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MOUSE:WNT5A
Contents
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0071542 |
dopaminergic neuron differentiation |
ECO:0000314 |
P |
Figure 4 shows that Wnt5a treatment improves the number of Tyrosine Hydroxylase positive cells developing into dopaminergic neurons. |
complete | |||||
| GO:0030901 |
midbrain development |
ECO:0000316 |
|
P |
Figure 2 shows the knockout of Wnt5a results in decrease in both Anterior and Posterior length and development of the midbrain. |
complete | ||||
| GO:0071542 |
dopaminergic neuron differentiation |
ECO:0000316 |
|
P |
Figure 2 shows lack of Wnt-1 and Wnt-5a interaction leads to reduced DA neurogenesis. |
complete | ||||
| GO:0016055 |
Wnt receptor signaling pathway |
ECO:0000314 |
P |
fg1. Canonical wnt signaling activated during fetal myogenisis and reduced in adult. fg2. Muscle-specific constitutive activation of each canonical wnt signaling promotes oxidative myofiber phenotype. fg5. induces slow myosin heavy chain expression in fetal myoblasts |
complete | |||||
| GO:0097325 |
melanocyte proliferation |
ECO:0000314 |
P |
The results displayed in figure 1 C and D. indicate the ratio of proliferating AdWnt5a-infected cells is lower than that in control cells. This would imply that “Wnt5a inhibited the proliferation of melan-a cells.” |
complete | |||||
| GO:0048022 |
negative regulation of melanin biosynthetic process |
ECO:0000314 |
P |
Wnt5a inhibited the tyrosinase activity of melan-a cells in a dose-dependent manner compared to the control as displayed in Fig. 2A. This was confirmed by the tyrosinase activity assay results in Fig. 2B, decreased protein levels of tyrosinase and TRP1 due to Wnt5a presented in Fig. 2 C and D, and also by subcutaneous implantation experiments presented in Fig. 2 E. |
complete | |||||
| GO:2000052 |
positive regulation of non-canonical Wnt receptor signaling pathway |
ECO:0000314 |
P |
The results displayed in Fig. 3 show that Wnt5a increased the expression levels of Ror2, c-JUN, JNK1 and JNK2 in a time-dependent manner which demonstrates activation of Wnt/Ror2 signaling pathways via Wnt5a. |
complete | |||||
| GO:0090090 |
negative regulation of canonical Wnt signaling pathway |
ECO:0000314 |
P |
Both RT-PCR and Western blot analyses, found in Fig. 4 A, showed that Wnt5a significantly decreased the expression level of β-catenin in melan-a cells. Co-infection analyses displayed in Fig 4 C and D each showed that Wnt5a down-regulated the expression levels of these pigmentation-related mRNAs and proteins upregulated by Wnt3a. These results, supported by the tyrosinase activity assay in Fig 4 B, suggested that Wnt5a antagonized the canonical Wnt signaling pathway in melan-a cells. |
complete | |||||
| GO:0003281 |
ventricular septum development |
ECO:0000316 |
|
P |
Figure 2 A and D show both the wild type and the double mutant Wnt5a -/-;Wnt11-/- which develop a single chamber heart. It can also be seen in figure 2 B and C that the single mutants do not fully develop the ventricular septum. |
complete | ||||
| GO:0003283 |
atrial septum development |
ECO:0000316 |
|
P |
Figure 2 A and D Hematoxylin and Eosin (H+E) staining of histological sections at E9.5 of the wild type and the double mutant Wnt5a -/-;Wnt11-/- are shown. It can be seen in the double mutant only single chamber hearts are formed from the double mutant. There is no atrial septum development in the double mutant. |
complete | ||||
| GO:0003139 |
secondary heart field specification |
ECO:0000316 |
|
P |
Figure 3 A-D,I and Figure 4 F,G,H. Figure 3: "sections of E9.5 double-mutant, single-mutant and wild-type embryos were stained for Isl1 protein expression". "Isl1+ cells in Wnt5a–/–; Wnt11–/– embryos stained much less intensely than those in wild-type and single-mutant controls". Figure 4 F shows that when treated with Wnt5a and Wnt11, there is an increase in expression of Tbx5, Isl1, and Nkx2.5. Tbx5 is "expressed in the precardiac mesoderm and cardiac crescent before being restricted to the venous pole of the heart" and Isl1 and Nkx2.5 both mark SHF cardiac progenitors. |
complete | ||||
| GO:0003138 |
primary heart field specification |
ECO:0000316 |
|
P |
Figure 4 E&H show the effect of recombinant Wnt5a and/or WNT11 proteins on gene expression in EBs. The expression of Mesp1 which is "expressed in early precardiac mesoderm and the cardiac crescent but later extinguished as the heart tube develops" and Nkx2.5 which "which marks both FHF and SHF cardiac progenitors" were both increased most when treated with both Wnt5a and Wnt11. |
complete | ||||
| GO:0090082 |
positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway |
ECO:0000316 |
|
P |
Figure 5 shows that Wnt5a and Wnt11 are both required to negatively regulate the canonical Wnt signaling pathway. In 5 A&B it shows that the double mutant Wnt5a-/-;Wnt11-/- shows more stained cells than the wild type controls when crossed with BAT-GAL strain Wnt reporter line and stained with X-gal. C-F shows increased expression of genes (in double mutants Wnt5a-/-;Wnt11-/-) which are upregulated by Beta-catenin signaling in the canonical wnt pathway. Figures 2&3 both show Wnt11 and Wnt5a's function as positive regulators of heart induction. |
complete | ||||
| GO:0070374 |
positive regulation of ERK1 and ERK2 cascade |
ECO:0000315 |
P |
Several inhibitors were used in Figure 5 which shows mapping of the WNT-5A-induced signaling pathway leading to ERK1/2 phosphorylation in primary microglia. |
complete | |||||
| GO:0070374 |
positive regulation of ERK1 and ERK2 cascade |
ECO:0000315 |
P |
Several inhibitors were used in Figure 5 which shows mapping of the WNT-5A-induced signaling pathway leading to ERK1/2 phosphorylation in primary microglia. |
complete | |||||
| GO:0070374 |
positive regulation of ERK1 and ERK2 cascade |
ECO:0000315 |
P |
Several inhibitors were used in Figure 5 which shows mapping of the WNT-5A-induced signaling pathway leading to ERK1/2 phosphorylation in primary microglia. |
complete | |||||
|
involved_in |
GO:0150012 |
positive regulation of neuron projection arborization |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
occurs_in:(CL:0002608) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1904469 |
positive regulation of tumor necrosis factor secretion |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0050718 |
positive regulation of interleukin-1 beta secretion |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
regulates_o_occurs_in:(CL:0002609) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043122 |
regulation of I-kappaB kinase/NF-kappaB signaling |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
regulates_o_occurs_in:(CL:0002609) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010628 |
positive regulation of gene expression |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1901216 |
positive regulation of neuron death |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
regulates_o_occurs_in:(CL:0002609) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1904469 |
positive regulation of tumor necrosis factor secretion |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
ComplexPortal:CPX-1134,UniProtKB:Q9EQD0 |
P |
|
Seeded From UniProt |
complete | |
|
involved_in |
GO:0050718 |
positive regulation of interleukin-1 beta secretion |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
ComplexPortal:CPX-1134,UniProtKB:Q9EQD0 |
P |
regulates_o_occurs_in:(CL:0002609) |
Seeded From UniProt |
complete | |
|
involved_in |
GO:1904948 |
midbrain dopaminergic neuron differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1904948 |
midbrain dopaminergic neuron differentiation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
NOT|involved_in |
GO:0060070 |
canonical Wnt signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0001934 |
positive regulation of protein phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_regulation_target:(UniProtKB:Q60838)|has_regulation_target:(UniProtKB:Q61062) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0035567 |
non-canonical Wnt signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
part_of:(GO:1904948) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001934 |
positive regulation of protein phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030901 |
midbrain development |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0090090 |
negative regulation of canonical Wnt signaling pathway |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1903827 |
