial cell apoptotic process	PMID:14997384^[12]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0032839	dendrite cytoplasm	PMID:9714150^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0031982	vesicle	PMID:16618812^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0031175	neuron projection development	PMID:16618812^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0031116	positive regulation of microtubule polymerization	PMID:16618812^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:9714150^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	PMID:12853963^[14]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0019894	kinesin binding	PMID:18932217^[15]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:621559	F	Seeded From UniProt	complete
involved_in	GO:0010666	positive regulation of cardiac muscle cell apoptotic process	PMID:11259632^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009408	response to heat	PMID:10772775^[17]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:12011047^[18]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006970	response to osmotic stress	PMID:10781376^[19]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:11435459^[20]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:12011047^[18]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:15504737^[21]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:15504737^[21]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:10773432^[22]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16699462^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15504737^[21]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:10773432^[22]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0004705	JUN kinase activity	PMID:17064355^[23]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004705	JUN kinase activity	PMID:11849756^[24]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0002052	positive regulation of neuroblast proliferation	PMID:24388750^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071310	cellular response to organic substance	PMID:21873635^[25]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001172432 RGD:70500	P	Seeded From UniProt	complete
involved_in	GO:0048666	neuron development	PMID:21873635^[25]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000622286 RGD:621506 RGD:628847	P	Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:21873635^[25]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001171983 RGD:621506 RGD:628847	P	Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:21873635^[25]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000622286 RGD:628847	C	Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:21873635^[25]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:106908 MGI:MGI:1201387 MGI:MGI:1201408 MGI:MGI:1346865 PANTHER:PTN000622075 RGD:3046 RGD:70500 RGD:71050 UniProtKB:P78362 UniProtKB:Q16539 UniProtKB:Q96SB4 UniProtKB:Q9UPZ9 WB:WBGene00004055 WB:WBGene00004056	P	Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	PMID:21873635^[25]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1346861 PANTHER:PTN000622075 UniProtKB:A9T142	P	Seeded From UniProt	complete
involved_in	GO:0009612	response to mechanical stimulus	PMID:21873635^[25]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001171983 RGD:628847	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[25]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0052703 FB:FBgn0267339 MGI:MGI:1201408 MGI:MGI:1346347 MGI:MGI:1346858 MGI:MGI:1346859 MGI:MGI:1346861 MGI:MGI:1346862 MGI:MGI:1346863 MGI:MGI:1346865 MGI:MGI:1354946 MGI:MGI:2444559 PANTHER:PTN000622075 PomBase:SPAC24B11.06c PomBase:SPBC119.08 PomBase:SPBC530.14c RGD:3046 RGD:621506 RGD:628847 RGD:70500 RGD:70975 RGD:71050 SGD:S000000112 SGD:S000004103 SGD:S000004829 TAIR:locus:2024887 TAIR:locus:2124943 UniProtKB:A9T142 UniProtKB:O77306 UniProtKB:P28482 UniProtKB:P78362 UniProtKB:Q10N20 UniProtKB:Q13164 UniProtKB:Q96SB4 WB:WBGene00002178 WB:WBGene00002187 WB:WBGene00003048 WB:WBGene00003401 WB:WBGene00004056 WB:WBGene00004057	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[25]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003256 FB:FBgn0015765 MGI:MGI:1201387 MGI:MGI:1201408 MGI:MGI:1336881 MGI:MGI:1346347 