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PMID:23497616
| Citation |
Kuroda, K, Kuang, S, Taketo, MM and Rudnicki, MA (2013) Canonical Wnt signaling induces BMP-4 to specify slow myofibrogenesis of fetal myoblasts. Skelet Muscle 3:5 |
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| Abstract |
The Wnts are secreted proteins that play important roles in skeletal myogenesis, muscle fiber type diversification, neuromuscular junction formation and muscle stem cell function. How Wnt proteins orchestrate such diverse activities remains poorly understood. Canonical Wnt signaling stabilizes β-catenin, which subsequently translocate to the nucleus to activate the transcription of TCF/LEF family genes. |
| Links |
PubMed PMC3602004 Online version:10.1186/2044-5040-3-5 |
| Keywords |
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| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0016055: Wnt receptor signaling pathway |
ECO:0000314: |
P |
fg1. Canonical wnt signaling activated during fetal myogenisis and reduced in adult. fg2. Muscle-specific constitutive activation of each canonical wnt signaling promotes oxidative myofiber phenotype. fg5. induces slow myosin heavy chain expression in fetal myoblasts |
complete | ||||
See also
References
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