regulation of cellular protein localization |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
transports_or_maintains_localization_of:(UniProtKB:Q60838) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045860 |
positive regulation of protein kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001934 |
positive regulation of protein phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0035567 |
non-canonical Wnt signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
occurs_in:(CL:0000700) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0090630 |
activation of GTPase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
enables |
GO:0005102 |
signaling receptor binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1904948 |
midbrain dopaminergic neuron differentiation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1904938 |
planar cell polarity pathway involved in axon guidance |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1904938 |
planar cell polarity pathway involved in axon guidance |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
occurs_in:(CL:0000700) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1904934 |
negative regulation of cell proliferation in midbrain |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032092 |
positive regulation of protein binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043547 |
positive regulation of GTPase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0036518 |
chemorepulsion of dopaminergic neuron axon |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
occurs_in:(UBERON:0001891) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007409 |
axonogenesis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
occurs_in:(UBERON:0001891) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1904953 |
Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0022008 |
neurogenesis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
occurs_in:(UBERON:0001891) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0036517 |
chemoattraction of serotonergic neuron axon |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0036518 |
chemorepulsion of dopaminergic neuron axon |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:1902379 |
chemoattractant activity involved in axon guidance |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
part_of:(GO:0036517) |
Seeded From UniProt |
complete | ||
|
NOT|involved_in |
GO:0090090 |
negative regulation of canonical Wnt signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1904948 |
midbrain dopaminergic neuron differentiation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030901 |
midbrain development |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071542 |
dopaminergic neuron differentiation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0090090 |
negative regulation of canonical Wnt signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2000052 |
positive regulation of non-canonical Wnt signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0048022 |
negative regulation of melanin biosynthetic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0097325 |
melanocyte proliferation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071542 |
dopaminergic neuron differentiation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051885 |
positive regulation of timing of anagen |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060070 |
canonical Wnt signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2000484 |
positive regulation of interleukin-8 secretion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0090090 |
negative regulation of canonical Wnt signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071219 |
cellular response to molecule of bacterial origin |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060070 |
canonical Wnt signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051964 |
negative regulation of synapse assembly |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050718 |
positive regulation of interleukin-1 beta secretion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046330 |
positive regulation of JNK cascade |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0038031 |
non-canonical Wnt signaling pathway via JNK cascade |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032755 |
positive regulation of interleukin-6 production |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032729 |
positive regulation of interferon-gamma production |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0009986 |
cell surface |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008595 |
anterior/posterior axis specification, embryo |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007223 |
Wnt signaling pathway, calcium modulating pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005125 |
cytokine activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005109 |
frizzled binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0048812 |
neuron projection morphogenesis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0021891 |
olfactory bulb interneuron development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019904 |
protein domain specific binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010976 |
positive regulation of neuron projection development |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007411 |
axon guidance |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045165 |
cell fate commitment |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:98957 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030182 |
neuron differentiation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000246517 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0016055 |
Wnt signaling pathway |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0010194 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0004009 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005109 |
frizzled binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0004009 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:2000049 |
positive regulation of cell-cell adhesion mediated by cadherin |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:1900020 |
positive regulation of protein kinase C activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0150012 |
positive regulation of neuron projection arborization |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:69250 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0099566 |
regulation of postsynaptic cytosolic calcium ion concentration |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0099175 |
regulation of postsynapse organization |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0098978 |
glutamatergic synapse |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0090179 |
planar cell polarity pathway involved in neural tube closure |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857617 |
P |
occurs_in:(EMAPA:16530) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0090103 |
cochlea morphogenesis |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:2135272 |
P |
has_participant:(EMAPA:17597) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0090103 |
cochlea morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857617 |
P |
has_participant:(EMAPA:17597) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0090090 |
negative regulation of canonical Wnt signaling pathway |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1888513 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0090090 |
negative regulation of canonical Wnt signaling pathway |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1347521 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0090090 |
negative regulation of canonical Wnt signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0090090 |
negative regulation of canonical Wnt signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
regulates_o_occurs_in:(EMAPA:16405) |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0090090 |
negative regulation of canonical Wnt signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0090037 |
positive regulation of protein kinase C signaling |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0090009 |
primitive streak formation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1298218 |
P |
has_participant:(EMAPA:16072) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0072201 |
negative regulation of mesenchymal cell proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0071542 |