MGI:MGI:1346858 MGI:MGI:1346859 MGI:MGI:1346861 MGI:MGI:1346865 MGI:MGI:1354946 MGI:MGI:1934157 MGI:MGI:2444559 MGI:MGI:96913 PANTHER:PTN000622075 PomBase:SPAC24B11.06c PomBase:SPAC31G5.09c PomBase:SPBC119.08 PomBase:SPBC530.14c RGD:3046 RGD:3663 RGD:621505 RGD:621506 RGD:628675 RGD:628847 RGD:70496 RGD:70500 SGD:S000000112 SGD:S000001072 SGD:S000003272 SGD:S000003642 SGD:S000004103 TAIR:locus:2024887 TAIR:locus:2124943 UniProtKB:A9T142 UniProtKB:O77306 UniProtKB:P20794 UniProtKB:P28482 UniProtKB:P45983 UniProtKB:P78362 UniProtKB:Q10N20 UniProtKB:Q13164 UniProtKB:Q5AZN7 UniProtKB:Q8GYQ5 UniProtKB:Q96SB4 UniProtKB:Q9LV37 UniProtKB:Q9P419 WB:WBGene00002178 WB:WBGene00003048 WB:WBGene00003401 WB:WBGene00004055 WB:WBGene00004057 dictyBase:DDB_G0283903 dictyBase:DDB_G0286353	C	Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	PMID:21873635^[25]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015765 FB:FBgn0024846 FB:FBgn0267339 MGI:MGI:1346858 MGI:MGI:1346859 MGI:MGI:1346865 MGI:MGI:1354946 PANTHER:PTN001172432 PomBase:SPAC31G5.09c PomBase:SPBC119.08 RGD:1309340 RGD:3045 RGD:3046 RGD:621505 RGD:70496 RGD:70500 RGD:70975 SGD:S000000112 SGD:S000003272 SGD:S000006258 UniProtKB:A0A1D8PFT5 UniProtKB:A0A1D8PT38 UniProtKB:O15264 UniProtKB:P27361 UniProtKB:Q15759 UniProtKB:Q16539 WB:WBGene00003401 WB:WBGene00004055 WB:WBGene00004056 dictyBase:DDB_G0286353	F	Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	PMID:21873635^[25]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	CGD:CAL0000183747 FB:FBgn0015765 FB:FBgn0024846 FB:FBgn0267339 MGI:MGI:1346858 MGI:MGI:1346859 MGI:MGI:1346865 MGI:MGI:1354946 PANTHER:PTN002372889 PomBase:SPAC31G5.09c PomBase:SPBC119.08 RGD:1309340 RGD:3045 RGD:3046 RGD:621505 RGD:70496 RGD:70500 RGD:70975 SGD:S000000112 SGD:S000003272 SGD:S000006258 UniProtKB:A0A1D8PFT5 UniProtKB:A0A1D8PT38 UniProtKB:O15264 UniProtKB:P27361 UniProtKB:Q15759 UniProtKB:Q16539 WB:WBGene00003401 WB:WBGene00004055 WB:WBGene00004056 dictyBase:DDB_G0286353	F	Seeded From UniProt	complete
involved_in	GO:0097150	neuronal stem cell population maintenance	PMID:24388750^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q5M9F2	P	Seeded From UniProt	complete
involved_in	GO:0097150	neuronal stem cell population maintenance	PMID:24388750^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007258	JUN phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004705	P	Seeded From UniProt	complete
involved_in	GO:0007258	JUN phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004705	P	Seeded From UniProt	complete
involved_in	GO:0007258	JUN phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004705	P	Seeded From UniProt	complete
involved_in	GO:0007258	JUN phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004705	P	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F	Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003527 InterPro:IPR008351	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR003527 InterPro:IPR008351	F	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR003527 InterPro:IPR008271 InterPro:IPR008351	P	Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.11.24	F	Seeded From UniProt	complete
enables	GO:0004705	JUN kinase activity	PMID:12011047^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-RNO-209184 Reactome:R-RNO-205027	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-RNO-209184	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F	Seeded From UniProt	complete
involved_in	GO:0048511	rhythmic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0090	P	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Prause, M et al. (2014) JNK1 protects against glucolipotoxicity-mediated beta-cell apoptosis. PLoS ONE 9 e87067 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Xu, D et al. (2014) Microcephaly-associated protein WDR62 regulates neurogenesis through JNK1 in the developing neocortex. Cell Rep 6 104-16 PubMed GONUTS page
↑ ^3.0 ^3.1 Fogarty, MP et al. (2003) A role for c-Jun N-terminal kinase 1 (JNK1), but not JNK2, in the beta-amyloid-mediated stabilization of protein p53 and induction of the apoptotic cascade in cultured cortical neurons. Biochem. J. 371 789-98 PubMed GONUTS page
