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PMID:10781376
| Citation |
Kim, RD, Darling, CE, Cerwenka, H and Chari, RS (2000) Hypoosmotic stress activates p38, ERK 1 and 2, and SAPK/JNK in rat hepatocytes. J. Surg. Res. 90:58-66 |
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| Abstract |
Following hepatocyte injury, changes in the perihepatocyte milieu modulate cell volume and influence growth. Hypoosmotic stress activates nuclear factor-kappa B (NF-kappaB), a transcription factor believed to prime cell cycle progression in hepatocytes. In this study, we investigate the role of mitogen-activated protein kinases (MAPKs) in the activation of NF-kappaB. |
| Links |
PubMed Online version:10.1006/jsre.2000.5866 |
| Keywords |
Animals; Hepatocyte Growth Factor/pharmacology; Hypotonic Solutions/pharmacology; Liver/cytology; Liver/enzymology; Male; Mitogen-Activated Protein Kinase 1/physiology; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinases/physiology; NF-kappa B/physiology; Phosphorylation; Rats; Rats, Sprague-Dawley; p38 Mitogen-Activated Protein Kinases |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0006970: response to osmotic stress |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
See also
References
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