dopaminergic neuron differentiation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:97845 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0071542 |
dopaminergic neuron differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857617 |
P |
|
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0071425 |
hematopoietic stem cell proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0071425 |
hematopoietic stem cell proliferation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0071425 |
hematopoietic stem cell proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0070245 |
positive regulation of thymocyte apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0062009 |
secondary palate development |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0061354 |
planar cell polarity pathway involved in pericardium morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857617 |
P |
occurs_in:(EMAPA:17174) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0061350 |
planar cell polarity pathway involved in cardiac muscle tissue morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857617 |
P |
occurs_in:(EMAPA:17318)|occurs_in:(EMAPA:17320)|occurs_in:(EMAPA:17324)|occurs_in:(EMAPA:17326)|occurs_in:(EMAPA:17339)|occurs_in:(EMAPA:17342) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0061349 |
planar cell polarity pathway involved in cardiac right atrium morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857617 |
P |
occurs_in:(EMAPA:17321) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0061348 |
planar cell polarity pathway involved in ventricular septum morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857617 |
P |
occurs_in:(EMAPA:17333) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0061347 |
planar cell polarity pathway involved in outflow tract morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857617 |
P |
occurs_in:(EMAPA:16346) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0061053 |
somite development |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:101948 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0061036 |
positive regulation of cartilage development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0061036 |
positive regulation of cartilage development |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0060907 |
positive regulation of macrophage cytokine production |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0060809 |
mesodermal to mesenchymal transition involved in gastrulation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:101948 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0060775 |
planar cell polarity pathway involved in gastrula mediolateral intercalation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:101948 |
P |
occurs_in:(EMAPA:16191) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0060762 |
regulation of branching involved in mammary gland duct morphogenesis |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:96079 |
P |
has_participant:(EMAPA:35538) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0060762 |
regulation of branching involved in mammary gland duct morphogenesis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_participant:(EMAPA:35538) |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0060760 |
positive regulation of response to cytokine stimulus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0060750 |
epithelial cell proliferation involved in mammary gland duct elongation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0060744 |
mammary gland branching involved in thelarche |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_participant:(EMAPA:35538) |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0060686 |
negative regulation of prostatic bud formation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857617 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0060638 |
mesenchymal-epithelial cell signaling |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857617 |
P |
occurs_in:(EMAPA:29919) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0060606 |
tube closure |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857617 |
P |
has_participant:(EMAPA:16569) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0060599 |
lateral sprouting involved in mammary gland duct morphogenesis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_participant:(EMAPA:35538) |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0060340 |
positive regulation of type I interferon-mediated signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0060324 |
face development |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0060157 |
urinary bladder development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857617 |
P |
results_in_development_of:(EMAPA:18321) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0060071 |
Wnt signaling pathway, planar cell polarity pathway |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:97845 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0060071 |
Wnt signaling pathway, planar cell polarity pathway |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:2135272 |
P |
occurs_in:(EMAPA:17597) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0060071 |
Wnt signaling pathway, planar cell polarity pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857617 |
P |
|
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0060071 |
Wnt signaling pathway, planar cell polarity pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857617 |
P |
occurs_in:(EMAPA:17597) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0060071 |
Wnt signaling pathway, planar cell polarity pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0060071 |
Wnt signaling pathway, planar cell polarity pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0060070 |
canonical Wnt signaling pathway |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:108520 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0060070 |
canonical Wnt signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0060070 |
canonical Wnt signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0060068 |
vagina development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857617 |
P |
results_in_development_of:(EMAPA:18986) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0060067 |
cervix development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857617 |
P |
results_in_development_of:(EMAPA:29927) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0060065 |
uterus development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857617 |
P |
results_in_development_of:(EMAPA:29919) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0060029 |
convergent extension involved in organogenesis |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1298218 |
P |
has_participant:(EMAPA:16757) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0060029 |
convergent extension involved in organogenesis |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:2135272 |
P |
has_participant:(EMAPA:17597) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0060028 |
convergent extension involved in axis elongation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:101948 |
P |
occurs_in:(EMAPA:16191)|occurs_in:(EMAPA:16183) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0060028 |
convergent extension involved in axis elongation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857617 |
P |
occurs_in:(EMAPA:16191)|occurs_in:(EMAPA:16191) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0060026 |
convergent extension |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857617 |
P |
has_participant:(EMAPA:17597) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0051092 |
positive regulation of NF-kappaB transcription factor activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0050919 |
negative chemotaxis |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:101766 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0050807 |
regulation of synapse organization |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0050729 |
positive regulation of inflammatory response |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0050718 |
positive regulation of interleukin-1 beta secretion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0050680 |
negative regulation of epithelial cell proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857617 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0050680 |