↑ Chaudhary, LR & Avioli, LV (1998) Activation of c-Jun NH2-terminal kinases by interleukin-1 beta in normal human osteoblastic and rat UMR-106 cells. J. Cell. Biochem. 69 87-93 PubMed GONUTS page
↑ Zhang, L et al. (2007) TNFalpha induces apoptosis through JNK/Bax-dependent pathway in differentiated, but not naïve PC12 cells. Cell Cycle 6 1479-86 PubMed GONUTS page
↑ Koski, CL et al. (2004) Regulation of cytokine-induced neuron death by ovarian hormones: involvement of antiapoptotic protein expression and c-JUN N-terminal kinase-mediated proapoptotic signaling. Endocrinology 145 95-103 PubMed GONUTS page
↑ Auer, KL et al. (1998) The Ras/Rac1/Cdc42/SEK/JNK/c-Jun cascade is a key pathway by which agonists stimulate DNA synthesis in primary cultures of rat hepatocytes. Mol. Biol. Cell 9 561-73 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Flood, DG et al. (1998) Immunolocalization of the mitogen-activated protein kinases p42MAPK and JNK1, and their regulatory kinases MEK1 and MEK4, in adult rat central nervous system. J. Comp. Neurol. 398 373-92 PubMed GONUTS page
↑ Engelbrecht, AM et al. (2004) p38 and JNK have distinct regulatory functions on the development of apoptosis during simulated ischaemia and reperfusion in neonatal cardiomyocytes. Basic Res. Cardiol. 99 338-50 PubMed GONUTS page
↑ ^10.0 ^10.1 Murayama, T et al. (2006) JNK (c-Jun NH2 terminal kinase) and p38 during ischemia reperfusion injury in the small intestine. Transplantation 81 1325-30 PubMed GONUTS page
↑ Wang, W et al. (2003) Regulation of c-Jun N-terminal kinase activation in hydrogen peroxide induced neurotoxicity. J. Neurocytol. 32 143-51 PubMed GONUTS page
↑ ^12.0 ^12.1 Tseng, SH et al. (2004) Activation of c-Jun N-terminal kinase 1 and caspase 3 in the tamoxifen-induced apoptosis of rat glioma cells. J. Cancer Res. Clin. Oncol. 130 285-93 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Tararuk, T et al. (2006) JNK1 phosphorylation of SCG10 determines microtubule dynamics and axodendritic length. J. Cell Biol. 173 265-77 PubMed GONUTS page
↑ Huang, C et al. (2003) JNK phosphorylates paxillin and regulates cell migration. Nature 424 219-23 PubMed GONUTS page
↑ Lalioti, VS et al. (2009) Daxx functions as a scaffold of a protein assembly constituted by GLUT4, JNK1 and KIF5B. J. Cell. Physiol. 218 416-26 PubMed GONUTS page
↑ Hreniuk, D et al. (2001) Inhibition of c-Jun N-terminal kinase 1, but not c-Jun N-terminal kinase 2, suppresses apoptosis induced by ischemia/reoxygenation in rat cardiac myocytes. Mol. Pharmacol. 59 867-74 PubMed GONUTS page
↑ Maroni, P et al. (2000) Cellular signalling after in vivo heat shock in the liver. Cell Biol. Int. 24 145-52 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 Kaneto, H et al. (2002) Involvement of c-Jun N-terminal kinase in oxidative stress-mediated suppression of insulin gene expression. J. Biol. Chem. 277 30010-8 PubMed GONUTS page
↑ Kim, RD et al. (2000) Hypoosmotic stress activates p38, ERK 1 and 2, and SAPK/JNK in rat hepatocytes. J. Surg. Res. 90 58-66 PubMed GONUTS page
↑ Han, Z et al. (2001) c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis. J. Clin. Invest. 108 73-81 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 Eminel, S et al. (2004) JNK2 translocates to the mitochondria and mediates cytochrome c release in PC12 cells in response to 6-hydroxydopamine. J. Biol. Chem. 279 55385-92 PubMed GONUTS page
↑ ^22.0 ^22.1 Hayashi, T et al. (2000) c-Jun N-terminal kinase (JNK) and JNK interacting protein response in rat brain after transient middle cerebral artery occlusion. Neurosci. Lett. 284 195-9 PubMed GONUTS page
↑ Wang, R et al. (2006) Inhibition of MLK3-MKK4/7-JNK1/2 pathway by Akt1 in exogenous estrogen-induced neuroprotection against transient global cerebral ischemia by a non-genomic mechanism in male rats. J. Neurochem. 99 1543-54 PubMed GONUTS page
↑ Trotter, L et al. (2002) Mitogen-activated protein kinase kinase 7 is activated during low potassium-induced apoptosis in rat cerebellar granule neurons. Neurosci. Lett. 320 29-32 PubMed GONUTS page
↑ ^25.00 ^25.01 ^25.02 ^25.03 ^25.04 ^25.05 ^25.06 ^25.07 ^25.08 ^25.09 ^25.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:24475223-1] 1.0 ^1.1 Prause, M et al. (2014) JNK1 protects against glucolipotoxicity-mediated beta-cell apoptosis. PLoS ONE 9 e87067 PubMed GONUTS page