negative regulation of epithelial cell proliferation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0050679 |
positive regulation of epithelial cell proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857617 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0048850 |
hypophysis morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857617 |
P |
has_participant:(EMAPA:16724) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0048843 |
negative regulation of axon extension involved in axon guidance |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:101766 |
P |
|
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0048806 |
genitalia development |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0048706 |
embryonic skeletal system development |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0048570 |
notochord morphogenesis |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:101948 |
P |
results_in_morphogenesis_of:(EMAPA:16191) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0048546 |
digestive tract morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857617 |
P |
has_participant:(EMAPA:16247) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0048341 |
paraxial mesoderm formation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:101948 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0048146 |
positive regulation of fibroblast proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0046546 |
development of primary male sexual characteristics |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
has_participant:(EMAPA:18681) |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0045836 |
positive regulation of meiotic nuclear division |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:98957 |
P |
|
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0045807 |
positive regulation of endocytosis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0045778 |
positive regulation of ossification |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0045766 |
positive regulation of angiogenesis |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0045745 |
positive regulation of G protein-coupled receptor signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0045732 |
positive regulation of protein catabolic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0045599 |
negative regulation of fat cell differentiation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0045198 |
establishment of epithelial cell apical/basal polarity |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:101948 |
P |
|
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0045080 |
positive regulation of chemokine biosynthetic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0044212 |
transcription regulatory region DNA binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0043507 |
positive regulation of JUN kinase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857617 |
P |
|
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0043507 |
positive regulation of JUN kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0043032 |
positive regulation of macrophage activation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0042733 |
embryonic digit morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857617 |
P |
has_participant:(EMAPA:16405) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0042472 |
inner ear morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0042472 |
inner ear morphogenesis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0042060 |
wound healing |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0040037 |
negative regulation of fibroblast growth factor receptor signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857617 |
P |
regulates_o_occurs_in:(EMAPA:16896) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0036342 |
post-anal tail morphogenesis |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1298218 |
P |
has_participant:(EMAPA:16748) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0036342 |
post-anal tail morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857617 |
P |
has_participant:(EMAPA:16748) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0035567 |
non-canonical Wnt signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
occurs_in:(CL:0000451) |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0035108 |
limb morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857617 |
P |
has_participant:(EMAPA:16405) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0034613 |
cellular protein localization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857617 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0034613 |
cellular protein localization |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0033138 |
positive regulation of peptidyl-serine phosphorylation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1861437 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0032880 |
regulation of protein localization |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0032755 |
positive regulation of interleukin-6 production |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0032148 |
activation of protein kinase B activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031012 |
extracellular matrix |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0030514 |
negative regulation of BMP signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857617 |
P |
regulates_o_occurs_in:(EMAPA:16896) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0030326 |
embryonic limb morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857617 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0030324 |
lung development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857617 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0022409 |
positive regulation of cell-cell adhesion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:69250 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0021915 |
neural tube development |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1298218 |
P |
results_in_development_of:(EMAPA:16530) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0016477 |
cell migration |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1861437 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0016477 |
cell migration |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857617 |
P |
|
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0016055 |
Wnt signaling pathway |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:108460 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0016055 |
Wnt signaling pathway |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:108571 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0016055 |
Wnt signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0010820 |
positive regulation of T cell chemotaxis |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0010800 |
positive regulation of peptidyl-threonine phosphorylation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1861437 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0010595 |
positive regulation of endothelial cell migration |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0009952 |
anterior/posterior pattern specification |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857617 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0009952 |
anterior/posterior pattern specification |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857617 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0008584 |
male gonad development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
results_in_development_of:(EMAPA:17972) |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0008584 |
male gonad development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857617 |
P |
results_in_development_of:(EMAPA:17972) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0007494 |
midgut development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857617 |
P |
results_in_development_of:(EMAPA:16255) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0007442 |
hindgut morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857617 |
P |
has_participant:(EMAPA:19254) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0007368 |
determination of left/right symmetry |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857617 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0007257 |
activation of JUN kinase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0007254 |
JNK cascade |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0007223 |
Wnt signaling pathway, calcium modulating pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0007223 |
Wnt signaling pathway, calcium modulating pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0006468 |
protein phosphorylation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:98725 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:69250 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:69250 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005115 |
receptor tyrosine kinase-like orphan receptor binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005109 |
frizzled binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
has_input:(MGI:MGI:1888513) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005109 |
frizzled binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
has_input:(MGI:MGI:1888513) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005109 |
frizzled binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005102 |
signaling receptor binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0003402 |
planar cell polarity pathway involved in axis elongation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:101948 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0003402 |
planar cell polarity pathway involved in axis elongation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857617 |
P |
occurs_in:(EMAPA:16191)|occurs_in:(EMAPA:16183) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0003401 |
axis elongation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857617 |
P |
has_participant:(EMAPA:16748) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0003401 |
axis elongation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857617 |
P |
has_participant:(EMAPA:16255) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0003344 |
pericardium morphogenesis |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1298218 |
P |
has_participant:(EMAPA:16105) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0003323 |
type B pancreatic cell development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857617 |
P |
|
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0002741 |
positive regulation of cytokine secretion involved in immune response |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0002053 |
positive regulation of mesenchymal cell proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857617 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0002009 |
morphogenesis of an epithelium |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857617 |
P |
has_participant:(EMAPA:29915) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0001947 |
heart looping |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1298218 |
P |
has_participant:(EMAPA:16105) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0001938 |
positive regulation of endothelial cell proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0001934 |
positive regulation of protein phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0001843 |
neural tube closure |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1298218 |
P |
has_participant:(EMAPA:16757) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0001843 |
neural tube closure |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:2135272 |
P |
has_participant:(EMAPA:16039) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0001819 |
positive regulation of cytokine production |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
regulates_o_occurs_in:(CL:0000451) |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0001756 |
somitogenesis |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1298218 |
P |
has_participant:(EMAPA:16184) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0001736 |
establishment of planar polarity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857617 |
P |
occurs_in:(EMAPA:16975) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0001667 |
ameboidal-type cell migration |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857617 |
P |
|
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0000187 |
activation of MAPK activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0005125 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0098794 |
postsynapse |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0099566 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0098794 |
postsynapse |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0099566 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1900020 |
positive regulation of protein kinase C activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41221 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0099566 |
regulation of postsynaptic cytosolic calcium ion concentration |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41221 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0099175 |
regulation of postsynapse organization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41221 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0098978 |
glutamatergic synapse |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41221 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0090037 |
positive regulation of protein kinase C signaling |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41221 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0072201 |
negative regulation of mesenchymal cell proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41221 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0071560 |
cellular response to transforming growth factor beta stimulus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41221 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0071425 |
hematopoietic stem cell proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41221 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0071346 |
cellular response to interferon-gamma |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41221 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0071277 |
cellular response to calcium ion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41221 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0071222 |
cellular response to lipopolysaccharide |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41221 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0062009 |
secondary palate development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41221 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060907 |
positive regulation of macrophage cytokine production |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41221 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060760 |
positive regulation of response to cytokine stimulus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41221 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060340 |
positive regulation of type I interferon-mediated signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41221 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060324 |
face development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41221 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051092 |
positive regulation of NF-kappaB transcription factor activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41221 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0050807 |
regulation of synapse organization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41221 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0050729 |
positive regulation of inflammatory response |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41221 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0050718 |
positive regulation of interleukin-1 beta secretion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41221 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0048806 |
genitalia development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41221 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0048706 |
embryonic skeletal system development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41221 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0048146 |
positive regulation of fibroblast proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41221 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41221 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41221 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41221 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045778 |