[PMID:24388750-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Xu, D et al. (2014) Microcephaly-associated protein WDR62 regulates neurogenesis through JNK1 in the developing neocortex. Cell Rep 6 104-16 PubMed GONUTS page

[PMID:12534344-3] 3.0 ^3.1 Fogarty, MP et al. (2003) A role for c-Jun N-terminal kinase 1 (JNK1), but not JNK2, in the beta-amyloid-mediated stabilization of protein p53 and induction of the apoptotic cascade in cultured cortical neurons. Biochem. J. 371 789-98 PubMed GONUTS page

[PMID:9513050-4] Chaudhary, LR & Avioli, LV (1998) Activation of c-Jun NH2-terminal kinases by interleukin-1 beta in normal human osteoblastic and rat UMR-106 cells. J. Cell. Biochem. 69 87-93 PubMed GONUTS page

[PMID:17568197-5] Zhang, L et al. (2007) TNFalpha induces apoptosis through JNK/Bax-dependent pathway in differentiated, but not naïve PC12 cells. Cell Cycle 6 1479-86 PubMed GONUTS page

[PMID:14512437-6] Koski, CL et al. (2004) Regulation of cytokine-induced neuron death by ovarian hormones: involvement of antiapoptotic protein expression and c-JUN N-terminal kinase-mediated proapoptotic signaling. Endocrinology 145 95-103 PubMed GONUTS page

[PMID:9487126-7] Auer, KL et al. (1998) The Ras/Rac1/Cdc42/SEK/JNK/c-Jun cascade is a key pathway by which agonists stimulate DNA synthesis in primary cultures of rat hepatocytes. Mol. Biol. Cell 9 561-73 PubMed GONUTS page

[PMID:9714150-8] 8.0 ^8.1 ^8.2 Flood, DG et al. (1998) Immunolocalization of the mitogen-activated protein kinases p42MAPK and JNK1, and their regulatory kinases MEK1 and MEK4, in adult rat central nervous system. J. Comp. Neurol. 398 373-92 PubMed GONUTS page

[PMID:15309413-9] Engelbrecht, AM et al. (2004) p38 and JNK have distinct regulatory functions on the development of apoptosis during simulated ischaemia and reperfusion in neonatal cardiomyocytes. Basic Res. Cardiol. 99 338-50 PubMed GONUTS page