positive regulation of ossification |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41221 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045766 |
positive regulation of angiogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41221 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045745 |
positive regulation of G protein-coupled receptor signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41221 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045732 |
positive regulation of protein catabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41221 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045599 |
negative regulation of fat cell differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41221 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045080 |
positive regulation of chemokine biosynthetic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41221 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0044212 |
transcription regulatory region DNA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41221 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41221 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043032 |
positive regulation of macrophage activation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41221 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042060 |
wound healing |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41221 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0034613 |
cellular protein localization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41221 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032755 |
positive regulation of interleukin-6 production |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41221 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032148 |
activation of protein kinase B activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41221 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030216 |
keratinocyte differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41221 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0016055 |
Wnt signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41221 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010820 |
positive regulation of T cell chemotaxis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41221 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010595 |
positive regulation of endothelial cell migration |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41221 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010033 |
response to organic substance |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41221 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0008584 |
male gonad development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41221 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007257 |
activation of JUN kinase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41221 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007223 |
Wnt signaling pathway, calcium modulating pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41221 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41221 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005115 |
receptor tyrosine kinase-like orphan receptor binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41221 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005109 |
frizzled binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41221 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41221 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0002741 |
positive regulation of cytokine secretion involved in immune response |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41221 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001938 |
positive regulation of endothelial cell proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41221 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001837 |
epithelial to mesenchymal transition |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41221 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0000187 |
activation of MAPK activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41221 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005102 |
signaling receptor binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007275 |
multicellular organism development |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016055 |
Wnt signaling pathway |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007413 |
axonal fasciculation |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
occurs_in:(CL:0000700) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005788 |
endoplasmic reticulum lumen |
Reactome:R-MMU-3238692 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005576 |
extracellular region |
Reactome:R-NUL-517516 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0009887 |
animal organ morphogenesis |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0007267 |
cell-cell signaling |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0007165 |
signal transduction |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005102 |
signaling receptor binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016055 |
Wnt signaling pathway |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051216 |
cartilage development |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007275 |
multicellular organism development |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030154 |
cell differentiation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Andersson, ER et al. (2013) Wnt5a cooperates with canonical Wnts to generate midbrain dopaminergic neurons in vivo and in stem cells. Proc. Natl. Acad. Sci. U.S.A. 110 E602-10 PubMed GONUTS page
- ↑ Kuroda, K et al. (2013) Canonical Wnt signaling induces BMP-4 to specify slow myofibrogenesis of fetal myoblasts. Skelet Muscle 3 5 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 Zhang, J et al. (2013) Wnt5a inhibits the proliferation and melanogenesis of melanocytes. Int J Med Sci 10 699-706 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 Cohen, ED et al. (2012) Wnt5a and Wnt11 are essential for second heart field progenitor development. Development 139 1931-40 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Halleskog, C et al. (2012) Heterotrimeric G protein-dependent WNT-5A signaling to ERK1/2 mediates distinct aspects of microglia proinflammatory transformation. J Neuroinflammation 9 111 PubMed GONUTS page
- ↑ Bian, WJ et al. (2015) A novel Wnt5a-Frizzled4 signaling pathway mediates activity-independent dendrite morphogenesis via the distal PDZ motif of Frizzled 4. Dev Neurobiol 75 805-22 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 7.4 7.5 7.6 Li, B et al. (2011) WNT5A signaling contributes to Aβ-induced neuroinflammation and neurotoxicity. PLoS ONE 6 e22920 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 8.4 8.5 8.6 Andersson, ER et al. (2008) Wnt5a regulates ventral midbrain morphogenesis and the development of A9-A10 dopaminergic cells in vivo. PLoS ONE 3 e3517 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 9.3 9.4 Bryja, V et al. (2007) Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism. J. Cell. Sci. 120 586-95 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 10.3 Schulte, G et al. (2005) Purified Wnt-5a increases differentiation of midbrain dopaminergic cells and dishevelled phosphorylation. J. Neurochem. 92 1550-3 PubMed GONUTS page
- ↑ 11.0 11.1 11.2 Castelo-Branco, G et al. (2003) Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a. Proc. Natl. Acad. Sci. U.S.A. 100 12747-52 PubMed GONUTS page
- ↑ 12.0 12.1 12.2 12.3 Blakely, BD et al. (2011) Wnt5a regulates midbrain dopaminergic axon growth and guidance. PLoS ONE 6 e18373 PubMed GONUTS page
- ↑ Bourhis, E et al. (2010) Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6. J. Biol. Chem. 285 9172-9 PubMed GONUTS page
- ↑ 14.0 14.1 14.2 14.3 Fenstermaker, AG et al. (2010) Wnt/planar cell polarity signaling controls the anterior-posterior organization of monoaminergic axons in the brainstem. J. Neurosci. 30 16053-64 PubMed GONUTS page
- ↑ 15.0 15.1 15.2 15.3 Blakely, BD et al. (2013) Ryk, a receptor regulating Wnt5a-mediated neurogenesis and axon morphogenesis of ventral midbrain dopaminergic neurons. Stem Cells Dev. 22 2132-44 PubMed GONUTS page
- ↑ 16.0 16.1 Čajánek, L et al. (2013) Tiam1 regulates the Wnt/Dvl/Rac1 signaling pathway and the differentiation of midbrain dopaminergic neurons. Mol. Cell. Biol. 33 59-70 PubMed GONUTS page
- ↑ 17.0 17.1 Rognoni, E et al. (2014) Kindlin-1 controls Wnt and TGF-β availability to regulate cutaneous stem cell proliferation. Nat. Med. 20 350-9 PubMed GONUTS page
- ↑ 18.0 18.1 18.2 18.3 Pereira, C et al. (2008) Wnt5A/CaMKII signaling contributes to the inflammatory response of macrophages and is a target for the antiinflammatory action of activated protein C and interleukin-10. Arterioscler. Thromb. Vasc. Biol. 28 504-10 PubMed GONUTS page
- ↑ 19.0 19.1 19.2 Davis, EK et al. (2008) Wnts acting through canonical and noncanonical signaling pathways exert opposite effects on hippocampal synapse formation. Neural Dev 3 32 PubMed GONUTS page
- ↑ 20.0 20.1 Blumenthal, A et al. (2006) The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation. Blood 108 965-73 PubMed GONUTS page
- ↑ 21.0 21.1 Verkaar, F et al. (2009) Stably overexpressed human Frizzled-2 signals through the beta-catenin pathway and does not activate Ca2+-mobilization in Human Embryonic Kidney 293 cells. Cell. Signal. 21 22-33 PubMed GONUTS page
- ↑ 22.0 22.1 Bilkovski, R et al. (2010) Role of WNT-5a in the determination of human mesenchymal stem cells into preadipocytes. J. Biol. Chem. 285 6170-8 PubMed GONUTS page
- ↑ 23.0 23.1 Smolich, BD et al. (1993) Wnt family proteins are secreted and associated with the cell surface. Mol. Biol. Cell 4 1267-75 PubMed GONUTS page
- ↑ He, X et al. (1997) A member of the Frizzled protein family mediating axis induction by Wnt-5A. Science 275 1652-4 PubMed GONUTS page
- ↑ Gazit, A et al. (1999) Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response. Oncogene 18 5959-66 PubMed GONUTS page
- ↑ 26.0 26.1 Pino, D et al. (2011) Wnt5a controls neurite development in olfactory bulb interneurons. ASN Neuro 3 e00059 PubMed GONUTS page
- ↑ 27.0 27.1 27.2 27.3 Keeble, TR et al. (2006) The Wnt receptor Ryk is required for Wnt5a-mediated axon guidance on the contralateral side of the corpus callosum. J. Neurosci. 26 5840-8 PubMed GONUTS page
- ↑ 28.0 28.1 28.2 28.3 28.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 29.0 29.1 Toyofuku, T et al. (2000) Wnt/frizzled-2 signaling induces aggregation and adhesion among cardiac myocytes by increased cadherin-beta-catenin complex. J. Cell Biol. 150 225-41 PubMed GONUTS page
- ↑ 30.0 30.1 30.2 30.3 30.4 30.5 30.6 Bryja, V et al. (2009) The extracellular domain of Lrp5/6 inhibits noncanonical Wnt signaling in vivo. Mol. Biol. Cell 20 924-36 PubMed GONUTS page
- ↑ 31.0 31.1 31.2 31.3 31.4 31.5 31.6 31.7 Qian, D et al. (2007) Wnt5a functions in planar cell polarity regulation in mice. Dev. Biol. 306 121-33 PubMed GONUTS page
- ↑ 32.0 32.1 Sato, A et al. (2010) Wnt5a regulates distinct signalling pathways by binding to Frizzled2. EMBO J. 29 41-54 PubMed GONUTS page
- ↑ 33.0 33.1 Mikels, AJ & Nusse, R (2006) Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context. PLoS Biol. 4 e115 PubMed GONUTS page
- ↑ 34.0 34.1 34.2 Liang, H et al. (2007) Noncanonical Wnt signaling promotes apoptosis in thymocyte development. J. Exp. Med. 204 3077-84 PubMed GONUTS page
- ↑ Topol, L et al. (2003) Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation. J. Cell Biol. 162 899-908 PubMed GONUTS page
- ↑ 36.00 36.01 36.02 36.03 36.04 36.05 36.06 36.07 36.08 36.09 36.10 36.11 36.12 Andersson, ER et al. (2010) Genetic interaction between Lrp6 and Wnt5a during mouse development. Dev. Dyn. 239 237-45 PubMed GONUTS page
- ↑ 37.0 37.1 37.2 37.3 Austin, TW et al. (1997) A role for the Wnt gene family in hematopoiesis: expansion of multilineage progenitor cells. Blood 89 3624-35 PubMed GONUTS page
- ↑ 38.0 38.1 38.2 38.3 38.4 38.5 38.6 38.7 38.8 38.9 Andre, P et al. (2015) Wnt5a and Wnt11 regulate mammalian anterior-posterior axis elongation. Development 142 1516-27 PubMed GONUTS page
- ↑ 39.0 39.1 39.2 39.3 Liu, W et al. (2008) Coordinated molecular control of otic capsule differentiation: functional role of Wnt5a signaling and opposition by sfrp3 activity. Growth Factors 26 343-54 PubMed GONUTS page
- ↑ 40.0 40.1 40.2 40.3 40.4 40.5 40.6 40.7 Roarty, K & Serra, R (2007) Wnt5a is required for proper mammary gland development and TGF-beta-mediated inhibition of ductal growth. Development 134 3929-39 PubMed GONUTS page
- ↑ 41.0 41.1 41.2 41.3 Allgeier, SH et al. (2008) WNT5A selectively inhibits mouse ventral prostate development. Dev. Biol. 324 10-7 PubMed GONUTS page
- ↑ 42.0 42.1 42.2 42.3 42.4 42.5 Mericskay, M et al. (2004) Wnt5a is required for proper epithelial-mesenchymal interactions in the uterus. Development 131 2061-72 PubMed GONUTS page
- ↑ 43.0 43.1 43.2 43.3 43.4 43.5 Cervantes, S et al. (2009) Wnt5a is essential for intestinal elongation in mice. Dev. Biol. 326 285-94 PubMed GONUTS page
- ↑ 44.0 44.1 44.2 44.3 Matsuyama, M et al. (2009) Sfrp controls apicobasal polarity and oriented cell division in developing gut epithelium. PLoS Genet. 5 e1000427 PubMed GONUTS page
- ↑ 45.0 45.1 Zaghetto, AA et al. (2007) Activation of the Wnt-beta catenin pathway in a cell population on the surface of the forebrain is essential for the establishment of olfactory axon connections. J. Neurosci. 27 9757-68 PubMed GONUTS page
- ↑ Cha, KB et al. (2004) WNT5A signaling affects pituitary gland shape. Mech. Dev. 121 183-94 PubMed GONUTS page
- ↑ 47.0 47.1 Warr, N et al. (2009) Sfrp1 and Sfrp2 are required for normal male sexual development in mice. Dev. Biol. 326 273-84 PubMed GONUTS page
- ↑ Naillat, F et al. (2010) Wnt4/5a signalling coordinates cell adhesion and entry into meiosis during presumptive ovarian follicle development. Hum. Mol. Genet. 19 1539-50 PubMed GONUTS page
- ↑ 49.0 49.1 Onishi, K et al. (2013) Antagonistic functions of Dishevelleds regulate Frizzled3 endocytosis via filopodia tips in Wnt-mediated growth cone guidance. J. Neurosci. 33 19071-85 PubMed GONUTS page
- ↑ 50.0 50.1 Potok, MA et al. (2008) WNT signaling affects gene expression in the ventral diencephalon and pituitary gland growth. Dev. Dyn. 237 1006-20 PubMed GONUTS page
- ↑ 51.0 51.1 Oderup, C et al. (2013) Canonical and noncanonical Wnt proteins program dendritic cell responses for tolerance. J. Immunol. 190 6126-34 PubMed GONUTS page
- ↑ 52.0 52.1 52.2 Yamamoto, H et al. (2007) Wnt5a modulates glycogen synthase kinase 3 to induce phosphorylation of receptor tyrosine kinase Ror2. Genes Cells 12 1215-23 PubMed GONUTS page
- ↑ Yamaguchi, TP et al. (1999) A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo. Development 126 1211-23 PubMed GONUTS page
- ↑ Li, C et al. (2002) Wnt5a participates in distal lung morphogenesis. Dev. Biol. 248 68-81 PubMed GONUTS page
- ↑ 55.0 55.1 Kim, HJ et al. (2005) Wnt5 signaling in vertebrate pancreas development. BMC Biol. 3 23 PubMed GONUTS page
- ↑ Takada, R et al. (2005) Analysis of combinatorial effects of Wnts and Frizzleds on beta-catenin/armadillo stabilization and Dishevelled phosphorylation. Genes Cells 10 919-28 PubMed GONUTS page
- ↑ Ishikawa, T et al. (2001) Mouse Wnt receptor gene Fzd5 is essential for yolk sac and placental angiogenesis. Development 128 25-33 PubMed GONUTS page
- ↑ Welsh, IC et al. (2013) Integration of left-right Pitx2 transcription and Wnt signaling drives asymmetric gut morphogenesis via Daam2. Dev. Cell 26 629-44 PubMed GONUTS page
- ↑ Oishi, I et al. (2003) The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway. Genes Cells 8 645-54 PubMed GONUTS page
- ↑ González-Sancho, JM et al. (2004) Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin. Mol. Cell. Biol. 24 4757-68 PubMed GONUTS page
- ↑ Kele, J et al. (2012) SFRP1 and SFRP2 dose-dependently regulate midbrain dopamine neuron development in vivo and in embryonic stem cells. Stem Cells 30 865-75 PubMed GONUTS page
- ↑ 62.0 62.1 62.2 62.3 Loureiro, JJ (1999) The Wnts. Curr. Biol. 9 R4 PubMed GONUTS page
a
- GO:0032148 ! activation of protein kinase B activity
- GO:0090630 ! activation of GTPase activity
- GO:0001667 ! ameboidal-type cell migration
- GO:0009887 ! animal organ morphogenesis
- GO:0008595 ! anterior/posterior axis specification, embryo
- GO:0009952 ! anterior/posterior pattern specification
- GO:0003283 ! atrial septum development
- GO:0003401 ! axis elongation
- GO:0007413 ! axonal fasciculation
- GO:0007409 ! axonogenesis
- GO:0007411 ! axon guidance
c
- GO:0060070 ! canonical Wnt signaling pathway
- GO:0051216 ! cartilage development
- GO:0007267 ! cell-cell signaling
- GO:0034613 ! cellular protein localization
- GO:0071219 ! cellular response to molecule of bacterial origin
- GO:0071222 ! cellular response to lipopolysaccharide
- GO:0071560 ! cellular response to transforming growth factor beta stimulus