[PMID:16699462-10] 10.0 ^10.1 Murayama, T et al. (2006) JNK (c-Jun NH2 terminal kinase) and p38 during ischemia reperfusion injury in the small intestine. Transplantation 81 1325-30 PubMed GONUTS page

[PMID:14707549-11] Wang, W et al. (2003) Regulation of c-Jun N-terminal kinase activation in hydrogen peroxide induced neurotoxicity. J. Neurocytol. 32 143-51 PubMed GONUTS page

[PMID:14997384-12] 12.0 ^12.1 Tseng, SH et al. (2004) Activation of c-Jun N-terminal kinase 1 and caspase 3 in the tamoxifen-induced apoptosis of rat glioma cells. J. Cancer Res. Clin. Oncol. 130 285-93 PubMed GONUTS page

[PMID:16618812-13] 13.0 ^13.1 ^13.2 Tararuk, T et al. (2006) JNK1 phosphorylation of SCG10 determines microtubule dynamics and axodendritic length. J. Cell Biol. 173 265-77 PubMed GONUTS page

[PMID:12853963-14] Huang, C et al. (2003) JNK phosphorylates paxillin and regulates cell migration. Nature 424 219-23 PubMed GONUTS page

[PMID:18932217-15] Lalioti, VS et al. (2009) Daxx functions as a scaffold of a protein assembly constituted by GLUT4, JNK1 and KIF5B. J. Cell. Physiol. 218 416-26 PubMed GONUTS page

[PMID:11259632-16] Hreniuk, D et al. (2001) Inhibition of c-Jun N-terminal kinase 1, but not c-Jun N-terminal kinase 2, suppresses apoptosis induced by ischemia/reoxygenation in rat cardiac myocytes. Mol. Pharmacol. 59 867-74 PubMed GONUTS page

[PMID:10772775-17] Maroni, P et al. (2000) Cellular signalling after in vivo heat shock in the liver. Cell Biol. Int. 24 145-52 PubMed GONUTS page

[PMID:12011047-18] 18.0 ^18.1 ^18.2 Kaneto, H et al. (2002) Involvement of c-Jun N-terminal kinase in oxidative stress-mediated suppression of insulin gene expression. J. Biol. Chem. 277 30010-8 PubMed GONUTS page

[PMID:10781376-19] Kim, RD et al. (2000) Hypoosmotic stress activates p38, ERK 1 and 2, and SAPK/JNK in rat hepatocytes. J. Surg. Res. 90 58-66 PubMed GONUTS page

[PMID:11435459-20] Han, Z et al. (2001) c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis. J. Clin. Invest. 108 73-81 PubMed GONUTS page

[PMID:15504737-21] 21.0 ^21.1 ^21.2 Eminel, S et al. (2004) JNK2 translocates to the mitochondria and mediates cytochrome c release in PC12 cells in response to 6-hydroxydopamine. J. Biol. Chem. 279 55385-92 PubMed GONUTS page

[PMID:10773432-22] 22.0 ^22.1 Hayashi, T et al. (2000) c-Jun N-terminal kinase (JNK) and JNK interacting protein response in rat brain after transient middle cerebral artery occlusion. Neurosci. Lett. 284 195-9 PubMed GONUTS page

[PMID:17064355-23] Wang, R et al. (2006) Inhibition of MLK3-MKK4/7-JNK1/2 pathway by Akt1 in exogenous estrogen-induced neuroprotection against transient global cerebral ischemia by a non-genomic mechanism in male rats. J. Neurochem. 99 1543-54 PubMed GONUTS page

[PMID:11849756-24] Trotter, L et al. (2002) Mitogen-activated protein kinase kinase 7 is activated during low potassium-induced apoptosis in rat cerebellar granule neurons. Neurosci. Lett. 320 29-32 PubMed GONUTS page

[PMID:21873635-25] 25.00 ^25.01 ^25.02 ^25.03 ^25.04 ^25.05 ^25.06 ^25.07 ^25.08 ^25.09 ^25.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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