- GO:0071346 ! cellular response to type II interferon
- GO:0071277 ! cellular response to calcium ion
- GO:0030154 ! cell differentiation
- GO:0045165 ! cell fate commitment
- GO:0016477 ! cell migration
- GO:0009986 ! cell surface
- GO:0060067 ! cervix development
- GO:0036517 ! chemoattraction of serotonergic neuron axon
- GO:1902379 ! chemoattractant activity involved in axon guidance
- GO:0036518 ! chemorepulsion of dopaminergic neuron axon
- Chordata
- GO:0090103 ! cochlea morphogenesis
- GO:0060026 ! convergent extension
- GO:0060028 ! convergent extension involved in axis elongation
- GO:0060029 ! convergent extension involved in organogenesis
- Craniata
- GO:0005125 ! cytokine activity
- GO:0005737 ! cytoplasm
d
e
- GO:0042733 ! embryonic digit morphogenesis
- GO:0030326 ! embryonic limb morphogenesis
- GO:0048706 ! embryonic skeletal system development
- GO:0005788 ! endoplasmic reticulum lumen
- GO:0060750 ! epithelial cell proliferation involved in mammary gland duct elongation
- GO:0001837 ! epithelial to mesenchymal transition
- GO:0001736 ! establishment of planar polarity
- GO:0045198 ! establishment of epithelial cell apical/basal polarity
- Euarchontoglires
- Eukaryota
- Euteleostomi
- Eutheria
- GO:0031012 ! extracellular matrix
- GO:0005615 ! extracellular space
- GO:0005576 ! extracellular region
h
l
m
- GO:0008584 ! male gonad development
- Mammalia
- GO:0060744 ! mammary gland branching involved in thelarche
- GO:0097325 ! melanocyte proliferation
- GO:0060638 ! mesenchymal-epithelial cell signaling
- GO:0060809 ! mesodermal to mesenchymal transition involved in gastrulation
- Metazoa
- GO:0030901 ! midbrain development
- GO:1904948 ! midbrain dopaminergic neuron differentiation
- GO:0007494 ! midgut development
- GO:0002009 ! morphogenesis of an epithelium
- GO:0007275 ! multicellular organism development
- Muridae
- Murinae
- Muroidea
- Mus
- Mus musculus
n
- GO:0050919 ! negative chemotaxis
- GO:0060686 ! negative regulation of prostatic bud formation
- GO:0030514 ! negative regulation of BMP signaling pathway
- GO:0043066 ! negative regulation of apoptotic process
- GO:0051964 ! negative regulation of synapse assembly
- GO:0045599 ! negative regulation of fat cell differentiation
- GO:0045892 ! negative regulation of DNA-templated transcription
- GO:1904934 ! negative regulation of cell proliferation in midbrain
- GO:0040037 ! negative regulation of fibroblast growth factor receptor signaling pathway
- GO:0048843 ! negative regulation of axon extension involved in axon guidance
- GO:0050680 ! negative regulation of epithelial cell proliferation
- GO:0072201 ! negative regulation of mesenchymal cell proliferation
- GO:0090090 ! negative regulation of canonical Wnt signaling pathway
- GO:0048022 ! negative regulation of melanin biosynthetic process
- GO:0021915 ! neural tube development
- GO:0001843 ! neural tube closure
- GO:0022008 ! neurogenesis
- GO:0030182 ! neuron differentiation
- GO:0048812 ! neuron projection morphogenesis
- GO:0035567 ! non-canonical Wnt signaling pathway
- GO:0048570 ! notochord morphogenesis
o
- GO:0000187 ! obsolete activation of MAPK activity
- GO:0007257 ! obsolete activation of JUN kinase activity
- GO:0038031 ! obsolete non-canonical Wnt signaling pathway via JNK cascade
- GO:0061349 ! obsolete planar cell polarity pathway involved in cardiac right atrium morphogenesis
- GO:0060775 ! obsolete planar cell polarity pathway involved in gastrula mediolateral intercalation
- GO:0061354 ! obsolete planar cell polarity pathway involved in pericardium morphogenesis
- GO:0061348 ! obsolete planar cell polarity pathway involved in ventricular septum morphogenesis
- GO:1904938 ! obsolete planar cell polarity pathway involved in axon guidance
- GO:0061347 ! obsolete planar cell polarity pathway involved in outflow tract morphogenesis
- GO:0090179 ! obsolete planar cell polarity pathway involved in neural tube closure
- GO:0003402 ! obsolete planar cell polarity pathway involved in axis elongation
- GO:0061350 ! obsolete planar cell polarity pathway involved in cardiac muscle tissue morphogenesis
- GO:1901216 ! obsolete positive regulation of neuron death
- GO:0090082 ! obsolete positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway
- GO:0010033 ! obsolete response to organic substance
- GO:1904953 ! obsolete Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation
- GO:0021891 ! olfactory bulb interneuron development
p
- GO:0048341 ! paraxial mesoderm formation
- GO:0003344 ! pericardium morphogenesis
- GO:0032729 ! positive regulation of type II interferon production
- GO:0002741 ! positive regulation of cytokine secretion involved in immune response
- GO:0032755 ! positive regulation of interleukin-6 production
- GO:0002053 ! positive regulation of mesenchymal cell proliferation
- GO:0043547 ! positive regulation of GTPase activity
- GO:0045893 ! positive regulation of DNA-templated transcription
- GO:0001934 ! positive regulation of protein phosphorylation
- GO:2000052 ! positive regulation of non-canonical Wnt signaling pathway
- GO:0070374 ! positive regulation of ERK1 and ERK2 cascade
- GO:0150012 ! positive regulation of neuron projection arborization
- GO:1904469 ! positive regulation of tumor necrosis factor secretion
- GO:0050718 ! positive regulation of interleukin-1 beta secretion
- GO:0010628 ! positive regulation of gene expression
- GO:0045860 ! positive regulation of protein kinase activity
- GO:0046330 ! positive regulation of JNK cascade
- GO:0032092 ! positive regulation of protein binding
- GO:0010976 ! positive regulation of neuron projection development
- GO:0051885 ! positive regulation of timing of anagen
- GO:2000484 ! positive regulation of interleukin-8 secretion
- GO:0001819 ! positive regulation of cytokine production
- GO:0001938 ! positive regulation of endothelial cell proliferation
- GO:0008284 ! positive regulation of cell population proliferation
- GO:0010595 ! positive regulation of endothelial cell migration
- GO:0050679 ! positive regulation of epithelial cell proliferation
- GO:0045836 ! positive regulation of meiotic nuclear division
- GO:0045080 ! positive regulation of chemokine biosynthetic process
- GO:0070245 ! positive regulation of thymocyte apoptotic process
- GO:0045732 ! positive regulation of protein catabolic process
- GO:0045745 ! positive regulation of G protein-coupled receptor signaling pathway
- GO:0045766 ! positive regulation of angiogenesis
- GO:0045807 ! positive regulation of endocytosis
- GO:0045944 ! positive regulation of transcription by RNA polymerase II
- GO:0043032 ! positive regulation of macrophage activation
- GO:0048146 ! positive regulation of fibroblast proliferation
- GO:0050729 ! positive regulation of inflammatory response
- GO:0051092 ! positive regulation of NF-kappaB transcription factor activity
- GO:0061036 ! positive regulation of cartilage development
- GO:0060907 ! positive regulation of macrophage cytokine production
- GO:0060340 ! positive regulation of type I interferon-mediated signaling pathway
- GO:0060760 ! positive regulation of response to cytokine stimulus
- GO:0043507 ! positive regulation of JUN kinase activity
- GO:0045778 ! positive regulation of ossification
- GO:2000049 ! positive regulation of cell-cell adhesion mediated by cadherin
- GO:1900020 ! positive regulation of protein kinase C activity
- GO:0010800 ! positive regulation of peptidyl-threonine phosphorylation
- GO:0010820 ! positive regulation of T cell chemotaxis
- GO:0090037 ! positive regulation of protein kinase C signaling
- GO:0022409 ! positive regulation of cell-cell adhesion
- GO:0033138 ! positive regulation of peptidyl-serine phosphorylation
- GO:0036342 ! post-anal tail morphogenesis
- GO:0098794 ! postsynapse
- GO:0003138 ! primary heart field specification
- GO:0090009 ! primitive streak formation
- GO:0019904 ! protein domain specific binding
- GO:0006468 ! protein phosphorylation
r
- GO:0005115 ! receptor tyrosine kinase-like orphan receptor binding
- GO:0050807 ! regulation of synapse organization
- GO:0060762 ! regulation of branching involved in mammary gland duct morphogenesis
- GO:0099175 ! regulation of postsynapse organization
- GO:0043122 ! regulation of canonical NF-kappaB signal transduction
- GO:0010469 ! regulation of signaling receptor activity
- GO:0099566 ! regulation of postsynaptic cytosolic calcium ion concentration
- GO:1903827 ! regulation of cellular protein localization
- GO:0032880 ! regulation of protein localization
- Rodentia
s
t
